MA37765A1 - Composés de pyrazole substitués utilisés comme antagonistes de lpar - Google Patents
Composés de pyrazole substitués utilisés comme antagonistes de lparInfo
- Publication number
- MA37765A1 MA37765A1 MA37765A MA37765A MA37765A1 MA 37765 A1 MA37765 A1 MA 37765A1 MA 37765 A MA37765 A MA 37765A MA 37765 A MA37765 A MA 37765A MA 37765 A1 MA37765 A1 MA 37765A1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds used
- pyrazole compounds
- substituted pyrazole
- lpar antagonists
- lpar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
L'invention concerne des composés de formule (i) ainsi que des sels pharmaceutiquement acceptables de ceux-ci, les substituants étant ceux qui sont indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies et de troubles inflammatoires tels que le fibrose pulmonaire par exemple.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661958P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062458 WO2013189862A1 (fr) | 2012-06-20 | 2013-06-17 | Composés de pyrazole substitués utilisés comme antagonistes de lpar |
Publications (1)
Publication Number | Publication Date |
---|---|
MA37765A1 true MA37765A1 (fr) | 2017-04-28 |
Family
ID=48656033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37765A MA37765A1 (fr) | 2012-06-20 | 2013-06-17 | Composés de pyrazole substitués utilisés comme antagonistes de lpar |
Country Status (22)
Country | Link |
---|---|
US (1) | US20150259295A1 (fr) |
EP (1) | EP2864294A1 (fr) |
JP (1) | JP2015520201A (fr) |
KR (1) | KR20150011003A (fr) |
CN (1) | CN104411690A (fr) |
AU (1) | AU2013279510A1 (fr) |
BR (1) | BR112014031108A2 (fr) |
CA (1) | CA2869602A1 (fr) |
CL (1) | CL2014003242A1 (fr) |
CO (1) | CO7160077A2 (fr) |
CR (1) | CR20140516A (fr) |
EA (1) | EA201492283A1 (fr) |
HK (1) | HK1206341A1 (fr) |
IL (1) | IL236091A0 (fr) |
IN (1) | IN2014DN09347A (fr) |
MA (1) | MA37765A1 (fr) |
MX (1) | MX2014014105A (fr) |
PE (1) | PE20142445A1 (fr) |
PH (1) | PH12014502364A1 (fr) |
SG (1) | SG11201407229UA (fr) |
UA (1) | UA109867C2 (fr) |
WO (1) | WO2013189862A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140067048A (ko) | 2011-08-15 | 2014-06-03 | 인터뮨, 인크. | 라이소포스파티드산 수용체 길항제 |
KR102090231B1 (ko) | 2013-03-15 | 2020-03-17 | 에피젠 바이오싸이언시즈, 아이엔씨. | 질환의 치료에 유용한 헤테로환식 화합물 |
ES2824801T3 (es) | 2014-06-27 | 2021-05-13 | Ube Industries | Sal de compuesto heterocíclico sustituido con halógeno |
AU2018388482A1 (en) * | 2017-12-19 | 2020-07-30 | Bristol-Myers Squibb Company | Pyrazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
CN111434655A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 溶血磷脂酸受体拮抗剂及其制备方法 |
US11548871B2 (en) | 2019-11-15 | 2023-01-10 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof |
US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
TW202344504A (zh) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
US20220411405A1 (en) * | 2021-05-11 | 2022-12-29 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005063241A1 (fr) * | 2003-12-26 | 2005-07-14 | Ono Pharmaceutical Co., Ltd. | Agent pour prevenir et/ou de traiter des maladies faisant intervenir un recepteur de benzodiazepine mitochondrial |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
EP2462128B1 (fr) * | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Composés en tant qu'antagonistes du récepteur de l'acide lysophosphatidique |
PE20140879A1 (es) * | 2010-12-07 | 2014-08-06 | Amira Pharmaceuticals Inc | Antagonistas del receptor de acido lisofosfatidico para el tratamiento de fibrosis |
WO2012138648A1 (fr) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions et procédés pour la modulation de récepteurs au lpa |
KR20140067048A (ko) * | 2011-08-15 | 2014-06-03 | 인터뮨, 인크. | 라이소포스파티드산 수용체 길항제 |
-
2013
- 2013-06-17 JP JP2015517702A patent/JP2015520201A/ja active Pending
- 2013-06-17 MA MA37765A patent/MA37765A1/fr unknown
- 2013-06-17 CN CN201380032266.8A patent/CN104411690A/zh active Pending
- 2013-06-17 BR BR112014031108A patent/BR112014031108A2/pt not_active Application Discontinuation
- 2013-06-17 SG SG11201407229UA patent/SG11201407229UA/en unknown
- 2013-06-17 AU AU2013279510A patent/AU2013279510A1/en not_active Abandoned
- 2013-06-17 WO PCT/EP2013/062458 patent/WO2013189862A1/fr active Application Filing
- 2013-06-17 EP EP13729940.0A patent/EP2864294A1/fr not_active Withdrawn
- 2013-06-17 MX MX2014014105A patent/MX2014014105A/es unknown
- 2013-06-17 KR KR1020147035552A patent/KR20150011003A/ko not_active Application Discontinuation
- 2013-06-17 IN IN9347DEN2014 patent/IN2014DN09347A/en unknown
- 2013-06-17 PE PE2014002212A patent/PE20142445A1/es not_active Application Discontinuation
- 2013-06-17 CA CA2869602A patent/CA2869602A1/fr not_active Abandoned
- 2013-06-17 US US14/402,128 patent/US20150259295A1/en not_active Abandoned
- 2013-06-17 UA UAA201500427A patent/UA109867C2/ru unknown
- 2013-06-17 EA EA201492283A patent/EA201492283A1/ru unknown
-
2014
- 2014-10-22 PH PH12014502364A patent/PH12014502364A1/en unknown
- 2014-11-11 CR CR20140516A patent/CR20140516A/es unknown
- 2014-11-28 CL CL2014003242A patent/CL2014003242A1/es unknown
- 2014-12-04 IL IL236091A patent/IL236091A0/en unknown
- 2014-12-19 CO CO14279332A patent/CO7160077A2/es unknown
-
2015
- 2015-07-21 HK HK15106926.9A patent/HK1206341A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2015520201A (ja) | 2015-07-16 |
CR20140516A (es) | 2014-12-01 |
EP2864294A1 (fr) | 2015-04-29 |
CL2014003242A1 (es) | 2015-03-20 |
US20150259295A1 (en) | 2015-09-17 |
IN2014DN09347A (fr) | 2015-07-17 |
AU2013279510A1 (en) | 2014-10-16 |
WO2013189862A1 (fr) | 2013-12-27 |
BR112014031108A2 (pt) | 2017-06-27 |
CO7160077A2 (es) | 2015-01-15 |
UA109867C2 (ru) | 2015-10-12 |
EA201492283A1 (ru) | 2015-04-30 |
CA2869602A1 (fr) | 2013-12-27 |
SG11201407229UA (en) | 2014-12-30 |
HK1206341A1 (en) | 2016-01-08 |
PH12014502364A1 (en) | 2015-01-12 |
KR20150011003A (ko) | 2015-01-29 |
IL236091A0 (en) | 2015-02-01 |
PE20142445A1 (es) | 2015-01-28 |
CN104411690A (zh) | 2015-03-11 |
MX2014014105A (es) | 2015-03-05 |
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