JP5905448B2 - 12−ヒドロキシステアリン酸を含有するスキンコンディショニング組成物 - Google Patents
12−ヒドロキシステアリン酸を含有するスキンコンディショニング組成物 Download PDFInfo
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- JP5905448B2 JP5905448B2 JP2013508357A JP2013508357A JP5905448B2 JP 5905448 B2 JP5905448 B2 JP 5905448B2 JP 2013508357 A JP2013508357 A JP 2013508357A JP 2013508357 A JP2013508357 A JP 2013508357A JP 5905448 B2 JP5905448 B2 JP 5905448B2
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- 229960001669 kinetin Drugs 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 210000005053 lamin Anatomy 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229960004738 nicotinyl alcohol Drugs 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- CCCMONHAUSKTEQ-UHFFFAOYSA-N octadecene Natural products CCCCCCCCCCCCCCCCC=C CCCMONHAUSKTEQ-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- IIGMITQLXAGZTL-UHFFFAOYSA-N octyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCC IIGMITQLXAGZTL-UHFFFAOYSA-N 0.000 description 1
- FPLYNRPOIZEADP-UHFFFAOYSA-N octylsilane Chemical compound CCCCCCCC[SiH3] FPLYNRPOIZEADP-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- QUBQYFYWUJJAAK-UHFFFAOYSA-N oxymethurea Chemical compound OCNC(=O)NCO QUBQYFYWUJJAAK-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000003614 peroxisome proliferator Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
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- 150000007965 phenolic acids Chemical class 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
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- 210000002826 placenta Anatomy 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 208000010744 skin desquamation Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 1
- 235000003687 soy isoflavones Nutrition 0.000 description 1
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- 235000012424 soybean oil Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Description
(a) 組成物の約0.01から約15質量%までの12-ヒドロキシステアリン酸、
(b) アミノシリコーン対12-ヒドロキシステアリン酸の質量比が少なくとも約2:1であるアミノシリコーン、
(c) 組成物の約1から約99質量%までの水
を含み、水の量が組成物の20質量%を上回る場合、組成物が、組成物のpHを下回る等電点を有する粒子をさらに含み、
組成物の粘度が約1Pasから約500Pasまでの範囲内である、組成物を含む。
(a) 組成物の約0.01から約15質量%までの12-ヒドロキシステアリン酸、および
(b) アミノシリコーン対12-ヒドロキシステアリン酸の質量比が少なくとも約2:1であるアミノシリコーンを含む組成物を含む。
本発明の組成物は12HSAを含む。本明細書で使用されるように、12HSAとは酸、その塩およびそのエステルを含むことを意味する。好ましくは、生物学的利用率、したがって効率を最適にするために、組成物は通常、全12HSAの少なくとも40%、好ましくは少なくとも50%、より好ましくは少なくとも60%を酸の形態で含有する。他の脂肪酸のように、12HSAの見かけ上のpKaは8を上回ることが予測される。このpKaでは、脂肪酸は50%が石鹸として、および50%が酸として存在するだろう。したがって、好ましくは本発明の組成物のpHは、約8未満、より好ましくは3.5から8.0までの範囲、最も好ましくは5から7.8までである。12HSAは、0.01から15%まで、好ましくは0.1から12%まで、より好ましくは0.5から10%まで、最適には1から5%までの量で本発明の組成物に含まれる。本明細書では12HSAの量には、酸および塩の両方の量が含まれる。12HSAまたはその塩の量は、本明細書の界面活性剤の量の内には含まれないことを意味する。
本発明で有用なアミノシリコーンには、一級、二級および三級アミンが含まれる。好ましくは、アミノシリコーンは以下の一般式Iを有する:
m=5〜1,000,000、好ましくは10〜500,000、より好ましくは20-300,000、最も好ましくは50〜100,000であり、
k=1〜50、好ましくは2〜40、より好ましくは3〜30、最も好ましくは5〜20であり、
p、qおよびrは独立して1〜30、好ましくは1〜20、より好ましくは1〜10、最も好ましくは1〜4の範囲であり、
R1およびR4は独立してCnH2n+1であり、式中、n=1〜30、好ましくは1〜25、より好ましくは1〜20、最も好ましくは1〜12であり、
R2、R3およびR6は独立してフェニルおよびナフチルなどのアリール基、ベンジルおよびナフチルなどのアリールアルキル基、ならびにアルキル基、すなわちCnH2n+1から選択される。好ましいR2およびR3基はフェニル基である。より好ましいR2およびR3基は、アルキル基であり、式中、n=1〜20、好ましくは1〜10、より好ましくは1〜5、最も好ましくは1〜2である。
R5は水素、およびまたはアルキル基、すなわちCnH2n+1であって、式中、n=1〜10、好ましくは1〜5、より好ましくは1〜2である。最も好ましいR5は水素基である。
a=5〜1,000,000、好ましくは10〜500,000、より好ましくは20-300,000、最も好ましくは50〜100,000であり、
b=1〜50、好ましくは2〜40、より好ましくは3〜30、最も好ましくは5〜20であり、
xおよびy=1〜10、好ましくは1〜8、より好ましくは1〜6、最も好ましくは1〜4であり、
R8、R9およびR10は独立してアルキル基、すなわちCnH2n+1から選択され、式中、n=1〜20、好ましくは1〜10、より好ましくは1〜5、最も好ましくは1〜2であり、
R11=3級アルキル基、例えば、-C(CnH2n+1)3であり、式中、n=1〜10、好ましくは1〜5、より好ましくは1〜3、最も好ましくは1〜2であり、
R12、R13およびR14は独立して水素、およびまたはアルキル基、すなわち、CnH2n+1からなる群から選択され、式中、n=1〜10、好ましくは1〜5、より好ましくは1〜2である。最も好ましいR12、R13およびR14は水素基である。
本発明の添加剤組成物は、水の非存在下で調製することができるが、水がまだ含まれていてもよい。本発明のスキンコンディショニング非添加剤組成物は、水を含む。本発明の組成物は、一般的に1から99%までの範囲の水、好ましくは20から98%まで、最も好ましくは30から90%まで、最適には35から80%までの水を含む。
本発明のエマルジョン中における水分含量が組成物の20質量%を上回る場合、組成物は組成物のpHを下回る等電点を有する粒子を含むことが必要である。通常、粒子は11より低い、好ましくは7.5より低い等電点を有する。
本発明の添加剤組成物は、前述した通り、12HSAおよびアミノシリコーンを含む。この添加剤組成物は非固形状であり、実質的に非結晶性形態の12HSAを含む。添加剤組成物は水を含んでいてもよく、その場合上記で論じたように、水の量が20%を上回る場合に任意選択で粒子を含むための同じ規則に従う。添加剤組成物は、スキンコンディショニング組成物用のためのプレミックスとして使用してもよく、または別々の組成物として販売してもよい。
本発明の組成物は、水に加えて担体を含んでいてもよい。有用な追加の担体の中には、皮膚軟化剤、脂肪酸、脂肪アルコール、増粘剤およびそれらの組み合わせがある。
a) 炭素原子10から24個までを有する飽和脂肪酸のアルキルエステル。それらの例には、ネオペンタン酸ベヘニル、イソノナン酸イソノニル、ミリスチン酸イソプロピルおよびステアリン酸オクチルが含まれる。
b) エトキシ化飽和脂肪アルコールの脂肪酸エステルなどのエーテル-エステル。
