JP5620408B2 - デバイス表面から突出する配向カーボンナノチューブを有するナノ強化デバイスにより促進された、薬物送達及び物質移送 - Google Patents
デバイス表面から突出する配向カーボンナノチューブを有するナノ強化デバイスにより促進された、薬物送達及び物質移送 Download PDFInfo
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Description
本出願は、2009年1月27日に出願され、「CARBON NANOTUBE−BASED DEVICE FOR SUB−DERMAL BLOOD AND FLUID PROPERTY MONITORING」と題した、米国仮出願第61/206,071号、及び2009年5月19日に出願され、「METHOD, DEVICE AND DESIGN FOR DELIVERY OF DRUGS BE A NANO−ENHANCED ANGIOPLASTY BALLOON」と題した、米国仮出願第61/179,639号の利益を主張する、特許本出願である。
Creel, C. J., M.A. Lovich, and E.R. Edelman, Arterial paclitaxel distribution and deposition. Circulation Research, 2000. 86(8):p.879−884. Scheller, B., U. Speck, C. Abramjuk, U. Bernhardt, M. Bohm, and G. Nickenig, Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis. Circulation, 2004. 110(7):p.810−814. Bronikowski, M. J., Longer nanotubes at lower temperatures: The influence of effective activation energies on carbon nanotube growth by thermal chemical vapor deposition. Journal of Physical Chemistry C, 2007. 111(48):p.17705−17712.
本発明は、ナノ構造強化型の、薬剤送達及び血液モニタリングデバイスに関し、具体的には、デバイスと生体組織との間で薬物又は物質の移送を促進するための、デバイス表面から突出する配向カーボンナノチューブを備えるデバイスに関する。
カーボンナノチューブは、いくつかの方法により形成することができ、最も単純な方法は、触媒で被覆した基質を用いる化学蒸着法である。一般的に、前もって準備され、エチレンなどの炭素含有の供給ガス流を有する条件のチューブ炉内に設置され、そして、適正温度、例えば725℃まで昇温されることで、シリコン上を被覆した数ナノメートルの鉄が挙げられる。熱化学気相蒸着によるカーボンナノチューブの成長(非特許文献3参照)は、一般的にはシリコンの成長基質上に、垂直に配向したカーボンナノチューブを生じさせる。
(3.1)ニードル
本発明の一態様は、容易に皮層に差し込むことができ、毛細血管又は組織液に到達するマイクロニードルとして機能するカーボンナノチューブを、パターン化して分散させて使用するデバイスである。このようなデバイスは、ニードル又はリバースニードル(reverse needle)として用いることができ、それぞれ体に対する又は体からの物質の移送を促進する。図4Aは、カーボンナノチューブ102がナノニードルを形成するように、基質100中に固定した一群のカーボンナノチューブ102を示す。図示する実施形態では、基質は多孔質基質400である。両矢印402は、カーボンナノチューブ102を通じて、基質に対する又は基質からの物質の移動が生じ得る方向を示す。ニードルとして機能する際には、カーボンナノチューブベースのニードルは、図2Bに示す突き刺す作用と同様に、皮下で流体と接触することにより、血液又は組織液を多孔質基質400中に取り出す作用も有する。流体の分析は、光学的分析などの何らかの別の手段によりなされる。リバースニードル(reverse needle)として機能する際には、多孔質基質400に、何らかの薬剤、例えば、医薬を前もって充填し、これを、カーボンナノチューブベースのニードルを通じて、皮下領域中に送達させることができる。図4Bは、複数のニードル様のナノチューブ102のクラスターを備えるデバイスを示す。
ナノニードルデバイスは、センサーと組み合わせて、血糖値、又は他の血液若しくは体液の物性、例えばpH、糖値、酸素含有量等をモニターするためのプローブとして機能させることができる。このデバイスは、カーボンナノチューブの固有の電気伝導性に基づいて機能する。図5Aは、本発明に従うナノプローブを図示する。プローブは、センサー500と連結した基質100中に固定した、一つ又は複数のカーボンナノチューブ102のクラスターを備える。このセンサーは、所望の作動形態に依存して、カーボンナノチューブ102又は基質100又は両方と、動作可能なように連結させることができる。図5Aでは、センサー500は、カーボンナノチューブ102のクラスターと動作可能なように連結される。図5Bの上面図に示す、望ましい実施形態では、ナノチューブクラスターが、互いに電気的に絶縁されるようにパターン化される。図示のパターンは、ナノチューブクラスターの内輪502及び外輪504を備える。図5Bに示す態様についての具体的な用途としては、血糖値の測定が挙げられる。本出願では、カーボンナノチューブクラスターのサブセット(例えば、内輪502)を、グルコースオキシダーゼで処理し、一方で、カーボンナノチューブクラスターの別のサブセット(例えば、外輪504)を、フェリシアン化物で処理することにより、血液中に導電性を生じさせ、血糖値の測定を可能にする。本発明は、図5Bに示す具体的な実施形態に加えて、さまざまなパターンのナノチューブクラスターを用いることができることに留意されたい。また、このデバイスは、被覆プローブとして用いることもでき、ここで、薬物などの薬剤で、図3A及び3Bに示すカーボンナノチューブの表面上又は内部を、前もって被覆することができ、そして、カーボンナノチューブを生体組織中に差し込むことにより、薬剤を送達し、または放出することができる。
