JP2015515474A - ワクチンの経頬送達のための溶解性微小針アレイ - Google Patents
ワクチンの経頬送達のための溶解性微小針アレイ Download PDFInfo
- Publication number
- JP2015515474A JP2015515474A JP2015504704A JP2015504704A JP2015515474A JP 2015515474 A JP2015515474 A JP 2015515474A JP 2015504704 A JP2015504704 A JP 2015504704A JP 2015504704 A JP2015504704 A JP 2015504704A JP 2015515474 A JP2015515474 A JP 2015515474A
- Authority
- JP
- Japan
- Prior art keywords
- microneedle
- microneedle patch
- vaccine
- patch
- microneedles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 85
- 238000002255 vaccination Methods 0.000 claims abstract description 26
- 210000005178 buccal mucosa Anatomy 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims description 23
- 239000004375 Dextrin Substances 0.000 claims description 16
- 229920001353 Dextrin Polymers 0.000 claims description 16
- 235000019425 dextrin Nutrition 0.000 claims description 16
- 210000004400 mucous membrane Anatomy 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 13
- 206010043376 Tetanus Diseases 0.000 claims description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 10
- 210000000981 epithelium Anatomy 0.000 claims description 10
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 10
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 9
- 235000010980 cellulose Nutrition 0.000 claims description 9
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 208000002672 hepatitis B Diseases 0.000 claims description 7
- 206010008631 Cholera Diseases 0.000 claims description 6
- 206010014596 Encephalitis Japanese B Diseases 0.000 claims description 6
- 208000007514 Herpes zoster Diseases 0.000 claims description 6
- 241000701806 Human papillomavirus Species 0.000 claims description 6
- 201000005807 Japanese encephalitis Diseases 0.000 claims description 6
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 6
- 208000016604 Lyme disease Diseases 0.000 claims description 6
- 201000005505 Measles Diseases 0.000 claims description 6
- 208000005647 Mumps Diseases 0.000 claims description 6
- 201000005702 Pertussis Diseases 0.000 claims description 6
- 206010035148 Plague Diseases 0.000 claims description 6
- 208000000474 Poliomyelitis Diseases 0.000 claims description 6
- 206010037742 Rabies Diseases 0.000 claims description 6
- 241000702670 Rotavirus Species 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 208000037386 Typhoid Diseases 0.000 claims description 6
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 6
- 208000003152 Yellow Fever Diseases 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 6
- 206010013023 diphtheria Diseases 0.000 claims description 6
- 208000005252 hepatitis A Diseases 0.000 claims description 6
- 206010022000 influenza Diseases 0.000 claims description 6
- 208000010805 mumps infectious disease Diseases 0.000 claims description 6
- 201000005404 rubella Diseases 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 201000008827 tuberculosis Diseases 0.000 claims description 6
- 201000008297 typhoid fever Diseases 0.000 claims description 6
- 241000701161 unidentified adenovirus Species 0.000 claims description 6
- 208000007089 vaccinia Diseases 0.000 claims description 6
