KR890017362A - 폴리에테르 항생물질 - Google Patents

폴리에테르 항생물질 Download PDF

Info

Publication number
KR890017362A
KR890017362A KR1019890005813A KR890005813A KR890017362A KR 890017362 A KR890017362 A KR 890017362A KR 1019890005813 A KR1019890005813 A KR 1019890005813A KR 890005813 A KR890005813 A KR 890005813A KR 890017362 A KR890017362 A KR 890017362A
Authority
KR
South Korea
Prior art keywords
antibiotic
alkyl
benzeneamine
derivative
agriculturally acceptable
Prior art date
Application number
KR1019890005813A
Other languages
English (en)
Inventor
엘.해밀 로버트
체-펑 요 레이몬드
Original Assignee
메리 앤 터커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메리 앤 터커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 터커
Publication of KR890017362A publication Critical patent/KR890017362A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

폴리에테르 항생물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 클로로포름중의 A82810의 적외선 흡수 스펙트럼을 도시한 도이다. 제2도는 클로로포름중의 A82810나트륨염의 적외선 흡수 스펙트럼을 도시한 도이다. 제3도는 A82810아세틸 에스테르 유도체의 IR스펙트럼을 도시한 도이다.

Claims (10)

  1. 일반식(1)의 항생물질 A82810(여기에서, R은 수소이다)또는 그의 유도체(여기에서, R은 -CONHR1이고 R1은 알킬, 아릴, 알킬-아릴, 아릴알킬, 할로아릴, 니트로아릴, 할로아릴-알킬, 알콕시아릴, 아릴록시아릴, 아릴사이클로알킬, 아실아릴 및 사이클로알킬이다); 또는 그의 아실 또는 알킬 에스테르 또는 알킬 에테르 유도체; 또는 그의 염.
  2. 항생물질 A82810 또는 그의 농업적으로 허용할 수 있는 염.
  3. 항생물질 A82810.
  4. R이 수소가 아닌 A82810의 유도체.
  5. 탄소, 질소 및 무기염의 동화성 공급원을 함유한 배양배지에서 악티노마두라 피브로사(Actinomadura fibrosa)종 nov.NRRL 18348 또는 그의 A82810-생산 돌연변이체를 침수(浸水)된 호기성 발효 조건하에 항생물질 A82810을 제조하도록 배양하고; 임의로 적절하게 염화(鹽化)시키고, 에스테르화시키고, 아실화시키고, 그의 에테르 유도체를 생성시키거나 또는 일반식 R1-NCO의 이소시아네이트와 반응시킴을 포함하는, 제1항 내지 제4항중 어느 한 항에 청구한 바와 같은 항생물질 A82810 또는 그의 유도체의 제조방법.
  6. 악티노마두라 피브로사 종 nov.NRRL 18348 또는 그의 A82810-생산 돌연변이체의 생물학적으로 순수한 배양물.
  7. 농업적으로 허용할 수 있는 담체와 함께, 활성성분으로 제1항 내지 제4항 중 어느 한 항에서 청구한 바와같은 항생물질 A82810 또는 그의 유도체를 포함하는 항콕시드 조성물.
  8. 하나이상의 농업적으로 허용할 수 있는 동물사료 예비혼합물용 담체와 함께, 활성성분으로 제1항 내지 제4항 중 어느 한 항에서 청구한 바와같은 항생물질 A82810 또는 그의 유도체를 포함하는 동물사료 예비혼합물.
  9. 제7항 또는 제8항중 어느 한 항에 있어서, a) 니카바진, b) 4,4'-디니트로카바닐라이드, c) 하기 일반식의 나프탈렌아민, d) 2,4-디니트로-N-[4-(트리플루오로메톡시)페닐]-6-(트리플루오로메틸)벤젠아민, 2,4-디니트로-N-[4-(1,1,2,2-테트라플루오로에톡시)페닐]-6-(트리플루오로메틸)벤젠아민 또는 2,4-디니트로-N-[4-펜타플루오로에톡시)페닐]-6-(트리플루오로메틸)벤젠아민 중에서 선택된 벤젠아민; e) 메티클로르핀돌; 또는 f) (a) 내지 (e)화합물의 약제학적으로 허용할 수 있는 염으로 이루어진 그룹 중에서 선택된 제2성분을 또한 함유하는 항콕시드 조성물.
    상기 식에서, R2는 C1내지 C4알킬이고; R3는 할로겐, C1내지 C4플루오로알킬, C1내지 C4플루오로알콕시 또는 C1내지 C4플루올알킬티오이고; R4는 할로겐이고; R5는 수소 또는 할로겐이고; m은 0,1 또는 2이고; n은 0 또는 1이며, 이때 R4치환기가 존재한다면 R4치환기는 2-위치가 아닌 다른 위치이어야 한다.
  10. 활성성분으로 A82810 또는 그의 농업적으로 허용할 수 있는 염과 2,4-디니트로-N-[4-(1,1,2,2-테트라플루오로에톡시)페닐]-6-(트리플루오로메틸)벤젠아민 또느 그의 농업적으로 허용할 수 있는 염을 포함하는 항콕시드 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005813A 1988-05-02 1989-05-01 폴리에테르 항생물질 KR890017362A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18949988A 1988-05-02 1988-05-02
US189499 1988-05-02

Publications (1)

Publication Number Publication Date
KR890017362A true KR890017362A (ko) 1989-12-15

Family

ID=22697597

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890005813A KR890017362A (ko) 1988-05-02 1989-05-01 폴리에테르 항생물질

Country Status (19)

