KR830010039A - 페닐 지방성 카복실린산 유도체의 제조방법 - Google Patents

페닐 지방성 카복실린산 유도체의 제조방법 Download PDF

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Publication number
KR830010039A
KR830010039A KR1019820001678A KR820001678A KR830010039A KR 830010039 A KR830010039 A KR 830010039A KR 1019820001678 A KR1019820001678 A KR 1019820001678A KR 820001678 A KR820001678 A KR 820001678A KR 830010039 A KR830010039 A KR 830010039A
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South Korea
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formula
product
hydrogen atom
necessary
iii
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KR1019820001678A
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English (en)
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KR870001537B1 (ko
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크리스티디스 야니
프르넥스 로베르뜨
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허버트 후리텔
로우셀 우크라프
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

페닐 지방성 카복실린산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 구조식(Ⅱ)의 글리옥실린산 또는 하나의 그 알킬에스테르를 다음 구조식(Ⅲ)의 아세톤페논과 반응시켜 A가 수소원자를 나타내고 B가 히드록시 그룹을 나타내는 구조식(Ⅰ)의 생성물에 상응하는 구조식(ⅠA)의 생성물을 얻고, 또는 A및 B가 다같이 (E)배위의 이중 결합을 나타내는 구조식(Ⅰ)의 생성물에 상응하는구조식(ⅠB)의 생성물을 얻고, 필요하다면 구조식(ⅠA)의 생성물을 탈수제에 주입시켜 (E)배위의 구조식(ⅠB)에 상응하는 생성물을 얻고, 그리고 필요하다면 구조식(ⅠA)의 얻어진 생성물을 그것의 광학활성 이성체로 회절시키고, 그리고 필요하다면 (E)배위의 구조식(ⅠB)의 화합물을 이성화시켜 (Z)배위의 구조식(ⅠB)의 화합물을 형성시키고 그리고 필요하다면 R이 수소 원자를 나타내는 구조식(Ⅰ)의 얻어진 생성물을 통상적인 방법에 따라 염기화 또는 에스테르화시킴을 특징으로 하는 가능한 다른 입체 이성질체로 다음 구조식(Ⅰ)의 생성물들뿐 아니라 R이 수소원자를 나타내는 구조식(Ⅰ)의 생성물의 알칼리, 알칼리-도 또는 아민 염들의 제조방법.
    (Ⅰ)
    OHC-COOR (Ⅱ)
    (Ⅲ)
    상기 구조식에서
    세개의 메톡시 기들은 3,4,5 또는 2,4,6 또는 2,3,5 또는 2,3,6위에 위치하고 여기서 A 및 B는 다같이 이중결합을 나타내거나 A는 수소 원자를 나타내고 B는 히드록 시기를 나타내고 R은 수소 원자 또는 1내지 5탄소 함유의 알킬기를 나타낸다.
  2. 1항에 있어서 세개의 메톡시 기들이 3,4,5 또는 2,4,5위에 위치하는 구조식(Ⅲ)의 아세톤페논을 출발물질로 사용함을 특징으로 하는 1항에 따른 제조방법.
  3. (E) 4-(3,4,5-트리메톡시페닐) 4-옥소 2-부레노인산이 제조됨을 특징으로 하는 1 또는 2항에 따른 제조방법.
  4. (E) 4-(2,4,5-트리메톡시페닐) 4-옥소 2-부테노인산이 제조됨을 특징으로 하는 1항 또는 2항에 따른 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8201678A 1981-04-17 1982-04-16 페닐지방성 카복실린산유도체의 제조방법 KR870001537B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR81-07801 1981-04-17
FR8107801A FR2504127B1 (fr) 1981-04-17 1981-04-17 Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
KR830010039A true KR830010039A (ko) 1983-12-24
KR870001537B1 KR870001537B1 (ko) 1987-09-02

Family

ID=9257553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8201678A KR870001537B1 (ko) 1981-04-17 1982-04-16 페닐지방성 카복실린산유도체의 제조방법

Country Status (27)