図4Bに示すカーボンナノチューブの集合体は、カーボンナノチューブの固有の毛細管作用により、湿式の絵筆として作用することもできる。同様の方法は、米国特許出願第11/124,523号明細書に記載されており、この参照により本明細書に取り込まれたものとする。
本発明の別の望ましい実施形態は、血管の一部を開くためにバルーンを膨張させることに続いて、組織細胞の過剰増殖を防止するためにパクリタキセル薬を送達するための血管形成術におけるものである。しかしながら、本発明は、血管形成術での使用又はパクリタキセルの送達に限定されるとみなすべきではない。本発明は、これらに限定されないが、皮膚、子宮、気管支、及び直腸を含む消化管の様々な部位を含めて、身体の様々な部位に、多様な物質を送達するために、適切に用いることができる。
d(図1では、106)は、個々のカーボンナノチューブの直径であり;
h(図1では、108)は、個々のカーボンナノチューブの長さであり;
s(図1では、110)は、個々のカーボンナノチューブ間の距離であり;
R(図6Bでは、604)は、バルーンの半径であり;そして、
L(図6Aでは、602)は、バルーンの長さであり、また、
以下の、一般的な前提値:
d=10nm;
s=100nm;及び
h=500nm
を用いて、
下記の結果が得られた:
本発明のナノ強化された表面は、皮膚上に付着させる表皮パッチに用いることができる。図7Aは、ナノ強化された表皮パッチの一例700を示す。このパッチは、皮膚に付着する表面から突出する配向カーボンナノチューブ102を有する。パッチ700の一部、例えば周縁部702を、皮膚に対する付着を容易にするために、接着剤で被覆してもよい。図7Bに示すように、パッチ700を皮膚に適用するとき、カーボンナノチューブ102は、図2Bに示す形で皮膚に差し込まれ、そこに被覆されたあらゆる薬物又は薬剤を皮膚に放出する。このパッチは、先述のいかなる本発明の実施形態とも併用して用いることができる。
Claims (9)
- デバイスと組織との間で物質を移送するためのナノ強化デバイスであって、
前記デバイスは、基質及び二つの端を有する実質的に配向されたカーボンナノチューブ配列を含み、
前記カーボンナノチューブは、少なくとも一端が前記基質から突出した状態で前記基質内に固定され、
前記カーボンナノチューブは、カーボンナノチューブクラスターとして配置され、各々のクラスターがニードルとして効果的に機能することができるよう構成され、
突出する前記カーボンナノチューブが、前記デバイスの物質移送能力を強化する、
ナノ強化されたデバイス。 - 前記カーボンナノチューブ配列は、薬物で被覆される、請求項1に記載のデバイス。
- 前記デバイスは、組織上に付着するパッチである、請求項2に記載のデバイス。
- 前記基質は多孔質材料を含み、
前記物質を、前記カーボンナノチューブの固有の毛細管作用により、前記デバイス及び前記組織に対して又は前記デバイス及び前記組織から移送することができる、請求項1に記載のデバイス。 - 前記基質の前記多孔質材料に、前記カーボンナノチューブを通じて前記組織に移送するための前記物質が充填される、請求項4に記載のデバイス。
- 前記カーボンナノチューブクラスターは、それらが互いに電気的に絶縁されるようにパターン化され、
前記デバイスは、前記ナノチューブクラスターの電位を読み取るセンサーを含む、請求項1に記載のデバイス。 - 前記カーボンナノチューブは、固有の電気伝導性を有し、
前記カーボンナノチューブの前記固有の電気伝導性は、前記カーボンナノチューブを前もって化学物質で被覆する処理により調整される、請求項6に記載のデバイス。 - 前記カーボンナノチューブクラスターのサブセットが、グルコースオキシダーゼで処理され、
前記カーボンナノチューブの別のサブセットが、フェリシアン化物で処理されていることで、血液中に導電性を生じさせ、血糖値の測定を可能にする、請求項7に記載のデバイス。 - 前記デバイスは、組織上に付着するパッチであり、
前記カーボンナノチューブクラスターは、輪状にパターン化される、請求項1に記載のデバイス。
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PCT/US2010/000243 WO2010087971A2 (en) | 2009-01-27 | 2010-01-27 | Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface |
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Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7959969B2 (en) | 2007-07-10 | 2011-06-14 | California Institute Of Technology | Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion |
WO2010008627A1 (en) * | 2008-03-28 | 2010-01-21 | Georgia Tech Research Corporation | Electrode arrays and methods of making and using same |
CN102292114A (zh) | 2009-01-27 | 2011-12-21 | 加州理工学院 | 通过具有从装置表面突出的排列的碳纳米管的纳米增强的装置促进的药物递送和物质传递 |
EP2528540A4 (en) * | 2010-01-29 | 2013-11-13 | Icon Medical Corp | BIODEGRADABLE LEAKS ON AN INFLATABLE DEVICE |
WO2011127207A2 (en) | 2010-04-07 | 2011-10-13 | California Institute Of Technology | Simple method for producing superhydrophobic carbon nanotube array |
CA2796965C (en) | 2010-04-28 | 2019-04-16 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
RU2585159C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Устройство доставки лекарственного средства, применяемого при ревматоидном артрите |
EP2563453B1 (en) | 2010-04-28 | 2017-02-08 | Kimberly-Clark Worldwide, Inc. | Nanopatterned medical device with enhanced cellular interaction and method for its forming |
MX336139B (es) | 2010-04-28 | 2016-01-08 | Kimberly Clark Co | Dispositivos medicos para la entrega de arn de interferencia corta. |
WO2012031164A2 (en) * | 2010-09-02 | 2012-03-08 | California Institute Of Technology | Drug delivery by carbon nanotube arrays |
WO2012079066A2 (en) | 2010-12-10 | 2012-06-14 | California Institute Of Technology | Method for producing graphene oxide with tunable gap |
EP2651820A1 (en) | 2010-12-14 | 2013-10-23 | Styron Europe GmbH | Improved elastomer formulations |
US8976507B2 (en) | 2011-03-29 | 2015-03-10 | California Institute Of Technology | Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
CN104039382B (zh) * | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
US8764681B2 (en) | 2011-12-14 | 2014-07-01 | California Institute Of Technology | Sharp tip carbon nanotube microneedle devices and their fabrication |
US9349543B2 (en) | 2012-07-30 | 2016-05-24 | California Institute Of Technology | Nano tri-carbon composite systems and manufacture |
US20140094900A1 (en) * | 2012-10-01 | 2014-04-03 | Brigham Young University | Compliant biocompatible device and method of manufacture |
GB201304669D0 (en) * | 2013-03-15 | 2013-05-01 | Univ Singapore | Micro-needles integrated with nanotubes |
US20140296780A1 (en) * | 2013-04-01 | 2014-10-02 | California Institute Of Technology | Polymer composite carbon nanotube microneedle devices and their fabrication |
US20150182703A1 (en) * | 2013-12-02 | 2015-07-02 | Biltmore Technologies, Inc. | Nanofluidic delivery system |
US20150182473A1 (en) * | 2013-12-30 | 2015-07-02 | Molecular Rebar Design, Llc | Transdermal patches with discrete carbon nanotubes |
US20160139069A1 (en) * | 2014-11-13 | 2016-05-19 | Neem Scientific, Inc. | Large scale, low cost nanosensor, nano-needle, and nanopump arrays |
CN107210319B (zh) * | 2014-11-13 | 2021-10-08 | 丽盟科技有限公司 | 大规模低成本纳米传感器、纳米针和纳米泵阵列 |
US10517903B2 (en) | 2015-09-14 | 2019-12-31 | Amnio Technology Llc | Amnion derived therapeutic composition and process of making same |
US11273295B2 (en) | 2018-04-19 | 2022-03-15 | Spiral Therapeutics, Inc. | Inner ear drug delivery devices and methods of use |
CN109011130A (zh) * | 2018-05-29 | 2018-12-18 | 上海大学 | 一种基于纳米针的经皮光电驱动离子药物输送装置 |
CN108969869B (zh) * | 2018-07-01 | 2021-09-14 | 刘征宇 | 一种体内流量可控式减少缺血再灌注损伤的球囊 |
US11844955B2 (en) * | 2019-09-21 | 2023-12-19 | Nano Hesgarsazan Salamat Arya Incubation Center For Medical Equipment And Devices | Electrostatic drug delivery |
CN111991840A (zh) * | 2020-08-26 | 2020-11-27 | 恒天(厦门)健康产业发展有限公司 | 一种制备纳米中药的工艺方法 |
KR102566813B1 (ko) * | 2021-09-02 | 2023-08-11 | 서울대학교산학협력단 | 뉴럴 다기능 소자 및 그 제조 방법 |
WO2023107950A1 (en) * | 2021-12-06 | 2023-06-15 | Case Western Reserve University | Implant medical devices |
Family Cites Families (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
IT1220172B (it) | 1987-07-17 | 1990-06-06 | Il Consiglio Nazionale Delle R | Dispositivo a fibra ottica per la trasmissione e la irradiazione laterale di energia laser,particolarmente per trattamenti di angioplastica |
US5116317A (en) | 1988-06-16 | 1992-05-26 | Optimed Technologies, Inc. | Angioplasty catheter with integral fiber optic assembly |
US5109046A (en) | 1991-02-28 | 1992-04-28 | Atochem North America, Inc. | Liquid organotinthioalkanol stabilizer compositions and vinyl halide resin compositions containing the same |
CH685506A5 (de) | 1993-06-23 | 1995-07-31 | Zellweger Uster Ag | Vorrichtung zur Messung der Masse oder des Substanzquerschnitts von Faserbändern und Verwendung der Vorrichtung. |
US6734451B2 (en) * | 1993-11-02 | 2004-05-11 | Matsushita Electric Industrial Co., Ltd. | Aggregate of semiconductor micro-needles and method of manufacturing the same, and semiconductor apparatus and method of manufacturing the same |
US5457041A (en) * | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
WO1996021938A1 (en) | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Video-rate confocal scanning laser microscope |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
EP1161702B1 (en) | 1999-02-17 | 2014-07-23 | Lucid, Inc. | Tissue specimen holder |
US6720547B1 (en) | 1999-03-18 | 2004-04-13 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
AUPQ304199A0 (en) | 1999-09-23 | 1999-10-21 | Commonwealth Scientific And Industrial Research Organisation | Patterned carbon nanotubes |
AU2573801A (en) * | 1999-11-02 | 2001-05-14 | University Of Hawaii | Method for fabricating arrays of micro-needles |
US7335603B2 (en) | 2000-02-07 | 2008-02-26 | Vladimir Mancevski | System and method for fabricating logic devices comprising carbon nanotube transistors |
EP1311310A4 (en) | 2000-08-21 | 2004-11-24 | Cleveland Clinic Foundation | MICRO NEEDLE NETWORK AND MANUFACTURING METHOD |
US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
DE10051910A1 (de) | 2000-10-19 | 2002-05-02 | Membrana Mundi Gmbh | Flexible, poröse Membranen und Adsorbentien, und Verfahren zu deren Herstellung |
US8029734B2 (en) | 2001-03-29 | 2011-10-04 | The Board Of Trustees Of The Leland Stanford Junior University | Noncovalent sidewall functionalization of carbon nanotubes |
KR101008294B1 (ko) * | 2001-03-30 | 2011-01-13 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 나노구조체 및 나노와이어의 제조 방법 및 그로부터 제조되는 디바이스 |
US6686299B2 (en) * | 2001-06-21 | 2004-02-03 | Carlo D. Montemagno | Nanosyringe array and method |
US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
US7166266B2 (en) | 2001-07-10 | 2007-01-23 | Gb Tech, Inc. | Isolation and purification of single walled carbon nanotube structures |
US6730398B2 (en) * | 2001-08-31 | 2004-05-04 | Showa Denko K.K. | Fine carbon and method for producing the same |
US6689100B2 (en) * | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US6713519B2 (en) | 2001-12-21 | 2004-03-30 | Battelle Memorial Institute | Carbon nanotube-containing catalysts, methods of making, and reactions catalyzed over nanotube catalysts |
US7037562B2 (en) * | 2002-01-14 | 2006-05-02 | Vascon Llc | Angioplasty super balloon fabrication with composite materials |
US7147894B2 (en) | 2002-03-25 | 2006-12-12 | The University Of North Carolina At Chapel Hill | Method for assembling nano objects |
US8062573B2 (en) | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
CN1296994C (zh) | 2002-11-14 | 2007-01-24 | 清华大学 | 一种热界面材料及其制造方法 |
EP1479738A1 (en) | 2003-05-20 | 2004-11-24 | DSM IP Assets B.V. | Hydrophobic coatings comprising reactive nano-particles |
US20050011858A1 (en) | 2003-07-16 | 2005-01-20 | Industrial Technology Research Institute | Method for fabricating a hollow micro-needle array |
US20070114658A1 (en) | 2004-08-24 | 2007-05-24 | Carlos Dangelo | Integrated Circuit Micro-Cooler with Double-Sided Tubes of a CNT Array |
JP4945888B2 (ja) | 2003-10-09 | 2012-06-06 | 富士ゼロックス株式会社 | 複合体およびその製造方法 |
EP1713533A4 (en) | 2003-11-21 | 2008-01-23 | Univ California | METHOD AND / OR DEVICE FOR PUNKING A SURFACE FOR EXTRACTION, IN-SITU ANALYSIS AND / OR SUBSTANCE DELIVERY USING MICRONED NEEDLES |
US7459839B2 (en) | 2003-12-05 | 2008-12-02 | Zhidan Li Tolt | Low voltage electron source with self aligned gate apertures, and luminous display using the electron source |
TWI253467B (en) | 2003-12-23 | 2006-04-21 | Hon Hai Prec Ind Co Ltd | Thermal interface material and method for making same |
TWM253898U (en) | 2004-03-05 | 2004-12-21 | Harvatek Corp | Packaging structure of photosensitive chip |
WO2005088288A1 (ja) * | 2004-03-10 | 2005-09-22 | National Institute Of Advanced Industrial Science And Technology | カーボンナノチューブバイオセンサ |
TWI299358B (en) | 2004-03-12 | 2008-08-01 | Hon Hai Prec Ind Co Ltd | Thermal interface material and method for making same |
JP4399581B2 (ja) * | 2004-03-23 | 2010-01-20 | 独立行政法人産業技術総合研究所 | バイオセンサ |
US20050238539A1 (en) | 2004-04-01 | 2005-10-27 | Gal Shafirstein | Apparatus for automated fresh tissue sectioning |
CN100383213C (zh) | 2004-04-02 | 2008-04-23 | 清华大学 | 一种热界面材料及其制造方法 |
CN100345472C (zh) | 2004-04-10 | 2007-10-24 | 清华大学 | 一种热界面材料及其制造方法 |
