JP2006520672A - 電気刺激に起因する不快感を軽減するための装置 - Google Patents
電気刺激に起因する不快感を軽減するための装置 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/008—Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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Abstract
Description
本出願は、2003年3月7日出願済み米国仮出願第60/452,477号、表題"Device,Method,and System for the Reduction of Discomfort Associated with and Facilitating Treatment via Magnetic Stimulation"「磁気刺激を介した治療に伴う不快感を軽減し、前記磁気刺激を容易にするための装置と方法とシステム」(この参照によりその全体が本明細書に組み込まれる)に対して米国特許法119条(35 U.S.C.§119)に基づく優先権を主張するものである。
1831年、導体に誘導される電場の大きさは、その導体を横切る磁束密度の変化速度に比例することをマイケル・ファラデーが発見した。当業者に広く知られているこのファラデーの法則は、E〜−(dB/dt)と表すことができる。ここで、Eは誘導される電場(ボルト/メートル単位)、dB/dtは磁束密度の時間変化率(テスラ/秒)である。すなわち、導体などの物体中に誘導される電場の大きさは、磁束密度と、磁束密度の時間変化率との2要因により決定される。磁束密度とその微分が大きいほど、誘導される電場とその結果生じる電流密度も大きくなる。磁束密度は磁場源からの距離の2乗に反比例して減少するため、磁束密度は導体が磁場源に近づくほど大きくなる。導体がコイルである場合、電場によりコイル内に誘導される電流はコイルの巻き数に比例して増加しうる。
図1は、電気刺激に起因する不快感を軽減する技術を例示したブロック図である。図1に示したように、システム100は磁気刺激回路101を含む。磁気刺激回路101は、主要磁石(図示せず)に電気信号を提供する電気回路である。この電気信号は、電場および/または磁場を起こす能力を伴う時間変化する任意の電気信号であってよい。前記主要磁石は、米国特許第5,725,471号、第6,132,361号、第6,086,525号、および第6,425,852号(この参照により本明細書に組み込まれる)の記載どおり、経頭蓋磁気刺激(TMS)および/または反復経頭蓋磁気刺激(rTMS)の実施に使用しうるものである。
時間(μs) 電流(A) 1対の導体(V) 2対A(V) 2対B(V)
5 620 5.289 2.568 4.654
10 1100 5.334 2.590 4.693
15 1620 5.416 2.630 4.766
20 2100 5.406 2.625 4.757
25 2740 4.961 2.409 4.365
30 3100 3.982 1.934 3.504
35 3580 2.516 1.222 2.214
40 3620 0.858 0.417 0.755
45 3660 −0.590 −0.286 −0.519
50 3500 −1.749 −0.849 −1.539
55 3260 −2.589 −1.258 −2.278
60 3020 −3.307 −1.606 −2.909
65 2700 −4.011 −1.948 −3.529
70 2220 −4.508 −2.189 −3.967
75 1740 −4.666 −2.266 −4.105
80 1300 −4.640 −2.254 −4.083
85 860 −4.619 −2.243 −4.064
90 420 −4.677 −2.271 −4.115
95 0 −4.788 −2.325 −4.213
100 −560 −4.715 −2.290 −4.148
105 −1040 −4.373 −2.124 −3.848
110 −1320 −4.097 −1.990 −3.605
115 −1800 −3.869 −1.879 −3.404
120 −2080 −3.515 −1.707 −3.093
125 −2520 −2.873 −1.395 −2.528
130 −2720 −1.908 −0.927 −1.679
135 −2840 −0.883 −0.429 −0.777
145 −2840 1.082 0.526 0.952
150 −2640 1.879 0.912 1.653
155 −2440 2.470 1.200 2.174
160 −2240 2.991 1.452 2.632
165 −1800 3.290 1.598 2.894
170 −1560 3.418 1.660 3.008
175 −1200 3.561 1.729 3.133
180 −920 3.655 1.775 3.216
185 −480 3.439 1.670 3.026
190 −160 2.690 1.306 2.367
195 100 1.532 0.744 1.348
200 220 0.310 0.150 0.273
205 0 −0.358 −0.174 −0.315
210 0 −0.463 −0.225 −0.408
Claims (40)
- 経皮的刺激に起因する不快感を軽減する方法であって、
経皮的刺激を提供する工程と、
第1の位置で前記経皮的刺激を低減する工程と、
第2の位置で前記経皮的刺激を実質的に維持する工程と
を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記第2の位置に少なくとも1つの導電材料を位置決めする工程を有する方法。 - 請求項2の方法であって、この方法は、さらに、
前記導電材料を使って前記第2の位置で経皮的刺激に起因する不快感を軽減する工程を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記第2の位置に物質を適用する工程を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記第1の位置で前記経皮的磁気刺激を提供する工程を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記第2の位置に電気信号を適用する工程を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記経皮的磁気刺激により前記第1の位置を治療する工程を有する方法。 - 請求項1の方法であって、この方法は、さらに、
前記第2の位置で前記経皮的刺激に起因する不快感を軽減する工程を有する方法。 - 請求項1の方法において、前記経皮的刺激は磁気刺激装置が提供し、前記磁気刺激装置は、0.5テスラ若しくはそれ以上で飽和する非トロイダル構造を伴った磁気コア部材を有するものである。
- 請求項1の方法であって、この方法は、さらに、
前記第1の位置で前記経皮的刺激の低減を調整する工程を有する方法。 - 請求項10の方法であって、この方法は、さらに、
前記第1の位置で前記経皮的刺激の低減を調整する前記工程をもたらすため信号を適用する工程であって、前記信号は、経皮的刺激の生成に使用される異なる別の信号に反比例する工程、を有する方法。 - 請求項1の方法において、前記低減する工程は、前記経皮的刺激により生成された電場を修正する工程を有するものである。
- 請求項1の方法において、前記低減する工程は、前記経皮的刺激により生成された磁場を修正する工程を有するものである。
- 磁気刺激装置に起因する不快感を軽減するシステムであって、
前記磁気刺激装置の周辺に位置する少なくとも1つの導体であって、前記磁気刺激装置により誘導される表面近接刺激を低減するように適合した導体
を有するシステム。 - 請求項14のシステムにおいて、前記導体は回路パッド上に位置するものである。
- 請求項14のシステムであって、この方法は、さらに、
第1の位置を治療するための経皮的磁気刺激装置を有するシステム。 - 請求項14のシステムであって、この方法は、さらに、
第2の位置に電気信号を提供する電気信号発生器を有するシステム。 - 請求項17のシステムにおいて、前記導体は前記電気信号発生器と通信自在であり、前記導体は電気信号を前記第2の位置に伝達するものである。
- 請求項14のシステムであって、この方法は、さらに、
前記磁気刺激装置の出力を決定する検出装置を有するシステム。 - 請求項19のシステムにおいて、前記検出装置は、前記磁気刺激装置により生成される磁場の特性を決定するものである。
- 請求項19のシステムにおいて、前記検出装置は、前記磁気刺激装置の出力に基づき複数の巻きを有するループである。
- 請求項19のシステムにおいて、前記検出装置は、前記磁気刺激装置の出力を表す信号を回路経由で前記導体に提供するものである。
- 請求項22のシステムにおいて、前記信号は、前記磁気刺激装置に適用される刺激波形に反比例するものである。
- 請求項14のシステムにおいて、前記導体は、前記磁気刺激装置により誘導される表面近接刺激を低減するための物理的特定および電気的特性を有するものである。
- 請求項14のシステムにおいて、前記磁気刺激装置により誘導される表面近接刺激の低減は、磁束密度を低減することにより起こるものである。
- 請求項14のシステムにおいて、前記磁気刺激装置により誘導される表面近接刺激の低減は、前記磁気刺激装置により生成される磁場を、前記導体により生成される磁場と重ね合わせることにより起こるものである。
- 請求項14のシステムにおいて、前記導体は、前記磁気刺激装置により誘導される治療刺激を避けるように適合しているものである。
- 請求項14のシステムにおいて、前記磁気刺激装置は、弧形状のコア部材を少なくとも1つ有するものである。
- 請求項14のシステムにおいて、前記導体に提供される前記電気エネルギーと、前記磁気刺激装置に提供される電気エネルギーとは、互いに極性が反対である。
- 請求項14のシステムにおいて、前記導体に提供される電気エネルギーは、前記磁気刺激装置に提供される電圧から導出される電流である。
- 経皮的磁気刺激を使って患者を治療する方法であって、
磁気刺激装置により生成される磁場を患者の治療領域へ方向付ける工程と、
可撓性回路パッドであって、前記磁気刺激装置により誘導される刺激を低減するように適合した少なくとも1つの導体を有する可撓性回路パッドを適用する工程と、
前記磁場で患者を治療する工程と
を有する方法。 - 請求項31の方法であって、この方法は、さらに、
前記治療領域および前記磁気刺激装置の少なくとも一方に前記可撓性回路パッドを適用する工程を有する方法。 - 請求項31の方法であって、この方法は、さらに、
前記可撓性回路パッドを患者に適用する工程を有する方法。 - 請求項31の方法であって、この方法は、さらに、
前記可撓性回路パッドと患者との間に導電性ゲル材料を適用する工程を有する方法。 - 請求項31の方法であって、この方法は、さらに、
前記可撓性回路パッドを動作不能にする処分機構を起動する工程を有する方法。 - 請求項35の方法において、前記処分機構を起動する工程は、患者が磁場で治療された後に起こるものである。
- 請求項35の方法において、前記処分機構を起動する工程は、患者から取り外した時点で自動的に起こるものである。
- 請求項35の方法において、前記処分機構を起動する工程は、前記導体の物理的特性および電気的特性を変更する工程を有するものである。
- 請求項35の方法において、前記処分機構を起動する工程は、前記可撓性回路パッドとの通信を切断する工程を有するものである。
- 請求項35の方法において、前記処分機構を起動する工程は、所定の使用回数後に起こるものである。
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US45247703P | 2003-03-07 | 2003-03-07 | |
PCT/US2004/006763 WO2004080527A2 (en) | 2003-03-07 | 2004-03-05 | Reducing discomfort caused by electrical stimulation |
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JP2006509170A Expired - Lifetime JP4638417B2 (ja) | 2003-03-07 | 2004-03-05 | 電気刺激に起因する不快感を軽減するための装置 |
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US8864641B2 (en) | 2003-03-07 | 2014-10-21 | Neuronetics, Inc. | Reducing discomfort caused by electrical stimulation |
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