JPS582946B2 - ８− チオメチルエルゴリンルイノ セイホウ - Google Patents

８− チオメチルエルゴリンルイノ セイホウ

Info

Publication number
JPS582946B2
JPS582946B2 JP50059191A JP5919175A JPS582946B2 JP S582946 B2 JPS582946 B2 JP S582946B2 JP 50059191 A JP50059191 A JP 50059191A JP 5919175 A JP5919175 A JP 5919175A JP S582946 B2 JPS582946 B2 JP S582946B2
Authority
JP
Japan
Prior art keywords
methyl
alk
general formula
acid
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50059191A
Other languages
English (en)
Japanese (ja)
Other versions
JPS50160300A (da
Inventor
エドマンド・シー・コーンフエルド
ニコラス・ジエイ・バーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS50160300A publication Critical patent/JPS50160300A/ja
Publication of JPS582946B2 publication Critical patent/JPS582946B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50059191A 1974-06-06 1975-05-16 ８− チオメチルエルゴリンルイノ セイホウ Expired JPS582946B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477136A US3901894A (en) 1974-06-06 1974-06-06 8-thiomethylergolines

Publications (2)

Publication Number Publication Date
JPS50160300A JPS50160300A (da) 1975-12-25
JPS582946B2 true JPS582946B2 (ja) 1983-01-19

Family

ID=23894677

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50059191A Expired JPS582946B2 (ja) 1974-06-06 1975-05-16 ８− チオメチルエルゴリンルイノ セイホウ

Country Status (27)

Country Link
US (1) US3901894A (da)
JP (1) JPS582946B2 (da)
AR (1) AR210736A1 (da)
AT (1) AT344333B (da)
AU (1) AU507574B2 (da)
BE (1) BE829887A (da)
BG (1) BG24812A3 (da)
CA (1) CA1071623A (da)
CH (1) CH617196A5 (da)
CS (1) CS199591B2 (da)
DD (1) DD120438A5 (da)
DE (1) DE2524575A1 (da)
DK (1) DK144160C (da)
ES (1) ES438313A1 (da)
FR (1) FR2273542A1 (da)
GB (1) GB1505296A (da)
HU (1) HU173590B (da)
IE (1) IE41474B1 (da)
IL (1) IL47424A (da)
NL (1) NL180911C (da)
PH (1) PH10992A (da)
PL (1) PL95738B1 (da)
RO (1) RO77543A (da)
SE (1) SE420095B (da)
SU (1) SU613724A3 (da)
YU (1) YU145575A (da)
ZA (1) ZA753638B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
JPS5283894A (en) * 1976-01-01 1977-07-13 Lilly Co Eli 88thiomethyl ergoline
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (it) * 1977-07-05 1988-03-31 Simes Derivati di ergoline-2-tioeteri e loro solfossidi
US4180582A (en) * 1978-02-08 1979-12-25 Eli Lilly And Company 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
FR2526797A1 (fr) * 1982-05-12 1983-11-18 Roussel Uclaf Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
GB8427536D0 (en) * 1984-10-31 1984-12-05 Lilly Industries Ltd Ergoline derivatives
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
BR0210915A (pt) * 2001-06-08 2004-06-08 Sod Conseils Rech Applic Análogos quiméricos de somatostatina-dopamina
EP1485382B1 (en) * 2002-03-15 2008-11-19 Antibioticos S.p.A. Process for the synthesis of pergolide
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
RU2015120570A (ru) 2012-11-01 2016-12-20 Ипсен Фарма С.А.С. Аналоги соматостатина и их димеры
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5012398A (da) * 1973-06-08 1975-02-07

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE712054A (da) * 1967-03-16 1968-07-15
DE1935556A1 (de) * 1969-07-12 1971-01-21 Hoechst Ag Verfahren zur Herstellung von Lysergol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5012398A (da) * 1973-06-08 1975-02-07

Also Published As

Publication number Publication date
AR210736A1 (es) 1977-09-15
DD120438A5 (da) 1976-06-12
NL180911C (nl) 1987-05-18
PH10992A (en) 1977-10-20
ZA753638B (en) 1977-01-26
CS199591B2 (en) 1980-07-31
JPS50160300A (da) 1975-12-25
AU8182775A (en) 1976-12-09
IL47424A (en) 1979-11-30
FR2273542A1 (fr) 1976-01-02
NL7506584A (nl) 1975-12-09
NL180911B (nl) 1986-12-16
ES438313A1 (es) 1977-05-16
DK144160C (da) 1982-06-07
RO77543A (ro) 1982-02-26
AT344333B (de) 1978-07-10
FR2273542B1 (da) 1978-10-06
SE7506327L (sv) 1975-12-08
DK249975A (da) 1975-12-07
BE829887A (fr) 1975-12-05
CA1071623A (en) 1980-02-12
IE41474B1 (en) 1980-01-16
AU507574B2 (en) 1980-02-21
CH617196A5 (da) 1980-05-14
GB1505296A (en) 1978-03-30
YU145575A (en) 1982-02-28
DK144160B (da) 1981-12-28
SU613724A3 (ru) 1978-06-30
US3901894A (en) 1975-08-26
SE420095B (sv) 1981-09-14
HU173590B (hu) 1979-06-28
BG24812A3 (en) 1978-05-12
PL95738B1 (pl) 1977-11-30
IL47424A0 (en) 1975-08-31
DE2524575A1 (de) 1975-12-18
IE41474L (en) 1975-12-06
ATA427975A (de) 1977-11-15

Similar Documents

Publication Publication Date Title
JPS582946B2 (ja) ８− チオメチルエルゴリンルイノ セイホウ
US4054660A (en) Method of inhibiting prolactin
JPS6160830B2 (da)
FR2466465A1 (fr) Derives de d-6-n-propylergolines, leur procede de preparation et compositions pharmaceutiques en contenant
SU568366A3 (ru) Способ получени производных бензодиазепина или их 5-окисей или солей
US4075212A (en) Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
DE3438351A1 (de) 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung
EP0231671B1 (en) Gonatriene derivatives and process for preparing them
IL42730A (en) D-6-methyl-2,8-disubstituted ergolines,their preparation and pharmaceutical compositions containing them
JPS59210085A (ja) 新規エルゴリン誘導体の製造法
US3968112A (en) Synthesis of penniclavine and elymoclavine
SU1181551A3 (ru) Способ получени производных 3-хлорпрегнана
CZ284321B6 (cs) Způsob přípravy fysostigminkarbamátových derivátů z fysostigminu
US4098790A (en) Ergoline chlorination process
KR790001074B1 (ko) 8,8-이치환-6-메틸에르골린류의 제조방법
IL44119A (en) Esters of 1,6-dimethyl-10alpha-metho esters of 1,6-dimethyl-10alpha-methoxy-8beta-hydroxyethylergo -ine and process for their preparation
US3929796A (en) Synthesis of penniclavine and elymoclavine
DE2938313C2 (da)
US4001242A (en) D-6-methyl-8-formyl-10α-alkoxy-8-ergolene
KR800000413B1 (ko) 6-메틸-8-(치환)메틸 에르골린류의 제조방법
US4054567A (en) 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US3347866A (en) 4-(indol-3-yl)-hexahydro-1h-azepines and their method of preparation
US3923812A (en) Synthesis of elymoclavine
US3557096A (en) 5,6,8,9 - tetrahydro - 1,3 - benzoxazacycyloundecane - 2,4,7(3h) - triones and their preparation
JPS5910358B2 (ja) 新規エルゴリン誘導体