IT1225484B - Procedimento di sintesi dell'amikacina - Google Patents

Procedimento di sintesi dell'amikacina

Info

Publication number
IT1225484B
IT1225484B IT8722783A IT2278387A IT1225484B IT 1225484 B IT1225484 B IT 1225484B IT 8722783 A IT8722783 A IT 8722783A IT 2278387 A IT2278387 A IT 2278387A IT 1225484 B IT1225484 B IT 1225484B
Authority
IT
Italy
Prior art keywords
amikacina
synthesis procedure
synthesis
derivative
economicity
Prior art date
Application number
IT8722783A
Other languages
English (en)
Other versions
IT8722783A0 (it
Inventor
Alberto Mangia
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of IT8722783A0 publication Critical patent/IT8722783A0/it
Priority to IT8722783A priority Critical patent/IT1225484B/it
Priority to AT88119460T priority patent/ATE125544T1/de
Priority to DE3854225T priority patent/DE3854225T2/de
Priority to EP88119460A priority patent/EP0317970B1/en
Priority to ES88119460T priority patent/ES2074431T3/es
Priority to BG86218A priority patent/BG49048A3/xx
Priority to CS887779A priority patent/CS277017B6/cs
Priority to CA000584227A priority patent/CA1324375C/en
Priority to HU886072A priority patent/HU201771B/hu
Priority to DK661588A priority patent/DK170050B1/da
Priority to FI885489A priority patent/FI90243C/fi
Priority to DD88322213A priority patent/DD283564A5/de
Priority to SU884356995A priority patent/RU1776262C/ru
Priority to NO885270A priority patent/NO171505C/no
Priority to PH37859A priority patent/PH25818A/en
Priority to ZA888855A priority patent/ZA888855B/xx
Priority to JP63299382A priority patent/JPH0637512B2/ja
Priority to YU218888A priority patent/YU47063B/sh
Priority to PL1988276047A priority patent/PL161416B1/pl
Priority to AU25963/88A priority patent/AU608665B2/en
Priority to NZ227113A priority patent/NZ227113A/en
Priority to RO88136098A priority patent/RO102339B1/ro
Application granted granted Critical
Publication of IT1225484B publication Critical patent/IT1225484B/it
Priority to US07/834,991 priority patent/US5763587A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IT8722783A 1987-11-27 1987-11-27 Procedimento di sintesi dell'amikacina IT1225484B (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT8722783A IT1225484B (it) 1987-11-27 1987-11-27 Procedimento di sintesi dell'amikacina
AT88119460T ATE125544T1 (de) 1987-11-27 1988-11-23 Verfahren zur herstellung von amikacin.
DE3854225T DE3854225T2 (de) 1987-11-27 1988-11-23 Verfahren zur Herstellung von Amikacin.
EP88119460A EP0317970B1 (en) 1987-11-27 1988-11-23 A process for the synthesis of amikacin
ES88119460T ES2074431T3 (es) 1987-11-27 1988-11-23 Un procedimiento para la sintesis de amicacina.
FI885489A FI90243C (fi) 1987-11-27 1988-11-25 Menetelmä amikasiinin valmistamiseksi
PH37859A PH25818A (en) 1987-11-27 1988-11-25 A process for the synthesis of amikacin
CA000584227A CA1324375C (en) 1987-11-27 1988-11-25 Process for the synthesis of amikacin
HU886072A HU201771B (en) 1987-11-27 1988-11-25 Process for producing amikacin
DK661588A DK170050B1 (da) 1987-11-27 1988-11-25 Fremgangsmåde til fremstilling af amikacin
BG86218A BG49048A3 (en) 1987-11-27 1988-11-25 Method for preparing of amickacine
DD88322213A DD283564A5 (de) 1987-11-27 1988-11-25 Verfahren fuer die synthese von amikacin
SU884356995A RU1776262C (ru) 1987-11-27 1988-11-25 Способ получени амикацина
NO885270A NO171505C (no) 1987-11-27 1988-11-25 Fremgangsmaate for syntese av amikacin
CS887779A CS277017B6 (en) 1987-11-27 1988-11-25 Process of amikacin
ZA888855A ZA888855B (en) 1987-11-27 1988-11-25 A process for the synthesis of amikacin
JP63299382A JPH0637512B2 (ja) 1987-11-27 1988-11-26 アミカシンの合成方法
YU218888A YU47063B (sh) 1987-11-27 1988-11-28 Postupak sinteze amikacina
PL1988276047A PL161416B1 (pl) 1987-11-27 1988-11-28 Sposób wytwarzania amykacyny PL
AU25963/88A AU608665B2 (en) 1987-11-27 1988-11-28 A process for the synthesis of amikacin
NZ227113A NZ227113A (en) 1987-11-27 1988-11-28 Synthesis of amikacin
RO88136098A RO102339B1 (ro) 1987-11-27 1988-11-28 Procedeu pentru prepararea amicacinei
US07/834,991 US5763587A (en) 1987-11-27 1992-02-14 Process for the synthesis of amikacin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8722783A IT1225484B (it) 1987-11-27 1987-11-27 Procedimento di sintesi dell'amikacina

