RU1825377C - Способ получени антибиотика А 82810 или его производных, и штамм АстINомаDURа FIвRоSа - продуцент антибиотика А 82810 - Google Patents

Способ получени антибиотика А 82810 или его производных, и штамм АстINомаDURа FIвRоSа - продуцент антибиотика А 82810

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RU1825377C
RU1825377C SU894613956A SU4613956A RU1825377C RU 1825377 C RU1825377 C RU 1825377C SU 894613956 A SU894613956 A SU 894613956A SU 4613956 A SU4613956 A SU 4613956A RU 1825377 C RU1825377 C RU 1825377C
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antibiotic
derivatives
strain
producing
producer
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SU894613956A
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English (en)
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Л.Хэмилл Роберт
Че-Фонг Йао Рэймонд
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Эли Лилли Энд Компани
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Genetics & Genomics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Birds (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Cephalosporin Compounds (AREA)
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Abstract

Использование: в микробиологической промышленности дл  получени  нового полиэфирного антибиотика А82810, примен емого в ветеринарии. Сущность изобретени : штамм Actlnomadura fibrose NRRL 18348 выращивают в услови х аэрации и перемешивани  в питательной среде. Экстрагируют мицелий и выдел ют новый поли- эфирный антибиотик А 82810. При необходимости провод т реакцию антибиотиков с изоцианатом или ацилируют, или этерифицируют, или перевод т его в соль. Приведены морфологические, физиологические , биохимические характеристики нового штамма A. fibrosa NRRL 18348. 1 з. п. ф-лы, 6 ил, 3 табл.

Description

Агарова  среда
ISP
№2 №
ISP
№3
Мг
ISP №4 ISP №5 №
ISP
№7
N:
АТСС N: 172
М;
Беннет Эммерсон
Глюкоза Аспарагин
Йсексен
Питательна 
Картофельна  Морковна 
ТРО
Характеристика А82810.1
G обильный R : 55. SBr
Am: обильный, белый
Sp: светлокоричневый
G: хороший
R: 39. gy.ro.
Am : следы : розовый
Sp: нет
G: обильный
R: 43. m.rBr
Am: сйеды: розовый
Sp: нет
G:обильный
R: 37.rn.ro
Am: нет
Sp: нет
G:обильный
R: 43.m.rBr.
Am : нет
Sp : нет
G: хороший .
R: 39. gy.ro.
Am: следы: 5 cat. у розовый
Sp: нет
G:обильный
R:42.1.r.Br.
Am: хороший: белый
Sp: нет G: обильный
R: 54. bro Am: следы : белый
Sp: нет
G: обильный
R: 39. gy.ro
Am: следы: 5 ca l.y. розовый
нет G: умеренный . .
R: 39. gy.ro. Am: следы: белый
Sp: нет
G: хороший
R: 53.т.о.
Am: нет
Sp: нет
G: хороший
R: 39. gy.ro.
Am: следы: белый
Sp: нет
G: обильный
R: 58.rn.Br
m: хороший: 5 ев gy.y. розовый
Sp: нет G: хороший R: 43. m. rBr
Продолжение табл.1
Примечание, При выращивании при 30°С 14 сут; G - рост, R обратна  сторона, Am воздушный мицелий; Sp растворимый пигмент.
Таблица 2
Сравнение А82810.1 с несколькими видами Actlnomadura, использу  коэффициенты общности а)
Примечание. Данные дл  A. coerulea получить не удалось.
Таблица 3 Различи  между А82810.1, A. pulveraceus и A. verrucosospora
Примечание. ND - не дано.
л. о
8
CJ
Ј
1
g
§ I
U
8
л
о
J
8
|
и. О
8
.
о
§
00О
о о АI
(«
1
I 8.
о оэ
§
оэ
(О 1Л U
-J
-J
ю
8
% КОЭФФИЦИЕНТ ПРОПУСКАНИЯ
100
4000 3600
3200 2800 2400 2000 ВОЛНОВОЕ ЧИСЛО ()
фиг. 5
1600 1200
800
SU894613956A 1988-05-02 1989-04-28 Способ получени антибиотика А 82810 или его производных, и штамм АстINомаDURа FIвRоSа - продуцент антибиотика А 82810 RU1825377C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18949988A 1988-05-02 1988-05-02

