JP2002515086A - 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 - Google Patents
癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製Info
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下を有する生体適合性架橋ヒドロゲルを含有する断片化重合体組成物: 完全に水和したとき、0.05mm〜5mmの範囲のサブユニットサイズ; 400%〜1300%の平衡膨潤;および 湿潤組織環境にて、1日〜1年の範囲のインビボ分解時間。 2.0.01mm〜1.5mmの範囲の粒径および20重量%未満の水分含量を有する乾燥粉 末を含有する、請求項1に記載の組成物。 3.平衡膨潤での水和が50%〜95%の範囲の水和度を有する部分水和ヒドロゲル を含有する、請求項1に記載の組成物。 4.95%を超える水和度を有する完全水和ヒドロゲルを含有する、請求項1に記 載の組成物。 5.前記ヒドロゲルが架橋後に破壊されている、請求項1〜4のいずれか1項に 記載の組成物。 6.前記ヒドロゲルが架橋前に破壊されている、請求項1〜4のいずれか1項に 記載の組成物。 7.ポリエチレングリコール、ソルビトールおよびグリセロールからなる群から 選択される可塑剤をさらに含有する、請求項1〜4のいずれか1項に記載の組成 物。 8.前記可塑剤が、前記重合体成分の組成物の0.1重量%〜30重量%で存在する 、請求項7に記載の組成物。 9.さらに、活性剤を含有する、請求項1〜4のいずれか1項に記載の組成物。 10.前記活性剤が、止血剤である、請求項9に記載の組成物。 11.前記活性剤が、トロンビンである、請求項10に記載の組成物。 12.前記分子架橋ゲルが、架橋タンパク質ヒドロゲルを含有する、請求項1〜4 のいずれか1項に記載の組成物。 13.前記タンパク質が、ゼラチン、可溶性コラーゲン、アルブミン、ヘモグロビ ン、フィブロゲン(fibrogen)、フィブリン、カゼイン、フィブロネクチン、エラ スチン、ケラチン、ラミニン、およびそれらの誘導体および組合せからなる群か ら選択される、請求項12に記載の組成物。 14.前記分子架橋ゲルが、架橋多糖類を含有する、請求項1〜4のいずれか1項 に記載の組成物。 15.前記多糖類が、グリコサミノグリカン、デンプン誘導体、セルロース誘導体 、ヘミセルロース誘導体、キシラン、アガロース、アルギン酸塩、キトサン、お よびそれらの誘導体および組合せからなる群から選択される、請求項14に記載の 組成物。 16.前記分子架橋ゲルが、架橋非生物性重合体を含有する、請求項1〜4のいず れか1項に記載の組成物。 17.前記重合体が、ポリアクリレート、ポリメタクリレート、ポリアクリルアミ ド、ポリビニル樹脂、ポリラクチド−グリコリド、ポリカプロラクトン、ポリオ キシエチレン、およびそれらの誘導体および組合せからなる群から選択される、 請求項16に記載の組成物。 18.前記再吸収可能な分子架橋ヒドロゲルが、架橋タンパク質、架橋多糖類およ び架橋非生物性重合体からなる群から選択される少なくとも2個の成分を含有す る、請求項1〜4のいずれか1項に記載の組成物。 19.前記分子架橋ヒドロゲルが、重合体および架橋剤を含有し、該重合体および 該架橋剤が、重合体分子の架橋を生じる条件下にて反応させられている、請求項 1〜4のいずれか1項に記載の組成物。 20.前記分子架橋ヒドロゲルが、重合体分子の架橋を生じる条件下にて、該重合 体の照射により、生成される、請求項1〜4のいずれか1項に記載の組成物。 21.前記分子架橋ヒドロゲルが、重合体分子の架橋を生じる条件下にて、モノ不 飽和モノマーおよびポリ不飽和モノマーの反応により、生成される、請求項1〜 4のいずれか1項に記載の組成物。 22.重合体組成物を製造する方法であって、該方法は、以下を包含する: 生体適合性で再吸収可能な重合体を提供する工程; 該重合体を水性緩衝液と配合して、ゲルを形成する工程; 該ゲルを架橋する工程;および 該架橋ゲルを破壊する工程。 23.重合体組成物を製造する方法であって、該方法は、以下を包含する: 生体適合性で再吸収可能な重合体を提供する工程; 該重合体を破壊する工程; 該破壊された重合体を架橋する工程;および 該架橋した破壊された重合体を水性緩衝液と配合する工程。 24.前記架橋工程が、前記重合体を放射線に暴露することを包含する、請求項22 または23に記載の方法。 25.前記架橋組成物を、殺菌放射線に暴露したとき前記重合体の変性を抑制する のに効果的な一定量の安定剤を配合する工程をさらに包含する、請求項24に記載 の方法。 26.前記安定剤が、アスコルビン酸、アスコルビン酸ナトリウム、アスコルビン 酸の他の塩、または酸化防止剤である、請求項25に記載の方法。 27.組織路を封鎖する方法であって、該方法は、該組織路を、請求項1に記載の 組成物で少なくとも一部満たす工程を包含する。 28.患者の体内の標的部位での出血を抑制する方法であって、該方法は、請求項 1に記載の組成物を、出血を抑制するのに充分な量で、該標的部位に送達する工 程を包含する。 29.患者の体内の標的部位に生体活性物質を送達する方法であって、該方法は、 該生体活性物質と組み合わせて、請求項1に記載の組成物を該標的部位に送達す る工程を包含する。 30.膨潤可能組成物を、組織の標的部位に送達する方法であって、該方法は、請 求項1に記載の組成物を提供する工程、および該組成物を該標的部位に適用する 工程を包含し、該組成物は、その平衡膨潤未満で水和されており、それは、平衡 膨潤値まで膨潤する。 31.以下を包含するキット: 無菌の生体適合性で再吸収可能な分子架橋ゲルを含有する組成物; 該ゲルを組織の標的部位に適用するための説明書;および 該組成物および該説明書を保持する容器。 32.前記ゲルが、脱水されている、請求項31に記載のキット。 33.前記ゲルが、水和されている、請求項31に記載のキット。 34.重合体組成物を、患者の体内の標的部位に適用する方法であって、該方法は 、以下を包含する: 生体適合性で再吸収可能な分子架橋ヒドロゲルを提供する工程;および 該ゲルを、該標的部位でオリフィスを通して押し出す工程。 35.前記押出工程が、前記ヒドロゲルを、0.01mm〜5.0mmの範囲のオリフィスサ イズを有する注射器を通して手動で送達する工程を包含する、請求項34に記載の 方法。 36.前記ヒドロゲルが、前記押出工程前に破壊されている、請求項34に記載の方 法。 37.前記標的部位が、筋肉、皮膚、上皮組織、結合または支持組織、神経組織、 眼部および他の感覚器官の組織、血管および心臓組織、消化管器官およびその組 織、胸膜および他の肺組織、腎臓、内分秘腺、男性および女性生殖器、脂肪組織 、肝臓、膵臓、リンパ腺、軟骨、骨、口蓋組織、および粘膜組織、および脾臓お よび他の腹部臓器からなる群から選択した組織に存在する、請求項34に記載の方 法。 38.前記標的部位が、前記選択した組織内の空孔領域である、請求項37に記載の 方法。 39.前記空孔領域が、組織窪み、組織路、椎骨内空間および体腔からなる群から 選択される、請求項38に記載の方法。 40.さらに、前記ゲルを押し出した後、前記空孔上に、隔膜層を固定化する工程 を包含する、請求項38に記載の方法。 41.前記押出工程が、0.05mm〜3.0mmの範囲の大きさを有するサブユニットへの 、前記ヒドロゲルの破壊を引き起こす、請求項33に記載の方法。 42.分子架橋ヒドロゲルを含有するアプリケータであって、該アプリケータは、 以下を包含する: 内部レセプタクル容量および押出オリフィスを有するアプリケータ本体;およ び 該内部レセプタクル内の一定量の生体適合性で再吸収可能な分子架橋ヒドロゲ ル。 43.前記アプリケータ本体が、0.01mm〜5.0mmの範囲のオリフィスサイズを有す る注射器である、請求項42に記載のアプリケータ。 44.以下を含有する無菌パッケージ: 密封内部を有する容器;および 請求項42または43のいずれかに記載のアプリケータであって、該アプリケータ は、該容器内にて、無菌状態で維持される。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US70485296A | 1996-08-27 | 1996-08-27 | |
US08/704,852 | 1996-08-27 | ||
US08/903,674 US6063061A (en) | 1996-08-27 | 1997-07-31 | Fragmented polymeric compositions and methods for their use |
US08/903,674 | 1997-07-31 | ||
PCT/US1997/015262 WO1998008550A1 (en) | 1996-08-27 | 1997-08-14 | Fragmented polymeric hydrogels for adhesion prevention and their preparation |
Related Child Applications (2)
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JP2006157904A Division JP4842713B2 (ja) | 1996-08-27 | 2006-06-06 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
JP2009187571A Division JP4843079B2 (ja) | 1996-08-27 | 2009-08-12 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
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JP2002515086A true JP2002515086A (ja) | 2002-05-21 |
JP4418535B2 JP4418535B2 (ja) | 2010-02-17 |
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JP51197098A Expired - Lifetime JP4418535B2 (ja) | 1996-08-27 | 1997-08-14 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
JP2006157904A Expired - Lifetime JP4842713B2 (ja) | 1996-08-27 | 2006-06-06 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
