CA1071623A - 8-thiomethylergolines - Google Patents

8-thiomethylergolines

Info

Publication number
CA1071623A
CA1071623A CA228,332A CA228332A CA1071623A CA 1071623 A CA1071623 A CA 1071623A CA 228332 A CA228332 A CA 228332A CA 1071623 A CA1071623 A CA 1071623A
Authority
CA
Canada
Prior art keywords
methyl
alk
formula
phenyl
didehydroergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA228,332A
Other languages
English (en)
French (fr)
Inventor
Edmund C. Kornfeld
Nicholas J. Bach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1071623A publication Critical patent/CA1071623A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA228,332A 1974-06-06 1975-06-03 8-thiomethylergolines Expired CA1071623A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477136A US3901894A (en) 1974-06-06 1974-06-06 8-thiomethylergolines

Publications (1)

Publication Number Publication Date
CA1071623A true CA1071623A (en) 1980-02-12

Family

ID=23894677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA228,332A Expired CA1071623A (en) 1974-06-06 1975-06-03 8-thiomethylergolines

Country Status (27)

Country Link
US (1) US3901894A (da)
JP (1) JPS582946B2 (da)
AR (1) AR210736A1 (da)
AT (1) AT344333B (da)
AU (1) AU507574B2 (da)
BE (1) BE829887A (da)
BG (1) BG24812A3 (da)
CA (1) CA1071623A (da)
CH (1) CH617196A5 (da)
CS (1) CS199591B2 (da)
DD (1) DD120438A5 (da)
DE (1) DE2524575A1 (da)
DK (1) DK144160C (da)
ES (1) ES438313A1 (da)
FR (1) FR2273542A1 (da)
GB (1) GB1505296A (da)
HU (1) HU173590B (da)
IE (1) IE41474B1 (da)
IL (1) IL47424A (da)
NL (1) NL180911C (da)
PH (1) PH10992A (da)
PL (1) PL95738B1 (da)
RO (1) RO77543A (da)
SE (1) SE420095B (da)
SU (1) SU613724A3 (da)
YU (1) YU145575A (da)
ZA (1) ZA753638B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
JPS5283894A (en) * 1976-01-01 1977-07-13 Lilly Co Eli 88thiomethyl ergoline
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (it) * 1977-07-05 1988-03-31 Simes Derivati di ergoline-2-tioeteri e loro solfossidi
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4180582A (en) * 1978-02-08 1979-12-25 Eli Lilly And Company 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
FR2526797A1 (fr) * 1982-05-12 1983-11-18 Roussel Uclaf Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
GB8427536D0 (en) * 1984-10-31 1984-12-05 Lilly Industries Ltd Ergoline derivatives
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
ATE424414T1 (de) 2001-06-08 2009-03-15 Sod Conseils Rech Applic Chimere somatostatin-dopamin-analoga
US7019140B2 (en) * 2002-03-15 2006-03-28 Antibioticos S.P.A. Process for the synthesis of pergolide
RU2015120570A (ru) 2012-11-01 2016-12-20 Ипсен Фарма С.А.С. Аналоги соматостатина и их димеры
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
WO2019234069A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
DE1935556A1 (de) * 1969-07-12 1971-01-21 Hoechst Ag Verfahren zur Herstellung von Lysergol
JPS5012398A (da) * 1973-06-08 1975-02-07

Also Published As

Publication number Publication date
YU145575A (en) 1982-02-28
DD120438A5 (da) 1976-06-12
ES438313A1 (es) 1977-05-16
NL180911B (nl) 1986-12-16
AR210736A1 (es) 1977-09-15
IE41474L (en) 1975-12-06
US3901894A (en) 1975-08-26
CS199591B2 (en) 1980-07-31
DK249975A (da) 1975-12-07
IL47424A (en) 1979-11-30
BG24812A3 (en) 1978-05-12
SU613724A3 (ru) 1978-06-30
HU173590B (hu) 1979-06-28
PL95738B1 (pl) 1977-11-30
FR2273542B1 (da) 1978-10-06
JPS582946B2 (ja) 1983-01-19
SE7506327L (sv) 1975-12-08
DE2524575A1 (de) 1975-12-18
ATA427975A (de) 1977-11-15
BE829887A (fr) 1975-12-05
NL180911C (nl) 1987-05-18
AT344333B (de) 1978-07-10
IL47424A0 (en) 1975-08-31
RO77543A (ro) 1982-02-26
FR2273542A1 (fr) 1976-01-02
GB1505296A (en) 1978-03-30
IE41474B1 (en) 1980-01-16
AU507574B2 (en) 1980-02-21
NL7506584A (nl) 1975-12-09
PH10992A (en) 1977-10-20
JPS50160300A (da) 1975-12-25
DK144160C (da) 1982-06-07
SE420095B (sv) 1981-09-14
ZA753638B (en) 1977-01-26
AU8182775A (en) 1976-12-09
CH617196A5 (da) 1980-05-14
DK144160B (da) 1981-12-28

Similar Documents

Publication Publication Date Title
CA1071623A (en) 8-thiomethylergolines
CA1114368A (en) 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4054660A (en) Method of inhibiting prolactin
EP0026671B1 (en) Novel ergoline derivatives, compositions containing them, their preparation and use as pharmaceuticals
CA1064918A (en) 8,8-disubstituted-6-methylergolines and related compounds
US4180582A (en) 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
CA1062253A (en) Process for preparing 6-methyl-8-(substituted) methylergolines
IL42730A (en) D-6-methyl-2,8-disubstituted ergolines,their preparation and pharmaceutical compositions containing them
EP0016274B1 (en) 2-azaergolines and 2-aza-8(or 9)-ergolenes, process for their preparation and pharmaceutical compositions containing them
US4609731A (en) Process for brominating ergot alkaloids
US4098790A (en) Ergoline chlorination process
US4001242A (en) D-6-methyl-8-formyl-10α-alkoxy-8-ergolene
US4843073A (en) 1-t-butyl ergolines useful in the treatment of cerebral insufficiency and senile dementia
USRE30218E (en) 8,8-Disubstituted-6-methylergolines and related compounds
USRE30219E (en) Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
US4054567A (en) 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
CA1051879A (en) Synthesis of elymoclavine and derivatives
US3929796A (en) Synthesis of penniclavine and elymoclavine
US3923812A (en) Synthesis of elymoclavine
US4321380A (en) Alkyl cyanomethyl ergoline-I derivatives and salts thereof, and methods for their preparation
CA1101848A (en) Process for preparing ergoline derivatives
JPH0240647B2 (ja) Purorakuchinbunpyokuseizai
KR800000413B1 (ko) 6-메틸-8-(치환)메틸 에르골린류의 제조방법
GB2031890A (en) Process for the preparation of brominated ergot alkaloids
JPH0240044B2 (ja) Paakinsonshokogunchiryozai

Legal Events

Date Code Title Description
MKEX Expiry