KR850005407A - 류코트리엔 길항제 - Google Patents

류코트리엔 길항제 Download PDF

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KR850005407A
KR850005407A KR1019850000304A KR850000304A KR850005407A KR 850005407 A KR850005407 A KR 850005407A KR 1019850000304 A KR1019850000304 A KR 1019850000304A KR 850000304 A KR850000304 A KR 850000304A KR 850005407 A KR850005407 A KR 850005407A
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alkyl
compound
alkoxy
phenyl
trifluoromethyl
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제럴드 글리슨 죤 (외 1)
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리챠드 도미니크 포기오
스미스 클라인 베크만 코퍼레이션
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Abstract

내용 없음

Description

류코트리엔 길항제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 구조식(Ⅰ)로 대표하는 화합물의 제조방법
    이 식에서 m은 1 또는 2, n은 1,2 또는 3, R'은 수소 또는 메틸, R은 다음의 그룹에서 선택한 기;
    여기에서 R1은 C8내지 C13알킬, C7내지 C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 11-도데시닐, 1-트랜스-도데시닐, 5-(4-아세틸-3-하이드록시-2-프로필페녹시)-펜톡시, 2(Z), 5(Z)운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C10알킬또는
    각 q는 0,1,2 또는 3 그러나 q의 합은 3을 초과하지 못하고, R2는 수소, 브로모, 클로로, 메틸, 트리플루오로메틸, 히드록시, 메톡시 또는 니트로, 혹은 R1은 수소, 브로모, 클로로, 메틸, 트리플루오로메틸히드록시, 메톡시, 또는 니트로이며 R2는 C8내지 C13알킬, C7내지, C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 11-도데시닐, 1-트랜스-도데세닐, 5-(4-아세틸-3-히드록시-2-프로필페녹시)-펜톡시, 2(Z), 5(Z) 운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C10알킬, 혹은
    여기에서 각 q는 0,1,2 혹은 3 그러나 q의 합은 3이하이며, p는 0 또는 1, 단 R은 티오펜기가 아니고, p가 1일때 상기 R1과 R2의 어느 것도 티오알킬이 아니며, 식(Ⅳ)의 화합물을
    RR'CO (Ⅳ)
    이식에서 R과 R'는 상기와 같고 적당한 머켑토알카노인산과 반응시키는 것을 포함하며 이리하여, 제조한 p가 0인 식(Ⅰ)의 화합물을 임의대로 산화하여 p가 1인 식(Ⅰ)의 화합물로 한다. 및 그 약제 허용염
  2. 구조식(Ⅱ)로 대표하는 청구범위 제1항의 화합물의 제조방법.
    및 그 약제 허용염.
  3. 구조식(Ⅲ)에 의하여 표시하는 청구범위 제2항의 화합물의 제조방법.
    이 식에서 R3는 C8내지 C13알킬, C7내지 C12알콕시, C7내지 C12티오알킬, C10내지 C121-알키닐, 2(Z), 5(Z)-운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 사이클로헥실-C4내지 C9알킬, 2-나프틸메톡시 및
    여기에서 각 q는 0,1,2 또는 3이나 q의 합은 3을 넘지 못한다. 으로 구성되는 그룹에서 선택한 것이며, 또 R4는 수소, 브로모, 클로로, 메틸, 트리플루오로메틸, 메톡시 또는 니트로임.
  4. 구조식(Ⅳ)로 표시되는 청구범위 제2항의 화합물의 제조방법.
    이 식에서 R5는 수소, 브로모, 클로로, 메틸,트리플루오로메틸, 메톡시 또는 니트로이며 R6는 C8내지 C13알킬, C7내지 C12알콕시, 내지 C7티오알킬 C12, C10내지 C121-알키닐, 2(Z),5(Z)-운데카디에닐옥시, 페닐-C4내지 C10알킬, 페닐-C3내지 C9알콕시, 트리플루오로메틸-C7내지 C12알킬, 시이클로헥실-C4내지 C10알킬, 2-나프틸 메톡시 및
    여기에서 각 q는 0,1,2 또는 3이나 q의 합은 3이하임.
  5. 구조식(Ⅴ)로 나타내는 청구범위 1항의 화합물 및 그 약제 허용염의 제조방법.
  6. 청구범위 제1항 화합물의 상기 억제를 야기하게 하는 충분한 무독성양과 약제담체 또는 희석제를 포함하는 이러한 억제가 필요한 목적물에 류코트리엔의 효과를 억제하기 위한 약제조성물.
  7. 흡입에 의하여 투여함에 적당한 형태로한 청구범위 제6항에 의한 약제 조성물.
  8. 에어로졸 형태로한 청구범위 제6항에 의거한 약제 조성물.
  9. 비경구적 투여에 의하여 투여함에 적당한 형태의 청구범위 제6항에 의한 약제 조성물.
  10. 무균용액의 형태로한 청구범위 제6항에 의거한 약제조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000304A 1984-01-19 1985-01-19 류코트리엔 길항제 KR900000683B1 (ko)

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CA1276937C (en) * 1985-04-19 1990-11-27 Smith Kline & French Canada Ltd. Leukotriene antagonists
US4871771A (en) * 1988-02-04 1989-10-03 Smithkline Beckman Corporation Leukotriene antagonists

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FR2468362A1 (fr) * 1978-07-12 1981-05-08 Oreal Compositions cosmetiques a base de dithioethers pour le traitement de l'etat gras des cheveux et de la peau, nouveaux composes et leur procede d'obtention
US4269731A (en) * 1979-08-27 1981-05-26 Argus Chemical Corporation Antimony mercaptocarboxylic acid ester stabilizers for polyvinyl chloride resin compositions and process

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DK21085D0 (da) 1985-01-17
NO160576C (no) 1989-05-03
PT79835A (en) 1985-02-01
CA1243035A (en) 1988-10-11
HUT37748A (en) 1986-02-28
FI850226L (fi) 1985-07-20
DE3560717D1 (en) 1987-11-05
DK21085A (da) 1985-07-20
NO850154L (no) 1985-07-22
HU195638B (en) 1988-06-28
PT79835B (en) 1986-10-28
ES8609230A1 (es) 1986-07-16
GR850106B (ko) 1985-05-16
FI79698C (fi) 1990-02-12
AU3777985A (en) 1985-08-01
EP0168902A1 (en) 1986-01-22
EP0168902B1 (en) 1987-09-30
FI850226A0 (fi) 1985-01-17
KR900000683B1 (ko) 1990-02-03
FI79698B (fi) 1989-10-31
IL74068A (en) 1988-08-31
ZW1085A1 (en) 1985-04-24
NZ210839A (en) 1987-10-30
AU571635B2 (en) 1988-04-21
NO160576B (no) 1989-01-23
ES539566A0 (es) 1986-07-16

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