KR910014509A - 항생성 알리사마이신, 이의 제조방법 및 용도 - Google Patents

항생성 알리사마이신, 이의 제조방법 및 용도 Download PDF

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KR910014509A
KR910014509A KR1019910000308A KR910000308A KR910014509A KR 910014509 A KR910014509 A KR 910014509A KR 1019910000308 A KR1019910000308 A KR 1019910000308A KR 910000308 A KR910000308 A KR 910000308A KR 910014509 A KR910014509 A KR 910014509A
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South Korea
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culturing
carried out
alisamycin
antibiotic
compound
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KR1019910000308A
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밀톤 매튜 프랑코 크리스토퍼
코테스와라 사티아 비야와쿠마르 에라
차터예 수가타
나레쉬 강굴리 바이말
불룸바흐 위르겐
코글러 헤르베르트
펠하버 한스-볼프람
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오일러, 라피체
훽스트 아크티엔게젤샤프트
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Publication of KR910014509A publication Critical patent/KR910014509A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/04—Actinomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

내용 없음

Description

항생선 알리사마이신, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 알리사마이신(Alisamycin)의 IR 분석 결과를 도시한 것이다.

Claims (10)

  1. 구조식(Ⅰ)로 표시되는 알리사마이신(Alisamycin) 화합물.
  2. 호기성 조건하에 탄소 공급원, 질소 공급원, 영양물 무기염 및 미량 원소를 함유하는 영양 배지 중에서 악티노마이세트(actinomycete) 배양균 Y-88, 31582(DSM 5559)를 배양시킴을 특징으로 하여, 제1항의 청구된 화합물을 제조하는 방법.
  3. 제2항에 있어서, 배양을 18 내지 40℃ 에서 수행하는 방법.
  4. 제2항에 또는 3항에 있어서, 배양을 pH 6내지 9에서 수행하는 방법.
  5. 제2항 내지 4항 중 어느 한 항에 있어서, 배양을 27℃(±1℃) 및 pH 7에서 수행하는 방법.
  6. 제2항 내지 5항 중 어느 한 항에 있어서, 배양을 23시간 이상 동안 수행하는 방법.
  7. 제2항 내지 6항 중 어느 한 항에 있어서, 배양을 침수 배양으로서 수행하는 방법.
  8. 경우에 따라, 통상적인 보조제 및/또는 부형제와 혼합된 제1항에 따른 화합물을 포함하는 약제.
  9. 항생 활성, 항종양 활성 및 기생충 억제 활성을 갖는 약제를 제조하기 위한 제1항에 따른 화합물의 용도.
  10. 악티노마이세트 배양균 Y-88, 31582(DSM 5559).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910000308A 1990-01-12 1991-01-11 항생성 알리사마이신, 이의 제조방법 및 용도 KR910014509A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90100591 1990-01-12
EP901005918 1990-01-12

Publications (1)

Publication Number Publication Date
KR910014509A true KR910014509A (ko) 1991-08-31

Family

ID=8203484

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910000308A KR910014509A (ko) 1990-01-12 1991-01-11 항생성 알리사마이신, 이의 제조방법 및 용도

Country Status (13)

Country Link
US (1) US5114967A (ko)
EP (1) EP0436935A1 (ko)
JP (1) JPH0515385A (ko)
KR (1) KR910014509A (ko)
AU (1) AU634331B2 (ko)
CA (1) CA2034101A1 (ko)
FI (1) FI910139A (ko)
IE (1) IE910094A1 (ko)
IL (1) IL96921A0 (ko)
NO (1) NO910135L (ko)
NZ (1) NZ236734A (ko)
PT (1) PT96451A (ko)
ZA (1) ZA91227B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444087A (en) * 1993-10-19 1995-08-22 Bristol-Myers Squibb Company Manumycin compounds
JPH08151373A (ja) * 1994-09-30 1996-06-11 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｅｉ−１５１１類およびｅｉ−１６２５−２
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595770A (en) * 1982-06-21 1986-06-17 The Upjohn Company Antibiotic compound and process for recovery thereof from a fermentation broth

Also Published As

Publication number Publication date
AU634331B2 (en) 1993-02-18
IL96921A0 (en) 1992-03-29
NZ236734A (en) 1993-02-25
FI910139A0 (fi) 1991-01-10
US5114967A (en) 1992-05-19
CA2034101A1 (en) 1991-07-13
NO910135L (no) 1991-07-15
NO910135D0 (no) 1991-01-11
IE910094A1 (en) 1991-07-17
EP0436935A1 (en) 1991-07-17
PT96451A (pt) 1991-10-15
AU6925291A (en) 1991-07-18
FI910139A (fi) 1991-07-13
ZA91227B (en) 1991-09-25
JPH0515385A (ja) 1993-01-26

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