KR920701153A - 옥시인돌 유도체 - Google Patents
옥시인돌 유도체Info
- Publication number
- KR920701153A KR920701153A KR1019910700315A KR910700315A KR920701153A KR 920701153 A KR920701153 A KR 920701153A KR 1019910700315 A KR1019910700315 A KR 1019910700315A KR 910700315 A KR910700315 A KR 910700315A KR 920701153 A KR920701153 A KR 920701153A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- oxyindole
- lower alkoxy
- lower alkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식으로 표시되는 옥시인돌유도체, 식중, R1은 수소원자, 할로겐원자, 저급알킬기 또는 저급알콕시기, R2는 수소원자 또는 저급알킬기, R3는 -CH2-R5(R5는 고리를 형성할 수 있는 알킬기, 벤조디옥사닐기 또는 치환기로서 할로겐원자, 저급알킬기, 저급알콕시기, 히드록시기, 디에틸아미노기, 트리플루오로메틸기, 니트릴기, 니트로기 또는 벤질 옥시기를 복수개 가질 수 있는 페닐기)를 표시함, 또, R2와 R3는 함께 =CH-R5기(R5는 상기와 같다)를 형성할 수 있다.R4는 1-프로필부틸기, 피리딜기 또는 치환기로서 저급알콕시, 할로겐원자, 디에틸아미노기, 벤질옥시기, 트리플루오로메틸기, 니트릴기, 니트로기 또는 저급 알킬기를 가질 수 있는 페닐기를 표시함.
- 제1항에 있어서, R1은 수소원자 또는 저급알콕시기, R2는 수소원자, R3는 -CH2-R5기(R5는 치환기로서 할로겐원자, 저급알킬기, 저급알콕시기, 히드록시기, 디에틸아미노기를 복수개 가질수 있는 페닐기), R4는 1-프로필 부틸기, 피리딜기 또는 치환기로서 저급알콕시기를 복수개 가질수 있는 페닐기인 것을 특징으로 하는 옥시인돌유도체.
- 제1항에 있어서, R1, R2는 수소원자, R3는 -CH2-R5기(R5는 메톡시기를 1∼3개 가지는 페닐기), R4는 4-메톡시페닐기 혹은 페닐기인 것을 특징으로 하는 옥시인돌유도체.
- 제1항에 있어서, 1-(4-메톡시벤조일)-3-(4-메톡시벤질)옥시인돌인 것을 특징으로 하는 옥시인돌유도체.
- 제1항에 있어서, 1-(4-메톡시벤조일)-3-(2,3,4-트리메톡시벤질)옥시인돌인 것을 특징으로 하는 옥시인돌유도체.
- 제1항의 옥시인돌유도체의 유효량과 약리학적 허용 담체를 함유하는 것을 특징으로 하는 뇌기능개선 및 뇌대사부활ㆍ보호제.
- 제1항의 옥시인돌유도체의 유효량을 환자에 투여하는 것을 특징으로 하는 뇌기능개선 및 뇌대사 부활, 보호 방법.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19182289 | 1989-07-25 | ||
JP1-191822 | 1989-07-25 | ||
PCT/JP1990/000945 WO1991001306A1 (fr) | 1989-07-25 | 1990-07-23 | Derive oxoindole |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920701153A true KR920701153A (ko) | 1992-08-11 |
KR930011300B1 KR930011300B1 (ko) | 1993-11-29 |
Family
ID=16281100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910700315A KR930011300B1 (ko) | 1989-07-25 | 1990-07-23 | 옥시인돌유도체 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5206261A (ko) |
EP (1) | EP0429685B1 (ko) |
JP (1) | JP2739188B2 (ko) |
KR (1) | KR930011300B1 (ko) |
AT (1) | ATE159718T1 (ko) |
CA (1) | CA2037923C (ko) |
DE (1) | DE69031649T2 (ko) |
DK (1) | DK0429685T3 (ko) |
ES (1) | ES2110965T3 (ko) |
WO (1) | WO1991001306A1 (ko) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
CA2128233A1 (en) * | 1992-01-16 | 1993-07-22 | Wendell Wilkie Wilkerson | Novel neurotransmitter releasers useful for cognition enhancement |
US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
US5310935A (en) * | 1992-06-30 | 1994-05-10 | Pharmagroup International | Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids |
FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
DE69722858T2 (de) * | 1996-01-17 | 2004-05-13 | Taiho Pharmaceutical Co. Ltd. | Intimale verdickungsinhibitoren |
US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
US6531502B1 (en) * | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
AU760039B2 (en) | 1998-12-17 | 2003-05-08 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of JNK protein kinases |
TR200101860T2 (tr) | 1998-12-17 | 2001-12-21 | F.Hoffmann-La Roche Ag | Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
CN1158283C (zh) | 1998-12-17 | 2004-07-21 | 霍夫曼-拉罗奇有限公司 | 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 |
US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
CA2396319A1 (en) * | 2000-01-18 | 2001-07-26 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
NZ520640A (en) * | 2000-02-15 | 2005-04-29 | Upjohn Co | Pyrrole substituted 2-indolinone protein kinase inhibitors |
FR2807038B1 (fr) * | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
WO2003031438A1 (en) | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
ES2334578T3 (es) | 2005-02-07 | 2010-03-12 | F. Hoffmann-La Roche Ag | Fenil-metanonas sustituidas por heterociclo como inhibidores del transportador 1 de la glicina. |
WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
EP2073806B1 (en) | 2006-10-12 | 2012-02-15 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
RU2544852C2 (ru) | 2009-10-14 | 2015-03-20 | Ксенон Фармасьютикалз Инк. | Способы синтеза спиро-оксиндольных соединений |
BR112012021086A2 (pt) | 2010-02-26 | 2016-05-17 | Xenon Pharmaceuticals Inc | composições farmacêuticas de composto espiro-oxindole para administração tópica e seu uso como agentes terapêuticos |
TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
CN106946759B (zh) * | 2017-03-22 | 2020-02-14 | 中南大学 | 2-吲哚酮衍生物及其开环衍生物及合成方法与用途 |
CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3428649A (en) * | 1968-01-23 | 1969-02-18 | Mcneilab Inc | Oxindole derivatives |
DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
-
1990
- 1990-07-23 DK DK90910878.9T patent/DK0429685T3/da active
- 1990-07-23 KR KR1019910700315A patent/KR930011300B1/ko not_active IP Right Cessation
- 1990-07-23 JP JP2510214A patent/JP2739188B2/ja not_active Expired - Fee Related
- 1990-07-23 ES ES90910878T patent/ES2110965T3/es not_active Expired - Lifetime
- 1990-07-23 DE DE69031649T patent/DE69031649T2/de not_active Expired - Fee Related
- 1990-07-23 WO PCT/JP1990/000945 patent/WO1991001306A1/ja active IP Right Grant
- 1990-07-23 AT AT90910878T patent/ATE159718T1/de not_active IP Right Cessation
- 1990-07-23 US US07/663,960 patent/US5206261A/en not_active Expired - Lifetime
- 1990-07-23 EP EP90910878A patent/EP0429685B1/en not_active Expired - Lifetime
- 1990-07-23 CA CA002037923A patent/CA2037923C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1991001306A1 (fr) | 1991-02-07 |
US5206261A (en) | 1993-04-27 |
EP0429685A4 (en) | 1991-12-04 |
DK0429685T3 (da) | 1997-12-15 |
CA2037923C (en) | 1996-08-06 |
ES2110965T3 (es) | 1998-03-01 |
ATE159718T1 (de) | 1997-11-15 |
EP0429685A1 (en) | 1991-06-05 |
DE69031649D1 (de) | 1997-12-04 |
DE69031649T2 (de) | 1998-02-26 |
AU617621B2 (en) | 1991-11-28 |
AU6032190A (en) | 1991-02-22 |
CA2037923A1 (en) | 1991-01-26 |
JP2739188B2 (ja) | 1998-04-08 |
EP0429685B1 (en) | 1997-10-29 |
KR930011300B1 (ko) | 1993-11-29 |
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