JPH09502357A - Grb3−3遺伝子、その変異体およびそれらの使用 - Google Patents
Grb3−3遺伝子、その変異体およびそれらの使用Info
- Publication number
- JPH09502357A JPH09502357A JP7509015A JP50901595A JPH09502357A JP H09502357 A JPH09502357 A JP H09502357A JP 7509015 A JP7509015 A JP 7509015A JP 50901595 A JP50901595 A JP 50901595A JP H09502357 A JPH09502357 A JP H09502357A
- Authority
- JP
- Japan
- Prior art keywords
- grb3
- vector
- sequence
- virus
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.配列番号1の配列の全部または一部を含んで成るヌクレオチド配列。 2.配列番号1の配列に由来し、かつGrb2またはGrb3−3タンパク質の 発現を少なくとも部分的に抑制することができるヌクレオチド配列。 3.請求の範囲第1または第2項に記載のヌクレオチド配列を含んで成るベクタ ー。 4.ウイルスベクターであることを特徴とする、請求の範囲第3項に記載のベク ター。 5.アデノウイルス、レトロウイルス、AAV、HSVウイルス、CMVまたは ワクシニアウイルスに由来するベクターであることを特徴とする請求の範囲第4 項に記載のベクター。 6.複製しないウイルスであることを特徴とする請求の範囲第4または第5項に 記載のベクター。 7.請求の範囲第3ないし第6項のいずれか1項に記載の1つ以上のベクターを 含んで成る医薬組成物。 8.請求の範囲第1または第2項に記載の1つ以上のヌクレオチド配列を、DE AE−デキストランと、核タンパク質と、または脂質との複合体状態で、粗状態 で、あるいはリポソーム中に包含された状態で含んで成る医薬組成物。 9.癌の治療を目的とした医薬組成物の調製のために、請求の範囲第1または第 2項に記載の配列、あるいは該配列を含むベクターの使用。 10.AIDSの治療を目的とする医薬組成物の調製のために、Grb3−3の 細胞効果を少なくとも部分的に排除または遮断することができ る化合物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR93/10971 | 1993-09-15 | ||
FR9310971A FR2710074B1 (fr) | 1993-09-15 | 1993-09-15 | Gène GRB3-3, ses variants et leurs utilisations. |
PCT/FR1994/000542 WO1995007981A1 (fr) | 1993-09-15 | 1994-05-09 | Gene grb3-3, ses variants et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09502357A true JPH09502357A (ja) | 1997-03-11 |
JP3794697B2 JP3794697B2 (ja) | 2006-07-05 |
Family
ID=9450882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50901595A Expired - Fee Related JP3794697B2 (ja) | 1993-09-15 | 1994-05-09 | Grb3−3遺伝子、その変異体およびそれらの使用 |
Country Status (27)
Country | Link |
---|---|
US (2) | US5831048A (ja) |
EP (1) | EP0719328B1 (ja) |
JP (1) | JP3794697B2 (ja) |
KR (1) | KR100330477B1 (ja) |
CN (1) | CN1098930C (ja) |
AT (1) | ATE196926T1 (ja) |
AU (1) | AU698819B2 (ja) |
BR (1) | BR9407693A (ja) |
CA (1) | CA2169938A1 (ja) |
CZ (1) | CZ288882B6 (ja) |
DE (1) | DE69426121T2 (ja) |
DK (1) | DK0719328T3 (ja) |
ES (1) | ES2152313T3 (ja) |
FI (1) | FI120499B (ja) |
FR (1) | FR2710074B1 (ja) |
GR (1) | GR3034600T3 (ja) |
HU (1) | HU221516B (ja) |
IL (2) | IL126756A (ja) |
NO (1) | NO319144B1 (ja) |
NZ (1) | NZ266162A (ja) |
PL (1) | PL178402B1 (ja) |
PT (1) | PT719328E (ja) |
RU (1) | RU2159815C2 (ja) |
SK (1) | SK281123B6 (ja) |
UA (1) | UA46715C2 (ja) |
WO (1) | WO1995007981A1 (ja) |
ZA (1) | ZA947059B (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2732348B1 (fr) * | 1995-03-31 | 1997-04-30 | Rhone Poulenc Rorer Sa | Systeme d'expression conditionnel |
US6171800B1 (en) | 1995-06-07 | 2001-01-09 | Biogen, Inc. | Method of making and binding CAIP polypeptides |
US5837844A (en) * | 1995-06-07 | 1998-11-17 | Biogen, Inc. | CAIP-like gene family |
US6423824B1 (en) | 1995-06-07 | 2002-07-23 | Biogen, Inc. | CAIP-like gene family |
US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
AU6342696A (en) * | 1996-06-27 | 1998-01-14 | Biogen, Inc. | The caip-like gene family |
US7309692B1 (en) | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
US6977244B2 (en) * | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
EP0998945A1 (en) * | 1998-09-30 | 2000-05-10 | Transgene S.A. | Use of magnesium (Mg2+) for the enhancement of gene delivery in gene therapy |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
RU2322500C2 (ru) | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
US20040043950A1 (en) * | 2002-01-03 | 2004-03-04 | Board Of Regents, The University Of Texas System | WT1 antisense oligos for the inhibition of breast cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE187772T1 (de) | 1991-01-18 | 2000-01-15 | Univ New York | Cdns-klonierungsverfahren für rezeptortyrosinkinasezielprotein und hgrb- proteine |
AU5136093A (en) * | 1992-09-25 | 1994-04-26 | Warner-Lambert Company | Peptide antagonists of sh2 binding and therapeutic uses thereof |
-
1993
- 1993-09-15 FR FR9310971A patent/FR2710074B1/fr not_active Expired - Fee Related
-
1994
- 1994-05-09 BR BR9407693A patent/BR9407693A/pt not_active Application Discontinuation
- 1994-05-09 DK DK94915598T patent/DK0719328T3/da active
