IT8721616A0 - Procedimento per la preparazione dell'ormone della crescita umano - Google Patents

Procedimento per la preparazione dell'ormone della crescita umano

Info

Publication number
IT8721616A0
IT8721616A0 IT8721616A IT2161687A IT8721616A0 IT 8721616 A0 IT8721616 A0 IT 8721616A0 IT 8721616 A IT8721616 A IT 8721616A IT 2161687 A IT2161687 A IT 2161687A IT 8721616 A0 IT8721616 A0 IT 8721616A0
Authority
IT
Italy
Prior art keywords
procedure
preparation
growth hormone
human growth
human
Prior art date
Application number
IT8721616A
Other languages
English (en)
Other versions
IT1228925B (it
Inventor
Guido Grandi
Elisabetta Franchi
Federico Maisano
Silvia Astrua Testori
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT8721616A priority Critical patent/IT1228925B/it
Publication of IT8721616A0 publication Critical patent/IT8721616A0/it
Priority to ES88111842T priority patent/ES2053635T3/es
Priority to DE8888111842T priority patent/DE3879823T2/de
Priority to AT88111842T priority patent/ATE87654T1/de
Priority to EP88111842A priority patent/EP0306673B1/en
Priority to JP63194701A priority patent/JPH074254B2/ja
Application granted granted Critical
Publication of IT1228925B publication Critical patent/IT1228925B/it
Priority to US07/834,486 priority patent/US5268277A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
IT8721616A 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano IT1228925B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano
ES88111842T ES2053635T3 (es) 1987-08-07 1988-07-22 Metodo para la preparacion de la hormona humana del crecimiento.
DE8888111842T DE3879823T2 (de) 1987-08-07 1988-07-22 Verfahren zur herstellung von menschlichem wachstumshormon.
AT88111842T ATE87654T1 (de) 1987-08-07 1988-07-22 Verfahren zur herstellung von menschlichem wachstumshormon.
EP88111842A EP0306673B1 (en) 1987-08-07 1988-07-22 A method for the preparation of human growth hormone
JP63194701A JPH074254B2 (ja) 1987-08-07 1988-08-05 ヒト成長ホルモンの製法
US07/834,486 US5268277A (en) 1987-08-07 1992-02-12 Method for the preparation of human growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano

Publications (2)

Publication Number Publication Date
IT8721616A0 true IT8721616A0 (it) 1987-08-07
IT1228925B IT1228925B (it) 1991-07-10

Family

ID=11184375

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano

Country Status (6)

Country Link
EP (1) EP0306673B1 (it)
JP (1) JPH074254B2 (it)
AT (1) ATE87654T1 (it)
DE (1) DE3879823T2 (it)
ES (1) ES2053635T3 (it)
IT (1) IT1228925B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
IT1231156B (it) * 1989-07-19 1991-11-19 Eniricerche Spa Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
JP3869874B2 (ja) * 1995-11-15 2007-01-17 大日本住友製薬株式会社 急性肝不全治療剤
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
SI0866720T1 (en) * 1995-11-22 2004-10-31 Amgen Inc. Ob protein for increasing lean tissue mass
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
CN1190494C (zh) * 1997-06-10 2005-02-23 宝生物工程株式会社 表达超热稳定蛋白酶的***
AU731758B2 (en) * 1998-07-08 2001-04-05 Mitsui Chemicals, Inc. Method for secretory production of human growth hormone
JP5160878B2 (ja) * 2007-12-21 2013-03-13 浜松ホトニクス株式会社 試料同定装置および試料同定方法
US9902753B2 (en) * 2012-06-05 2018-02-27 Cj Healthcare Corporation Method of purifying a long-acting human growth hormone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
JP2500312B2 (ja) * 1986-01-13 1996-05-29 工業技術院長 ヒト成長ホルモンの生産法
DE3788592T2 (de) * 1986-05-07 1994-04-28 Eniricerche Spa Plasmidvektor zur Expression im Bazillus, dessen Umwendung für die Klonierung des menschlichen Wachstumshormongens und Verfahren zur Produktion des Hormons.

Also Published As

Publication number Publication date
ES2053635T3 (es) 1994-08-01
EP0306673B1 (en) 1993-03-31
IT1228925B (it) 1991-07-10
ATE87654T1 (de) 1993-04-15
EP0306673A1 (en) 1989-03-15
DE3879823T2 (de) 1993-07-08
JPH074254B2 (ja) 1995-01-25
DE3879823D1 (de) 1993-05-06
JPH02446A (ja) 1990-01-05

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970829