- 210000004443 dendritic cell Anatomy 0.000 claims description 5
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 4
- 150000002016 disaccharides Chemical class 0.000 claims description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 229920002101 Chitin Polymers 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 229920000858 Cyclodextrin Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 229920002177 Icodextrin Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 3
- 230000035587 bioadhesion Effects 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 229940016836 icodextrin Drugs 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
- -1 tulanose Chemical compound 0.000 claims description 3
- 229920000945 Amylopectin Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- 239000007787 solid Substances 0.000 description 25
- 210000001519 tissue Anatomy 0.000 description 19
- 238000000034 method Methods 0.000 description 15
- 239000011159 matrix material Substances 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 12
- 239000003814 drug Substances 0.000 description 11
- 230000035515 penetration Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 7
- 210000004876 tela submucosa Anatomy 0.000 description 7
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 6
- 238000007907 direct compression Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000007908 dry granulation Methods 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 239000011812 mixed powder Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000005550 wet granulation Methods 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000002200 mouth mucosa Anatomy 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 210000002845 virion Anatomy 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108010041986 DNA Vaccines Proteins 0.000 description 3
- 229940021995 DNA vaccine Drugs 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 210000002469 basement membrane Anatomy 0.000 description 3
- 229920002988 biodegradable polymer Polymers 0.000 description 3
- 239000004621 biodegradable polymer Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000002716 delivery method Methods 0.000 description 3
- 210000001787 dendrite Anatomy 0.000 description 3
- 210000005081 epithelial layer Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000001821 langerhans cell Anatomy 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 229960005030 other vaccine in atc Drugs 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 239000000277 virosome Substances 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000000227 bioadhesive Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920006184 cellulose methylcellulose Polymers 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000021472 generally recognized as safe Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000006104 solid solution Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 208000006373 Bell palsy Diseases 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 101710146739 Enterotoxin Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000004929 Facial Paralysis Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000000147 enterotoxin Substances 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000010903 husk Substances 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940031348 multivalent vaccine Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (20)
- 経内頬投与を介してワクチン接種するための微小針パッチであって、所定のワクチンを保有し、該所定のワクチンを迅速に送達するために内頬粘膜の外側層を貫通するように設計された少なくとも1本の微小針を含んでいることを特徴とする微小針パッチ。
- 前記少なくとも1本の微小針は、前記内頬粘膜の上皮を貫通し、粘膜固有層に前記所定のワクチンを送達するように設計されている、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針は、溶解性、生物溶解性及び/又は生分解性の物質で製造され、前記内頬粘膜の表面への生物接着性を提供する、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針は、セルロース、デキストリン、デキストラン、二糖類、キトサン、キチン、ゼラチン、アミロペクチン、プルラン、およびそれらの混合物のうちの少なくとも1種により製造され、
前記セルロースには、セルロース、カルボキシメチルセルロースナトリウム、ヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、およびヒドロキシプロピルメチルセルロースが含まれ、
前記デキストリンには、マルトデキストリン、シクロデキストリン、アミロデキストリン、イコデキストリン、イエローデキストリン、およびホワイトデキストリンが含まれ、
前記二糖類には、スクロース、ラクトース、マルトース、トレハロース、ツラノース、およびセロビオースが含まれる、
請求項1記載の微小針パッチ。 - 前記少なくとも1本の微小針は、スクロースとカルボキシメチルセルロースナトリウムとの混合物、マンノースとカルボキシメチルセルロースナトリウムとの混合物、およびデキストリンとトレハロースとの混合物のうちの少なくとも1種により製造される、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針は、最広直径が約900μm未満である漸減形状を有する、請求項1記載の微小針パッチ。
- 本微小針パッチは、約0.5cmから約1.5cmの直径を有し、5本から400本の前記微小針を含む円形体である、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針は、前記内頬粘膜の外側層を貫通するのに充分な長さを有し、前記所定のワクチンを粘膜固有層のデンドライト細胞に送達するが、粘膜下組織には侵入せず、貫通しない、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針の長さは、約200μmから500μmの範囲である、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針の長さは、約20μmから900μmの範囲である、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針の長さは、約250μmから750μmの範囲である、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針の長さは、1000μm未満である、請求項1記載の微小針パッチ。
- 前記少なくとも1本の微小針は、アデノウィルス、炭素症、BCGライブ、ジフテリア−破傷風、百日咳、ポリオ、ヘモフィルス、A型肝炎、B型肝炎、ヒトパピロマウィルス、インフルエンザ、日本脳炎、髄膜炎菌、ライム病、狂犬病、ペスト、肺炎球菌、コレラ、ワクシニア、結核、風疹、麻疹、おたふく風、ロタウィルス、破傷風、腸チフス、黄熱病、および帯状ヘルペスの少なくとも1種のワクチンを含む、請求項1記載の微小針パッチ。
- 経内頬投与を介してワクチン接種するための微小針パッチであって、複数の部位を含んでおり、それぞれの部位は、所定のワクチンを保有し、該所定のワクチンを迅速に送達するために内頬粘膜の外側層を貫通するように設計された少なくとも1本の微小針を含んでいることを特徴とする微小針パッチ。
- 1つの前記部位の微小針は、別部位の微小針に含まれるワクチンとは異なるワクチンを含む、請求項14記載の微小針パッチ。
- 1つの前記部位の微小針の形状と長さは、別部位の微小針の形状と長さとは異なる、請求項14記載の微小針パッチ。
- 1つの前記部位の微小針の数は、別部位の微小針の数とは異なる、請求項14記載の微小針パッチ。
- 前記少なくとも1本の微小針は、前記内頬粘膜の外側層を貫通するのに充分な長さを有して前記所定のワクチンを粘膜固有層のデンドライト細胞に送達するが、粘膜下組織には侵入せず、貫通しない、請求項14記載の微小針パッチ。
- 前記少なくとも1本の微小針の長さは、約200μmから500μmの範囲である、請求項14記載の微小針パッチ。
- 前記少なくとも1本の微小針は、アデノウィルス、炭素症、BCGライブ、ジフテリア−破傷風、百日咳、ポリオ、ヘモフィルス、A型肝炎、B型肝炎、ヒトパピロマウィルス、インフルエンザ、日本脳炎、髄膜炎菌、ライム病、狂犬病、ペスト、肺炎球菌、コレラ、ワクシニア、結核、風疹、麻疹、おたふく風、ロタウィルス、破傷風、腸チフス、黄熱病、および帯状ヘルペスの少なくとも1種のワクチンを含んでいる、請求項14記載の微小針パッチ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261619623P | 2012-04-03 | 2012-04-03 | |
US61/619,623 | 2012-04-03 | ||
PCT/US2013/035101 WO2013152092A1 (en) | 2012-04-03 | 2013-04-03 | Soluble microneedle arrays for buccal delivery of vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015515474A true JP2015515474A (ja) | 2015-05-28 |
JP2015515474A5 JP2015515474A5 (ja) | 2016-05-12 |
Family
ID=49301014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015504704A Pending JP2015515474A (ja) | 2012-04-03 | 2013-04-03 | ワクチンの経頬送達のための溶解性微小針アレイ |
Country Status (9)
Country | Link |
---|---|
US (1) | US20150112250A1 (ja) |
EP (1) | EP2817027A4 (ja) |
JP (1) | JP2015515474A (ja) |
KR (1) | KR20140143216A (ja) |
CN (1) | CN104185475A (ja) |
AU (1) | AU2013243546A1 (ja) |
CA (1) | CA2867158A1 (ja) |
IN (1) | IN2014MN01840A (ja) |
WO (1) | WO2013152092A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017061447A (ja) * | 2015-09-21 | 2017-03-30 | ビーアンドエル バイオテック インコーポレイティッド | 歯茎の屈曲に合うように柔軟な、歯科用物質伝達のためのマイクロニードルおよびその製作方法 |
WO2017175650A1 (ja) * | 2016-04-07 | 2017-10-12 | 日本写真印刷株式会社 | マイクロニードルシート |
WO2019035489A1 (ja) | 2017-08-17 | 2019-02-21 | コスメディ製薬株式会社 | ***用マイクロニードルアレイ |
WO2019088227A1 (ja) | 2017-11-02 | 2019-05-09 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
KR102369762B1 (ko) * | 2021-08-03 | 2022-03-03 | 주식회사 라파스 | 마이크로니들 패치의 시트, 이러한 시트를 포함하는 마이크로니들 패치 및 마이크로니들 패치 시트의 제조 방법 |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9381680B2 (en) | 2008-05-21 | 2016-07-05 | Theraject, Inc. | Method of manufacturing solid solution perforator patches and uses thereof |
US11524058B2 (en) | 2008-09-29 | 2022-12-13 | The Corporation Of Mercer University | Oral dissolving films containing microencapsulated vaccines and methods of making same |
US10004790B2 (en) | 2008-09-29 | 2018-06-26 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
US10463608B2 (en) | 2008-09-29 | 2019-11-05 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
ES2897659T3 (es) | 2013-09-03 | 2022-03-02 | Georgia Tech Res Inst | Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas |
CA2931862C (en) | 2013-11-08 | 2024-01-23 | Carlos Filipe | Method of stabilizing molecules without refrigeration using water soluble polymers and applications thereof in performing chemical reactions |
JP6249885B2 (ja) * | 2014-05-30 | 2017-12-20 | 株式会社ワークス | マイクロニードル構造体及びマイクロニードル構造体の製造方法 |
CN104083759B (zh) * | 2014-07-02 | 2016-08-24 | 安徽医科大学 | 脂质修饰载体构建的微针阵列疫苗佐剂传递*** |
CN104645331A (zh) * | 2015-01-26 | 2015-05-27 | 西安交通大学 | 一种受纳米金光热效应促控的载药微针 |
JP2016189844A (ja) * | 2015-03-31 | 2016-11-10 | 日本写真印刷株式会社 | マイクロニードルパッチ |
CN104815398B (zh) * | 2015-05-25 | 2017-10-17 | 成都凤磐生物科技有限公司 | 结合微针贴的光子嫩肤*** |
CN104826228B (zh) * | 2015-05-25 | 2017-12-29 | 成都凤磐生物科技有限公司 | 用于皮肤修复与保养的生物贴 |
KR102494543B1 (ko) * | 2015-09-15 | 2023-02-02 | 주식회사 엘지생활건강 | Hpv 백신 전달용 용해성 미세바늘 패치 |
KR102494067B1 (ko) * | 2015-09-15 | 2023-01-31 | 주식회사 엘지생활건강 | 홍역 백신을 포함하는 용해성 미세바늘 패치 |
US11628208B2 (en) | 2015-10-05 | 2023-04-18 | The Corporation Of Mercer University | System and method for microneedle delivery of microencapsulated vaccine and bioactive proteins |
WO2017062463A1 (en) | 2015-10-05 | 2017-04-13 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
CN109069817B (zh) * | 2016-04-15 | 2021-07-13 | 富士胶片株式会社 | 微针阵列 |
CN105999537A (zh) * | 2016-05-26 | 2016-10-12 | 杭州元力医疗器械有限公司 | 透皮贴式可排湿排毒的无痛揿针 |
CN105903121A (zh) * | 2016-06-22 | 2016-08-31 | 成都市亿泰科技有限公司 | 一种基于负光刻胶的高密度空心微针阵列及其制造工艺 |
WO2018056584A1 (ko) | 2016-09-21 | 2018-03-29 | 삼성전자 주식회사 | 피부 상태 측정 방법 및 이를 위한 전자 장치 |
EP3538116A4 (en) * | 2016-11-14 | 2020-05-27 | The Corporation Of Mercer University | MICRO NEEDLE-BASED TRANSDERMAL DELIVERY SYSTEM AND METHOD FOR PRODUCING THE SAME |
BR112019021396A2 (pt) | 2017-04-14 | 2020-04-28 | Capsugel Belgium Nv | processo para fabricação de pululano |
WO2018189584A1 (en) | 2017-04-14 | 2018-10-18 | Capsugel Belgium Nv | Pullulan capsules |