CN100370604C (zh) | 2004-04-15 | 2008-02-20 | 鸿富锦精密工业(深圳)有限公司 | 一种热界面材料及其制造方法 |
CN100389166C (zh) | 2004-04-29 | 2008-05-21 | 鸿富锦精密工业(深圳)有限公司 | 一种热界面材料及其制造方法 |
TWM256877U (en) | 2004-05-03 | 2005-02-11 | Chan San Glass Co Ltd | The structure of glasses |
WO2006041535A2 (en) | 2004-05-05 | 2006-04-20 | California Institute Of Technology | Capillary lithography of nanofiber arrays |
CN1290764C (zh) | 2004-05-13 | 2006-12-20 | 清华大学 | 一种大量制造均一长度碳纳米管的方法 |
US7611628B1 (en) | 2004-05-13 | 2009-11-03 | University Of Kentucky Research Foundation | Aligned nanotubule membranes |
US20080292840A1 (en) | 2004-05-19 | 2008-11-27 | The Regents Of The University Of California | Electrically and thermally conductive carbon nanotube or nanofiber array dry adhesive |
JP2005334594A (ja) * | 2004-05-27 | 2005-12-08 | I-Com:Kk | カーボンナノチューブ突起を有する薬剤投与パッチ |
KR101005754B1 (ko) | 2004-07-27 | 2011-01-06 | 도꾸리쯔교세이호진 상교기쥬쯔 소고겡뀨죠 | 단층 카본 나노튜브 및 배향 단층 카본 나노튜브·벌크구조체 및 그들의 제조방법·장치 및 용도 |
WO2006022933A2 (en) * | 2004-08-05 | 2006-03-02 | Apogee Technologies, Inc. | System and method for drug delivery and microfluidic applications using microneedles |
US8696619B2 (en) * | 2004-08-10 | 2014-04-15 | Robert P. Schnall | Drug delivery devices |
US20060057388A1 (en) * | 2004-09-10 | 2006-03-16 | Sungho Jin | Aligned and open-ended nanotube structure and method for making the same |
US7279916B2 (en) | 2004-10-05 | 2007-10-09 | Nanoconduction, Inc. | Apparatus and test device for the application and measurement of prescribed, predicted and controlled contact pressure on wires |
JP2006114265A (ja) | 2004-10-13 | 2006-04-27 | Sony Corp | 微小電子源装置の製造方法 |
US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
US7785459B2 (en) | 2004-10-22 | 2010-08-31 | Hewlett-Packard Development Company, L.P. | Microneedles and methods of fabricating |
US7097776B2 (en) | 2004-10-22 | 2006-08-29 | Hewlett-Packard Development Company, L.P. | Method of fabricating microneedles |
US8021967B2 (en) * | 2004-11-01 | 2011-09-20 | California Institute Of Technology | Nanoscale wicking methods and devices |
US20060093642A1 (en) * | 2004-11-03 | 2006-05-04 | Ranade Shrirang V | Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology |
US20080009801A1 (en) | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
JP2006164835A (ja) | 2004-12-09 | 2006-06-22 | Sony Corp | 微小電子源装置及び平面型表示装置 |
US7850645B2 (en) * | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
US8048028B2 (en) | 2005-02-17 | 2011-11-01 | Boston Scientific Scimed, Inc. | Reinforced medical balloon |
CN1837147B (zh) | 2005-03-24 | 2010-05-05 | 清华大学 | 热界面材料及其制备方法 |
CN100337981C (zh) | 2005-03-24 | 2007-09-19 | 清华大学 | 热界面材料及其制造方法 |
WO2006107998A2 (en) | 2005-04-05 | 2006-10-12 | Pettit John W | High-reliability optical fiber having a nanocomposite coating |
TWI253898B (en) | 2005-04-08 | 2006-04-21 | Hon Hai Prec Ind Co Ltd | Thermal interface material and method of making the same |
CN100404242C (zh) | 2005-04-14 | 2008-07-23 | 清华大学 | 热界面材料及其制造方法 |
CN100358132C (zh) | 2005-04-14 | 2007-12-26 | 清华大学 | 热界面材料制备方法 |
TWI256877B (en) | 2005-04-15 | 2006-06-11 | Hon Hai Prec Ind Co Ltd | Thermal interface material and method of making the same |
US8043250B2 (en) | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US8048017B2 (en) | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
CN100454526C (zh) | 2005-06-30 | 2009-01-21 | 鸿富锦精密工业(深圳)有限公司 | 热界面材料制造方法 |
TWI263288B (en) | 2005-07-06 | 2006-10-01 | Powerchip Semiconductor Corp | Method for fabricating conductive line |
WO2007025023A2 (en) | 2005-08-24 | 2007-03-01 | The Trustees Of Boston College | Apparatus and methods for optical switching using nanoscale optics |
DE102005042367B4 (de) | 2005-09-07 | 2009-11-12 | Leica Microsystems Cms Gmbh | Vorrichtung zum Erzeugen von 3-D Bildern einer Probe |
US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
US9283314B2 (en) | 2005-09-21 | 2016-03-15 | Abiomed, Inc. | Cannula systems |
FI120195B (fi) | 2005-11-16 | 2009-07-31 | Canatu Oy | Hiilinanoputket, jotka on funktionalisoitu kovalenttisesti sidotuilla fullereeneilla, menetelmä ja laitteisto niiden tuottamiseksi ja niiden komposiitit |
US20070191766A1 (en) * | 2006-02-10 | 2007-08-16 | Boston Scientific Scimed, Inc. | Balloon catheter having nanotubes |
US20070207182A1 (en) * | 2006-03-06 | 2007-09-06 | Jan Weber | Medical devices having electrically aligned elongated particles |
CN101054467B (zh) | 2006-04-14 | 2010-05-26 | 清华大学 | 碳纳米管复合材料及其制备方法 |
JP5771873B2 (ja) | 2006-05-04 | 2015-09-02 | エルジー・ケム・リミテッド | 伝導性(導電性)高分子複合体を用いた高容量/高出力の電気化学エネルギー貯蔵素子 |
US20070276330A1 (en) | 2006-05-28 | 2007-11-29 | Beck Patricia A | Microneedles and methods of fabricating thereof |
US7534648B2 (en) | 2006-06-29 | 2009-05-19 | Intel Corporation | Aligned nanotube bearing composite material |
US8535791B2 (en) | 2006-06-30 | 2013-09-17 | The University Of Akron | Aligned carbon nanotube-polymer materials, systems and methods |
US7927666B2 (en) | 2006-06-30 | 2011-04-19 | The University Of Akron | Aligned carbon nanotube-polymer materials, systems and methods |
EP2081869B1 (en) | 2006-07-10 | 2020-11-04 | California Institute of Technology | Method for selectively anchoring large numbers of nanoscale structures |
US8846143B2 (en) | 2006-07-10 | 2014-09-30 | California Institute Of Technology | Method for selectively anchoring and exposing large numbers of nanoscale structures |
US8389119B2 (en) | 2006-07-31 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Composite thermal interface material including aligned nanofiber with low melting temperature binder |