Publications (1)

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RU1825377C true RU1825377C (ru) 1993-06-30

Family

ID=22697597

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894613956A RU1825377C (ru) 1988-05-02 1989-04-28 Способ получени антибиотика А 82810 или его производных, и штамм АстINомаDURа FIвRоSа - продуцент антибиотика А 82810

Country Status (19)

Country Link
EP (1) EP0341019B1 (ru)
JP (1) JPH0215085A (ru)
KR (1) KR890017362A (ru)
CN (1) CN1038838A (ru)
AT (1) ATE84535T1 (ru)
AU (1) AU625818B2 (ru)
CY (1) CY1699A (ru)
DE (1) DE68904348T2 (ru)
DK (1) DK211289A (ru)
FI (1) FI892077A (ru)
GR (1) GR3007507T3 (ru)
HK (1) HK54893A (ru)
HU (1) HU204893B (ru)
IE (1) IE891420L (ru)
IL (1) IL90130A (ru)
NZ (1) NZ228935A (ru)
PT (1) PT90434B (ru)
RU (1) RU1825377C (ru)
ZA (1) ZA893234B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006963A1 (en) * 1988-02-08 1989-08-10 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
US4920050A (en) * 1989-02-27 1990-04-24 Pfizer Inc. Acidic polycyclic ether antibiotic
US5278053A (en) * 1991-09-16 1994-01-11 Eli Lilly And Company Method of producing a polyether antibiotic from actinomadura fibrosa sp. nov. NRRL 18348 and actinomadura sp. NRRL 18880
US5217993A (en) * 1992-07-20 1993-06-08 Eli Lilly And Company Monensin derivatives
US5331003A (en) * 1993-03-26 1994-07-19 Eli Lilly And Company Anticoccidial methods
DE69837795T2 (de) 1998-03-13 2008-01-31 Hitachi Plant Technologies, Ltd. Zentrifugalkompressor und wellendichtung
CN104877925B (zh) * 2014-02-28 2018-05-25 中国科学院沈阳应用生态研究所 一种异壁放线菌和三种新的抗真菌maclafungins类化合物及其制备和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58637B1 (en) * 1984-10-09 1993-10-20 Lilly Co Eli Polyether antibiotic A80190
WO1989006963A1 (en) * 1988-02-08 1989-08-10 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity

Also Published As

Publication number Publication date
KR890017362A (ko) 1989-12-15
ATE84535T1 (de) 1993-01-15
HUT54418A (en) 1991-02-28
DE68904348T2 (de) 1993-05-27
HK54893A (en) 1993-06-11
IE891420L (en) 1989-11-02
PT90434B (pt) 1994-08-31
PT90434A (pt) 1989-11-30
GR3007507T3 (ru) 1993-08-31
FI892077A0 (fi) 1989-05-02
CN1038838A (zh) 1990-01-17
IL90130A (en) 1994-02-27
NZ228935A (en) 1991-05-28
JPH0215085A (ja) 1990-01-18
EP0341019A3 (en) 1990-04-04
AU3391689A (en) 1989-11-02
HU204893B (en) 1992-02-28
DK211289D0 (da) 1989-05-01
EP0341019B1 (en) 1993-01-13
AU625818B2 (en) 1992-07-16
EP0341019A2 (en) 1989-11-08
FI892077A (fi) 1989-11-03
ZA893234B (en) 1991-01-30
DK211289A (da) 1989-11-02
CY1699A (en) 1994-01-14
DE68904348D1 (de) 1993-02-25
IL90130A0 (en) 1989-12-15

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