KR970706027A - 골 형성용 이식체(Osteoplastic graft) - Google Patents

골 형성용 이식체(Osteoplastic graft)

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Publication number
KR970706027A
KR970706027A KR1019970701932A KR19970701932A KR970706027A KR 970706027 A KR970706027 A KR 970706027A KR 1019970701932 A KR1019970701932 A KR 1019970701932A KR 19970701932 A KR19970701932 A KR 19970701932A KR 970706027 A KR970706027 A KR 970706027A
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acid
bioabsorbable
gelatin
polylactic acid
group
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KR1019970701932A
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쇼지 요코타
세이타로 시모카와
리쓰 소노하라
아키라 오카다
고이치로 다카하시
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오노타 마사요시
야마노우치세야쿠 가부시키가이샤
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Publication of KR970706027A publication Critical patent/KR970706027A/ko

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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Dermatology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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Abstract

본 발명은 생체 흡수성 친수성 재료로 이루어지는 다공성 구조체의 표면에 생체 흡수성 고분자 재료로 이루어지는 표면층을 갖는 복합 다공질체에, 골 유도인자를 함유하는 것을 특징으로 하는 골 형성용 이식체에 관한 것이다. 바람직하게, 생체 흡수성 친수성 재료는 젤라틴, 히알루론산, 히알루론산 유도체, 콜라겐, 콜라겐 유도체, 키토산, 키토산 유도체 및 트리에탄올아민 알기네이트로 이루어지는 그룹에서 선택되는 1종 이상의 화합물을 포함하며, 생체 흡수성 고분자 재료는 폴리락트산, 폴리락트산 폴리글리콜산 공중합체 및 폴리〔비스b-카복시페녹시)프로판〕무수물과 세바신산과의 공중합체로 이루어지는 그룹에서 선택되는 1종 이상의 화합물을 포함한다. 본 발명의 골 형성용 이식체는 성형성 ·조적성에 있어 우수하고, 생체내 골 신현성에 적하한 내부 구조를 지니기 때문에, 골 이식은 이식체의 주변부 뿐만 아니라 이식체의 내부에서도 일어난다.

Description

골 형성용 이식체(Osteoplastic graft)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 생체 흡수성 친수성 재료로 이루어지는 다공성 구조체의 표면에 생체 흡수성 고분자 재료로 이루어지는 표면층을 갖는 복합 다공질체에, 골 유도 인자를 담지하는 것을 특징으로 하는 골 형성용 이식체.
  2. 제1항에 있어서, 생체 흡수성 친수성 재료가, 젤라틴, 히알루론산, 히알루론산 유도체, 콜라겐, 콜라겐 유도체, 키토산, 키토산 유도체 및 알긴산 트리에탄올 아민으로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 화합물이고, 생체 흡수성 고분자 재료가 폴리락트산, 폴리락트산 폴리글리콜산 공중합체 및 폴리〔비스(P-카복시페녹시)프로판〕 무수물과 세바신산과의 공중합체로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 화합물인 골 형성용 이식체.
  3. 제2항에 있어서, 생체 흡수성 친수성 재료가, 젤라틴, 젤라턴/히알루론산폴리이온복합체, 및 콜라겐으로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 화합물인 글 형성용 이식체.
  4. 제2항 또는 제3항에 있어서, 생체 흡수성 고분자 재료가, 평균 분자량 5,OOO 내지 1,500,O0O의 폴리락트산 및 평균 분자량 5,00O 내지 1,500,000의 폴리락트산의 함유율(몰비)이 40% 이상인 폴리락트산 폴리글리콜산 공중합체로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 화합물인 골 형성용 이식체.
  5. 제1항에 있어서, 복합 다공질체의 표면층에 추가로 계면활성체를 첨가한 골 형성용 이식체.
  6. 제1항에 있어서, 복합 다공질체의 평균 구멍 직경이 1O 내지 1,OOO㎛이고, 기공율이 60% 이상인 골 형성용 이식체.
  7. 제6항에 있어서, 복합 다공질체의 평균 구멍 직경이 4O 내지 600㎛이고, 기공율이 80% 이상인 골 형성용 이식체.
  8. 제3항 또는 제7항에 있어서, 다공성 구조체가 평균 구멍 직경 5O 내지 500㎛이고 기공율 90% 이상의 젤라틴 스폰지인 골 형성용 이식체.
  9. 젤라틴, 히알루론산 및 히알루론산 유도체로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 생체흡수성 친수성 재료로 이루어지는 다공성 구조체의 표면에, 폴리락트산, 폴리락트산 폴리글리콜산 공중합체 및 폴리〔비스-(p-카르복시페녹시)프로판〕 무수물과 세바신산과의 공중합체로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 생체 흡수성 고분자 재료를 부여하여 형성되는 복합 다공질체.
  10. 제9항에 있어서, 생체 흡수성 친수성 재료가, 젤라틴 및 젤라틴/히알루론산 폴리 이온 복합체로 이루어지는 그룹에서 선택되는 1종 또는 2종 이상의 화합물인 복합 다공질체.
  11. 제9항 또는 제1O항에 있어서, 생체 흡수성 고분자 재료가, 평균 분자량5,OOO 내지 1,500,OO의 폴리락트산 및 평균 분자량 5,0OO 내지 1,500,OOO의 폴리락트산의 함유율(몰비)이 40% 이상인 폴리락트산 폴리글리콜산공중합체로 이루어지는 그룹에서 선택되는 l종 또는 2종 이상의 화합물인 복합 다공질체.
  12. 제11항에 있어서, 다공성 구조체가, 평균구멍 직경 5O 내지 500㎛이고 기공율90% 이상의 젤라틴 스폰지인 다공질체.
  13. 제9항에 있어서, 복합 다공질체의 표면층에 추가로 계면활성체를 첨가한 복합 다공질체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701932A 1994-09-30 1995-09-28 골 형성용 이식체(Osteoplastic graft) KR970706027A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP94-261980 1994-09-30
JP26198094 1994-09-30
PCT/JP1995/001970 WO1996010426A1 (fr) 1994-09-30 1995-09-28 Greffon osteoplastique

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KR970706027A true KR970706027A (ko) 1997-11-03

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Country Link
US (1) US5830493A (ko)
EP (1) EP0784985A4 (ko)
KR (1) KR970706027A (ko)
CN (1) CN1158573A (ko)
AU (1) AU3577895A (ko)
CA (1) CA2200052A1 (ko)
MX (1) MX9702305A (ko)
TW (1) TW369414B (ko)
WO (1) WO1996010426A1 (ko)

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TW369414B (en) 1999-09-11
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