KR830003415A - 15-설폰 아미도 프로스타글란딘 유도체 - Google Patents
15-설폰 아미도 프로스타글란딘 유도체 Download PDFInfo
- Publication number
- KR830003415A KR830003415A KR1019800003623A KR800003623A KR830003415A KR 830003415 A KR830003415 A KR 830003415A KR 1019800003623 A KR1019800003623 A KR 1019800003623A KR 800003623 A KR800003623 A KR 800003623A KR 830003415 A KR830003415 A KR 830003415A
- Authority
- KR
- South Korea
- Prior art keywords
- prostaglandin derivative
- carbon atoms
- sulfon amido
- sulfon
- amido
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- SXXLKZCNJHJYFL-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-5-ium-3-olate Chemical group C1CNCC2=C1ONC2=O SXXLKZCNJHJYFL-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- -1 tetrahydropyranyloxy Chemical group 0.000 claims 1
- 208000028292 transient congenital hypothyroidism Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 탄소수 2내지 4의 희알카노산 및 물과 다음 구조식 II의 중간체를 반응시키고, THPO그룹을 가수분해 하는 것을 특징으로 하여 다음 구조식 I의 15-설폰아미도 프로스타글란딘 유도체를 제조하는 방법.상기식에서Q는-CO2H,-CO2R, 테트라졸-5-릴, -CONHSO2R 또는 -CONHCOR이며;A는 에틸렌 또는 시스-비닐렌이며;X는 H, F, Cl, Br, OCH3, CF3또는 CH3이며,R은 탄소수 1내지 4의 알킬 또는 페닐이며, THOP는 테트라하이드로피라닐옥시이다.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US076.520 | 1979-09-17 | ||
US06/076,520 US4232173A (en) | 1979-09-17 | 1979-09-17 | 15-Sulfonamidoprostaglandin derivatives |
US076520 | 1993-06-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830003415A true KR830003415A (ko) | 1983-06-20 |
KR840000964B1 KR840000964B1 (ko) | 1984-07-02 |
Family
ID=22132532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800003623A KR840000964B1 (ko) | 1979-09-17 | 1980-09-16 | 15-설폰아미도프로스타글란딘 유도체의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4232173A (ko) |
EP (1) | EP0025687B1 (ko) |
JP (1) | JPS5951938B2 (ko) |
KR (1) | KR840000964B1 (ko) |
AR (1) | AR225776A1 (ko) |
AT (1) | ATE1858T1 (ko) |
AU (1) | AU518068B2 (ko) |
CA (1) | CA1153368A (ko) |
DE (1) | DE3061160D1 (ko) |
DK (1) | DK392580A (ko) |
ES (1) | ES8106489A1 (ko) |
FI (1) | FI68615C (ko) |
GR (1) | GR70288B (ko) |
IE (1) | IE50266B1 (ko) |
IL (1) | IL61038A (ko) |
PH (1) | PH15098A (ko) |
PT (1) | PT71807B (ko) |
YU (1) | YU236180A (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61126069A (ja) * | 1984-11-21 | 1986-06-13 | Res Dev Corp Of Japan | プロスタグランジン誘導体 |
JPS63207015A (ja) * | 1987-02-23 | 1988-08-26 | 株式会社日立製作所 | 遮断器装置 |
JPS6429564A (en) * | 1987-07-25 | 1989-01-31 | Oyo Kikaku Kk | Common joist mechanism |
US5387608A (en) * | 1993-08-17 | 1995-02-07 | Allergan, Inc. | Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl sulfonamidomethyl and derivatives thereof as therapeutic agents |
US5607415A (en) * | 1994-08-18 | 1997-03-04 | Kimberly-Clark Corporation | Flexible absorbent article |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3835179A (en) * | 1972-07-24 | 1974-09-10 | American Cyanamid Co | Novel 15-substituted prostanoic acids and esters |
US4033996A (en) * | 1973-04-25 | 1977-07-05 | Merck & Co., Inc. | 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins |
GB1507211A (en) * | 1975-02-14 | 1978-04-12 | Ono Pharmaceutical Co | Prostaglandin analogues |
-
1979
- 1979-09-17 US US06/076,520 patent/US4232173A/en not_active Expired - Lifetime
-
1980
- 1980-09-09 DE DE8080303155T patent/DE3061160D1/de not_active Expired
- 1980-09-09 AT AT80303155T patent/ATE1858T1/de not_active IP Right Cessation
- 1980-09-09 EP EP80303155A patent/EP0025687B1/en not_active Expired
- 1980-09-15 PT PT71807A patent/PT71807B/pt unknown
- 1980-09-15 GR GR62889A patent/GR70288B/el unknown
- 1980-09-15 CA CA000360249A patent/CA1153368A/en not_active Expired
- 1980-09-15 IL IL61038A patent/IL61038A/xx unknown
- 1980-09-15 YU YU02361/80A patent/YU236180A/xx unknown
- 1980-09-15 IE IE1927/80A patent/IE50266B1/en unknown
- 1980-09-16 AU AU62436/80A patent/AU518068B2/en not_active Ceased
- 1980-09-16 ES ES495101A patent/ES8106489A1/es not_active Expired
- 1980-09-16 PH PH24591A patent/PH15098A/en unknown
- 1980-09-16 JP JP55128465A patent/JPS5951938B2/ja not_active Expired
- 1980-09-16 FI FI802904A patent/FI68615C/fi not_active IP Right Cessation
- 1980-09-16 DK DK392580A patent/DK392580A/da not_active Application Discontinuation
- 1980-09-16 KR KR1019800003623A patent/KR840000964B1/ko active
- 1980-09-17 AR AR282561A patent/AR225776A1/es active
Also Published As
Publication number | Publication date |
---|---|
EP0025687B1 (en) | 1982-11-24 |
PT71807B (en) | 1981-07-02 |
IE801927L (en) | 1981-03-17 |
KR840000964B1 (ko) | 1984-07-02 |
FI68615B (fi) | 1985-06-28 |
IE50266B1 (en) | 1986-03-19 |
PH15098A (en) | 1982-08-10 |
JPS5651448A (en) | 1981-05-09 |
IL61038A (en) | 1983-12-30 |
DE3061160D1 (en) | 1982-12-30 |
AU6243680A (en) | 1981-03-26 |
GR70288B (ko) | 1982-09-03 |
PT71807A (en) | 1980-10-01 |
FI802904A (fi) | 1981-03-18 |
ATE1858T1 (de) | 1982-12-15 |
EP0025687A1 (en) | 1981-03-25 |
US4232173A (en) | 1980-11-04 |
DK392580A (da) | 1981-03-18 |
IL61038A0 (en) | 1980-11-30 |
CA1153368A (en) | 1983-09-06 |
JPS5951938B2 (ja) | 1984-12-17 |
FI68615C (fi) | 1985-10-10 |
ES495101A0 (es) | 1981-08-16 |
AR225776A1 (es) | 1982-04-30 |
ES8106489A1 (es) | 1981-08-16 |
YU236180A (en) | 1983-01-21 |
AU518068B2 (en) | 1981-09-10 |
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