Country Link
EP (1) EP0341019B1 (ko)
JP (1) JPH0215085A (ko)
KR (1) KR890017362A (ko)
CN (1) CN1038838A (ko)
AT (1) ATE84535T1 (ko)
AU (1) AU625818B2 (ko)
CY (1) CY1699A (ko)
DE (1) DE68904348T2 (ko)
DK (1) DK211289A (ko)
FI (1) FI892077A (ko)
GR (1) GR3007507T3 (ko)
HK (1) HK54893A (ko)
HU (1) HU204893B (ko)
IE (1) IE891420L (ko)
IL (1) IL90130A (ko)
NZ (1) NZ228935A (ko)
PT (1) PT90434B (ko)
RU (1) RU1825377C (ko)
ZA (1) ZA893234B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006963A1 (en) * 1988-02-08 1989-08-10 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
US4920050A (en) * 1989-02-27 1990-04-24 Pfizer Inc. Acidic polycyclic ether antibiotic
US5278053A (en) * 1991-09-16 1994-01-11 Eli Lilly And Company Method of producing a polyether antibiotic from actinomadura fibrosa sp. nov. NRRL 18348 and actinomadura sp. NRRL 18880
US5217993A (en) * 1992-07-20 1993-06-08 Eli Lilly And Company Monensin derivatives
US5331003A (en) * 1993-03-26 1994-07-19 Eli Lilly And Company Anticoccidial methods
DE69837795T2 (de) 1998-03-13 2008-01-31 Hitachi Plant Technologies, Ltd. Zentrifugalkompressor und wellendichtung
CN104877925B (zh) * 2014-02-28 2018-05-25 中国科学院沈阳应用生态研究所 一种异壁放线菌和三种新的抗真菌maclafungins类化合物及其制备和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58637B1 (en) * 1984-10-09 1993-10-20 Lilly Co Eli Polyether antibiotic A80190
WO1989006963A1 (en) * 1988-02-08 1989-08-10 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity

Also Published As

Publication number Publication date
ATE84535T1 (de) 1993-01-15
HUT54418A (en) 1991-02-28
DE68904348T2 (de) 1993-05-27
HK54893A (en) 1993-06-11
IE891420L (en) 1989-11-02
PT90434B (pt) 1994-08-31
PT90434A (pt) 1989-11-30
GR3007507T3 (ko) 1993-08-31
FI892077A0 (fi) 1989-05-02
CN1038838A (zh) 1990-01-17
IL90130A (en) 1994-02-27
NZ228935A (en) 1991-05-28
JPH0215085A (ja) 1990-01-18
EP0341019A3 (en) 1990-04-04
AU3391689A (en) 1989-11-02
HU204893B (en) 1992-02-28
DK211289D0 (da) 1989-05-01
EP0341019B1 (en) 1993-01-13
AU625818B2 (en) 1992-07-16
EP0341019A2 (en) 1989-11-08
FI892077A (fi) 1989-11-03
RU1825377C (ru) 1993-06-30
ZA893234B (en) 1991-01-30
DK211289A (da) 1989-11-02
CY1699A (en) 1994-01-14
DE68904348D1 (de) 1993-02-25
IL90130A0 (en) 1989-12-15

Similar Documents

Publication Publication Date Title
PT74846B (en) Process for preparing compounds of macrolides isolated from the fermentation broth of a strain of streptomyces avermitilis
MY102919A (en) Pleuromutilin derivatives process for their preparation and their use.
ES474215A1 (es) Procedimiento para la preparacion de derivados imidazolile- tiloxialcoxilicos y sus analogos con agrupacion tio
KR890017362A (ko) 폴리에테르 항생물질
LU83820A1 (fr) Derives de la 2-oxoazetidine,leur preparation et leur utilisation
ATE16190T1 (de) Derivate von c-076 verbindungen, deren herstellung und benuetzung, und sie enthaltende zusammensetzungen.
ATE164161T1 (de) Antiparasitäre makrolid-antibiotika
GB1500965A (en) Cyclic ether antibiotics
HUT46945A (en) Process for producing new azoxy derivatives and pharmaceutical compositions containing them as active components
ES8102188A1 (es) Procedimiento para la obtencion de derivados de la rifamici-na-s
KR910014509A (ko) 항생성 알리사마이신, 이의 제조방법 및 용도
SE7712429L (sv) Antibiotikum 890 a9
KR890003746A (ko) 항생물질 a80577 및 이의 제조방법
GB1110581A (en) Animal feed compositions
KR880001802A (ko) 악티노마두라 파르보사타에 의해 생성된 항생물질
ES506478A0 (es) Un procedimiento para la preparacion de nuevas lactonas macrociclicas.
NO174432C (no) FremgangsmÕte for fremstilling av antitumor-aktive forbindelser, samt biologisk ren kultur av streptomyces hygroscopicus ATCC 53709
SE7712430L (sv) Antibiotikum a 10
TH5586B (ko)
GB1549320A (en) Aminoglycoside antibiotic compounds and process for preparing the same
SE8200320L (sv) Nya derivat av spiro-1 isobensofuraner och spiro-1 isobensotiofener, derasframstellningssett och terapeutiska anvendning
TH5431A (ko)
BR8108862A (pt) Hidroximidato e tiol-hidroximidatos heterobiciclicos e seus derivados ester -carbamato com atividade biologica
DK457485A (da) Polyether-antibiotikum benaevnt a80190 og derivater heraf samt fremgangsmaade til fremstilling af saadanne forbindelser
JPS5521754A (en) Production in high yield of antibiotic sf-1293

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid