JP2002518366A - コンビナトリアルアミンライブラリイの調製方法 - Google Patents

コンビナトリアルアミンライブラリイの調製方法

Info

Publication number
JP2002518366A
JP2002518366A JP2000554690A JP2000554690A JP2002518366A JP 2002518366 A JP2002518366 A JP 2002518366A JP 2000554690 A JP2000554690 A JP 2000554690A JP 2000554690 A JP2000554690 A JP 2000554690A JP 2002518366 A JP2002518366 A JP 2002518366A
Authority
JP
Japan
Prior art keywords
group
substituted
alkyl
alkoxy
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000554690A
Other languages
English (en)
Japanese (ja)
Inventor
ヘルヴィック ブッホルツ，
ウルス ヴェルツ−ビエルマン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19827165A external-priority patent/DE19827165A1/de
Priority claimed from DE19827166A external-priority patent/DE19827166A1/de
Priority claimed from DE19827164A external-priority patent/DE19827164A1/de
Priority claimed from DE19827163A external-priority patent/DE19827163A1/de
Priority claimed from DE19827161A external-priority patent/DE19827161A1/de
Priority claimed from DE19844194A external-priority patent/DE19844194A1/de
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2002518366A publication Critical patent/JP2002518366A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0201—Oxygen-containing compounds
    • B01J31/0211—Oxygen-containing compounds with a metal-oxygen link
    • B01J31/0212—Alkoxylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0237—Amines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0272—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255
    • B01J31/0274—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255 containing silicon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/66—Preparation of compounds containing amino groups bound to a carbon skeleton from or via metallo-organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2000554690A 1998-06-18 1999-06-18 コンビナトリアルアミンライブラリイの調製方法 Pending JP2002518366A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
DE19827163.8 1998-06-18
DE19827165.4 1998-06-18
DE19827165A DE19827165A1 (de) 1998-06-18 1998-06-18 Katalytisch Titan(IV)-oxid-vermittelte geminale unsymmetrische Dialkylierung von Carbonsäureamiden
DE19827167 1998-06-18
DE19827164.6 1998-06-18
DE19827166A DE19827166A1 (de) 1998-06-18 1998-06-18 Verfahren zur katalytischen Disubstitution von Carbonsäureamiden mit wenigstens einem Grignardreagenz
DE19827164A DE19827164A1 (de) 1998-06-18 1998-06-18 Katalytisch Titan(IV)-oxid vermittelte geminale symmetrische Dialkylierung von Carbonsäureamiden
DE19827163A DE19827163A1 (de) 1998-06-18 1998-06-18 Verfahren zur katalytischen, unsymmetrischen Disubstitution von Carbonsäureamiden mit 2 unterschiedlichen Grignardreagenzien
DE19827161A DE19827161A1 (de) 1998-06-18 1998-06-18 Verfahren zur katalytischen, symmetrischen Disubstitution von Carbonsäureamiden mit Grignardreagenzien
DE19827166.2 1998-06-18
DE19827161.1 1998-06-18
DE19844194.0 1998-09-26
DE19844194A DE19844194A1 (de) 1998-06-18 1998-09-26 Verfahren zur symmetrischen oder unsymmetrischen Disubstitution von Carbonsäureamiden mit Organotitanaten und Grignardreagenzien
DE19827167.0 1998-09-26
PCT/EP1999/004257 WO1999065863A1 (de) 1998-06-18 1999-06-18 Verfahren zur herstellung von kombinatorischen aminbibliotheken

Publications (1)

Publication Number Publication Date
JP2002518366A true JP2002518366A (ja) 2002-06-25

Family

ID=27561759

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000554690A Pending JP2002518366A (ja) 1998-06-18 1999-06-18 コンビナトリアルアミンライブラリイの調製方法
JP2000554208A Pending JP2003524588A (ja) 1998-06-18 1999-06-18 ジェミナルに置換されたアミン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2000554208A Pending JP2003524588A (ja) 1998-06-18 1999-06-18 ジェミナルに置換されたアミン

Country Status (3)

Country Link
EP (2) EP1087929A1 (de)
JP (2) JP2002518366A (de)
WO (4) WO1999065864A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19960377A1 (de) * 1999-12-14 2001-06-21 Merck Patent Gmbh Verfahren zur Herstellung kombinatorischer Aminbibliotheken
DE19961372A1 (de) * 1999-12-17 2001-06-21 Merck Patent Gmbh Verfahren zur Herstellung kombinatorischer Bibliotheken arylsubstituierter Amine
ES2888231T3 (es) * 2010-09-20 2022-01-03 Sirna Therapeutics Inc Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos
GB201208775D0 (en) * 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807835A (en) * 1955-07-01 1959-01-21 Thomae Gmbh Dr K New tertiary amines and their salts and process for their preparation
US3067101A (en) * 1959-11-25 1962-12-04 Lilly Co Eli Method for controlling hypertension
US4020059A (en) * 1975-06-02 1977-04-26 Nippon Shokubai Kagaku Kogyo Co., Ltd. Process for preparing tertiary amines
BE842528R (fr) * 1976-06-03 1976-12-03 Derives actifs de methylamine, compositions therapeutiques les contenant ainsi que les procedes de preparation de ces derives et compositions
DE2657476A1 (de) * 1976-12-18 1978-06-22 Basf Ag Morpholinderivate
CA2207137A1 (en) * 1996-06-14 1997-12-14 James Erwin Fritz Scavenger assisted combinatorial process for preparing libraries of secondary amine compounds
AU3718397A (en) * 1996-06-28 1998-01-21 University Of Southern California Method for the synthesis of amines and amino acids with organoboron derivatives

Also Published As

Publication number Publication date
JP2003524588A (ja) 2003-08-19
EP1088029A1 (de) 2001-04-04
WO1999065318A3 (de) 2003-04-17
WO1999065864A3 (de) 2003-05-22
WO1999065855A2 (de) 1999-12-23
WO1999065855A3 (de) 2003-12-11
WO1999065864A2 (de) 1999-12-23
WO1999065318A2 (de) 1999-12-23
WO1999065863A1 (de) 1999-12-23
EP1087929A1 (de) 2001-04-04

Similar Documents

Publication Publication Date Title
JPH052678B2 (de)
JP2002518366A (ja) コンビナトリアルアミンライブラリイの調製方法
JPS63295520A (ja) 非対称なビフェニル誘導体の製造法
US20070259776A1 (en) Preparation of Mono-N-sulphonylated diamines
JP2000219646A (ja) アダマンタノール類の製造方法
JPH11505234A (ja) 触媒の存在下で塩化チオニルによる塩素化により５−アミノ−２，４，６−トリヨードイソフタル酸二塩化物を製造する方法
KR20010052929A (ko) 아민의 조합 라이브러리를 제조하는 방법
JPS59225151A (ja) １，２−ジフエニル−１−〔４−（２−ジメチルアミノエトキシ）フエニル〕−１−ブテンのＥ異性体をタモキシフエンＨＣｌに転化させる方法
CN111825594B (zh) (Z)-β-三氟甲基脱氢色氨酸类化合物及其合成方法和应用
JP3902121B2 (ja) ４，６−ジメチルインドールの製造方法
KR101521092B1 (ko) 유기아지드화합물과 이리튬 촉매를 이용한 아릴아미드와 엔아미드의 제조방법
KR20010052877A (ko) 2종의 상이한 그리냐르 시약을 사용하는 카복시산아미드의 촉매에 의한 비대칭 이치환 방법
JP2002536353A (ja) Ｎ（ｃｆ３）２アニオンの生成およびその使用
Tebben et al. Development of a convenient new synthetic route to [3] ferrocenophanones
KR20010053015A (ko) 1종 이상의 그리냐르 시약을 사용하여 카복실산 아미드를촉매적으로 이치환시키는 방법
JP3034063B2 (ja) 光学活性４−置換−２，６−ビス（オキサゾリル）ピリジン誘導体のロジウム錯体及びその錯体を使用した不斉アルコ−ルの製造方法
JPS5946255A (ja) ２−アルコキシメチレン−３，３−ジアルコキシプロパンニトリル類の製法
JP3019116B2 (ja) Ｎ−クロル芳香族カルボン酸アミドの製造方法
JP2002053585A (ja) 白金−アルケニルポリシロキサン−錯体の製造法、そのようにして得られた白金−アルケニルポリシロキサン及びその使用
JP2003503394A (ja) ４−クロロ−６−ヒドロキシピリミジンの製造方法
HU207709B (en) Process for producing n-/n-propyl/-n-/2-/2,4,6-trichloro-phenoxy/-ethyl/-amine
JPH09124569A (ja) ベンズアミド誘導体の製造方法
JPH0414650B2 (de)
JP2005232103A (ja) 光学活性なビシナルジアミンおよびその製造方法
JP2002518365A (ja) グリニャール試薬を用いたカルボキサミドの触媒性対称二置換法