DK165451C - Fremgangsmaade til selektiv blokering af aminogrupper i aminocyclitolaminoglycosider samt selektivt aminoblokerede aminocyclitolaminoglycosider, der kan fremstilles ved fremgangsmaaden, til anvendelse som mellemprodukter ved fremstilling af 1-n-substituerede derivater af 4,6-di-o-)aminoglycosyl)-1,3-diaminocyclitoler - Google Patents

Fremgangsmaade til selektiv blokering af aminogrupper i aminocyclitolaminoglycosider samt selektivt aminoblokerede aminocyclitolaminoglycosider, der kan fremstilles ved fremgangsmaaden, til anvendelse som mellemprodukter ved fremstilling af 1-n-substituerede derivater af 4,6-di-o-)aminoglycosyl)-1,3-diaminocyclitoler

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Publication number
DK165451C
DK165451C DK263277A DK263277A DK165451C DK 165451 C DK165451 C DK 165451C DK 263277 A DK263277 A DK 263277A DK 263277 A DK263277 A DK 263277A DK 165451 C DK165451 C DK 165451C
Authority
DK
Denmark
Prior art keywords
aminocyclitolaminoglycosider
selective
diaminocyclitoler
aminoglycosyl
intermediates
Prior art date
Application number
DK263277A
Other languages
English (en)
Other versions
DK263277A (da
DK165451B (da
Inventor
Tattanahalli Laksh Nagabhushan
Alan Cooper
William Nelson Turner
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of DK263277A publication Critical patent/DK263277A/da
Publication of DK165451B publication Critical patent/DK165451B/da
Application granted granted Critical
Publication of DK165451C publication Critical patent/DK165451C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK263277A 1976-06-17 1977-06-14 Fremgangsmaade til selektiv blokering af aminogrupper i aminocyclitolaminoglycosider samt selektivt aminoblokerede aminocyclitolaminoglycosider, der kan fremstilles ved fremgangsmaaden, til anvendelse som mellemprodukter ved fremstilling af 1-n-substituerede derivater af 4,6-di-o-)aminoglycosyl)-1,3-diaminocyclitoler DK165451C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69729776 1976-06-17
US05/697,297 US4136254A (en) 1976-06-17 1976-06-17 Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby

Publications (3)

Publication Number Publication Date
DK263277A DK263277A (da) 1977-12-18
DK165451B DK165451B (da) 1992-11-30
DK165451C true DK165451C (da) 1993-04-13

Family

ID=24800569

Family Applications (1)

Application Number Title Priority Date Filing Date
DK263277A DK165451C (da) 1976-06-17 1977-06-14 Fremgangsmaade til selektiv blokering af aminogrupper i aminocyclitolaminoglycosider samt selektivt aminoblokerede aminocyclitolaminoglycosider, der kan fremstilles ved fremgangsmaaden, til anvendelse som mellemprodukter ved fremstilling af 1-n-substituerede derivater af 4,6-di-o-)aminoglycosyl)-1,3-diaminocyclitoler

Country Status (18)

Country Link
US (1) US4136254A (da)
JP (5) JPS52153944A (da)
AR (1) AR216648A1 (da)
BE (1) BE855704A (da)
CA (1) CA1265130A (da)
CH (1) CH639979A5 (da)
DE (3) DE2760317C2 (da)
DK (1) DK165451C (da)
ES (1) ES459791A1 (da)
FR (2) FR2374331A1 (da)
GB (1) GB1575982A (da)
HK (1) HK484A (da)
HU (1) HU182050B (da)
IE (1) IE45734B1 (da)
IL (1) IL52318A (da)
MY (1) MY8500081A (da)
NL (1) NL177014C (da)
SE (2) SE447481B (da)

