JP5955934B2 - 血液凝固分析装置 - Google Patents
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
- G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
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- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G01N33/483—Physical analysis of biological material
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- G01N33/4905—Determining clotting time of blood
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Description
たとえば特許文献1記載の技術によると、複数の波長の光を照射し、被測定検体に応じ干渉物質の影響の少ない波長のデータを選択して凝固時間の算出に用いる技術が開示されている。
応が終了したとして、散乱光測定を終了する。このとき、測定終了までに第1検出器103aおよび第2検出器103bからの信号が、ともに信号強度上限値Smaxを予め設定された一定時間(例えば3秒間)連続で超えたことを判断部106が検出した場合、即時、測定を終了し、制御部109に希釈再検依頼のフラグを送信する。
102…単一波長光源
103a〜103b…検出器
104…増幅部
105…A/D変換部
106…判断部
107…記憶部
108…演算部
109…制御部
110…出力部
502a〜502b…単一波長光源
503…検出器
Claims (3)
- 試料と試薬を混合し反応させるための反応容器(101)と、前記反応容器(101)に光を照射するための互いに異なる角度で配置され、それぞれが単一の波長の光を発生する複数の点滅光源(502a、502b)と、前記反応容器(101)周辺に配置され試料と試薬の混合液から発せられる散乱光を検出する単一の検出器(503)と、前記検出器(503)から得られる経時的な光強度変化データを取り込み記憶する記憶部(107)と、前記記憶部(107)に保管された光強度変化データから血液凝固時間を算出する演算部(108)を備えた血液凝固分析装置において、
前記記憶部(107)に保管された光強度変化データから前記点滅光源(502a、502b)ごとのデータを分離し、光強度変化量に基づき血液凝固時間の算出に用いる光強度変化データを選択する判断部(106)を備え、
前記複数の点滅光源(502a、502b)が互いに発光タイミングが重ならないように点滅し、
前記点滅光源(502a、502b)に予め優先順位が設定されており、優先順位の高い点滅光源(502a、502b)の光強度変化データの変化量が予め設定された閾値以下の場合、次の優先順位の点滅光源(502a、502b)の光強度データを血液凝固時間の算出に用いることを特徴とする血液凝固分析装置。 - 請求項1記載の血液凝固分析装置において、
前記複数の点滅光源は、長波長の点滅光源と、短波長の点滅光源とからなることを特徴とする血液凝固分析装置。 - 請求項1又は2記載の血液凝固分析装置において、
前記点滅光源(502a、502b)で優先順位の高い点滅光源(502a、502b)の光強度変化データがノイズ等の影響で血液凝固時間の算出が困難な場合に、次の優先順位の点滅光源(502a、502b)の光強度変化データを血液凝固時間の算出に用いることを特徴とする血液凝固分析装置。
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US (1) | US9395298B2 (ja) |
EP (1) | EP2508891B1 (ja) |
JP (2) | JP5667989B2 (ja) |
CN (1) | CN102640004B (ja) |
WO (1) | WO2011068049A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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JP5216051B2 (ja) * | 2010-06-23 | 2013-06-19 | 株式会社日立ハイテクノロジーズ | 自動分析装置および自動分析方法 |
JP5822534B2 (ja) | 2011-05-13 | 2015-11-24 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
JP6035329B2 (ja) * | 2011-05-26 | 2016-11-30 | ザ ジェネラル ホスピタル コーポレイション | 光学的トロンボエラストグラフィーシステム及び血液凝固基準の評価方法 |
JP6013796B2 (ja) * | 2012-06-25 | 2016-10-25 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料測定方法 |
JP6073117B2 (ja) * | 2012-11-26 | 2017-02-01 | 株式会社日立ハイテクノロジーズ | 自動分析装置、自動分析方法 |
US11172888B2 (en) | 2012-12-19 | 2021-11-16 | The General Hospital Corporation | Optical blood-coagulation sensor |
EP3088901A4 (en) * | 2013-12-25 | 2017-08-23 | Hitachi High-Technologies Corporation | Automatic analysis device and analysis method |
JP5920409B2 (ja) * | 2014-06-18 | 2016-05-18 | 栗田工業株式会社 | 凝集モニタリング装置、凝集モニタリング方法および凝集システム |
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JP6696963B2 (ja) * | 2015-02-27 | 2020-05-20 | 学校法人東日本学園 | 凝固時間の延長原因に関する情報を取得する方法とそれを実施するための装置及びプログラム |
JP6871673B2 (ja) * | 2015-03-31 | 2021-05-12 | 学校法人東日本学園 | 血液検体を判定するための方法、装置及びコンピュータプログラム、並びに血液検体分析装置 |
CN104897615A (zh) * | 2015-06-03 | 2015-09-09 | 何祖玲 | 智能血凝仪 |
WO2019130668A1 (ja) * | 2017-12-26 | 2019-07-04 | 株式会社日立ハイテクノロジーズ | 自動分析装置および自動分析方法 |
JP6952668B2 (ja) * | 2018-09-28 | 2021-10-20 | シスメックス株式会社 | 血液凝固分析方法、血液凝固分析装置、プログラム |
CN113039436A (zh) * | 2018-11-15 | 2021-06-25 | 积水医疗株式会社 | 分析方法、分析装置和分析程序 |
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