IT1239268B - Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio - Google Patents

Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio

Info

Publication number
IT1239268B
IT1239268B IT22575A IT2257589A IT1239268B IT 1239268 B IT1239268 B IT 1239268B IT 22575 A IT22575 A IT 22575A IT 2257589 A IT2257589 A IT 2257589A IT 1239268 B IT1239268 B IT 1239268B
Authority
IT
Italy
Prior art keywords
cefem
phenylacetamide
chlorine
amino
procedure
Prior art date
Application number
IT22575A
Other languages
English (en)
Other versions
IT8922575A0 (it
IT8922575A1 (it
Inventor
Leonardo Ambrosini
Original Assignee
I R C A Ind Ricerche Chimiche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I R C A Ind Ricerche Chimiche filed Critical I R C A Ind Ricerche Chimiche
Priority to IT22575A priority Critical patent/IT1239268B/it
Publication of IT8922575A0 publication Critical patent/IT8922575A0/it
Priority to CA002028954A priority patent/CA2028954A1/en
Priority to EP90121179A priority patent/EP0429895A1/en
Priority to JP2313790A priority patent/JPH03181485A/ja
Priority to KR1019900019443A priority patent/KR910011866A/ko
Priority to AU67646/90A priority patent/AU6764690A/en
Publication of IT8922575A1 publication Critical patent/IT8922575A1/it
Application granted granted Critical
Publication of IT1239268B publication Critical patent/IT1239268B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT22575A 1989-12-01 1989-12-01 Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio IT1239268B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT22575A IT1239268B (it) 1989-12-01 1989-12-01 Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio
CA002028954A CA2028954A1 (en) 1989-12-01 1990-11-01 Process for preparing monohydrate 7-(d-2amino-2-phenylacetamido)-3-cefem-4-carboxylic acid and intermediate formed in the process
EP90121179A EP0429895A1 (en) 1989-12-01 1990-11-06 Process for preparing monohydrate 7-(D-2-amino-2-phenylacetamido)-3-cefem-4-carboxylic acid and intermediate formed in the process
JP2313790A JPH03181485A (ja) 1989-12-01 1990-11-19 ７―（ｄ―２―アミノ―２―フェニルアセトアミド）―３―セフェム―４―カルボン酸一水和物の製造方法及びその方法で生成される中間体
KR1019900019443A KR910011866A (ko) 1989-12-01 1990-11-29 모노하이드레이트 7-(d-2-아미노-2-페닐 아세트 아미도)-3-클로로-3-세펨-4-카복실산의 제조방법 및 공정중 형성된 중간체
AU67646/90A AU6764690A (en) 1989-12-01 1990-11-30 Process for preparing 7-(d-2-amino-2-phenylacetamido)-3-cefem-4-carboxylic acid monohydrate and intermediate formed in the process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22575A IT1239268B (it) 1989-12-01 1989-12-01 Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio

Publications (3)

Publication Number Publication Date
IT8922575A0 IT8922575A0 (it) 1989-12-01
IT8922575A1 IT8922575A1 (it) 1991-06-01
IT1239268B true IT1239268B (it) 1993-10-01

Family

ID=11198006

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22575A IT1239268B (it) 1989-12-01 1989-12-01 Procedimento per la preparazione dell'acido 7-(d-2-amino-2-fenilacetamido)-3-cloro-3-cefem-4-carbossilico monoidrato e intermedio

Country Status (6)

Country Link
EP (1) EP0429895A1 (it)
JP (1) JPH03181485A (it)
KR (1) KR910011866A (it)
AU (1) AU6764690A (it)
CA (1) CA2028954A1 (it)
IT (1) IT1239268B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251999B (it) * 1991-11-11 1995-05-27 Opos Biochimica Srl Forma cristallina di un antibiotico cefalosporinico
US5589593A (en) * 1991-11-11 1996-12-31 Biochimica Opos Spa Crystalline form of a cephalosporin antibiotic
CN101805357B (zh) * 2010-04-28 2012-01-11 陶灵刚 一种头孢克洛化合物及其制法
CN104086573A (zh) * 2014-07-24 2014-10-08 孙巧玲 头孢克洛的一锅法制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
DE3211034A1 (de) * 1982-03-25 1983-09-29 Bayer Ag, 5090 Leverkusen 7-(alpha)-aminoacyl-3-chlorcephalosporine, verfahren zu ihrer herstellung sowie ihrer verwendung als arzneimittel

Also Published As

Publication number Publication date
KR910011866A (ko) 1991-08-07
AU6764690A (en) 1991-06-06
JPH03181485A (ja) 1991-08-07
IT8922575A0 (it) 1989-12-01
IT8922575A1 (it) 1991-06-01
EP0429895A1 (en) 1991-06-05
CA2028954A1 (en) 1991-06-02

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971231