CN100594379C (zh) * | 2007-06-29 | 2010-03-17 | 浙江大学 | 一种碳纳米管修饰的血糖生物传感器 |
US7959969B2 (en) | 2007-07-10 | 2011-06-14 | California Institute Of Technology | Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion |
CN101343532B (zh) | 2007-07-13 | 2011-06-08 | 清华大学 | 碳纳米管复合热界面材料的制备方法 |
WO2009037717A2 (en) | 2007-09-18 | 2009-03-26 | Council Of Scientific & Industrial Research | Nanocomposite material useful for the preparation superhydrophobic coating and a process for the preparation thereof |
CN101126735B (zh) * | 2007-09-30 | 2010-06-23 | 董益阳 | 一种场效应晶体管生物传感器的制备方法 |
WO2009061510A1 (en) | 2007-11-09 | 2009-05-14 | Kirt Lander | Insole pad for open backed hoof boots |
CN100579901C (zh) * | 2007-11-20 | 2010-01-13 | 浙江大学 | 酸胆碱基仿生聚合物包覆的碳纳米管及其制备方法 |
WO2009070796A1 (en) | 2007-11-29 | 2009-06-04 | President And Fellows Of Harvard College | Assembly and deposition of materials using a superhydrophobic surface structure |
US9168364B2 (en) * | 2008-11-04 | 2015-10-27 | Janisys Limited | Transfer device for transferring a substance between the device and a subject |
CN102292114A (zh) | 2009-01-27 | 2011-12-21 | 加州理工学院 | 通过具有从装置表面突出的排列的碳纳米管的纳米增强的装置促进的药物递送和物质传递 |
US20110045080A1 (en) | 2009-03-24 | 2011-02-24 | William Marsh Rice University | Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto |
US10138120B2 (en) * | 2009-03-31 | 2018-11-27 | The Regents Of The University Of Michigan | Shaping nanostructure arrays |
US8272124B2 (en) | 2009-04-03 | 2012-09-25 | Formfactor, Inc. | Anchoring carbon nanotube columns |
JP2011204769A (ja) | 2010-03-24 | 2011-10-13 | Toshiba Corp | 半導体装置及びその製造方法 |
WO2011127207A2 (en) | 2010-04-07 | 2011-10-13 | California Institute Of Technology | Simple method for producing superhydrophobic carbon nanotube array |
WO2012031164A2 (en) | 2010-09-02 | 2012-03-08 | California Institute Of Technology | Drug delivery by carbon nanotube arrays |
US8976507B2 (en) | 2011-03-29 | 2015-03-10 | California Institute Of Technology | Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles |
US8764681B2 (en) | 2011-12-14 | 2014-07-01 | California Institute Of Technology | Sharp tip carbon nanotube microneedle devices and their fabrication |
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2010
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- 2010-01-27 WO PCT/US2010/000243 patent/WO2010087971A2/en active Application Filing
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US20130158377A1 (en) | 2013-06-20 |
US20150238742A1 (en) | 2015-08-27 |
US9050444B2 (en) | 2015-06-09 |
WO2010087971A3 (en) | 2010-12-23 |
CN102292114A (zh) | 2011-12-21 |
JP2012516202A (ja) | 2012-07-19 |
EP2381972A2 (en) | 2011-11-02 |
US20100196446A1 (en) | 2010-08-05 |
WO2010087971A2 (en) | 2010-08-05 |
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