CN107096013B (zh) * | 2017-06-09 | 2020-10-27 | 广州新济薇娜生物科技有限公司 | 鲑鱼降钙素可溶性微针贴片及其制备方法 |
WO2019036609A1 (en) * | 2017-08-17 | 2019-02-21 | New York University | BONE GROWTH STIMULATOR AND METHODS OF USE |
KR102068025B1 (ko) | 2018-01-26 | 2020-01-20 | 한국수력원자력 주식회사 | Atf3 단백질을 이용한 방사선 선량별 스크리닝 방법 |
KR102208945B1 (ko) * | 2018-07-27 | 2021-01-29 | 주식회사 쿼드메디슨 | 다종 약물 투여가 가능한 마이크로 니들 어레이, 이를 포함하는 마이크로 니들 구조체, 및 이의 제조방법 |
CN109674737B (zh) * | 2019-01-07 | 2021-05-18 | 华中科技大学 | 一种基于水溶性小分子的可快速溶解微针及其制备与应用 |
US11844920B2 (en) * | 2020-07-23 | 2023-12-19 | Microneedles Inc | Microneedle immunotherapeutic multi-component system and a method for vaccination |
KR20220065661A (ko) * | 2020-11-13 | 2022-05-20 | 주식회사 대웅테라퓨틱스 | 마이크로니들 어레이 및 이의 제조방법 |
CN112206202A (zh) * | 2020-11-20 | 2021-01-12 | 南京鼓楼医院 | 一种载活菌的微针的制备方法及应用 |
US20230404929A1 (en) * | 2020-12-01 | 2023-12-21 | Carnegie Mellon University | Intradermal Delivery of Extracellular Vesicle-Encapsulated Curcumin Using Dissolvable Microneedle Arrays |
CN113262391A (zh) * | 2021-05-17 | 2021-08-17 | 哈尔滨医科大学 | 紧致皮肤微针贴 |
CN113332588B (zh) * | 2021-05-26 | 2023-05-09 | 四川大学 | 用于口腔黏膜给药的尖端载药可溶性微针贴片及其制备方法 |
CN114367022A (zh) * | 2021-10-19 | 2022-04-19 | 中日友好医院(中日友好临床医学研究所) | 一种用于治疗干燥综合征的微针预处理挂耳式中药外敷装置 |
DE102021130954A1 (de) * | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Orales Micronadel Patch |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000128779A (ja) * | 1998-10-20 | 2000-05-09 | Mitsui Chemicals Inc | 薬物放出制御型製剤 |
JP2001149485A (ja) * | 1999-09-22 | 2001-06-05 | Becton Dickinson & Co | 物質の経皮投与の方法及び装置 |
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
JP2008514644A (ja) * | 2004-09-28 | 2008-05-08 | アルザ コーポレイション | ミョウバンアジュバント免疫活性剤の安定化 |
JP2010046548A (ja) * | 2002-06-25 | 2010-03-04 | Sung-Yun Kwon | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
JP2011520550A (ja) * | 2008-05-21 | 2011-07-21 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6945952B2 (en) * | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
EP1590034B1 (en) * | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
US7572405B2 (en) * | 2003-06-02 | 2009-08-11 | Corium International Inc. | Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation |
US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
WO2008053481A1 (en) * | 2006-11-01 | 2008-05-08 | Svip 6 Llc | Microneedle arrays |
WO2008130587A2 (en) * | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
-
2013
- 2013-04-03 CA CA 2867158 patent/CA2867158A1/en not_active Abandoned
- 2013-04-03 WO PCT/US2013/035101 patent/WO2013152092A1/en active Application Filing
- 2013-04-03 US US14/386,033 patent/US20150112250A1/en not_active Abandoned
- 2013-04-03 JP JP2015504704A patent/JP2015515474A/ja active Pending
- 2013-04-03 EP EP13772588.3A patent/EP2817027A4/en not_active Ceased
- 2013-04-03 KR KR1020147030681A patent/KR20140143216A/ko not_active Application Discontinuation
- 2013-04-03 CN CN201380013360.9A patent/CN104185475A/zh active Pending
- 2013-04-03 AU AU2013243546A patent/AU2013243546A1/en not_active Abandoned
-
2014
- 2014-09-18 IN IN1840MUN2014 patent/IN2014MN01840A/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
JP2000128779A (ja) * | 1998-10-20 | 2000-05-09 | Mitsui Chemicals Inc | 薬物放出制御型製剤 |
JP2001149485A (ja) * | 1999-09-22 | 2001-06-05 | Becton Dickinson & Co | 物質の経皮投与の方法及び装置 |
JP2010046548A (ja) * | 2002-06-25 | 2010-03-04 | Sung-Yun Kwon | 薬物送達のための急速に溶解する微小穿孔器および他の適用 |
JP2008514644A (ja) * | 2004-09-28 | 2008-05-08 | アルザ コーポレイション | ミョウバンアジュバント免疫活性剤の安定化 |
JP2011520550A (ja) * | 2008-05-21 | 2011-07-21 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017061447A (ja) * | 2015-09-21 | 2017-03-30 | ビーアンドエル バイオテック インコーポレイティッド | 歯茎の屈曲に合うように柔軟な、歯科用物質伝達のためのマイクロニードルおよびその製作方法 |
US10980991B2 (en) | 2015-09-21 | 2021-04-20 | B&L Biotech, Inc. | Flexible microneedle for dental material delivery and method of manufacturing the same |
WO2017175650A1 (ja) * | 2016-04-07 | 2017-10-12 | 日本写真印刷株式会社 | マイクロニードルシート |
WO2019035489A1 (ja) | 2017-08-17 | 2019-02-21 | コスメディ製薬株式会社 | ***用マイクロニードルアレイ |
KR20200007016A (ko) | 2017-08-17 | 2020-01-21 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 입술용 마이크로니들 어레이 |
WO2019088227A1 (ja) | 2017-11-02 | 2019-05-09 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
KR20200007017A (ko) | 2017-11-02 | 2020-01-21 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 치과용 국소 마취 마이크로니들 어레이 |
KR102369762B1 (ko) * | 2021-08-03 | 2022-03-03 | 주식회사 라파스 | 마이크로니들 패치의 시트, 이러한 시트를 포함하는 마이크로니들 패치 및 마이크로니들 패치 시트의 제조 방법 |
Also Published As
Publication number | Publication date |
---|---|
AU2013243546A1 (en) | 2014-10-09 |
EP2817027A4 (en) | 2015-12-16 |
EP2817027A1 (en) | 2014-12-31 |
WO2013152092A1 (en) | 2013-10-10 |
IN2014MN01840A (ja) | 2015-07-03 |
KR20140143216A (ko) | 2014-12-15 |
CN104185475A (zh) | 2014-12-03 |
US20150112250A1 (en) | 2015-04-23 |
CA2867158A1 (en) | 2013-10-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2015515474A (ja) | ワクチンの経頬送達のための溶解性微小針アレイ | |
RU2662432C2 (ru) | Массив микроструктур для доставки действующих агентов | |
US9498524B2 (en) | Method of vaccine delivery via microneedle arrays | |
JP7109188B2 (ja) | 活性剤の送達のための微細構造アレイ | |
EP2296557B1 (en) | Method of manufacturing microneedle arrays | |
Moore et al. | Trends in drug-and vaccine-based dissolvable microneedle materials and methods of fabrication | |
KR20060134050A (ko) | 주파수 보조 경피성 약제 전달 방법 및 시스템 | |
KR20070011481A (ko) | 다중 백신의 경피 전달용 기구 및 방법 | |
JP2013027742A (ja) | 薬物粒子および/または薬物を吸着した粒子を含む、固溶体穿孔器 | |
MXPA06005677A (es) | Metodo y sistema de suministro transdermico de vacuna asistido por ultrasonido. | |
JP2007521092A (ja) | 小突起アレイの免疫化パッチおよび方法 | |
TW200528153A (en) | System and method for transdermal vaccine delivery | |
US20120193840A1 (en) | Method of manufacturing solid solution perforator patches | |
TW202100197A (zh) | 含有流感疫苗的微針陣列及微針陣列之製造方法 | |
KR20120036577A (ko) | 고용체 퍼포레이터 패치의 제조 방법 | |
Queiroz et al. | Microneedles as an alternative technology for transdermal drug delivery systems: a patent | |
Chauhan et al. | Microneedle Array Patches for the Delivery of Therapeutic Agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160316 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160316 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20161121 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161213 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20170704 |