GB2001974A - Vincinic acid derivatives and process for the preparation thereof - Google Patents

Vincinic acid derivatives and process for the preparation thereof

Info

Publication number
GB2001974A
GB2001974A GB7831093A GB7831093A GB2001974A GB 2001974 A GB2001974 A GB 2001974A GB 7831093 A GB7831093 A GB 7831093A GB 7831093 A GB7831093 A GB 7831093A GB 2001974 A GB2001974 A GB 2001974A
Authority
GB
United Kingdom
Prior art keywords
vincinic
acid derivatives
carbon atoms
acid
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7831093A
Other versions
GB2001974B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB2001974A publication Critical patent/GB2001974A/en
Application granted granted Critical
Publication of GB2001974B publication Critical patent/GB2001974B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Vincinic acid derivatives of the general formula (I): <IMAGE> wherein R represents hydrogen or an alkyl group containing from 2 to 6 carbon atoms, optionally substituted with hydroxyl, R1 represents hydroxyl, R2 represents hydrogen, or if R does not represent hydrogen, R1 and R2 together may form a valence bond between two adjacent carbon atoms, and acid addition salts and quaternary salts thereof, especially the esters thereof, show valuable vasodilating activity and may be used as active ingredients of pharmaceutical compositions. The compounds are prepared by hydrolysis of vincine to vincinic acid, optionally followed by esterification and/or dehydration and/or salt formation.
GB7831093A 1977-07-27 1978-07-25 Vincinic acid derivatives and process for the preparation thereof Expired GB2001974B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77RI642A HU177498B (en) 1977-07-27 1977-07-27 Process for preparing new vincinic acid and apovincinic acid esters

Publications (2)

Publication Number Publication Date
GB2001974A true GB2001974A (en) 1979-02-14
GB2001974B GB2001974B (en) 1982-02-10

Family

ID=11001039

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7831093A Expired GB2001974B (en) 1977-07-27 1978-07-25 Vincinic acid derivatives and process for the preparation thereof

Country Status (10)

Country Link
JP (1) JPS5436297A (en)
BE (1) BE869274A (en)
DE (1) DE2832645A1 (en)
FR (1) FR2398747A1 (en)
GB (1) GB2001974B (en)
HU (1) HU177498B (en)
IT (1) IT1097445B (en)
NL (1) NL7807948A (en)
SE (1) SE7808072L (en)
SU (1) SU793404A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114249721A (en) * 2021-11-29 2022-03-29 南京中医药大学 Vinblastine PEG derivative and application thereof in preparation of drugs for treating diabetic peripheral neuropathy, diabetic foot and pulmonary fibrosis

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829570Y2 (en) * 1979-11-19 1983-06-29 日本航空電子工業株式会社 socket
JPH065634B2 (en) * 1983-09-12 1994-01-19 株式会社東芝 Hybrid IC

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK139358B (en) * 1973-12-18 1979-02-05 Sandoz Ag Analogous process for the preparation of vincamine derivatives or acid addition salts thereof.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114249721A (en) * 2021-11-29 2022-03-29 南京中医药大学 Vinblastine PEG derivative and application thereof in preparation of drugs for treating diabetic peripheral neuropathy, diabetic foot and pulmonary fibrosis
CN114249721B (en) * 2021-11-29 2023-10-17 南京中医药大学 Application of vincamine PEG derivative in preparing medicament for treating diabetic peripheral neuropathy, diabetic foot and pulmonary fibrosis

Also Published As

Publication number Publication date
IT7826172A0 (en) 1978-07-27
FR2398747B1 (en) 1981-12-11
IT1097445B (en) 1985-08-31
FR2398747A1 (en) 1979-02-23
DE2832645A1 (en) 1979-02-08
BE869274A (en) 1978-11-16
SU793404A3 (en) 1980-12-30
NL7807948A (en) 1979-01-30
SE7808072L (en) 1979-01-28
HU177498B (en) 1981-10-28
JPS5436297A (en) 1979-03-16
GB2001974B (en) 1982-02-10

Similar Documents

Publication Publication Date Title
ES8506677A1 (en) Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions.
ES483767A1 (en) Alpha-(N-arylsulfonyl-L-argininamides, processes for their preparation and pharmaceutical compositions containing these substances.
DE3260262D1 (en) (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio acids, their salts and esters, their preparation and pharmaceutical compositions containing them
ES8505650A1 (en) Fat emulsion containing prostaglandin.
US4582857B1 (en) P-oxybenzoic acid derivatives processes for their production and their use as drugs
KR830010039A (en) Method for preparing phenyl fatty carboxylic acid derivative
ES8106289A1 (en) Derivatives of alpha-phenyl-2-pyrrolidine methanol and their salts, process for their preparation, use as medicines and compositions containing them.
ES8100283A1 (en) Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones.
ES454063A1 (en) Novel benzylalcohol derivatives and processes for preparing the same
GB2001974A (en) Vincinic acid derivatives and process for the preparation thereof
GB1097531A (en) Improvements in or relating to the preparation of cyclopentane derivatives
ES8106516A1 (en) Process for the preparation of halovincamone derivatives
ES459903A1 (en) Quinoline derivatives
ES8101592A1 (en) Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates.
ES461785A1 (en) Behenic acid esters, compositions thereof and a method of preparation thereof
ES8106517A1 (en) 10-halo-E-homoeburnane derivatives, a process for the preparation thereof, a process for the use thereof as vasodilators, and vasodilating compositions thereof
ES486049A1 (en) Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-ones, process for their preparation, and pharmaceutical compositions containing them.
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
GB1498394A (en) Behenic acid esters of 9-thiaxanthene propylidene heterocyclic alcohols and their use in pharmaceutical composition
ES445343A1 (en) Quaternary xanthinylalkyl nortropine
GB2001062A (en) Preparation of Pyridinecarboxylic acid piperazides
DE3462400D1 (en) Carboxylic acid derivatives, processes for their production and pharmaceutical preparations containing them
DE3260241D1 (en) Benzamido-alkyl-hydroxamic-acid derivatives, preparation thereof and therapeutical composition
DE3171537D1 (en) Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions
ES446239A1 (en) 8-azaprostaglandins and process for the preparation thereof

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee