KR100908166B1 - 5ht2c 수용체 조절제 - Google Patents
5ht2c 수용체 조절제 Download PDFInfo
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- KR100908166B1 KR100908166B1 KR1020087000551A KR20087000551A KR100908166B1 KR 100908166 B1 KR100908166 B1 KR 100908166B1 KR 1020087000551 A KR1020087000551 A KR 1020087000551A KR 20087000551 A KR20087000551 A KR 20087000551A KR 100908166 B1 KR100908166 B1 KR 100908166B1
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- tetrahydro
- benzazine
- methyl
- delete delete
- methoxy
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- KRBZRTWDEJCQIL-UHFFFAOYSA-N CC(CNCC1)c2c1ccc(Br)c2 Chemical compound CC(CNCC1)c2c1ccc(Br)c2 KRBZRTWDEJCQIL-UHFFFAOYSA-N 0.000 description 1
- UWFSZQMKPCCKFT-UHFFFAOYSA-N CC(CNCCc1c2)c1cc(Br)c2O Chemical compound CC(CNCCc1c2)c1cc(Br)c2O UWFSZQMKPCCKFT-UHFFFAOYSA-N 0.000 description 1
- IYWYWVMPIJVOBD-UHFFFAOYSA-N CC(CNCCc1c2)c1cc(Br)c2OCC=C Chemical compound CC(CNCCc1c2)c1cc(Br)c2OCC=C IYWYWVMPIJVOBD-UHFFFAOYSA-N 0.000 description 1
- DHJBSCDGORFSNH-UHFFFAOYSA-N CC(CNCCc1c2)c1ccc2-c([n](C)nc1)c1Br Chemical compound CC(CNCCc1c2)c1ccc2-c([n](C)nc1)c1Br DHJBSCDGORFSNH-UHFFFAOYSA-N 0.000 description 1
- QOPGXRGRPCHASN-UHFFFAOYSA-N CC(CNCCc1c2)c1ccc2-c1ccc(C(F)(F)F)cc1 Chemical compound CC(CNCCc1c2)c1ccc2-c1ccc(C(F)(F)F)cc1 QOPGXRGRPCHASN-UHFFFAOYSA-N 0.000 description 1
- KVGYVFPNKGJTTP-UHFFFAOYSA-N OC(CNCC1)c2c1ccc(Cl)c2 Chemical compound OC(CNCC1)c2c1ccc(Cl)c2 KVGYVFPNKGJTTP-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
체질량 지수 (BMI)에 의한 체중의 분류 | |
BMI | 분류 |
<18.5 | 저체중 |
18.5 - 24.9 | 정상 |
25.0 - 29.9 | 과체중 |
30.0 - 34.9 | 비만 (등급 I) |
35.0 - 39.9 | 비만 (등급 II) |
>40 | 극도 비만 (등급 III) |
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- 8-브로모-7-히드록시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-알릴옥시-8-브로모-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-벤질옥시-8-브로모-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-7-에톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-7-이소프로폭시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;N-프로필-8-브로모-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-히드록시-8-요오도-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-알릴옥시-8-요오도-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;3,5-디메틸-6,7,8,9-테트라히드로-5H-1-옥사-7-아자-시클로헵타인덴;7-알릴옥시-8-클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-메톡시-1-메틸-8-(2-티에닐)-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-시아노-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-1-시클로프로필-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-1-히드록시메틸-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-1-이소프로필-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-7-히드록시-1-이소프로필-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-알릴옥시-8-브로모-1-이소프로필-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-7-메톡시-1,4-디메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-알릴옥시-8-브로모-1,4-디메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-클로로-1-히드록시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-플루오로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7,8-디클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;N-메틸-8-클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-요오도-1-메틸-7-트리플루오로메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;N-프로필-8-요오도-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;1-에틸-8-요오도-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-(2-플루오로페닐)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-(2-클로로페닐)-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀; 및8-브로모-1-메톡시메틸-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀으로 이루어지는 군으로부터 선택되는 화합물의 수화물 또는 화합물의 제약학적으로 허용되는 염의 수화물.
- 8-브로모-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-클로로-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-요오도-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;N-메틸-8-브로모-7-메톡시-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-1-에틸-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-클로로-1-에틸-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-요오도-1-에틸-7-메톡시-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7-메톡시-1-메틸-8-트리플루오로메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀; 및7-메톡시-1-메틸-8-펜타플루오로에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀으로 이루어지는 군으로부터 선택되는 화합물의 수화물 또는 화합물의 제약학적으로 허용되는 염의 수화물.
- 8-브로모-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-요오도-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-트리플루오로메틸-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-트리플루오로메틸-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-클로로-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-브로모-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-요오도-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7,8-디클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;7,8-디클로로-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀;8-클로로-7-플루오로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀; 및8-클로로-7-플루오로-1-에틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀으로 이루어지는 군으로부터 선택되는 화합물의 수화물 또는 화합물의 제약학적으로 허용되는 염의 수화물.
- 8-클로로-1-메틸-2,3,4,5-테트라히드로-1H-3-벤즈아제핀의 수화물 또는 이의 제약학적으로 허용되는 염의 수화물.
- 제38항에 있어서, R 거울상 이성질체인 수화물.
- 제38항에 있어서, S 거울상 이성질체인 수화물.
- 제38항에 있어서, R 및 S 거울상 이성질체의 혼합물인 수화물.
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- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 요붕증 또는 수면 무호흡의 예방 또는 치료용 제약 조성물.
- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 우울증, 비정형 우울증, 양극성 장애, 불안 장애, 강박 장애, 사회 공포증 또는 공황 상태, 수면 장애, 성기능 장애, 정신병, 정신분열증, 두개내압 상승, 간질, 인격 장애, 연령 관련 행동 장애, 치매와 관련된 행동 장애, 기질성 정신 장애, 소아 정신 장애, 공격증, 연령 관련 기억 장애, 만성 피로 증후군, 약물 및 알코올 중독, 비만, 대식증, 신경성 식욕부진증 또는 월경전 긴장의 예방 또는 치료용 제약 조성물.
- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 비만의 예방 또는 치료용 제약 조성물.
- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 외상, 뇌졸중, 신경퇴행성 질환, 또는 독성 또는 감염성 CNS 질환에 의한 중추 신경계에 대한 손상의 예방 또는 치료용 제약 조성물.
- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 혈전증의 예방 또는 치료용 제약 조성물.
- 유효량의 제35항 내지 제41항 중 어느 한 항에 따른 수화물 및 제약학적으로 허용되는 담체 또는 부형제를 포함하는, 위장관 운동 기능장애의 예방 또는 치료용 제약 조성물.
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KR1020047016198A KR100812925B1 (ko) | 2002-04-12 | 2003-04-11 | 5ht2c 수용체 조절제 |
KR1020087000551A KR100908166B1 (ko) | 2002-04-12 | 2003-04-11 | 5ht2c 수용체 조절제 |
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- 2003-04-11 DK DK03718323T patent/DK1411881T3/da active
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- 2003-04-11 EP EP10010297.9A patent/EP2374796B1/en not_active Expired - Lifetime
- 2003-04-11 ES ES03718323T patent/ES2242165T3/es not_active Expired - Lifetime
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