JPS52153944A - Process for selective protection of amino group - Google Patents
Process for selective protection of amino groupInfo
- Publication number
- JPS52153944A JPS52153944A JP7094677A JP7094677A JPS52153944A JP S52153944 A JPS52153944 A JP S52153944A JP 7094677 A JP7094677 A JP 7094677A JP 7094677 A JP7094677 A JP 7094677A JP S52153944 A JPS52153944 A JP S52153944A
- Authority
- JP
- Japan
- Prior art keywords
- amino group
- selective protection
- selective
- protection
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/697,297 US4136254A (en) | 1976-06-17 | 1976-06-17 | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS52153944A true JPS52153944A (en) | 1977-12-21 |
JPS5549586B2 JPS5549586B2 (ja) | 1980-12-12 |
Family
ID=24800569
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7094677A Granted JPS52153944A (en) | 1976-06-17 | 1977-06-15 | Process for selective protection of amino group |
JP54126323A Expired JPS5822160B2 (ja) | 1976-06-17 | 1979-09-29 | 新規な4,6−ジ−0−(アミノグリコシル)−1,3−ジアミノシクリト−ル類 |
JP12632179A Granted JPS5569519A (en) | 1976-06-17 | 1979-09-29 | Amino group selective protection |
JP12632279A Granted JPS5569598A (en) | 1976-06-17 | 1979-09-29 | Manufacture of 4*66dii00*aminoglycosyl**1*33 diaminocyclitols |
JP23002584A Granted JPS6127997A (ja) | 1976-06-17 | 1984-10-31 | 3,2′,6′−トリ−n−アシル−3′,4′−ジデオキシカナマイシンb |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54126323A Expired JPS5822160B2 (ja) | 1976-06-17 | 1979-09-29 | 新規な4,6−ジ−0−(アミノグリコシル)−1,3−ジアミノシクリト−ル類 |
JP12632179A Granted JPS5569519A (en) | 1976-06-17 | 1979-09-29 | Amino group selective protection |
JP12632279A Granted JPS5569598A (en) | 1976-06-17 | 1979-09-29 | Manufacture of 4*66dii00*aminoglycosyl**1*33 diaminocyclitols |
JP23002584A Granted JPS6127997A (ja) | 1976-06-17 | 1984-10-31 | 3,2′,6′−トリ−n−アシル−3′,4′−ジデオキシカナマイシンb |
Country Status (18)
Country | Link |
---|---|
US (1) | US4136254A (ja) |
JP (5) | JPS52153944A (ja) |
AR (1) | AR216648A1 (ja) |
BE (1) | BE855704A (ja) |
CA (1) | CA1265130A (ja) |
CH (1) | CH639979A5 (ja) |
DE (3) | DE2759974C2 (ja) |
DK (1) | DK165451C (ja) |
ES (1) | ES459791A1 (ja) |
FR (2) | FR2374331A1 (ja) |
GB (1) | GB1575982A (ja) |
HK (1) | HK484A (ja) |
HU (1) | HU182050B (ja) |
IE (1) | IE45734B1 (ja) |
IL (1) | IL52318A (ja) |
MY (1) | MY8500081A (ja) |
NL (1) | NL177014C (ja) |
SE (2) | SE447481B (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE48972B1 (en) * | 1978-11-11 | 1985-06-26 | Microbial Chem Res Found | The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic |
US4226980A (en) * | 1978-12-07 | 1980-10-07 | Abbott Laboratories | Novel derivatives of fortimicin B and process for preparing same |
JPS5723281A (en) * | 1980-07-17 | 1982-02-06 | Mitsubishi Electric Corp | Semiconductor light-receiving element |
US4424344A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
US4424345A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
EP0054514A1 (de) * | 1980-12-16 | 1982-06-23 | Ciba-Geigy Ag | Neue antibiotisch wirksame Aminopapulacandin-Derivate |
JPS6253997A (ja) * | 1985-09-03 | 1987-03-09 | Kowa Co | 新規なアミノ配糖体及びこれを含有する製剤 |
JPS6281784A (ja) * | 1985-10-04 | 1987-04-15 | Nippon Telegr & Teleph Corp <Ntt> | 半導体レ−ザの発光強度監視方法および半導体レ−ザ装置 |
IT1200774B (it) * | 1985-10-10 | 1989-01-27 | Pierrel Spa | Procedimento di sentisi dell'amikacina |
IT1225484B (it) * | 1987-11-27 | 1990-11-14 | Pierrel Spa | Procedimento di sintesi dell'amikacina |
HU207338B (en) * | 1989-06-21 | 1993-03-29 | Schering Corp | Process for producing izepamycin |
US5442047A (en) * | 1991-12-04 | 1995-08-15 | Schering Corporation | Process for preparing isepamicin |
IT1237490B (it) * | 1989-09-22 | 1993-06-07 | Chementecno S R L Monza Milano | Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico |
CN1040177C (zh) * | 1993-04-23 | 1998-10-14 | 江苏省微生物研究所 | 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法 |
KR100467506B1 (ko) * | 2002-10-01 | 2005-01-24 | 경동제약 주식회사 | 이세파마이신의 제조방법 |