- 1994-05-09 EP EP94915598A patent/EP0719328B1/fr not_active Expired - Lifetime
- 1994-05-09 JP JP50901595A patent/JP3794697B2/ja not_active Expired - Fee Related
- 1994-05-09 AT AT94915598T patent/ATE196926T1/de not_active IP Right Cessation
- 1994-05-09 CN CN94193814A patent/CN1098930C/zh not_active Expired - Fee Related
- 1994-05-09 UA UA96030994A patent/UA46715C2/uk unknown
- 1994-05-09 SK SK345-96A patent/SK281123B6/sk not_active IP Right Cessation
- 1994-05-09 RU RU96107888/13A patent/RU2159815C2/ru active
- 1994-05-09 CZ CZ1996758A patent/CZ288882B6/cs not_active IP Right Cessation
- 1994-05-09 ES ES94915598T patent/ES2152313T3/es not_active Expired - Lifetime
- 1994-05-09 US US08/612,857 patent/US5831048A/en not_active Ceased
- 1994-05-09 PT PT94915598T patent/PT719328E/pt unknown
- 1994-05-09 KR KR1019960701323A patent/KR100330477B1/ko not_active IP Right Cessation
- 1994-05-09 US US09/641,640 patent/USRE37952E1/en not_active Expired - Fee Related
- 1994-05-09 DE DE69426121T patent/DE69426121T2/de not_active Expired - Fee Related
- 1994-05-09 NZ NZ266162A patent/NZ266162A/en not_active IP Right Cessation
- 1994-05-09 PL PL94313445A patent/PL178402B1/pl not_active IP Right Cessation
- 1994-05-09 CA CA002169938A patent/CA2169938A1/fr not_active Abandoned
- 1994-05-09 AU AU67247/94A patent/AU698819B2/en not_active Ceased
- 1994-05-09 WO PCT/FR1994/000542 patent/WO1995007981A1/fr active IP Right Grant
- 1994-05-09 HU HU9600668A patent/HU221516B/hu not_active IP Right Cessation
- 1994-09-12 IL IL126756A patent/IL126756A/en not_active IP Right Cessation
- 1994-09-12 IL IL11094294A patent/IL110942A/en not_active IP Right Cessation
- 1994-09-13 ZA ZA947059A patent/ZA947059B/xx unknown
-
1996
- 1996-03-08 NO NO19960965A patent/NO319144B1/no not_active IP Right Cessation
- 1996-03-14 FI FI961202A patent/FI120499B/fi active IP Right Grant
-
2000
- 2000-10-12 GR GR20000401514T patent/GR3034600T3/el not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hamel et al. | Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene | |
Stein et al. | Repression of insulin gene expression by adenovirus type 5 Ela proteins | |
US6468985B1 (en) | Retinoblastoma protein-interacting zinc finger proteins | |
JP4351896B2 (ja) | p38/JTV−1を有効成分とする癌治療用薬学的組成物及び癌治療用薬学的組成物のスクリーニング方法 | |
JPH09502357A (ja) | Grb3−3遺伝子、その変異体およびそれらの使用 | |
JP2007190020A (ja) | 特に神経変性疾患の治療のための医薬組成物およびその使用 | |
US6323335B1 (en) | Retinoblastoma protein-interacting zinc finger proteins | |
KR100517879B1 (ko) | 신경 퇴행성 질환의 치료를 위한 제약학적 조성물 및 이들의 사용방법 | |
KR101908593B1 (ko) | Cftr 유전자 소실 유도 가이드 rna, cftr 변이를 갖는 t84 세포 및 이의 용도 | |
US20100034775A1 (en) | RECOMBINANT ADENOVIRUS COMPRISING RECOMBINANT khp53 GENE AND THE PREPARATION METHOD AND USES THEREOF | |
AU722973B2 (en) | Grb3-3 gene, variants and uses thereof | |
Ibarra-Sánchez | Biochemical and cellular function of t-cell protein tyrosine phosphatase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20031202 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20040119 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040224 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040420 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20040720 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20040830 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041020 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050111 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050411 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050530 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20050822 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050927 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051226 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20060126 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060328 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060411 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090421 Year of fee payment: 3 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090421 Year of fee payment: 3 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090421 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100421 Year of fee payment: 4 |
|
LAPS | Cancellation because of no payment of annual fees |