DE69031649T2 - Oxoindolderivate - Google Patents
OxoindolderivateInfo
- Publication number
- DE69031649T2 DE69031649T2 DE69031649T DE69031649T DE69031649T2 DE 69031649 T2 DE69031649 T2 DE 69031649T2 DE 69031649 T DE69031649 T DE 69031649T DE 69031649 T DE69031649 T DE 69031649T DE 69031649 T2 DE69031649 T2 DE 69031649T2
- Authority
- DE
- Germany
- Prior art keywords
- lower alkyl
- halogen
- lower alkoxy
- alkyl
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19182289 | 1989-07-25 | ||
| PCT/JP1990/000945 WO1991001306A1 (fr) | 1989-07-25 | 1990-07-23 | Derive oxoindole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69031649D1 DE69031649D1 (de) | 1997-12-04 |
| DE69031649T2 true DE69031649T2 (de) | 1998-02-26 |
Family
ID=16281100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69031649T Expired - Fee Related DE69031649T2 (de) | 1989-07-25 | 1990-07-23 | Oxoindolderivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5206261A (de) |
| EP (1) | EP0429685B1 (de) |
| JP (1) | JP2739188B2 (de) |
| KR (1) | KR930011300B1 (de) |
| AT (1) | ATE159718T1 (de) |
| CA (1) | CA2037923C (de) |
| DE (1) | DE69031649T2 (de) |
| DK (1) | DK0429685T3 (de) |
| ES (1) | ES2110965T3 (de) |
| WO (1) | WO1991001306A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
| WO1993014085A1 (en) * | 1992-01-16 | 1993-07-22 | The Du Pont Merk Pharmaceutical Company | Novel neurotransmitter releasers useful for cognition enhancement |
| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
| US5310935A (en) * | 1992-06-30 | 1994-05-10 | Pharmagroup International | Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids |
| FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
| US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| ES2201266T3 (es) * | 1996-01-17 | 2004-03-16 | Taiho Pharmaceutical Company Limited | Inhibidores del espesamiento de la capa intima. |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| US6531502B1 (en) * | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| ATE387448T1 (de) | 1998-12-17 | 2008-03-15 | Hoffmann La Roche | 4,5-pyrazinoxindole als proteinkinasehemmer |
| US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| BR9916327A (pt) | 1998-12-17 | 2001-09-18 | Hoffmann La Roche | Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2 |
| EP1149093A1 (de) | 1998-12-17 | 2001-10-31 | F. Hoffmann-La Roche Ag | 4-aryloxindolen als inhibitoren von jnk proteinkinasen |
| US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| AU771130B2 (en) * | 2000-01-18 | 2004-03-11 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| CA2399358C (en) * | 2000-02-15 | 2006-03-21 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| FR2807038B1 (fr) * | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
| US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| JP2005508953A (ja) | 2001-10-10 | 2005-04-07 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 |
| DE602006010665D1 (en) | 2005-02-07 | 2010-01-07 | Hoffmann La Roche | Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1 |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY158766A (en) | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| BRPI0719210A2 (pt) | 2006-10-12 | 2015-05-05 | Xenon Pharmaceuticals Inc | Uso de compostos espiro-oxindol como agentes terapêuticos |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| SI2350090T1 (sl) | 2008-10-17 | 2015-10-30 | Xenon Pharmaceuticals Inc. | Spojine spiro-oksindola in njihova uporaba kot terapevtska sredstva |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
| PE20121699A1 (es) | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| CN106946759B (zh) * | 2017-03-22 | 2020-02-14 | 中南大学 | 2-吲哚酮衍生物及其开环衍生物及合成方法与用途 |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428649A (en) * | 1968-01-23 | 1969-02-18 | Mcneilab Inc | Oxindole derivatives |
| DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
-
1990
- 1990-07-23 EP EP90910878A patent/EP0429685B1/de not_active Expired - Lifetime
- 1990-07-23 WO PCT/JP1990/000945 patent/WO1991001306A1/ja active IP Right Grant
- 1990-07-23 US US07/663,960 patent/US5206261A/en not_active Expired - Lifetime
- 1990-07-23 JP JP2510214A patent/JP2739188B2/ja not_active Expired - Fee Related
- 1990-07-23 AT AT90910878T patent/ATE159718T1/de not_active IP Right Cessation
- 1990-07-23 DE DE69031649T patent/DE69031649T2/de not_active Expired - Fee Related
- 1990-07-23 ES ES90910878T patent/ES2110965T3/es not_active Expired - Lifetime
- 1990-07-23 CA CA002037923A patent/CA2037923C/en not_active Expired - Fee Related
- 1990-07-23 KR KR1019910700315A patent/KR930011300B1/ko not_active IP Right Cessation
- 1990-07-23 DK DK90910878.9T patent/DK0429685T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991001306A1 (fr) | 1991-02-07 |
| KR930011300B1 (ko) | 1993-11-29 |
| EP0429685A1 (de) | 1991-06-05 |
| DE69031649D1 (de) | 1997-12-04 |
| KR920701153A (ko) | 1992-08-11 |
| ATE159718T1 (de) | 1997-11-15 |
| CA2037923A1 (en) | 1991-01-26 |
| CA2037923C (en) | 1996-08-06 |
| JP2739188B2 (ja) | 1998-04-08 |
| AU617621B2 (en) | 1991-11-28 |
| DK0429685T3 (da) | 1997-12-15 |
| US5206261A (en) | 1993-04-27 |
| EP0429685A4 (en) | 1991-12-04 |
| ES2110965T3 (es) | 1998-03-01 |
| EP0429685B1 (de) | 1997-10-29 |
| AU6032190A (en) | 1991-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |