JP2011500550A5 - - Google Patents
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- Publication number
- JP2011500550A5 JP2011500550A5 JP2010528515A JP2010528515A JP2011500550A5 JP 2011500550 A5 JP2011500550 A5 JP 2011500550A5 JP 2010528515 A JP2010528515 A JP 2010528515A JP 2010528515 A JP2010528515 A JP 2010528515A JP 2011500550 A5 JP2011500550 A5 JP 2011500550A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- use according
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000011780 sodium chloride Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- -1 Salts compound Chemical class 0.000 claims 3
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- KXNPYQFUBNAICA-UHFFFAOYSA-N N-methyl-2-phenylacetamide;hydrochloride Chemical compound Cl.CNC(=O)CC1=CC=CC=C1 KXNPYQFUBNAICA-UHFFFAOYSA-N 0.000 claims 1
- VEQOALNAAJBPNY-UHFFFAOYSA-N Phenazone Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000008839 post-traumatic stress disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (9)
- 式Iaの化合物又はその薬学的に許容される塩が、R1がメトキシ又はエトキシを表すような化合物又は塩である、請求項1に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、R2がメトキシ又はエトキシを表すような化合物又は塩である、請求項1又は2に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、R3がアリール−(C1−C4)アルキルを表すような化合物又は塩である、請求項1〜3の1項に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、R3が2−(4−トリフルオロメチル−フェニル)−エチルを表すような化合物又は塩である、請求項4に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、R3がヘテロアリール−(C1−C4)アルキルを表すような化合物又は塩である、請求項1〜3の1項に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、R4がメチルを表すような化合物又は塩である、請求項1〜6の1項に記載の使用。
- 式Iaの化合物又はその薬学的に許容される塩が、(R)−2−{(S)−6,7−ジメ
トキシ−1−[2−(4−トリフルオロメチル−フェニル)−エチル]−3,4−ジヒドロ−1H−イソキノリン−2−イル}−N−メチル−2−フェニル−アセタミド又はその薬学的に許容される塩の1つである、請求項1に記載の使用。 - (R)−2−{(S)−6,7−ジメトキシ−1−[2−(4−トリフルオロメチル−フェニル)−エチル]−3,4−ジヒドロ−1H−イソキノリン−2−イル}−N−メチル−2−フェニル−アセタミド 塩酸塩が用いられる、請求項8に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB2007/054130 | 2007-10-10 | ||
IB2007054130 | 2007-10-10 | ||
PCT/IB2008/054138 WO2009047723A2 (en) | 2007-10-10 | 2008-10-09 | Tetrahydroquinoline derivatives for treating post-traumatic stress disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011500550A JP2011500550A (ja) | 2011-01-06 |
JP2011500550A5 true JP2011500550A5 (ja) | 2011-10-20 |
JP5883222B2 JP5883222B2 (ja) | 2016-03-09 |
Family
ID=40467356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010528515A Active JP5883222B2 (ja) | 2007-10-10 | 2008-10-09 | 心的外傷後ストレス障害の治療のためのテトラヒドロキノリン誘導体 |
Country Status (28)
Country | Link |
---|---|
US (1) | US9532985B2 (ja) |
EP (1) | EP2207550B1 (ja) |
JP (1) | JP5883222B2 (ja) |
KR (1) | KR101733247B1 (ja) |
CN (1) | CN101820878B (ja) |
AR (1) | AR068768A1 (ja) |
AU (1) | AU2008309194B2 (ja) |
BR (1) | BRPI0818617A2 (ja) |
CA (1) | CA2699504C (ja) |
CY (1) | CY1114799T1 (ja) |
DK (1) | DK2207550T3 (ja) |
EA (1) | EA017443B1 (ja) |
ES (1) | ES2444418T3 (ja) |
HK (1) | HK1145440A1 (ja) |
HR (1) | HRP20140214T1 (ja) |
IL (1) | IL204838A (ja) |
MA (1) | MA31800B1 (ja) |
MX (1) | MX2010003711A (ja) |
MY (1) | MY153044A (ja) |
NZ (1) | NZ585086A (ja) |
PE (1) | PE20091010A1 (ja) |
PL (1) | PL2207550T3 (ja) |
PT (1) | PT2207550E (ja) |
SI (1) | SI2207550T1 (ja) |
TW (1) | TWI428129B (ja) |
UA (1) | UA99150C2 (ja) |
WO (1) | WO2009047723A2 (ja) |
ZA (1) | ZA201003251B (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2125823B1 (en) | 2006-12-22 | 2012-02-15 | Actelion Pharmaceuticals Ltd. | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives |
CA2726834A1 (en) | 2008-06-25 | 2009-12-30 | Actelion Pharmaceuticals Ltd | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds |
EP2402322A1 (en) | 2010-07-02 | 2012-01-04 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist |
KR101802726B1 (ko) | 2010-08-24 | 2017-11-29 | 액테리온 파마슈티칼 리미티드 | 오렉신 수용체 안타고니스트로서의 프롤린 술폰아미드 유도체 |
JP4944286B1 (ja) | 2010-09-22 | 2012-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シクロプロパン化合物 |
EP2638008B1 (en) | 2010-11-10 | 2015-07-01 | Actelion Pharmaceuticals Ltd | Lactam derivatives useful as orexin receptor antagonists |
WO2012085852A1 (en) | 2010-12-22 | 2012-06-28 | Actelion Pharmaceuticals Ltd | 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides |
JP5987005B2 (ja) | 2011-02-18 | 2016-09-06 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | オレキシン拮抗薬として有用な新規なピラゾール及びイミダゾール誘導体 |