c) 多価アルコールエステル。エチレングリコールモノおよびジ脂肪酸エステル、ジエチレングリコールモノおよびジ脂肪酸エステル、ポリエチレングリコール(200〜6000)モノおよびジ脂肪酸エステル、プロピレングリコールモノおよびジ脂肪酸エステル、ポリプロピレングリコール2000モノステアレート、エトキシ化プロピレングリコールモノステアレート、グリセリルモノおよびジ脂肪酸エステル、ポリグリセロールポリ脂肪エステル、エトキシ化グリセリルモノステアレート、1,3-ブチレングリコールモノステアレート、1,3-ブチレングリコールジステアレート、ポリオキシエチレンポリオール脂肪酸エステル、ソルビタン脂肪酸エステルおよびポリオキシエチレンソルビタン脂肪酸エステルが良好な多価アルコールエステルである。特に有用なのは、ペンタエリスリトール、トリメチロールプロパンおよびC1〜C30アルコールのネオペンチルグリコールエステルである。
d) 蜜蝋、鯨蝋およびトリベヘニンワックスなどのワックスエステル。
e) ポリベヘン酸スクロースおよびポリ綿実脂肪酸スクロースなどの脂肪酸の糖エステルがある。
本発明の組成物は、非固形状であり、リンスオフであってもリーブオンであってもよい。リーブオン組成物は、皮膚上に広げた後に実質的に非結晶性のままである12HSAの効果が、特に本発明の組成物において特に有利なので、好ましい。基本的に、組成物の「非固形状」とは、例えば、Brookfield DV-I+粘度計(20RPM、RV6、30秒、25℃)を使用して測定した組成物の粘度を意味する。粘度は一般的に、1Pasから500Pasまで、好ましくは1Pasから200Pasまで、より好ましくは2Pasから100Pasまで、最も好ましくは3Pasから50Pasまでの範囲である。
本発明の組成物は、上記の理由のため、実質的に界面活性剤を含まない、すなわち、界面活性剤を最大2%、すなわち、0.0001から2%まで、好ましくは1%未満、最も好ましくは0.1%未満を含有することが好ましい。本発明の特長の1つは、界面活性剤が実質的に存在しなくても水分含量の高いエマルジョンを含むエマルジョンを形成できることである。しかし、界面活性剤は任意選択で添加することができる。存在する場合の界面活性剤の全濃度は、組成物の約0.1から約20質量%まで、好ましくは約1から約10質量%まで、最適には約1から約5質量%まで変動してもよく、パーソナルケア製品の種類に大きく左右される。界面活性剤は、アニオン、非イオン、カチオンおよび両性活性剤からなる群から選択することができる。特に好ましい非イオン性界面活性剤は、疎水基1モル当たり2から100モルまでのエチレンオキシドまたはプロピレンオキシドが縮合したC10〜C20脂肪アルコールまたは酸疎水基を有するもの、2から20モルまでのアルキレンオキシドが縮合したC2〜C10アルキルフェノール、エチレングリコールのモノおよびジ脂肪酸エステル、脂肪酸モノグリセリド、ソルビタン、モノおよびジC8〜C20脂肪酸、ならびにポリオキシエチレンソルビタンならびにそれらの組み合わせである。アルキルポリグリコシドおよび多糖脂肪アミド(例えば、メチルグルコンアミド)およびトリアルキルアミンオキシドはまた、適切な非イオン性界面活性剤である。
レオロジー改質剤を含めてもよく、レオロジー改質剤はヒュームドシリカまたは親水性シリカなどのシリカ、およびケイ酸マグネシウムアルミニウム、ベントナイト、ヘクトライト、ラポナイトなどの粘土およびそれらの混合物からなる群から選択される。レオロジー改質剤は、0.01から2%まで、好ましくは0.05から1%までの量で使用する。
本発明の組成物は、最適な費用で最適な皮膚美白成果を得るために、追加の皮膚美白化合物(12HSAに加えて)を含むことが好ましい。例示的な物質は、胎盤抽出物、乳酸、ナイアシンアミド、アルブチン、コウジ酸、フェルラ酸、ハイドロキノン、レゾルシノールおよび4-置換レゾルシノールを含む誘導体およびそれらの組み合わせである。より好ましくは、このような追加の皮膚美白化合物は、置換モノアミンのメラニン形成阻害活性を補うチロシナーゼ阻害剤、最も好ましくはコウジ酸、ハイドロキノンおよび4-置換レゾルシノールからなる群から選択された化合物である。また、式HOOC-(CxHy)-COOH(式中、x=4から20およびy=6から40である)によって表されるジカルボン酸、例えば、アゼライン酸、セバシン酸、シュウ酸、コハク酸、フマル酸、オクタデセン2酸またはそれらの塩または混合物、最も好ましくはフマル酸またはそれらの塩、特に二ナトリウム塩である。特に皮膚美白配合物には、12HSAとフマル酸またはその塩との組み合わせが特に好ましいことが発見された。これらの薬剤の量は、組成物の約0.1から約10質量%まで、好ましくは約0.5から約2質量%まで変動してもよい。本発明による皮膚美白共活性化物質は、ビタミンB3またはその誘導体で、ナイアシンアミド、ニコチン酸エステル、ニコチン酸の非血管拡張性エステル、ニコチニルアミノ酸、カルボン酸のニコチニルアルコールエステル、ニコチン酸N-オキシド、ナイアシンアミドN-オキシドおよびそれらの混合物からなる群から選択されることが好ましい。
本発明の範囲内の組成物は、好ましくは以下の方法に従って調製する。防腐剤、増粘ポリマー、任意選択のグリセリンおよび水を含む水溶性成分を全て混合し、70〜90℃の温度まで加熱する。別の容器で、12HSAを含む油溶性成分全て、任意選択の粒子(例えば、シリカ)および任意選択の界面活性剤を70〜90℃の温度で混合する。油相および水相を70〜90°Cの温度で撹拌しながら混合する。任意選択で、ナイアシンアミドを45°Cで添加し、その後芳香剤およびフェノキシエタノールを40°Cで添加する。混合物を撹拌しながら室温まで冷却する。
