JP7007365B2 - 静電分離のための帯電したイソポーラス材料 - Google Patents
静電分離のための帯電したイソポーラス材料 Download PDFInfo
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- JP7007365B2 JP7007365B2 JP2019508155A JP2019508155A JP7007365B2 JP 7007365 B2 JP7007365 B2 JP 7007365B2 JP 2019508155 A JP2019508155 A JP 2019508155A JP 2019508155 A JP2019508155 A JP 2019508155A JP 7007365 B2 JP7007365 B2 JP 7007365B2
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- vinylpyridine
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Description
本願は、2016年4月28日に出願した米国仮特許出願第62/328,707号に基づく優先権を主張するものであり、参照により全内容を本出願において援用する。
A-B-C (I)、
A-B-C-B (II)
A-B-C-D (III)
A-B-C-B-A (IV)
A-C-B-C-A (V)
によって定められる。
5 大きな孔径の領域
10 小さな孔径の領域
15 ほぼ同一の孔径の層
20 均一の流れを示す矢印
25 均一の流れを示す矢印
30 より多くの流量を示す矢印
35 より少ない流量を示す矢印
40 電荷を導入するための官能基化反応
45 官能基化反応から導入された官能基
50 正に帯電した材料
55 帯電していない溶質/溶媒分子
60 細胞残屑等の大きな溶質
65 負に帯電した核酸溶質
70 正に帯電した溶質
Claims (11)
- 溶質分離のための、帯電した多孔性の自己組織化ポリ(イソプレン-b-スチレン-b-4-ビニルピリジン)トリブロック共重合体材料であって、当該材料は細孔を含み、前記細孔のうち少なくとも一部がイソポーラスであり、1乃至200nmに及ぶ孔径を有しており、前記4-ビニルピリジンのブロックのうち少なくとも一部が四級化されて、当該材料に正の静止電荷を提供し、当該材料は、7.0のpHにおいて50Lm -2 hr -1 bar -1 より大きい透水率を示す(ただし、200Lm -2 hr -1 bar -1 より大きい透水率を示す部分を除く)、材料。
- 前記4-ビニルピリジンのブロックは、官能基化反応によって四級化され、前記官能基化反応は、前記正の静止電荷を提供する、請求項1に記載の材料。
- 細孔を有する、帯電したA-B-Cトリブロック共重合体材料であって、前記細孔のうち少なくとも一部がイソポーラスであり、1乃至200nmに及ぶ孔径を有しており、前記トリブロック共重合体のうち1つのポリマーブロックが、≦25℃のTgを有し、前記トリブロック共重合体のうち1つのポリマーブロックが、四級化されて当該材料に正の静止電荷を提供する芳香族複素環を含み、前記芳香族複素環は、ピリジン、ピラジン、ピリミジン、ピリダジン、キノロン、イソキノリン、キノキサリン、キナゾリン、フェナジン、イソキサゾール、イソチアゾール、イミダゾール、ベンゾイミダゾール、トリアゾール、及びテトラゾールを含む群から選択され、当該材料は、7.0のpHにおいて50Lm -2 hr -1 bar -1 より大きい透水率を示す(ただし、200Lm -2 hr -1 bar -1 より大きい透水率を示す部分を除く)、材料。
- a.前記≦25℃のTgを有するポリマーブロックは、ポリイソプレンブロックであり、さらに、
b.前記芳香族複素環を含むポリマーブロックは、ポリ(2-ビニルピリジン)ブロック又はポリ(4-ビニルピリジン)ブロックである、請求項3に記載の材料。 - 当該トリブロック共重合体材料は、ポリ(イソプレン-b-スチレン-b-4-ビニルピリジン)トリブロック共重合体であり、前記静止電荷は、前記4-ビニルピリジンのブロック上にある、請求項3に記載の材料。
- 請求項3に記載の材料を形成する方法であって、前記A-B-Cトリブロック共重合体を化学物質と接触させるステップを含み、前記化学物質は、前記芳香族複素環と反応して、その上に前記正の静止電荷を導入する、方法。
- 標的生体分子を、該標的生体分子を有する他の生体分子又は他の溶質の混合物から分離するプロセスであって、請求項1又は3に記載の材料と前記生体分子の混合物を接触させて、次に、前記標的生体分子を分離する及び/又は除去するステップを含むプロセス。
- 前記正の静止電荷は、式R-Xを有する四級化剤によって提供され、Rは、C1~C24の置換又は未置換の直鎖、環状又は分岐状アルキル又はアルケニル基又はポリエチレングリコール(PEG)であり、Xは脱離基である、請求項1又は3に記載の材料。
- 前記正の静止電荷は、式R-W-(R)-CH2-Xを有する四級化剤によって提供され、Rは、C1~C24の置換又は未置換のアルキル、アルケニル又はアリール基であり、Wはヘテロ原子であり、Xは脱離基である、請求項1又は3に記載の材料。
- 前記正の静止電荷は、式R-(W)-COCH2-Xを有する四級化剤によって提供され、Rは、C1~C24のアルキル又はアルケニル、又は、C6~C10のアリール基であり、Wはヘテロ原子であり、Xは脱離基である、請求項1又は3に記載の材料。
- 請求項1に記載の帯電したイソポーラスのブロック重合体材料を形成する方法であって、前記ポリ(イソプレン-b-スチレン-b-4-ビニルピリジン)トリブロック共重合体の前記4-ビニルピリジンのブロックを、化学物質と接触させるステップを含み、前記化学物質は、前記4-ビニルピリジンのブロックの少なくとも一部と反応して、その上に前記正の静止電荷を導入する、方法。
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US11628409B2 (en) | 2016-04-28 | 2023-04-18 | Terapore Technologies, Inc. | Charged isoporous materials for electrostatic separations |
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CA3045012A1 (en) * | 2016-11-28 | 2018-05-31 | John Ho | Wound treating system and methods of using and assembling |
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US20200360871A1 (en) * | 2017-09-19 | 2020-11-19 | Terapore Technologies, Inc. | Chemically resistant isoporous crosslinked block copolymer structure |
WO2019178045A1 (en) | 2018-03-12 | 2019-09-19 | Terapore Technologies, Inc. | Isoporous mesoporous asymmetric block copolymer materials with macrovoids and method of making the same |
US20210040281A1 (en) * | 2018-03-12 | 2021-02-11 | Terapore Technologies, Inc. | Free standing pleatable block copolymer materials and method of making the same |
KR20200140330A (ko) * | 2018-04-04 | 2020-12-15 | 테라포어 테크놀로지스, 인코포레이티드 | 캡슐화 입자 분획 장치 및 시스템과 이의 사용 방법 |
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KR102308085B1 (ko) | 2021-10-06 |
SG11201809515VA (en) | 2018-11-29 |
US11628409B2 (en) | 2023-04-18 |
CN109310955B (zh) | 2022-08-30 |
US20220097008A1 (en) | 2022-03-31 |
CN109310955A (zh) | 2019-02-05 |
CA3022510C (en) | 2023-12-19 |
CA3022510A1 (en) | 2017-11-02 |
EP3448551A1 (en) | 2019-03-06 |
WO2017189697A1 (en) | 2017-11-02 |
JP2022048176A (ja) | 2022-03-25 |
JP2019514687A (ja) | 2019-06-06 |
KR20190002572A (ko) | 2019-01-08 |
EP3448551B1 (en) | 2024-07-17 |
US20190039030A1 (en) | 2019-02-07 |
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MX2018013182A (es) | 2019-06-24 |
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