JP2020036784A - 人工血管 - Google Patents
人工血管 Download PDFInfo
- Publication number
- JP2020036784A JP2020036784A JP2018165849A JP2018165849A JP2020036784A JP 2020036784 A JP2020036784 A JP 2020036784A JP 2018165849 A JP2018165849 A JP 2018165849A JP 2018165849 A JP2018165849 A JP 2018165849A JP 2020036784 A JP2020036784 A JP 2020036784A
- Authority
- JP
- Japan
- Prior art keywords
- blood vessel
- artificial blood
- wall
- outer cylinder
- main body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/04—Coating on selected surface areas, e.g. using masks
- C23C16/045—Coating cavities or hollow spaces, e.g. interior of tubes; Infiltration of porous substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/303—Carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/22—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of inorganic material, other than metallic material
- C23C16/26—Deposition of carbon only
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/458—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
- C23C16/4581—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber characterised by material of construction or surface finish of the means for supporting the substrate
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
- C23C16/503—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using dc or ac discharges
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
- C23C16/505—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges
- C23C16/509—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges using internal electrodes
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
- C23C16/515—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using pulsed discharges
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
- C23C16/517—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using a combination of discharges covered by two or more of groups C23C16/503 - C23C16/515
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/0086—Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0025—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in roughness
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
図2に示す成膜装置により、試料の内壁面に炭素質膜を形成した。チャンバ101は、直径が200mmで、長さが500mmのステンレス容器とした。チャンバ101には真空排気部110及びガス供給部115が接続されており、電源部120は、電圧発生器121(IWATSU製SG-4104)と増幅器122(NF Corporation製HVA4321)とにより構成した。放電電極125は、直径6mm、長さ70mmのステンレス電極とした。ガス供給部115は、メタンガスのボンベ116からマスフローコントローラ117を介して原料ガスを供給する構成とした。バルブの開度及びガス供給量を制御することにより、チャンバ110内の圧力を調整した。
内径が4mmで長さが150mmのシリコンチューブ製の外筒内に、内径が3mm、厚さが0.35mmで、長さが150mmのePTFE製人工血管(ゴアテックス社製、SGTW-0315BT)を入れて所定の時間成膜を行った。
微細表面粗さは、人工血管の内壁面を撮影した電解放出型走査電子顕微鏡(日立ハイテクノロジーズ社、S-4800)写真を画像処理することにより算出した。まず、倍率100K倍の電子顕微鏡写真の1290×960の部分をピクセル数50×50の画像としてコンピュータに取り込んだ。取り込んだ各ピクセルの輝度に基づいて、各ピクセルの相対的な高さの値を算出しこれをピクセル値とした。次に、算出したピクセル値に含まれるノイズをTrend filtering(Tibshirani, R.: Adaptive piecewise polynomial estimation via trend filtering, Annals of Statistics, 42(1), 285-323, 2014を参照。)により除去した。ノイズ除去を行ったピクセル値から、以下の式(1)に基づいて画像解析による微細算術平均粗さ(IARa)を算出し、以下の式(2)に基づいて画像解析による微細二乗平均平方根高さ(IARq)を算出した。なお、nは2500とし、50×50のピクセルすべてを対象として演算を行った。また、得られたIARa及びIARqの値を未処理の人工血管のIARa及びIARqの値で割った値を、それぞれ規格化IARa及び規格化IARqとした。
長さ10mmに切断した人工血管を試料管に10個入れ、このサンプルについて、ガス吸着装置(マクロトラックベル社製、ベルソープ18)を用いて、水蒸気吸脱着等温線及び窒素吸脱着等温線を求めた。試料は脱ガスを行うため、前処理を行った。処理温度は100℃とした。処理時間は3〜8時間とし、脱ガスが充分にできた状態で終了させた。水蒸気については、吸着温度を25℃とした。0.4kPa〜2.9kPaの圧力範囲(相対圧0.11〜0.91)において、圧力を上げながらほぼ等間隔に20点について吸着量を測定した後、圧力を下げながら11点について測定した。窒素については、吸着温度を−196℃とした。5.3kPa〜101kPaの圧力範囲(相対圧0.05〜1.0)において、圧力を上げながらほぼ等間隔に27点について吸着量を測定した後、圧力を下げながら14点について測定した。
接触角測定器(協和界面科学社製、DropMaster500)を用いて、炭素質膜が形成された厚さが0.1mmのePTFEシート表面の水に対する接触角を測定した。水の滴下量は2μLとした。
体重35kgのオスヤギに全身麻酔・ヘパリン管理下にて左右側頚部にそれぞれ人工血管によりArterial-Venous(A-V)シャントを作成した。人工血管の長さは約5cmとした。
成膜時間を5分として人工血管の内壁に炭素質膜を形成した。得られた、炭素質膜を形成した人工血管の表面状態を図6Aに示す。図7Aに示すSEM画像におけるIARaは0.95、IARqは1.2であった。未処理の人工血管のIARaにより規格化した規格化IARaは0.34、未処理の人工血管のIARqにより規格化した規格化IARqは0.32であった。水蒸気吸着等温線は、脱離ヒステリシスを有していた(図8A)。一方、窒素吸着等温線には、脱離ヒステリシスは認められなかった(図9A)。また、水に対する接触角は98°であった。本実施例の人工血管をヤギの左側頚部に埋め込んだ結果、図10Aに示すように免疫系細胞の吸着は少なく吸着量の平均値は、3個/mmであった。
炭素質膜を形成していない人工血管の表面の表面状態を図7Bに示す。図7Bに示すSEM画像におけるIARaは2.8、IARqは3.6であった。水蒸気吸着等温線及び窒素吸着等温線のいずれにも、脱離ヒステリシスは認められなかった(図8B、図9B)。また、水に対する接触角は132°であった。本比較例の人工血管をヤギの右側頚部に埋め込んだ結果、図10Bに示すように人工血管の内壁面に多数の免疫系細胞が吸着しており、吸着量の平均値は、29個/mmであった。
成膜時間を1分とした以外は実施例1と同様にして炭素質膜を形成した。得られた、炭素質膜を形成した人工血管の表面状態を図7Cに示す。水蒸気吸着等温線及び窒素吸着等温線のいずれにも、脱離ヒステリシスは認められなかった。また、水に対する接触角は107°であった。
102 長尺細管
103 電極コネクタ
104 外筒
110 ガス供給部
120 電源部
121 電圧発生器
122 増幅器
125 放電電極
126 対向電極
Claims (5)
- 人工血管本体と、前記人工血管本体の内壁を被覆する炭素質膜とを備え、
前記炭素質膜に被覆された内壁は、水蒸気吸着等温線が脱離ヒステリシスを有する、人工血管。 - 前記炭素質膜に被覆された内壁は、画像解析による微細算術平均粗さが2.5以下である、請求項1に記載の人工血管。
- 前記炭素質膜に被覆された内壁は、免疫系細胞吸着量が、20個/mm以下である、請求項1又は2に記載の人工血管。
- 内部圧力を調整可能なチャンバ内に、多孔性の人工血管本体を配置し、炭化水素を含む原料ガスを供給した状態において、前記人工血管本体の内部にプラズマを発生させて、前記人工血管本体の内壁を炭素質膜により被覆する工程を備え、
前記人工血管本体は、内径が前記人工血管本体の外径よりも大きい非導電性の外筒内に収容された状態で前記チャンバ内に配置し、
前記外筒は、一方の端部に放電電極が配置され、他方の端部は開放されており、
前記放電電極と、前記外筒から離間して設けられた対向電極との間に断続的に交流バイアスを印加し、
前記炭素質膜により被覆された内壁は、水蒸気吸着等温線が脱離ヒステリシスを有する、人工血管の製造方法。 - 内部圧力を調整可能なチャンバと、
前記チャンバ内に炭化水素ガスを供給するガス供給部と、
前記チャンバ内に設けられた放電電極及び対向電極と、
前記放電電極と前記対向電極との間に断続的に交流電圧を印加する電源部とを備え、
前記放電電極を、人工血管本体を収容する外筒の一方の端部に取り付け、前記対向電極を前記外筒から離間した状態として放電させることにより、前記外筒内にプラズマを発生させて、前記人工血管本体の内壁に炭素質膜を形成し、
前記炭素質膜に被覆された内壁は、水蒸気吸着等温線が脱離ヒステリシスを有する、人工血管の製造装置。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018165849A JP2020036784A (ja) | 2018-09-05 | 2018-09-05 | 人工血管 |
TW108131989A TW202023494A (zh) | 2018-09-05 | 2019-09-05 | 人造血管、人造血管之製造方法以及人造血管之製造裝置 |
PCT/JP2019/034997 WO2020050365A1 (ja) | 2018-09-05 | 2019-09-05 | 人工血管 |
US17/273,970 US11969334B2 (en) | 2018-09-05 | 2019-09-05 | Artificial blood vessel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018165849A JP2020036784A (ja) | 2018-09-05 | 2018-09-05 | 人工血管 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2020036784A true JP2020036784A (ja) | 2020-03-12 |
Family
ID=69722022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018165849A Pending JP2020036784A (ja) | 2018-09-05 | 2018-09-05 | 人工血管 |
Country Status (4)
Country | Link |
---|---|
US (1) | US11969334B2 (ja) |
JP (1) | JP2020036784A (ja) |
TW (1) | TW202023494A (ja) |
WO (1) | WO2020050365A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021177229A1 (ja) | 2020-03-04 | 2021-09-10 | キヤノン株式会社 | 放射線撮影システム、制御装置、及び放射線撮影システムの制御方法 |
WO2022239490A1 (ja) * | 2021-05-10 | 2022-11-17 | デンカ株式会社 | 模擬血管及びそれを用いた潰瘍モデル |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6037735B2 (ja) * | 1978-10-18 | 1985-08-28 | 住友電気工業株式会社 | 人工血管 |
JPS60135062A (ja) * | 1983-12-23 | 1985-07-18 | 住友電気工業株式会社 | 人工血管 |