JP2009187571A Expired - Lifetime JP4843079B2 (ja) | 1996-08-27 | 2009-08-12 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
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JP2006157904A Expired - Lifetime JP4842713B2 (ja) | 1996-08-27 | 2006-06-06 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
JP2009187571A Expired - Lifetime JP4843079B2 (ja) | 1996-08-27 | 2009-08-12 | 癒着防止用の断片化重合体ヒドロゲルおよびそれらの調製 |
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US (1) | US6063061A (ja) |
EP (1) | EP0927053B1 (ja) |
JP (3) | JP4418535B2 (ja) |
AU (1) | AU719534B2 (ja) |
BR (1) | BR9711241B8 (ja) |
CA (1) | CA2264647C (ja) |
DE (1) | DE69720479T2 (ja) |
IL (1) | IL128496A (ja) |
RU (1) | RU2207882C2 (ja) |
WO (1) | WO1998008550A1 (ja) |
Cited By (11)
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WO2005000374A1 (ja) * | 2003-06-30 | 2005-01-06 | Denki Kagaku Kogyo Kabushiki Kaisha | 脊椎・脊髄手術用癒着防止材 |
JP2006516567A (ja) * | 2003-01-24 | 2006-07-06 | マグル ホールディング エービー | 経粘膜伝達用組成物材料 |
WO2007077660A1 (ja) * | 2005-12-28 | 2007-07-12 | Tohoku University | 組成物およびその製造方法 |
JP2008538315A (ja) * | 2005-04-12 | 2008-10-23 | ウォーソー・オーソペディック・インコーポレーテッド | 関節形成性人工円板の運動能力を保存する方法およびデバイス |
JP2011518780A (ja) * | 2008-04-03 | 2011-06-30 | ザイモジェネティクス, インコーポレイテッド | 止血マイクロスフェア |
JP2012179467A (ja) * | 2004-04-08 | 2012-09-20 | Q Med Ab | 軟組織増大用の粒子 |
WO2013018759A1 (ja) * | 2011-08-02 | 2013-02-07 | 大日精化工業株式会社 | 癒着防止用医用材料及びその製造方法 |
JP2013527217A (ja) * | 2010-06-01 | 2013-06-27 | バクスター・インターナショナル・インコーポレイテッド | 乾燥した安定な止血用組成物を作成するためのプロセス |
US8846075B2 (en) | 2003-01-24 | 2014-09-30 | Magle Holding Ab | Composition material for transmucosal delivery |
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JP2009256391A (ja) | 2009-11-05 |
AU4241297A (en) | 1998-03-19 |
DE69720479D1 (de) | 2003-05-08 |
CA2264647C (en) | 2009-11-24 |
IL128496A (en) | 2004-06-20 |
JP4418535B2 (ja) | 2010-02-17 |
EP0927053B1 (en) | 2003-04-02 |
BR9711241A (pt) | 1999-08-17 |
JP4843079B2 (ja) | 2011-12-21 |
JP2006231090A (ja) | 2006-09-07 |
BR9711241B8 (pt) | 2021-06-22 |
RU2207882C2 (ru) | 2003-07-10 |
IL128496A0 (en) | 2000-01-31 |
BRPI9711241B1 (pt) | 2016-12-20 |
JP4842713B2 (ja) | 2011-12-21 |
US6063061A (en) | 2000-05-16 |
CA2264647A1 (en) | 1998-03-05 |
DE69720479T2 (de) | 2004-03-04 |
EP0927053A1 (en) | 1999-07-07 |
AU719534B2 (en) | 2000-05-11 |
WO1998008550A1 (en) | 1998-03-05 |
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