KR850005407A - 류코트리엔 길항제 - Google Patents
류코트리엔 길항제 Download PDFInfo
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- KR850005407A KR850005407A KR1019850000304A KR850000304A KR850005407A KR 850005407 A KR850005407 A KR 850005407A KR 1019850000304 A KR1019850000304 A KR 1019850000304A KR 850000304 A KR850000304 A KR 850000304A KR 850005407 A KR850005407 A KR 850005407A
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- alkyl
- compound
- alkoxy
- phenyl
- trifluoromethyl
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
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- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- C07C317/00—Sulfones; Sulfoxides
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- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
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- C07C47/00—Compounds having —CHO groups
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- C07C47/542—Alkylated benzaldehydes
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- C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
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- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/86—Ketones containing a keto group bound to a six-membered aromatic ring containing —CHO groups
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- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 구조식(Ⅰ)로 대표하는 화합물의 제조방법이 식에서 m은 1 또는 2, n은 1,2 또는 3, R'은 수소 또는 메틸, R은 다음의 그룹에서 선택한 기;여기에서 R1은 C8내지 C13알킬, C7내지 C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 11-도데시닐, 1-트랜스-도데시닐, 5-(4-아세틸-3-하이드록시-2-프로필페녹시)-펜톡시, 2(Z), 5(Z)운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C10알킬또는각 q는 0,1,2 또는 3 그러나 q의 합은 3을 초과하지 못하고, R2는 수소, 브로모, 클로로, 메틸, 트리플루오로메틸, 히드록시, 메톡시 또는 니트로, 혹은 R1은 수소, 브로모, 클로로, 메틸, 트리플루오로메틸히드록시, 메톡시, 또는 니트로이며 R2는 C8내지 C13알킬, C7내지, C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 11-도데시닐, 1-트랜스-도데세닐, 5-(4-아세틸-3-히드록시-2-프로필페녹시)-펜톡시, 2(Z), 5(Z) 운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C10알킬, 혹은여기에서 각 q는 0,1,2 혹은 3 그러나 q의 합은 3이하이며, p는 0 또는 1, 단 R은 티오펜기가 아니고, p가 1일때 상기 R1과 R2의 어느 것도 티오알킬이 아니며, 식(Ⅳ)의 화합물을RR'CO (Ⅳ)이식에서 R과 R'는 상기와 같고 적당한 머켑토알카노인산과 반응시키는 것을 포함하며 이리하여, 제조한 p가 0인 식(Ⅰ)의 화합물을 임의대로 산화하여 p가 1인 식(Ⅰ)의 화합물로 한다. 및 그 약제 허용염
- 구조식(Ⅱ)로 대표하는 청구범위 제1항의 화합물의 제조방법.및 그 약제 허용염.
- 구조식(Ⅲ)에 의하여 표시하는 청구범위 제2항의 화합물의 제조방법.이 식에서 R3는 C8내지 C13알킬, C7내지 C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 2(Z), 5(Z)-운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C9알킬, 2-나프틸메톡시 및여기에서 각 q는 0,1,2 또는 3이나 q의 합은 3을 넘지 못한다. 으로 구성되는 그룹에서 선택한 것이며, 또 R4는 수소, 브로모, 클로로, 메틸, 트리플루오로메틸, 메톡시 또는 니트로임.
- 구조식(Ⅳ)로 표시되는 청구범위 제2항의 화합물의 제조방법.이 식에서 R5는 수소, 브로모, 클로로, 메틸,트리플루오로메틸, 메톡시 또는 니트로이며 R6는 C8내지 C13알킬, C7내지 C12알콕시, 내지 C7티오알킬 C12, C10내지 C121-알키닐, 2(Z),5(Z)-운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 시이클로헥실-C4내지 C10알킬, 2-나프틸 메톡시 및여기에서 각 q는 0,1,2 또는 3이나 q의 합은 3이하임.
- 구조식(Ⅴ)로 나타내는 청구범위 1항의 화합물 및 그 약제 허용염의 제조방법.
- 청구범위 제1항 화합물의 상기 억제를 야기하게 하는 충분한 무독성양과 약제담체 또는 희석제를 포함하는 이러한 억제가 필요한 목적물에 류코트리엔의 효과를 억제하기 위한 약제조성물.
- 흡입에 의하여 투여함에 적당한 형태로한 청구범위 제6항에 의한 약제 조성물.
- 에어로졸 형태로한 청구범위 제6항에 의거한 약제 조성물.
- 비경구적 투여에 의하여 투여함에 적당한 형태의 청구범위 제6항에 의한 약제 조성물.
