JPH08502986A - フィゾスチグミンの皮膚への投与のための経皮療法システム及びその製造方法 - Google Patents
フィゾスチグミンの皮膚への投与のための経皮療法システム及びその製造方法Info
- Publication number
- JPH08502986A JPH08502986A JP6511649A JP51164994A JPH08502986A JP H08502986 A JPH08502986 A JP H08502986A JP 6511649 A JP6511649 A JP 6511649A JP 51164994 A JP51164994 A JP 51164994A JP H08502986 A JPH08502986 A JP H08502986A
- Authority
- JP
- Japan
- Prior art keywords
- physostigmine
- storage layer
- transdermal therapeutic
- therapeutic system
- softening agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.活性物質を通さない下地層と、40から90重量パーセントの重合体材料お よび0.1から20重量パーセントのフィゾスチグミン塩基または調剤上許され るその塩の一つを含む感圧貯蔵層と、該貯蔵層を覆う可動保護層とから成り、前 記貯蔵層がアクリル酸塩および/またはメタクリル酸塩に基づく重合体材料と、 1.1から12.0までの範囲にあるHLB値をもつ0.1から40重量パーセ ントのハイドロキシル基含有軟化剤とを含むことを特徴とする、フィゾスチグミ ンの皮膚への投与のための経皮療法システム。 2.前記貯蔵層は、アクリル酸2−エチルヘキシルと、酢酸ビニルと、アクリル 酸エステルとのアクリル酸重合体を重合体材料として含むことを特徴とする、請 求項1記載の経皮療法システム。 3.前記メタクリル酸塩に基づく重合体材料は、メタクリル酸ジメチルアミノエ チルと中性メタクリル酸エステルとに基づく重合体を含むことを特徴とする、請 求項1記載の経皮療法システム。 4.前記軟化剤は、1−ドデカノールであることを特徴とする、請求項1記載の 経皮療法システム。 5.前記軟化剤は、2−オクチル ドデカノールであることを特徴とする、請求 項1記載の経皮療法システム。 6.前記軟化剤は、オレイル アルコールであることを特徴とする、請求項1記 載の経皮療法システム。 7.不浸透下地層には感圧貯蔵層が塗布され、該感圧貯蔵層は40から90重量 パーセントの重合体材料と0.1から20重量パーセントのフィゾスチグミン塩 基または調剤上許されるその塩の一つを活性物質として含むこと、および、前記 感圧貯蔵層は可動保護層で覆われ、該貯蔵層には、アクリル酸塩および/または メタクリル酸塩に基づく重合体材料と、1.1と12.0との間にあるHLB値 をもつ0.1から40重量パーセントのハイドロキシル基含有軟化剤とから成る 均一な混合物が使用されることを特徴とする、請求項1乃至6のいずれか1項に 記載の経皮療法システムの製造方法。 8.前記活性物質は接着貯蔵層の成分とともに溶液中に任意に均一に混合され活 性物質を通さない下地層の上に塗布された後、存在する一つまたは複数の溶媒を 取り除き、続いて接着層を保護層で覆った後、該積層物を個別のTTS中に分離 することによって製造し、該TTSは包装物中に密封されることを特徴とする、 請求項7に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4238223A DE4238223C1 (de) | 1992-11-12 | 1992-11-12 | Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung |
DE4238223.8 | 1992-11-12 | ||
PCT/EP1993/002970 WO1994010999A1 (de) | 1992-11-12 | 1993-10-27 | Transdermales therapeutisches system zur verabreichung von physostigmin an die haut und verfahren zu dessen herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08502986A true JPH08502986A (ja) | 1996-04-02 |
JP3407073B2 JP3407073B2 (ja) | 2003-05-19 |
Family
ID=6472735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51164994A Expired - Fee Related JP3407073B2 (ja) | 1992-11-12 | 1993-10-27 | フィゾスチグミンの皮膚への投与のための経皮療法システム及びその製造方法 |
Country Status (32)
Country | Link |
---|---|
US (1) | US5698216A (ja) |
EP (1) | EP0667774B1 (ja) |
JP (1) | JP3407073B2 (ja) |
KR (1) | KR100254573B1 (ja) |
CN (1) | CN1088457A (ja) |
AT (1) | ATE156356T1 (ja) |
AU (1) | AU684256B2 (ja) |
CA (1) | CA2147274C (ja) |
CZ (1) | CZ284008B6 (ja) |
DE (2) | DE4238223C1 (ja) |
DK (1) | DK0667774T3 (ja) |
EE (1) | EE03135B1 (ja) |
EG (1) | EG20527A (ja) |
ES (1) | ES2105334T3 (ja) |
FI (1) | FI952269A (ja) |
GR (1) | GR3024720T3 (ja) |
HR (1) | HRP931391B1 (ja) |
HU (1) | HUT72963A (ja) |
IL (1) | IL107547A (ja) |
LT (1) | LT3107B (ja) |
LV (1) | LV10749B (ja) |
MD (1) | MD937C2 (ja) |
MY (1) | MY111373A (ja) |
NO (1) | NO306760B1 (ja) |
NZ (1) | NZ257136A (ja) |
PL (1) | PL172999B1 (ja) |
RU (1) | RU2108812C1 (ja) |
SI (1) | SI9300589A (ja) |
SK (1) | SK280185B6 (ja) |
WO (1) | WO1994010999A1 (ja) |
YU (1) | YU71293A (ja) |
ZA (1) | ZA938413B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4446600A1 (de) * | 1994-12-24 | 1996-06-27 | Lohmann Therapie Syst Lts | Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen |
DE19828273B4 (de) * | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
DE19923551A1 (de) * | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3921363A (en) | 1974-05-17 | 1975-11-25 | Preston Metal & Roofing Prod | Cross member with end connector |
IL72684A (en) * | 1984-08-14 | 1989-02-28 | Israel State | Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs |
US4680172A (en) | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
DE3843239C1 (ja) | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
DE3843238C1 (ja) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
US5350581A (en) * | 1989-12-14 | 1994-09-27 | Pharmetrix Corporation | Method for manufacturing transdermal devices |
NZ237241A (en) * | 1990-03-02 | 1993-11-25 | Pharmetrix Corp | Method for increasing the storage stability of physostigmine |
WO1991015176A1 (en) * | 1990-04-06 | 1991-10-17 | Pharmetrix Corporation | Device and method for enhanced administration of physostigmine |
JP4355469B2 (ja) * | 2002-03-08 | 2009-11-04 | 日本碍子株式会社 | アルミナ担持担体、触媒体及びアルミナ担持担体の製造方法 |
-
1992
- 1992-11-12 DE DE4238223A patent/DE4238223C1/de not_active Expired - Lifetime
-
1993
- 1993-10-27 DE DE59307089T patent/DE59307089D1/de not_active Expired - Lifetime
- 1993-10-27 RU RU95113504A patent/RU2108812C1/ru active
- 1993-10-27 ES ES93923558T patent/ES2105334T3/es not_active Expired - Lifetime
- 1993-10-27 CZ CZ951244A patent/CZ284008B6/cs not_active IP Right Cessation
- 1993-10-27 KR KR1019950701873A patent/KR100254573B1/ko not_active IP Right Cessation
- 1993-10-27 WO PCT/EP1993/002970 patent/WO1994010999A1/de active IP Right Grant
- 1993-10-27 CA CA002147274A patent/CA2147274C/en not_active Expired - Fee Related
- 1993-10-27 JP JP51164994A patent/JP3407073B2/ja not_active Expired - Fee Related
- 1993-10-27 AU AU53385/94A patent/AU684256B2/en not_active Ceased
- 1993-10-27 US US08/433,459 patent/US5698216A/en not_active Expired - Lifetime
- 1993-10-27 HU HU9501390A patent/HUT72963A/hu unknown
- 1993-10-27 NZ NZ257136A patent/NZ257136A/en unknown
- 1993-10-27 AT AT93923558T patent/ATE156356T1/de active
- 1993-10-27 DK DK93923558.6T patent/DK0667774T3/da active
- 1993-10-27 PL PL93308531A patent/PL172999B1/pl unknown
- 1993-10-27 SK SK593-95A patent/SK280185B6/sk unknown
- 1993-10-27 EP EP93923558A patent/EP0667774B1/de not_active Expired - Lifetime
- 1993-11-05 LV LVP-93-1204A patent/LV10749B/lv unknown
- 1993-11-09 IL IL10754793A patent/IL107547A/en not_active IP Right Cessation
- 1993-11-10 YU YU71293A patent/YU71293A/sh unknown
- 1993-11-11 HR HRP4238223.8A patent/HRP931391B1/xx not_active IP Right Cessation
- 1993-11-11 MY MYPI93002363A patent/MY111373A/en unknown
- 1993-11-11 EG EG71993A patent/EG20527A/xx active
- 1993-11-11 CN CN93112909A patent/CN1088457A/zh active Pending
- 1993-11-11 ZA ZA938413A patent/ZA938413B/xx unknown
- 1993-11-11 SI SI9300589A patent/SI9300589A/sl unknown
- 1993-11-12 LT LTIP1469A patent/LT3107B/lt not_active IP Right Cessation
-
1994
- 1994-07-26 MD MD94-0311A patent/MD937C2/ro active IP Right Grant
- 1994-11-18 EE EE9400145A patent/EE03135B1/xx unknown
-
1995
- 1995-05-10 FI FI952269A patent/FI952269A/fi unknown
- 1995-05-11 NO NO951864A patent/NO306760B1/no not_active IP Right Cessation
-
1997
- 1997-09-16 GR GR970402363T patent/GR3024720T3/el unknown
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