MA31800B1 - Dérivés de tétrahydroquinoléine pour traiter des troubles de stress post-traumatique - Google Patents

Dérivés de tétrahydroquinoléine pour traiter des troubles de stress post-traumatique

Info

Publication number
MA31800B1
MA31800B1 MA32806A MA32806A MA31800B1 MA 31800 B1 MA31800 B1 MA 31800B1 MA 32806 A MA32806 A MA 32806A MA 32806 A MA32806 A MA 32806A MA 31800 B1 MA31800 B1 MA 31800B1
Authority
MA
Morocco
Prior art keywords
ptsd
treatment
tetrahydroquinoline derivatives
derivatives
group
Prior art date
Application number
MA32806A
Other languages
Arabic (ar)
English (en)
Inventor
François Jenck
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40467356&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31800(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA31800B1 publication Critical patent/MA31800B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de dérivés de tétrahydroquinoléine représentés par la formule (i), r1 et r2 représentant chacun indépendamment un groupe alcoxy en c1-c4, r3 représentant un groupe arylalkyle en c1-c4 ou hétéroarylalkyle en c1-c4, et r4 représentant un atome d'hydrogène ou un groupe alkyle en c1-c4, ou de sels pharmaceutiquement acceptables de ces dérivés, pour la préparation d'un médicament destiné à prévenir ou traiter des troubles de stress post-traumatique.
MA32806A 2007-10-10 2010-04-30 Dérivés de tétrahydroquinoléine pour traiter des troubles de stress post-traumatique MA31800B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2007054130 2007-10-10
PCT/IB2008/054138 WO2009047723A2 (fr) 2007-10-10 2008-10-09 Dérivés de tétrahydroquinoléine pour traiter des troubles de stress post-traumatique

Publications (1)

Publication Number Publication Date
MA31800B1 true MA31800B1 (fr) 2010-10-01

Family

ID=40467356

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32806A MA31800B1 (fr) 2007-10-10 2010-04-30 Dérivés de tétrahydroquinoléine pour traiter des troubles de stress post-traumatique

Country Status (28)

Country Link
US (1) US9532985B2 (fr)
EP (1) EP2207550B1 (fr)
JP (1) JP5883222B2 (fr)
KR (1) KR101733247B1 (fr)
CN (1) CN101820878B (fr)
AR (1) AR068768A1 (fr)
AU (1) AU2008309194B2 (fr)
BR (1) BRPI0818617A2 (fr)
CA (1) CA2699504C (fr)
CY (1) CY1114799T1 (fr)
DK (1) DK2207550T3 (fr)
EA (1) EA017443B1 (fr)
ES (1) ES2444418T3 (fr)
HK (1) HK1145440A1 (fr)
HR (1) HRP20140214T1 (fr)
IL (1) IL204838A (fr)
MA (1) MA31800B1 (fr)
MX (1) MX2010003711A (fr)
MY (1) MY153044A (fr)
NZ (1) NZ585086A (fr)
PE (1) PE20091010A1 (fr)
PL (1) PL2207550T3 (fr)
PT (1) PT2207550E (fr)
SI (1) SI2207550T1 (fr)
TW (1) TWI428129B (fr)
UA (1) UA99150C2 (fr)
WO (1) WO2009047723A2 (fr)
ZA (1) ZA201003251B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008078291A1 (fr) 2006-12-22 2008-07-03 Actelion Pharmaceuticals Ltd Dérivés de 5,6,7,8-tétrahydro-imidazo[1,5-a]pyrazine
CN102076694A (zh) 2008-06-25 2011-05-25 埃科特莱茵药品有限公司 5,6,7,8-四氢-咪唑并[1,5-a]吡嗪化合物
EP2402322A1 (fr) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. Dérivé de 1,2,3,4-tétrahydroisoquinoline et son utilisation comme antagoniste du récepteur de l'orexine
CA2807000C (fr) 2010-08-24 2018-12-04 Actelion Pharmaceuticals Ltd Derives de proline sulfonamide comme antagonistes des recepteurs de l'orexine
SI2626350T1 (sl) 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
US9242970B2 (en) 2010-11-10 2016-01-26 Actelion Pharmaceuticals Ltd. Lactam derivatives useful as orexin receptor antagonists
WO2012085857A1 (fr) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-3-ylamides
ES2541531T3 (es) 2011-02-18 2015-07-21 Actelion Pharmaceuticals Ltd. Nuevos derivados de pirazol e imidazol útiles como antagonistas de orexina
WO2012114252A1 (fr) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Nouveaux amides d'indole et de pyrrolopyridine
WO2013050938A1 (fr) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd Dérivés de 3,7-diazabicyclo[3.3.1]nonane et de 9-oxa-3,7- diazabicyclo[3.3.1]nonane
TWI565703B (zh) 2011-11-08 2017-01-11 艾克泰聯製藥有限公司 2-(1,2,3-***-2-基)苯甲醯胺及3-(1,2,3-***-2-基)吡啶醯胺衍生物
EP2855453B1 (fr) 2012-06-04 2016-12-07 Actelion Pharmaceuticals Ltd. Dérivés de benzimidazole-proline
CN104703980B (zh) 2012-10-10 2017-09-22 埃科特莱茵药品有限公司 属于[邻双(杂)芳基]‑[2‑(间双(杂)芳基)吡咯烷‑1‑基]甲酮衍生物的食欲素受体拮抗剂
KR20150130413A (ko) 2013-03-12 2015-11-23 액테리온 파마슈티칼 리미티드 오렉신 수용체 길항제로서의 아제티딘 아미드 유도체
PT3077389T (pt) 2013-12-03 2017-12-15 Idorsia Pharmaceuticals Ltd Forma cristalina de (s)-(2-(6-cloro-7-metil-1hbenzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e a sua utilização como como antagonistas do receptor de orexina
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
LT3077391T (lt) 2013-12-04 2018-10-25 Idorsia Pharmaceuticals Ltd Benzimidazolo prolino darinių panaudojimas
WO2016063995A1 (fr) 2014-10-23 2016-04-28 Eisai R&D Management Co., Ltd. Compositions et méthodes pour traiter l'insomnie
CN115710250A (zh) * 2017-08-01 2023-02-24 博健制药有限责任公司 一种食欲素受体拮抗剂的晶型及其制备方法和用途
WO2020007964A1 (fr) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd Dérivés de 2-(2-azabicyclo [3.1.0] hexan-1-yl)-1h-benzimidazole
WO2020007977A1 (fr) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd Dérivés de 7-trifluorométhyl-[1,4]diazépane
WO2020099511A1 (fr) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Dérivés de benzimidazole-2-méthyl-morpholine
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL150986A0 (en) * 2000-03-14 2003-02-12 Actelion Pharmaceuticals Ltd 1,2,3,4,- tetrahydroisoquinoline derivatives
CN100432056C (zh) * 2003-03-26 2008-11-12 埃科特莱茵药品有限公司 四氢异喹啉基乙酰胺衍生物作为阿立新受体拮抗剂的应用
AU2005250077B2 (en) * 2004-03-01 2011-06-09 Idorsia Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
US7501395B2 (en) 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
CA2644010A1 (fr) * 2006-03-15 2007-09-20 Actelion Pharmaceuticals Ltd Derives de tetrahydroisoquinoleine pour renforcer la fonction de la memoire
EP2402322A1 (fr) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. Dérivé de 1,2,3,4-tétrahydroisoquinoline et son utilisation comme antagoniste du récepteur de l'orexine

Also Published As

Publication number Publication date
WO2009047723A2 (fr) 2009-04-16
KR20100065203A (ko) 2010-06-15
TW200932231A (en) 2009-08-01
AU2008309194B2 (en) 2013-10-03
DK2207550T3 (da) 2014-01-27
JP2011500550A (ja) 2011-01-06
AU2008309194A1 (en) 2009-04-16
CN101820878B (zh) 2012-02-01
ZA201003251B (en) 2011-07-27
US20100234420A1 (en) 2010-09-16
CA2699504C (fr) 2015-11-24
IL204838A0 (en) 2010-11-30
BRPI0818617A2 (pt) 2015-04-07
KR101733247B1 (ko) 2017-05-08
AR068768A1 (es) 2009-12-02
TWI428129B (zh) 2014-03-01
HK1145440A1 (en) 2011-04-21
EP2207550A2 (fr) 2010-07-21
EA017443B1 (ru) 2012-12-28
CA2699504A1 (fr) 2009-04-16
HRP20140214T1 (hr) 2014-04-11
SI2207550T1 (sl) 2014-03-31
CY1114799T1 (el) 2016-12-14
PT2207550E (pt) 2014-02-07
MX2010003711A (es) 2010-04-30
NZ585086A (en) 2012-03-30
IL204838A (en) 2014-09-30
US9532985B2 (en) 2017-01-03
EA201000557A1 (ru) 2010-10-29
UA99150C2 (ru) 2012-07-25
EP2207550B1 (fr) 2013-12-11
PE20091010A1 (es) 2009-08-08
CN101820878A (zh) 2010-09-01
ES2444418T3 (es) 2014-02-25
WO2009047723A3 (fr) 2009-05-28
PL2207550T3 (pl) 2014-05-30
JP5883222B2 (ja) 2016-03-09
MY153044A (en) 2014-12-31

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