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* Cited by examiner, † Cited by third party
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IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4226980A (en) * 1978-12-07 1980-10-07 Abbott Laboratories Novel derivatives of fortimicin B and process for preparing same
JPS5723281A (en) * 1980-07-17 1982-02-06 Mitsubishi Electric Corp Semiconductor light-receiving element
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
EP0054514A1 (de) * 1980-12-16 1982-06-23 Ciba-Geigy Ag Neue antibiotisch wirksame Aminopapulacandin-Derivate
JPS6253997A (ja) * 1985-09-03 1987-03-09 Kowa Co 新規なアミノ配糖体及びこれを含有する製剤
JPS6281784A (ja) * 1985-10-04 1987-04-15 Nippon Telegr & Teleph Corp <Ntt> 半導体レ−ザの発光強度監視方法および半導体レ−ザ装置
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
ES2100380T3 (es) * 1989-06-21 1997-06-16 Schering Corp Compuestos de (s)-isoserina protegidos en n.
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
CN1040177C (zh) * 1993-04-23 1998-10-14 江苏省微生物研究所 一种含1-N-乙基庆大霉素C1a或其盐的药用制剂及制备方法
KR100467506B1 (ko) * 2002-10-01 2005-01-24 경동제약 주식회사 이세파마이신의 제조방법
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
KR101296099B1 (ko) 2007-11-21 2014-02-26 아카오젠, 인코포레이티드 항균성 아미노글리코사이드 동족체
AU2009299118B2 (en) 2008-10-03 2015-12-17 Glycan Biosciences Llc Anionic conjugates of glycosylated bacterial metabolite
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388141A (en) * 1965-10-05 1968-06-11 Thiokol Chemical Corp Di-schiff bases of hydroxyl substituted diamines and beta-diketones, derivatives, and metal chelates thereof
FR2015139A1 (da) * 1968-08-06 1970-04-24 Sanyo Chemical Cy Ltd
DE2061537A1 (de) * 1969-12-30 1971-07-08 Snam Progetti S.P.A., Mailand (Italien) Verfahren zur Herstellung von Kobalt(III>Komplexen
US3682995A (en) * 1970-05-04 1972-08-08 Minnesota Mining & Mfg Copper chelate
JPS5220991B2 (da) * 1972-08-23 1977-06-07
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof
US3878193A (en) * 1973-06-26 1975-04-15 Schering Corp Process for the preparation of garamine derivatives
US3872080A (en) * 1973-06-26 1975-03-18 Schering Corp Process for the preparation of garamine and intermediates produced thereby
JPS5512039B2 (da) * 1974-03-22 1980-03-29
JPS573679B2 (da) * 1974-03-07 1982-01-22
AR207582A1 (es) * 1974-03-19 1976-10-15 Scherico Ltd Procedimiento para preparar derivados de diaminociclitole
JPS5564598A (en) * 1978-11-11 1980-05-15 Microbial Chem Res Found Preparation of aminoglycoside antibiotic having selectively protected amino group

Also Published As

Publication number Publication date
FR2374331A1 (fr) 1978-07-13
HU182050B (en) 1983-12-28
GB1575982A (en) 1980-10-01
DE2726712A1 (de) 1977-12-22
JPS6127997A (ja) 1986-02-07
SE469131B (sv) 1993-05-17
SE8601074A (da) 1986-03-07
CH639979A5 (de) 1983-12-15
IL52318A (en) 1981-06-29
SE8601074D0 (sv) 1986-03-07
IE45734B1 (en) 1982-11-17
JPH0132232B2 (da) 1989-06-29
US4136254A (en) 1979-01-23
AR216648A1 (es) 1980-01-15
SE7706872L (sv) 1978-02-06
DE2759974C2 (da) 1988-05-26
IE45734L (en) 1977-12-17
FR2395277A1 (fr) 1979-01-19
JPS5576895A (en) 1980-06-10
JPS6227073B2 (da) 1987-06-12
JPS5549586B2 (da) 1980-12-12
ES459791A1 (es) 1978-08-16
SE447481B (sv) 1986-11-17
FR2374331B1 (da) 1981-07-31
IL52318A0 (en) 1977-08-31
MY8500081A (en) 1985-12-31
JPS6121558B2 (da) 1986-05-27
JPS5569519A (en) 1980-05-26
NL7706596A (nl) 1977-12-20
DK263277A (da) 1977-12-18
NL177014B (nl) 1985-02-18
DE2726712C2 (da) 1987-06-19
DE2760317C2 (da) 1987-11-26
CA1265130A (en) 1990-01-30
NL177014C (nl) 1985-07-16
JPS5569598A (en) 1980-05-26
JPS5822160B2 (ja) 1983-05-06
BE855704A (fr) 1977-12-15
DK165451B (da) 1992-11-30
FR2395277B1 (da) 1981-11-20
JPS52153944A (en) 1977-12-21
HK484A (en) 1984-01-13

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