Country Link
US (1) US4450292A (ko)
JP (2) JPS57183736A (ko)
KR (1) KR870001537B1 (ko)
AT (1) AT390054B (ko)
AU (1) AU550822B2 (ko)
BE (1) BE892886A (ko)
CA (1) CA1168255A (ko)
CH (1) CH652387A5 (ko)
DE (1) DE3214082A1 (ko)
DK (1) DK157673C (ko)
ES (1) ES8303279A1 (ko)
FI (1) FI73965C (ko)
FR (1) FR2504127B1 (ko)
GB (1) GB2096999B (ko)
GR (1) GR75457B (ko)
HU (1) HU186857B (ko)
IE (1) IE52444B1 (ko)
IL (1) IL65445A (ko)
IT (1) IT1147846B (ko)
LU (1) LU84090A1 (ko)
MA (1) MA19444A1 (ko)
NL (1) NL8201579A (ko)
OA (1) OA07539A (ko)
PT (1) PT74767B (ko)
SE (1) SE453493B (ko)
SU (1) SU1264836A3 (ko)
ZA (1) ZA822571B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515037A1 (fr) * 1981-10-22 1983-04-29 Roussel Uclaf A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant
IT1190340B (it) * 1986-06-06 1988-02-16 Roussel Maestretti Spa Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
DK49688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Propiolophenonderivater
HU198294B (en) * 1987-06-10 1989-09-28 Richter Gedeon Vegyeszet Process for producing butenoic acid amides and pharmaceutical compositions comprising such active ingredient
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
DE3881770T2 (de) * 1987-07-20 1993-10-07 Cometec Srl Zusammensetzungen zum Fördern der Tierwachstums.
HU198446B (en) * 1987-09-25 1989-10-30 Richter Gedeon Vegyeszet Process for production of new amids of buten acid and medical compositions containing such active substances
US5849729A (en) * 1995-12-26 1998-12-15 Hershey Foods Corporation Use of hydrolyzed cocoa butter for percutaneous absorption
US5837227A (en) * 1995-12-26 1998-11-17 Hershey Foods Corporation Use of cocoa butter or partially hydrolyzed cocoa butter for the treatment of burns and wounds
GB9816358D0 (en) 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
JP2003525200A (ja) 1998-07-27 2003-08-26 イスティトゥト ディ リチェルケ ディ ビオロジア モレコラーレ ピー．アンジェレッティ ソチエタ ペル アツィオニ ポリメラーゼ阻害剤としてのジケト酸誘導体
RU2771565C1 (ru) * 2021-05-28 2022-05-05 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые соединения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE708617A (ko) * 1966-12-30 1968-06-28
NL6717403A (ko) * 1966-12-30 1968-07-01
US3857949A (en) * 1970-06-26 1974-12-31 Inst Chemioterapico Italiano S Prophylaxis and treatment of cardiac disorders
US3803222A (en) * 1970-06-26 1974-04-09 Istituto Chem It Spa Oxo-trialkoxyphenyl-alkanoic acids and salts thereof
DE2116293A1 (de) * 1971-04-02 1972-10-19 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Ketonderivate und Verfahren zu ihrer Herstellung
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US4017517A (en) * 1971-09-13 1977-04-12 Takeda Chemical Industries, Ltd. 2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof
AT319215B (de) * 1972-09-13 1974-12-10 Takeda Chemical Industries Ltd Verfahren zur Herstellung von neuen 3-(2',4',5'-trisubst. Benzoyl)-propionsäuren
FR2481118A1 (fr) * 1980-04-24 1981-10-30 Roussel Uclaf Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique

Also Published As

Publication number Publication date
GB2096999A (en) 1982-10-27
DK157673C (da) 1990-07-16
CH652387A5 (fr) 1985-11-15
US4450292A (en) 1984-05-22
IT8248240A0 (it) 1982-04-16
ES511489A0 (es) 1983-02-01
OA07539A (fr) 1985-03-31
ATA144682A (de) 1989-08-15
CA1168255A (fr) 1984-05-29
DK170382A (da) 1982-10-18
SE8201840L (sv) 1982-10-18
AU550822B2 (en) 1986-04-10
FI73965B (fi) 1987-08-31
IT1147846B (it) 1986-11-26
DK157673B (da) 1990-02-05
BE892886A (fr) 1982-10-18
DE3214082A1 (de) 1982-11-04
FI73965C (fi) 1987-12-10
FR2504127A1 (fr) 1982-10-22
GB2096999B (en) 1984-08-15
GR75457B (ko) 1984-07-19
AU8269082A (en) 1982-10-21
MA19444A1 (fr) 1982-12-31
SE453493B (sv) 1988-02-08
NL8201579A (nl) 1982-11-16
LU84090A1 (fr) 1983-04-13
ZA822571B (en) 1983-02-23
JPS57183736A (en) 1982-11-12
ES8303279A1 (es) 1983-02-01
HU186857B (en) 1985-10-28
IL65445A (en) 1986-09-30
JPS6237027B2 (ko) 1987-08-10
JPH0120127B2 (ko) 1989-04-14
PT74767B (fr) 1985-01-07
KR870001537B1 (ko) 1987-09-02
SU1264836A3 (ru) 1986-10-15
FI821305A0 (fi) 1982-04-14
IL65445A0 (en) 1982-07-30
FR2504127B1 (fr) 1985-07-19
IE820896L (en) 1982-10-17
FI821305L (fi) 1982-10-18
AT390054B (de) 1990-03-12
PT74767A (fr) 1982-05-01
IE52444B1 (en) 1987-10-28
JPS62174012A (ja) 1987-07-30

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