KR20160035613A - Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 - Google Patents
Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 Download PDFInfo
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- KR20160035613A KR20160035613A KR1020167007069A KR20167007069A KR20160035613A KR 20160035613 A KR20160035613 A KR 20160035613A KR 1020167007069 A KR1020167007069 A KR 1020167007069A KR 20167007069 A KR20167007069 A KR 20167007069A KR 20160035613 A KR20160035613 A KR 20160035613A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161466841P | 2011-03-23 | 2011-03-23 | |
US61/466,841 | 2011-03-23 | ||
PCT/US2012/030007 WO2012129344A1 (en) | 2011-03-23 | 2012-03-21 | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137027960A Division KR101606250B1 (ko) | 2011-03-23 | 2012-03-21 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
Publications (1)
Publication Number | Publication Date |
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KR20160035613A true KR20160035613A (ko) | 2016-03-31 |
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ID=45926933
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020167007069A KR20160035613A (ko) | 2011-03-23 | 2012-03-21 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
KR1020137027960A KR101606250B1 (ko) | 2011-03-23 | 2012-03-21 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137027960A KR101606250B1 (ko) | 2011-03-23 | 2012-03-21 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
Country Status (19)
Country | Link |
---|---|
US (3) | US8623885B2 (de) |
EP (2) | EP2688887B1 (de) |
JP (1) | JP5647374B2 (de) |
KR (2) | KR20160035613A (de) |
CN (1) | CN103703000B (de) |
AR (1) | AR085544A1 (de) |
AU (1) | AU2012230896B9 (de) |
CA (1) | CA2830516C (de) |
DK (2) | DK2688887T3 (de) |
ES (2) | ES2543569T3 (de) |
HK (2) | HK1191014A1 (de) |
JO (1) | JO3073B1 (de) |
MX (1) | MX2013010871A (de) |
MY (1) | MY161199A (de) |
PT (2) | PT2688887E (de) |
SG (1) | SG193580A1 (de) |
TW (1) | TWI438204B (de) |
UY (1) | UY33969A (de) |
WO (1) | WO2012129344A1 (de) |
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