ES2110965T3 - Derivado de oxoindol. - Google Patents

Derivado de oxoindol.

Info

Publication number
ES2110965T3
ES2110965T3 ES90910878T ES90910878T ES2110965T3 ES 2110965 T3 ES2110965 T3 ES 2110965T3 ES 90910878 T ES90910878 T ES 90910878T ES 90910878 T ES90910878 T ES 90910878T ES 2110965 T3 ES2110965 T3 ES 2110965T3
Authority
ES
Spain
Prior art keywords
lower alkyl
halogen
lower alkoxy
alkyl
benzyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910878T
Other languages
English (en)
Inventor
Akihiro Kawaguchi
Atsushi Sato
Makoto Kajitani
Mitsugi Yasumoto
Junji Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2110965T3 publication Critical patent/ES2110965T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

LOS DERIVADOS OXOINDOLE DE LA FORMULA GENERAL (1), UTILES PARA EL TRATAMIENTO DE LA DEMENCIA SENIL, POR EJ; MEJORANDO LAS FUNCIONES DEL CEREBRO Y ACTIVANDO Y PROTEGIENDO EL METABOLISMO CEREBRAL. EN LA FORMULA, R ELEVADO 1 REPRESENTA EL HIDROGENO, HALOGENO, ALCALI BAJO O ALKOXI BAJO ; R (AL CUADRADO) REPRESENTA HIDROGENO O ALCALI BAJO; R ELEVADO 3 REPRESENTA UNA PLURALIDAD DE HALOGENOS, DE ALCALIS BAJOS, DE ALKOXI BAJOS, DE HIDROXILOS, DIETILAMINAS, TRIFLUOROMETIL, NITRILOS, NITRO O BENZILOXI; ALTERNATIVAMENTE R (AL CUADRADO) Y R ELEVADO 3 PUEDEN COMBINARSE DESDE = CH SEGUN SE DEFINE ANTERIORMENTE; Y R ELEVADO 4 REPRESENTA 1-PROPILBUTIL, PIRIDIL, O FENIL QUE PUEDEN SUSTITUIRSE CON ALKOXI BAJO, HALOGENO, DIETILAMINAS, BENZILOXIL, TRIFLUOROMETIL, NITRILO, NITRO O ALCALI BAJO.
ES90910878T 1989-07-25 1990-07-23 Derivado de oxoindol. Expired - Lifetime ES2110965T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19182289 1989-07-25

Publications (1)

Publication Number Publication Date
ES2110965T3 true ES2110965T3 (es) 1998-03-01

Family

ID=16281100

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910878T Expired - Lifetime ES2110965T3 (es) 1989-07-25 1990-07-23 Derivado de oxoindol.

Country Status (10)

Country Link
US (1) US5206261A (es)
EP (1) EP0429685B1 (es)
JP (1) JP2739188B2 (es)
KR (1) KR930011300B1 (es)
AT (1) ATE159718T1 (es)
CA (1) CA2037923C (es)
DE (1) DE69031649T2 (es)
DK (1) DK0429685T3 (es)
ES (1) ES2110965T3 (es)
WO (1) WO1991001306A1 (es)

Families Citing this family (39)

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RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
EP0623127B1 (en) * 1992-01-16 1997-04-02 The Du Pont Merck Pharmaceutical Company Novel neurotransmitter releasers useful for cognition enhancement
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2686878B1 (fr) * 1992-01-30 1995-06-30 Sanofi Elf Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant.
US5310935A (en) * 1992-06-30 1994-05-10 Pharmagroup International Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids
FR2694004B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6147106A (en) * 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
RU2145852C1 (ru) * 1996-01-17 2000-02-27 Тайхо Фармасьютикал Ко., Лтд Ингибитор гипертрофии интимы, применение оксиндолового производного для получения ингибитора гипертрофии интимы, композиция для ингибирования гипертрофии интимы, способ предупреждения и лечения гипертрофии интимы
US20040067531A1 (en) * 1997-08-20 2004-04-08 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
TR200101860T2 (tr) 1998-12-17 2001-12-21 F.Hoffmann-La Roche Ag Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller
DE69938258T2 (de) 1998-12-17 2009-02-26 F. Hoffmann-La Roche Ag 4,5-pyrazinoxindole als proteinkinasehemmer
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
BR9916223A (pt) 1998-12-17 2001-09-04 Hoffmann La Roche 4-ariloxindóis como inibidores de cinases de proteìna jnk
US6689806B1 (en) * 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
AU771130B2 (en) * 2000-01-18 2004-03-11 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
AR034118A1 (es) * 2000-02-15 2004-02-04 Sugen Inc Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
FR2807038B1 (fr) * 2000-04-03 2002-08-16 Sanofi Synthelabo Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
CA2462950A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
ATE449761T1 (de) * 2005-02-07 2009-12-15 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
WO2006105795A1 (en) * 2005-04-08 2006-10-12 Leo Pharma A/S Novel indolinone derivatives
MY158766A (en) 2005-04-11 2016-11-15 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
BRPI0719210A2 (pt) 2006-10-12 2015-05-05 Xenon Pharmaceuticals Inc Uso de compostos espiro-oxindol como agentes terapêuticos
EP2350091B1 (en) 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
ES2546302T3 (es) 2008-10-17 2015-09-22 Xenon Pharmaceuticals Inc. Compuestos de espiro-oxoindol y su uso como agentes terapéuticos
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20121350A1 (es) 2009-10-14 2012-10-20 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
CN102946859B (zh) 2010-02-26 2016-03-02 泽农医药公司 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
CN106946759B (zh) * 2017-03-22 2020-02-14 中南大学 2-吲哚酮衍生物及其开环衍生物及合成方法与用途
CN114957084B (zh) * 2022-01-21 2023-05-09 九江学院 一种吲哚酮类化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3428649A (en) * 1968-01-23 1969-02-18 Mcneilab Inc Oxindole derivatives
DE3114351A1 (de) * 1981-04-09 1982-11-04 Hoechst Ag, 6000 Frankfurt "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"

Also Published As

Publication number Publication date
EP0429685B1 (en) 1997-10-29
WO1991001306A1 (fr) 1991-02-07
KR930011300B1 (ko) 1993-11-29
EP0429685A4 (en) 1991-12-04
EP0429685A1 (en) 1991-06-05
AU617621B2 (en) 1991-11-28
CA2037923C (en) 1996-08-06
US5206261A (en) 1993-04-27
AU6032190A (en) 1991-02-22
JP2739188B2 (ja) 1998-04-08
CA2037923A1 (en) 1991-01-26
DE69031649T2 (de) 1998-02-26
ATE159718T1 (de) 1997-11-15
DE69031649D1 (de) 1997-12-04
DK0429685T3 (da) 1997-12-15
KR920701153A (ko) 1992-08-11

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