JPH07500122A (ja) * | 1991-06-14 | 1995-01-05 | ダブリュ.エル.ゴア アンド アソシエーツ,インコーポレイティド | 表面改質多孔質膨張延伸ポリテトラフルオロエチレンとその製造方法 |
US5628786A (en) * | 1995-05-12 | 1997-05-13 | Impra, Inc. | Radially expandable vascular graft with resistance to longitudinal compression and method of making same |
GB0406719D0 (en) * | 2004-03-25 | 2004-04-28 | Tayside Flow Technologies Ltd | A tubular conduit |
JP2006263144A (ja) | 2005-03-24 | 2006-10-05 | Mcrotech Kk | 生体軟組織代替移植材料およびその製造方法 |
GB2475338A (en) * | 2009-11-17 | 2011-05-18 | Tayside Flow Technologies Ltd | A tubular conduit with an internal and external helical formation |
JP2015167822A (ja) | 2014-03-10 | 2015-09-28 | テルモ株式会社 | 体内留置物 |
JP6506787B2 (ja) * | 2017-03-06 | 2019-04-24 | ストローブ株式会社 | 成膜方法 |
-
2018
- 2018-09-05 JP JP2018165849A patent/JP2020036784A/ja active Pending
-
2019
- 2019-09-05 TW TW108131989A patent/TW202023494A/zh unknown
- 2019-09-05 US US17/273,970 patent/US11969334B2/en active Active
- 2019-09-05 WO PCT/JP2019/034997 patent/WO2020050365A1/ja active Application Filing
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021177229A1 (ja) | 2020-03-04 | 2021-09-10 | キヤノン株式会社 | 放射線撮影システム、制御装置、及び放射線撮影システムの制御方法 |
WO2022239490A1 (ja) * | 2021-05-10 | 2022-11-17 | デンカ株式会社 | 模擬血管及びそれを用いた潰瘍モデル |
Also Published As
Publication number | Publication date |
---|---|
US20210353404A1 (en) | 2021-11-18 |
WO2020050365A1 (ja) | 2020-03-12 |
US11969334B2 (en) | 2024-04-30 |
TW202023494A (zh) | 2020-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2000064047A (ja) | ダイヤモンド様炭素(dlc)又は他の真空蒸着被膜を基体に被覆する装置及び方法 | |
US6464889B1 (en) | Surface modification of medical implants | |
WO2020050365A1 (ja) | 人工血管 | |
JP2009542917A (ja) | 中空体の内壁に関するプラズマ支援化学気相堆積方法 | |
JPH11229146A (ja) | 複合材料 | |
JP2011152447A (ja) | インプラント | |
US6692834B1 (en) | Method for coating implantable devices | |
CN103924202A (zh) | 一种金属支架表面改性方法 | |
WO2008146022A2 (en) | Elastomeric seals | |
JP2006314729A (ja) | 安全で鍼治療効果の優れた通電治療用絶縁鍼。 | |
JP7453637B2 (ja) | 内面被覆チューブ | |
JP6506787B2 (ja) | 成膜方法 | |
Klages | Modification and coating of biomaterial surfaces by glow‐discharge processes. A review | |
JP7229458B2 (ja) | 非晶質炭素膜とその製造方法 | |
EP2792380A2 (en) | Use of acrylic acid for hydrophilically coating a medicinal-technical device | |
JP2014069000A (ja) | 生体内摺動部材及びその表面処理方法 | |
US8834555B2 (en) | TiNxCy modified surface for an implantable device and a method of producing the same | |
JP5659362B2 (ja) | 内皮細胞増殖性材料 | |
WO2022097300A1 (ja) | 医療機器用金属材料、医療機器用金属材料の製造方法、及び医療機器 | |
CN1736345A (zh) | 生物陶瓷封堵器及其制作方法 | |
Harigai et al. | Hydrophilic DLC Surface Induced by Nanostructures Formed by RF O 2 Plasma Etching With Metal Micromasks | |
EP4129351A1 (en) | Method for production of nanostructured surfaces on stents for improved biocompatibility | |
JP2008019393A (ja) | 表面被覆フッ素樹脂基体及びその製造方法 | |
CN106661726A (zh) | 基体涂覆方法和装置 | |
LI et al. | Study on the Key Technology of Micro-arc Oxidation of TA2 Titanium for Medical Use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7426 Effective date: 20180925 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20180925 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190905 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191023 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20191220 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20200421 |