Publications (2)

Publication Number Publication Date
IT8722783A0 IT8722783A0 (it) 1987-11-27
IT1225484B true IT1225484B (it) 1990-11-14

Family

ID=11200418

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8722783A IT1225484B (it) 1987-11-27 1987-11-27 Procedimento di sintesi dell'amikacina

Country Status (23)

Country Link
US (1) US5763587A (it)
EP (1) EP0317970B1 (it)
JP (1) JPH0637512B2 (it)
AT (1) ATE125544T1 (it)
AU (1) AU608665B2 (it)
BG (1) BG49048A3 (it)
CA (1) CA1324375C (it)
CS (1) CS277017B6 (it)
DD (1) DD283564A5 (it)
DE (1) DE3854225T2 (it)
DK (1) DK170050B1 (it)
ES (1) ES2074431T3 (it)
FI (1) FI90243C (it)
HU (1) HU201771B (it)
IT (1) IT1225484B (it)
NO (1) NO171505C (it)
NZ (1) NZ227113A (it)
PH (1) PH25818A (it)
PL (1) PL161416B1 (it)
RO (1) RO102339B1 (it)
RU (1) RU1776262C (it)
YU (1) YU47063B (it)
ZA (1) ZA888855B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW465235B (en) 1998-09-17 2001-11-21 United Video Properties Inc Electronic program guide with digital storage
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
EP1928410A2 (en) 2005-09-29 2008-06-11 Nektar Therapeutics Antibiotic formulations, unit doses, kits, and methods
JP5256043B2 (ja) 2005-12-02 2013-08-07 アイシス ファーマシューティカルズ， インコーポレーテッド 複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
EP2148884A1 (en) * 2007-04-10 2010-02-03 Achaogen, Inc. Antibacterial 1,4,5-substituted aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8791245B2 (en) * 2008-10-03 2014-07-29 Glycan Bioscience LLC Anionic conjugates of glycosylated bacterial metabolite
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
EP2486044A2 (en) 2009-10-09 2012-08-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
JP2013542992A (ja) 2010-11-17 2013-11-28 アカオジェン インコーポレイテッド 抗菌性アミノグリコシド類似体
CN103113429B (zh) * 2013-03-05 2015-02-18 齐鲁天和惠世制药有限公司 一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) * 2014-08-27 2018-03-09 北大医药重庆大新药业股份有限公司 一种阿米卡星的合成方法
CN111233952A (zh) * 2020-04-02 2020-06-05 管炫棣 一种阿卡米星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL157910B (nl) * 1973-11-14 1978-09-15 Bristol Myers Co Werkwijze voor het bereiden van 1-(l-(-)-gamma-amino-alfa-hydroxybutyryl)kanamycine a.
JPS51127045A (en) * 1975-04-24 1976-11-05 Microbial Chem Res Found A process for preparing 3'- deoxykanamycin a derivatives.
GB1530201A (en) * 1976-04-14 1978-10-25 Pfizer Ltd Process for the preparation of aminoglycoside antibiotics and intermediates therefor
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE54288B1 (en) * 1982-03-05 1989-08-16 Fujisawa Pharmaceutical Co New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina

Also Published As

Publication number Publication date
ES2074431T3 (es) 1995-09-16
YU218888A (en) 1989-12-31
IT8722783A0 (it) 1987-11-27
DE3854225T2 (de) 1996-01-04
RU1776262C (ru) 1992-11-15
AU2596388A (en) 1989-06-01
CS277017B6 (en) 1992-11-18
AU608665B2 (en) 1991-04-11
CS777988A3 (en) 1992-06-17
DK170050B1 (da) 1995-05-08
ZA888855B (en) 1990-02-28
DK661588D0 (da) 1988-11-25
HUT49144A (en) 1989-08-28
ATE125544T1 (de) 1995-08-15
DE3854225D1 (de) 1995-08-31
FI90243C (fi) 1994-01-10
JPH01186900A (ja) 1989-07-26
JPH0637512B2 (ja) 1994-05-18
NO885270L (no) 1989-05-29
EP0317970A3 (en) 1991-08-28
US5763587A (en) 1998-06-09
FI885489A (fi) 1989-05-28
NO171505C (no) 1993-03-24
YU47063B (sh) 1994-12-28
PL276047A1 (en) 1989-07-10
EP0317970B1 (en) 1995-07-26
HU201771B (en) 1990-12-28
FI885489A0 (fi) 1988-11-25
RO102339B1 (ro) 1992-08-01
PH25818A (en) 1991-11-05
PL161416B1 (pl) 1993-06-30
BG49048A3 (en) 1991-07-15
NO885270D0 (no) 1988-11-25
NZ227113A (en) 1991-01-29
NO171505B (no) 1992-12-14
FI90243B (fi) 1993-09-30
CA1324375C (en) 1993-11-16
DK661588A (da) 1989-05-28
DD283564A5 (de) 1990-10-17
EP0317970A2 (en) 1989-05-31

Similar Documents

Publication Publication Date Title
IT1225484B (it) Procedimento di sintesi dell'amikacina
AR240830A2 (es) Procedimiento para preparar derivados de acidos naftiridin quinolin-y benzoxazincarboxilicos.
HU908495D0 (en) Process for the production of a-nor-steroid-3-carbonic acid derivatives
IE851917L (en) Hydroxylamine derivatives, azetidinones and process for¹preparing azetidinones
EP0237084A3 (en) 1,3-dioxolen-2-one derivative, 4-bromomethyl-5-methyl-1,3-dioxolen-2-one, and a process for the production thereof
PT86074A (en) Process for preparing new substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
JPS6466189A (en) Production of penicillanic acid derivative
PT89207A (pt) Processo para a preparcao de derivados de ciclopropano e de produtos intermediarios
IE892233L (en) Process for the production of¹o2,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine
HK1000109A1 (en) Process for the preparation of 3,3-diaryl acrylic acid amides 3,3-
LV5491A3 (lv) 2-tiazolidinona atvasinajumu iegusanas panemiens
CA1273347C (it)
GR3004216T3 (it)
EP0251327A3 (en) Process for production of anthracycline compound r2ox2
SG43092A1 (en) Process for preparing 5-arylhydantoin
ES2115239T3 (es) Procedimiento de produccion de alfa-hidroxiiminofenilacetonitrilos.
ES2007387A6 (es) Procedimiento para la obtencion de un derivado del acido cromoglicico
JPS54157593A (en) Preparation of high-purity 6-acylaminoacylamido penicillanic acid

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951127