- 무균용액의 형태로한 청구범위 제6항에 의거한 약제조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57202184A | 1984-01-19 | 1984-01-19 | |
US572021 | 1984-01-19 | ||
US63050084A | 1984-07-13 | 1984-07-13 | |
US630500 | 1984-07-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850005407A true KR850005407A (ko) | 1985-08-26 |
KR900000683B1 KR900000683B1 (ko) | 1990-02-03 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850000304A KR900000683B1 (ko) | 1984-01-19 | 1985-01-19 | 류코트리엔 길항제 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0168902B1 (ko) |
KR (1) | KR900000683B1 (ko) |
AU (1) | AU571635B2 (ko) |
CA (1) | CA1243035A (ko) |
DE (1) | DE3560717D1 (ko) |
DK (1) | DK21085A (ko) |
ES (1) | ES8609230A1 (ko) |
FI (1) | FI79698C (ko) |
GR (1) | GR850106B (ko) |
HU (1) | HU195638B (ko) |
IL (1) | IL74068A (ko) |
NO (1) | NO160576C (ko) |
NZ (1) | NZ210839A (ko) |
PT (1) | PT79835B (ko) |
ZW (1) | ZW1085A1 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1276937C (en) * | 1985-04-19 | 1990-11-27 | Smith Kline & French Canada Ltd. | Leukotriene antagonists |
US4871771A (en) * | 1988-02-04 | 1989-10-03 | Smithkline Beckman Corporation | Leukotriene antagonists |
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Publication number | Priority date | Publication date | Assignee | Title |
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NL277345A (ko) * | 1961-04-17 | 1900-01-01 | ||
FR2468362A1 (fr) * | 1978-07-12 | 1981-05-08 | Oreal | Compositions cosmetiques a base de dithioethers pour le traitement de l'etat gras des cheveux et de la peau, nouveaux composes et leur procede d'obtention |
US4269731A (en) * | 1979-08-27 | 1981-05-26 | Argus Chemical Corporation | Antimony mercaptocarboxylic acid ester stabilizers for polyvinyl chloride resin compositions and process |
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1985
- 1985-01-14 CA CA000472021A patent/CA1243035A/en not_active Expired
- 1985-01-14 NO NO850154A patent/NO160576C/no unknown
- 1985-01-15 GR GR850106A patent/GR850106B/el unknown
- 1985-01-15 NZ NZ210839A patent/NZ210839A/en unknown
- 1985-01-15 ES ES539566A patent/ES8609230A1/es not_active Expired
- 1985-01-16 EP EP85300276A patent/EP0168902B1/en not_active Expired
- 1985-01-16 ZW ZW10/85A patent/ZW1085A1/xx unknown
- 1985-01-16 IL IL74068A patent/IL74068A/xx unknown
- 1985-01-16 DE DE8585300276T patent/DE3560717D1/de not_active Expired
- 1985-01-17 PT PT79835A patent/PT79835B/pt unknown
- 1985-01-17 FI FI850226A patent/FI79698C/fi not_active IP Right Cessation
- 1985-01-17 HU HU85199A patent/HU195638B/hu not_active IP Right Cessation
- 1985-01-17 DK DK21085A patent/DK21085A/da unknown
- 1985-01-18 AU AU37779/85A patent/AU571635B2/en not_active Ceased
- 1985-01-19 KR KR1019850000304A patent/KR900000683B1/ko not_active IP Right Cessation
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Publication number | Publication date |
---|---|
DK21085D0 (da) | 1985-01-17 |
NO160576C (no) | 1989-05-03 |
PT79835A (en) | 1985-02-01 |
CA1243035A (en) | 1988-10-11 |
HUT37748A (en) | 1986-02-28 |
FI850226L (fi) | 1985-07-20 |
DE3560717D1 (en) | 1987-11-05 |
DK21085A (da) | 1985-07-20 |
NO850154L (no) | 1985-07-22 |
HU195638B (en) | 1988-06-28 |
PT79835B (en) | 1986-10-28 |
ES8609230A1 (es) | 1986-07-16 |
GR850106B (ko) | 1985-05-16 |
FI79698C (fi) | 1990-02-12 |
AU3777985A (en) | 1985-08-01 |
EP0168902A1 (en) | 1986-01-22 |
EP0168902B1 (en) | 1987-09-30 |
FI850226A0 (fi) | 1985-01-17 |
KR900000683B1 (ko) | 1990-02-03 |
FI79698B (fi) | 1989-10-31 |
IL74068A (en) | 1988-08-31 |
ZW1085A1 (en) | 1985-04-24 |
NZ210839A (en) | 1987-10-30 |
AU571635B2 (en) | 1988-04-21 |
NO160576B (no) | 1989-01-23 |
ES539566A0 (es) | 1986-07-16 |
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