US7794713B2 (en) * | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
US20080213274A1 (en) * | 2005-10-28 | 2008-09-04 | Sabbadini Roger A | Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye |
US20090074720A1 (en) * | 2005-10-28 | 2009-03-19 | Sabbadini Roger A | Methods for decreasing immune response and treating immune conditions |
US7862812B2 (en) * | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
CN101868472B (zh) | 2007-11-21 | 2013-05-29 | 尔察祯有限公司 | 抗菌性氨基糖苷类似物 |
EP2421877A4 (en) | 2008-10-03 | 2013-03-20 | Glycan Biosciences Llc | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE |
WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
WO2010132757A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3388141A (en) * | 1965-10-05 | 1968-06-11 | Thiokol Chemical Corp | Di-schiff bases of hydroxyl substituted diamines and beta-diketones, derivatives, and metal chelates thereof |
FR2015139A1 (ja) * | 1968-08-06 | 1970-04-24 | Sanyo Chemical Cy Ltd | |
DE2061537A1 (de) * | 1969-12-30 | 1971-07-08 | Snam Progetti S.P.A., Mailand (Italien) | Verfahren zur Herstellung von Kobalt(III>Komplexen |
US3682995A (en) * | 1970-05-04 | 1972-08-08 | Minnesota Mining & Mfg | Copper chelate |
JPS5220991B2 (ja) * | 1972-08-23 | 1977-06-07 | ||
US4001208A (en) | 1972-10-06 | 1977-01-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai | 1-N-[(S)-α-hydroxy-ω-aminoacyl] |
GB1441202A (en) * | 1973-05-15 | 1976-06-30 | Microbial Chem Res Found | 1-n-isoserylkanamycins and the production thereof |
US3878193A (en) * | 1973-06-26 | 1975-04-15 | Schering Corp | Process for the preparation of garamine derivatives |
US3872080A (en) * | 1973-06-26 | 1975-03-18 | Schering Corp | Process for the preparation of garamine and intermediates produced thereby |
JPS5512039B2 (ja) * | 1974-03-22 | 1980-03-29 | ||
JPS573679B2 (ja) * | 1974-03-07 | 1982-01-22 | ||
AR207582A1 (es) * | 1974-03-19 | 1976-10-15 | Scherico Ltd | Procedimiento para preparar derivados de diaminociclitole |
JPS5564598A (en) * | 1978-11-11 | 1980-05-15 | Microbial Chem Res Found | Preparation of aminoglycoside antibiotic having selectively protected amino group |
-
1976
- 1976-06-17 US US05/697,297 patent/US4136254A/en not_active Expired - Lifetime
-
1977
- 1977-06-13 CH CH723277A patent/CH639979A5/de not_active IP Right Cessation
- 1977-06-14 GB GB24812/77A patent/GB1575982A/en not_active Expired
- 1977-06-14 DE DE2759974A patent/DE2759974C2/de not_active Expired
- 1977-06-14 DE DE19772726712 patent/DE2726712A1/de active Granted
- 1977-06-14 DE DE2760317A patent/DE2760317C2/de not_active Expired
- 1977-06-14 IL IL52318A patent/IL52318A/xx unknown
- 1977-06-14 FR FR7718225A patent/FR2374331A1/fr active Granted
- 1977-06-14 AR AR268043A patent/AR216648A1/es active
- 1977-06-14 DK DK263277A patent/DK165451C/da not_active IP Right Cessation
- 1977-06-14 IE IE1219/77A patent/IE45734B1/en not_active IP Right Cessation
- 1977-06-14 SE SE7706872A patent/SE447481B/xx not_active IP Right Cessation
- 1977-06-15 BE BE178456A patent/BE855704A/xx not_active IP Right Cessation
- 1977-06-15 ES ES459791A patent/ES459791A1/es not_active Expired
- 1977-06-15 CA CA000280577A patent/CA1265130A/en not_active Expired - Fee Related
- 1977-06-15 NL NLAANVRAGE7706596,A patent/NL177014C/xx not_active IP Right Cessation
- 1977-06-15 JP JP7094677A patent/JPS52153944A/ja active Granted
- 1977-06-16 HU HU77SCHE610A patent/HU182050B/hu unknown
-
1978
- 1978-03-31 FR FR7809709A patent/FR2395277A1/fr active Granted
-
1979
- 1979-09-29 JP JP54126323A patent/JPS5822160B2/ja not_active Expired
- 1979-09-29 JP JP12632179A patent/JPS5569519A/ja active Granted
- 1979-09-29 JP JP12632279A patent/JPS5569598A/ja active Granted
-
1984
- 1984-01-05 HK HK4/84A patent/HK484A/xx unknown
- 1984-10-31 JP JP23002584A patent/JPS6127997A/ja active Granted
-
1985
- 1985-12-30 MY MY81/85A patent/MY8500081A/xx unknown
-
1986
- 1986-03-07 SE SE8601074A patent/SE469131B/sv not_active IP Right Cessation
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