JP6340416B2 - ホスファチジルイノシトール３−キナーゼ−ガンマの選択的インヒビター - Google Patents

ホスファチジルイノシトール３−キナーゼ−ガンマの選択的インヒビター Download PDF

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Publication number: JP6340416B2
Authority: JP; Japan
Prior art keywords: compound; pi3k; disease; composition; pharmaceutically acceptable
Prior art date: 2013-09-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2016516904A

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English (en)

Japanese (ja)

Other versions

JP2016531861A (ja

JP2016531861A5 (fr

Inventor

マイケルジョンボイド，

アレックスアロノフ，

ハードウィンオダウド，

ジェレミーグリーン，

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vertex Pharmaceuticals Inc

Original Assignee

Vertex Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-09-25

Filing date

2014-09-25

Publication date

2018-06-06

2014-09-25 Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc

2016-10-13 Publication of JP2016531861A publication Critical patent/JP2016531861A/ja

2017-10-05 Publication of JP2016531861A5 publication Critical patent/JP2016531861A5/ja

2018-06-06 Application granted granted Critical

2018-06-06 Publication of JP6340416B2 publication Critical patent/JP6340416B2/ja

Status Expired - Fee Related legal-status Critical Current

2034-09-25 Anticipated expiration legal-status Critical

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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

JP2016516904A 2013-09-25 2014-09-25 ホスファチジルイノシトール３−キナーゼ−ガンマの選択的インヒビター Expired - Fee Related JP6340416B2 (ja)

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US61/882,473		2013-09-25
PCT/US2014/057499 WO2015048318A1 (fr)	2013-09-25	2014-09-25	Inhibiteur sélectif de la phosphatidylinositol-3-kinase-gamma

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US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
BR112016007467B1 (pt)	2013-10-04	2022-09-20	Infinity Pharmaceuticals, Inc	Compostos heterocíclicos e usos dos mesmos
WO2015051241A1 (fr)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Composés hétérocycliques et leurs utilisations
CN106456628A (zh)	2014-03-19	2017-02-22	无限药品股份有限公司	用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2016054491A1 (fr)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Composés hétérocycliques et leurs utilisations
JP6786529B2 (ja) *	2015-06-29	2020-11-18	バイオメッドバレーディスカバリーズ，インコーポレイティド	Ｌｐｔ−７２３と免疫チェックポイント阻害剤との組み合わせおよび処置の方法
MX2018003058A (es)	2015-09-14	2018-08-01	Infinity Pharmaceuticals Inc	Formas solidas de derivados de isoquinolinona, proceso de fabricacion, composiciones que las contienen y metodos de uso de las mismas.
WO2017153527A1 (fr) *	2016-03-10	2017-09-14	Astrazeneca Ab	Nouveaux inhibiteurs de la phosphatidylinositol 3-kinase gamma
US10759806B2 (en)	2016-03-17	2020-09-01	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (fr)	2016-06-08	2017-12-14	Infinity Pharmaceuticals, Inc.	Composés hétérocycliques et leurs utilisations
WO2020210379A1 (fr)	2019-04-10	2020-10-15	Hangzhou Zhengxiang Pharmaceuticals Co., Ltd.	Inhibiteur de la phosphatidylinositol 3-kinase

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AR071717A1 (es) *	2008-05-13	2010-07-07	Array Biopharma Inc	Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
UY32582A (es) *	2009-04-28	2010-11-30	Amgen Inc	Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
JP5721187B2 (ja) *	2009-12-22	2015-05-20	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター

2014
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2016
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2017
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Publication number	Publication date
CL2016000695A1 (es)	2017-06-09
EP3412668A2 (fr)	2018-12-12
ES2687593T3 (es)	2018-10-26
SG11201602265PA (en)	2016-04-28
HK1223620A1 (zh)	2017-08-04
CN105722838B (zh)	2017-10-24
EP3049415B1 (fr)	2018-07-04
UA117032C2 (uk)	2018-06-11
EP3412668B1 (fr)	2020-02-05
JP2016531861A (ja)	2016-10-13
CN105722838A (zh)	2016-06-29
RU2675814C2 (ru)	2018-12-25
BR112016006388A2 (pt)	2017-08-01
RU2018142605A (ru)	2019-02-04
CA2925601C (fr)	2022-11-01
ZA201702252B (en)	2019-06-26
CA2925601A1 (fr)	2015-04-02
MX2016003823A (es)	2016-08-01
AU2014324873B2 (en)	2018-11-08
IL244742A0 (en)	2016-04-21
EP3049415A1 (fr)	2016-08-03
US10301304B2 (en)	2019-05-28
EP3412668A3 (fr)	2018-12-19
SG10201802061TA (en)	2018-05-30
WO2015048318A1 (fr)	2015-04-02
US20160214980A1 (en)	2016-07-28
KR20160058950A (ko)	2016-05-25
RU2016115726A3 (fr)	2018-06-20
ES2785053T3 (es)	2020-10-05
AU2014324873A1 (en)	2016-04-21
RU2016115726A (ru)	2017-10-30

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