WO2012114252A1 (en) | 2011-02-21 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Novel indole and pyrrolopyridine amides |
WO2013050938A1 (en) | 2011-10-04 | 2013-04-11 | Actelion Pharmaceuticals Ltd | 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives |
CN103917538B (zh) | 2011-11-08 | 2016-08-24 | 埃科特莱茵药品有限公司 | 2-(1,2,3-***-2-基)苯甲酰胺及3-(1,2,3-***-2-基)吡啶酰胺衍生物 |
ES2617863T3 (es) | 2012-06-04 | 2017-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de bencimidazol-prolina |
AU2013328301A1 (en) | 2012-10-10 | 2015-05-28 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives |
CN105051040A (zh) | 2013-03-12 | 2015-11-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物 |
UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
DK3077389T3 (da) | 2013-12-03 | 2017-11-13 | Idorsia Pharmaceuticals Ltd | Krystallinsk form af (s)-(2-(6-chlor-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanon og dens anvendelse som orexinreceptorantagonister |
US9914721B2 (en) | 2013-12-04 | 2018-03-13 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
MX2017004950A (es) | 2014-10-23 | 2018-01-16 | Eisai R&D Man Co Ltd | Composiciones y metodos para tratar el insomnio. |
WO2019024845A1 (zh) * | 2017-08-01 | 2019-02-07 | 苏州科睿思制药有限公司 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
WO2020007964A1 (en) | 2018-07-05 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives |
WO2020007977A1 (en) | 2018-07-06 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 7-trifluoromethyl-[1,4]diazepan derivatives |
WO2020099511A1 (en) | 2018-11-14 | 2020-05-22 | Idorsia Pharmaceuticals Ltd | Benzimidazole-2-methyl-morpholine derivatives |
TW202400149A (zh) | 2022-05-13 | 2024-01-01 | 瑞士商愛杜西亞製藥有限公司 | 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02008797A (es) * | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
JP4637089B2 (ja) * | 2003-03-26 | 2011-02-23 | アクテリオン ファーマシューティカルズ リミテッド | アセトアミド誘導体 |
SI1751111T1 (sl) * | 2004-03-01 | 2015-04-30 | Actelion Pharmaceuticals Ltd. | Substituirani 1,2,3,4-tetrahidroizokinolinski derivati |
US7501395B2 (en) * | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
MX2008011647A (es) * | 2006-03-15 | 2008-09-22 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroisoquinolina para mejorar la funcion de la memoria. |
EP2402322A1 (en) | 2010-07-02 | 2012-01-04 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist |
-
2008
- 2008-10-07 PE PE2008001739A patent/PE20091010A1/es not_active Application Discontinuation
- 2008-10-09 KR KR1020107010186A patent/KR101733247B1/ko active IP Right Grant
- 2008-10-09 PL PL08807937T patent/PL2207550T3/pl unknown
- 2008-10-09 BR BRPI0818617-0A patent/BRPI0818617A2/pt not_active Application Discontinuation
- 2008-10-09 EP EP08807937.1A patent/EP2207550B1/en active Active
- 2008-10-09 MX MX2010003711A patent/MX2010003711A/es active IP Right Grant
- 2008-10-09 AR ARP080104422A patent/AR068768A1/es unknown
- 2008-10-09 PT PT88079371T patent/PT2207550E/pt unknown
- 2008-10-09 AU AU2008309194A patent/AU2008309194B2/en not_active Ceased
- 2008-10-09 DK DK08807937.1T patent/DK2207550T3/da active
- 2008-10-09 EA EA201000557A patent/EA017443B1/ru not_active IP Right Cessation
- 2008-10-09 US US12/681,802 patent/US9532985B2/en active Active
- 2008-10-09 MY MYPI2010001561A patent/MY153044A/en unknown
- 2008-10-09 NZ NZ585086A patent/NZ585086A/en unknown
- 2008-10-09 CN CN2008801113334A patent/CN101820878B/zh active Active
- 2008-10-09 JP JP2010528515A patent/JP5883222B2/ja active Active
- 2008-10-09 TW TW097139093A patent/TWI428129B/zh active
- 2008-10-09 CA CA2699504A patent/CA2699504C/en active Active
- 2008-10-09 ES ES08807937.1T patent/ES2444418T3/es active Active
- 2008-10-09 UA UAA201005122A patent/UA99150C2/ru unknown
- 2008-10-09 WO PCT/IB2008/054138 patent/WO2009047723A2/en active Application Filing
- 2008-10-09 SI SI200831152T patent/SI2207550T1/sl unknown
-
2010
- 2010-04-06 IL IL204838A patent/IL204838A/en active IP Right Grant
- 2010-04-30 MA MA32806A patent/MA31800B1/fr unknown
- 2010-05-07 ZA ZA2010/03251A patent/ZA201003251B/en unknown
- 2010-12-17 HK HK10111852.2A patent/HK1145440A1/xx not_active IP Right Cessation
-
2014
- 2014-02-04 CY CY20141100085T patent/CY1114799T1/el unknown
- 2014-03-10 HR HRP20140214AT patent/HRP20140214T1/hr unknown
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