本発明による組成物は主としてヒトの皮膚に局所的に塗布するための製品として、特に皮膚を整え、滑らかにするため、しわの寄った皮膚もしくは老化皮膚、または年齢によるしみの出現を予防するか、または軽減するため、あるいは皮膚を美白するための作用物質として企図される。
本発明の範囲内の組成物(組成物1〜8)を本発明の範囲外の組成物(組成物A〜D)と比較した。組成物および観察結果を表1および表2にまとめて示す。
本発明の組成物(9〜12)および比較組成物(E、F)は、かなりの量の水を含有して調製した。組成物および観察結果を表3にまとめて示す。
本発明の範囲外の組成物(G〜L)は、12HSA以外の脂肪酸およびアミノシリコーン以外のシリコーンで調製した。組成物および結果を表4にまとめて示す。
本発明の範囲外の組成物(M、N)は、アミノシリコーンの代わりにアミンをベースにした炭化水素で調製した。組成物および結果を表5にまとめて示す。
本発明の範囲内の典型的な組成物は以下の通りである。
Claims (9)
- 非固形状スキンコンディショニング組成物であって、
(a) 前記組成物の0.01から15質量%までの12-ヒドロキシステアリン酸、
(b) アミノシリコーン対12-ヒドロキシステアリン酸の質量比が2:1から75:1の範囲内であるアミノシリコーン、
(c) 前記組成物の1から99質量%までの水
を含み、水の量が前記組成物の20質量%を上回る場合、前記組成物が、前記組成物のpHを下回る等電点を有する粒子をさらに含み、
前記組成物の粘度が1Pasから500Pasまでの範囲内である、組成物。 - 前記粒子が、ケイ素、亜鉛、鉄、セリウム、ジルコニウム、チタンまたはアルミニウムの酸化物、亜鉛、マグネシウムまたはカルシウムのステアリン酸塩、金属ケイ酸塩およびそれらの混合物からなる群から選択される、請求項1に記載の組成物。
- 少なくとも20%の水および二酸化ケイ素粒子を含む、請求項1に記載の組成物。
- リーブオン組成物である、請求項1に記載の組成物。
- 界面活性剤を実質的に含まない、請求項4に記載の組成物。
- フマル酸またはその塩をさらに含む、請求項1に記載の組成物。
- スキンコンディショニング組成物のための添加剤であって、
(a) 前記組成物の0.01から15質量%までの12-ヒドロキシステアリン酸、および
(b) アミノシリコーン対12-ヒドロキシステアリン酸の質量比が2:1から75:1の範囲内であるアミノシリコーン
を含む添加剤。 - 乾燥肌、ざ瘡、光線性皮膚障害、しわの出現、年齢によるしみ、老化皮膚、皮脂過剰産生を処置するための、請求項1に記載の組成物。
- 皮膚の色の美白方法であって、請求項1に記載の組成物を皮膚に塗布するステップを含む方法。
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WO2011138445A1 (en) | 2011-11-10 |
BR112012027145A2 (pt) | 2016-07-26 |
US20130108566A1 (en) | 2013-05-02 |
TW201204401A (en) | 2012-02-01 |
CN102869335B (zh) | 2015-09-23 |
CA2797251A1 (en) | 2011-11-10 |
EA201291200A1 (ru) | 2013-04-30 |
BR112012027371A2 (pt) | 2017-07-25 |
EP2566437A1 (en) | 2013-03-13 |
EA029536B1 (ru) | 2018-04-30 |
US20130079419A1 (en) | 2013-03-28 |
CA2795899A1 (en) | 2011-11-10 |
CA2797251C (en) | 2018-09-25 |
CA2795899C (en) | 2018-05-29 |
EP2566439A4 (en) | 2013-09-25 |
TWI535457B (zh) | 2016-06-01 |
JP2013525459A (ja) | 2013-06-20 |
US9539190B2 (en) | 2017-01-10 |
CN102869335A (zh) | 2013-01-09 |
MX2012012984A (es) | 2012-11-30 |
MX338243B (es) | 2016-04-08 |
MX2012012982A (es) | 2012-11-30 |
ES2598507T3 (es) | 2017-01-27 |
WO2011137664A1 (en) | 2011-11-10 |
WO2011137563A1 (en) | 2011-11-10 |
EP2566439B1 (en) | 2017-03-22 |
ES2627109T3 (es) | 2017-07-26 |
EP2566439A1 (en) | 2013-03-13 |
AR081370A1 (es) | 2012-08-29 |
EP2566437B1 (en) | 2016-07-20 |
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