JP7371851B2 - 肉体的疲労及び疲労感を予防又は改善するオレアナン型トリテルペンを含有する組成物 - Google Patents
肉体的疲労及び疲労感を予防又は改善するオレアナン型トリテルペンを含有する組成物 Download PDFInfo
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- JP7371851B2 JP7371851B2 JP2019129760A JP2019129760A JP7371851B2 JP 7371851 B2 JP7371851 B2 JP 7371851B2 JP 2019129760 A JP2019129760 A JP 2019129760A JP 2019129760 A JP2019129760 A JP 2019129760A JP 7371851 B2 JP7371851 B2 JP 7371851B2
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Description
(1)オレアナン型トリテルペン若しくはその塩又はそれらのプロドラッグを有効成分として含有する、抗疲労用組成物。
(2)オレアナン型トリテルペンが、マスリン酸、オレアノール酸及びそれらの混合物から成る群より選択される、(1)記載の抗疲労用組成物。
(3)主要トリテルペンとしてマスリン酸とオレアノール酸とを含有するオリーブ果実抽出物を有効成分として含有する、抗疲労用組成物。
(4)肉体的疲労及び/又は疲労感を予防及び/又は改善するための、(1)~(3)のいずれか1記載の抗疲労用組成物。
(5)(1)~(4)のいずれか1記載の組成物を含有する、抗疲労用飲食品。
(6)(1)~(4)のいずれか1記載の組成物を含有する、抗疲労用医薬品。
1.製造例1[オリーブ果実由来トリテルペンの製造方法]
圧搾等の公知の搾油法によりオリーブオイルを除去したオリーブ果実搾油粕を得た。
表1で示した配合で原料を混合し、スティックゼリーを調製した。スティックゼリー1本当たりの内容量は10gであり、マスリン酸及びオレアノール酸の含有量は各々30mg、12mgである。
(1) 被験者選択
国立大学法人筑波大学水球部に所属する健康な男子大学生12名を被験者として選択した。
(2) 試験内容
オリーブ果実由来トリテルペンが運動、及び日常生活で発生する疲労及び疲労感に及ぼす影響を評価するに当たり、被験者に表2に示す水球練習及び筋力トレーニングを含む運動介入を月曜日~日曜日の1週間行った。その際、製造例2に示すオリーブ果実由来トリテルペン剤を含む試験食(実施例)、又は含まない試験食(比較例)を運動後に毎日2本摂取させた。
(3-1) 自覚的疲労度の測定
運動により発生する肉体的な疲労や疲労感を評価する項目として、運動翌日起床時の自覚的疲労度をVASにて1週間継続して評価した。例えば、火曜日起床時のVASによる自覚的疲労度の評価は、月曜日の運動及び日常生活の結果現れた疲労感であるため、月曜日の数値として記載した(表3)。なお、VASは10cmの直線の左端を「全く疲労感がない」状態である0とし、右端を「これ以上ないくらい疲労感がある」状態である10として、現在の状態が直線上のどの位置にあるかを10cmの直線と垂直に交わる棒線で記入させ、測定値とした。測定値をもとに、曜日ごとでのT検定により統計解析を行った。
酸化ストレスマーカーを測定することにより、疲労の程度を評価することが可能とされている(新規抗疲労成分:イミダゾールジペプチド, 日本補完代替医療学会誌, 第6巻, 第3号, 2009年10月:123-129;P124「4. 酸化ストレスマーカーによる疲労評価」を参照)。
VASによる自覚的疲労度の測定の結果、表3で示す通り、全日程を通して、比較例と比べて実施例の方が低値を示していた。統計解析の結果、特に6日間試験食の摂取を続けた土曜日では、有意にVASの値が低値を示していた(P値<0.05)。
Claims (4)
- オレアナン型トリテルペン又はその塩を有効成分として含有する、抗疲労用組成物であって、
前記オレアナン型トリテルペンがマスリン酸及びオレアノール酸の混合物であり、
運動で発生する肉体的疲労及び/又は疲労感を予防及び/又は改善するための、前記抗疲労用組成物(ただし、3-ヒドロキシ-3-メチル酪酸を含む場合を除く)。 - 主要トリテルペンとしてマスリン酸とオレアノール酸とを含有するオリーブ果実抽出物を有効成分として含有する、抗疲労用組成物であって、
運動で発生する肉体的疲労及び/又は疲労感を予防及び/又は改善するための、前記抗疲労用組成物(ただし、3-ヒドロキシ-3-メチル酪酸を含む場合を除く)。 - 請求項1又は2記載の組成物を含有する、抗疲労用飲食品。
- 請求項1又は2記載の組成物を含有する、抗疲労用医薬品。
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JP2002097135A (ja) | 2000-09-19 | 2002-04-02 | Pola Chem Ind Inc | ストレスに起因する循環器障害改善用の皮膚外用剤 |
WO2003057224A1 (fr) | 2001-12-28 | 2003-07-17 | The Nisshin Oillio, Ltd. | Inducteur d'apoptose |
JP2008017734A (ja) | 2006-07-11 | 2008-01-31 | Memory Secret Inc | 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物 |
JP2016135804A (ja) | 2016-04-21 | 2016-07-28 | 公立大学法人福井県立大学 | 筋肉の糖取り込み促進剤、高血糖改善剤、並びに、糖尿病および/または糖尿病合併症の予防または治療剤 |
JP2016172695A (ja) | 2015-03-16 | 2016-09-29 | 日本製粉株式会社 | トリテルペンを有効成分として含有する変形性関節症の予防又は治療の為の組成物 |
CN106520426A (zh) | 2016-12-22 | 2017-03-22 | 广州聚注专利研发有限公司 | 一种缓解体力疲劳的女性保健酒 |
JP2017184718A (ja) | 2016-03-31 | 2017-10-12 | グレーシャス株式会社 | リンゴポリフェノール及びオレアノール酸を含有する食品組成物 |
JP2019058392A (ja) | 2017-09-27 | 2019-04-18 | 株式会社サンセイアールアンドディ | 遊技機 |
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002097135A (ja) | 2000-09-19 | 2002-04-02 | Pola Chem Ind Inc | ストレスに起因する循環器障害改善用の皮膚外用剤 |
WO2003057224A1 (fr) | 2001-12-28 | 2003-07-17 | The Nisshin Oillio, Ltd. | Inducteur d'apoptose |
JP2008017734A (ja) | 2006-07-11 | 2008-01-31 | Memory Secret Inc | 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物 |
JP2016172695A (ja) | 2015-03-16 | 2016-09-29 | 日本製粉株式会社 | トリテルペンを有効成分として含有する変形性関節症の予防又は治療の為の組成物 |
JP2017184718A (ja) | 2016-03-31 | 2017-10-12 | グレーシャス株式会社 | リンゴポリフェノール及びオレアノール酸を含有する食品組成物 |
JP2016135804A (ja) | 2016-04-21 | 2016-07-28 | 公立大学法人福井県立大学 | 筋肉の糖取り込み促進剤、高血糖改善剤、並びに、糖尿病および/または糖尿病合併症の予防または治療剤 |
CN106520426A (zh) | 2016-12-22 | 2017-03-22 | 广州聚注专利研发有限公司 | 一种缓解体力疲劳的女性保健酒 |
JP2019058392A (ja) | 2017-09-27 | 2019-04-18 | 株式会社サンセイアールアンドディ | 遊技機 |
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