IT1261667B - Tassano ad attivita' antitumorale. - Google Patents

Tassano ad attivita' antitumorale.

Info

Publication number
IT1261667B
IT1261667B ITRM930334A ITRM930334A IT1261667B IT 1261667 B IT1261667 B IT 1261667B IT RM930334 A ITRM930334 A IT RM930334A IT RM930334 A ITRM930334 A IT RM930334A IT 1261667 B IT1261667 B IT 1261667B
Authority
IT
Italy
Prior art keywords
tax
cancer activities
antileukemic
taxane
taxol
Prior art date
Application number
ITRM930334A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITRM930334A0 publication Critical patent/ITRM930334A0/it
Priority to ITRM930334A priority Critical patent/IT1261667B/it
Priority to US08/088,319 priority patent/US5407674A/en
Priority to DK93111366T priority patent/DK0625517T3/da
Priority to DE69322619T priority patent/DE69322619T2/de
Priority to EP93111366A priority patent/EP0625517B1/en
Priority to ES93111366T priority patent/ES2068166T3/es
Priority to AT93111366T priority patent/ATE174595T1/de
Priority to DE0625517T priority patent/DE625517T1/de
Priority to CA002140519A priority patent/CA2140519A1/en
Priority to PL94307089A priority patent/PL178363B1/pl
Priority to KR1019950700197A priority patent/KR100315495B1/ko
Priority to RU95105981A priority patent/RU2129551C1/ru
Priority to HU9500152A priority patent/HU221503B/hu
Priority to CZ1995122A priority patent/CZ286959B6/cs
Priority to PCT/EP1994/001405 priority patent/WO1994027984A1/en
Priority to JP7500149A priority patent/JPH07509259A/ja
Priority to AU67951/94A priority patent/AU6795194A/en
Priority to CN94190306A priority patent/CN1054381C/zh
Priority to SK60-95A priority patent/SK280873B6/sk
Publication of ITRM930334A1 publication Critical patent/ITRM930334A1/it
Priority to FI950207A priority patent/FI950207A0/fi
Priority to NO19950184A priority patent/NO310510B1/no
Priority to GR950300009T priority patent/GR950300009T1/el
Application granted granted Critical
Publication of IT1261667B publication Critical patent/IT1261667B/it
Priority to HK98113937A priority patent/HK1012628A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invenzione riguarda un nuovo tassano di struttura (1), isolabile dalla corteccia delle radici di piante del genere Taxus. Il composto (1) possiede attività antitumorali superiori a quelle del tassolo (2), essendo attivo, a differenza di quest'ultimo, anche nei confronti di cellule resistenti all'adriamicina e come antileucemico.
ITRM930334A 1993-05-20 1993-05-20 Tassano ad attivita' antitumorale. IT1261667B (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
ITRM930334A IT1261667B (it) 1993-05-20 1993-05-20 Tassano ad attivita' antitumorale.
US08/088,319 US5407674A (en) 1993-05-20 1993-07-07 Taxane having antitumor activity
DK93111366T DK0625517T3 (da) 1993-05-20 1993-07-15 Taxan med antitumoraktivitet
DE69322619T DE69322619T2 (de) 1993-05-20 1993-07-15 Taxane mit antitumor Wirkung
EP93111366A EP0625517B1 (en) 1993-05-20 1993-07-15 Taxane having antitumor activity
ES93111366T ES2068166T3 (es) 1993-05-20 1993-07-15 Taxano con actividad antitumoral.
AT93111366T ATE174595T1 (de) 1993-05-20 1993-07-15 Taxane mit antitumor wirkung
DE0625517T DE625517T1 (de) 1993-05-20 1993-07-15 Taxane mit antitumor Wirkung.
HU9500152A HU221503B (en) 1993-05-20 1994-05-03 Taxane having antitumor activity and pharmaceutical composition containing the same
CN94190306A CN1054381C (zh) 1993-05-20 1994-05-03 具有抗癌活性的红豆杉烷，其制法及药物组合物
KR1019950700197A KR100315495B1 (ko) 1993-05-20 1994-05-03 항종양활성을갖는탁산
RU95105981A RU2129551C1 (ru) 1993-05-20 1994-05-03 4,10-ДИАЦЕТАТ-2-БЕНЗОАТ 5β, 20-ЭПОКСИ-1,2α, 4,7; , 10β, 13α- ГЕКСАГИДРОКСИТАКС-11-ЕН-9-ОНА СО СЛОЖНОЙ ЭФИРНОЙ ГРУППОЙ В ПОЛОЖЕНИИ 13, ОБРАЗОВАННОЙ (2R, 2S)-N-ГЕКСАНОИЛ-3-ФЕНИЛИЗОСЕРИНОМ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
CA002140519A CA2140519A1 (en) 1993-05-20 1994-05-03 Taxane having antitumor activity
CZ1995122A CZ286959B6 (en) 1993-05-20 1994-05-03 Taxane, process of its preparation and pharmaceutical preparation containing thereof
PCT/EP1994/001405 WO1994027984A1 (en) 1993-05-20 1994-05-03 Taxane having antitumor activity
JP7500149A JPH07509259A (ja) 1993-05-20 1994-05-03 抗腫瘍活性を有するタクサン
AU67951/94A AU6795194A (en) 1993-05-20 1994-05-03 Taxane having antitumor activity
PL94307089A PL178363B1 (pl) 1993-05-20 1994-05-03 Taksan o działaniu przeciwnowotworowym
SK60-95A SK280873B6 (sk) 1993-05-20 1994-05-03 Taxán s protinádorovou aktivitou, spôsob jeho prípravy a farmaceutický prípravok
FI950207A FI950207A0 (fi) 1993-05-20 1995-01-18 Taksaani, jolla on kasvaimenvastaista vaikutusta
NO19950184A NO310510B1 (no) 1993-05-20 1995-01-18 Taxan med antitumoraktivitet
GR950300009T GR950300009T1 (en) 1993-05-20 1995-03-31 Taxane having antitumor activity.
HK98113937A HK1012628A1 (en) 1993-05-20 1998-12-17 Taxane having antitumor activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930334A IT1261667B (it) 1993-05-20 1993-05-20 Tassano ad attivita' antitumorale.

Publications (3)

Publication Number Publication Date
ITRM930334A0 ITRM930334A0 (it) 1993-05-20
ITRM930334A1 ITRM930334A1 (it) 1994-11-20
IT1261667B true IT1261667B (it) 1996-05-29

Family

ID=11401772

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930334A IT1261667B (it) 1993-05-20 1993-05-20 Tassano ad attivita' antitumorale.

Country Status (22)

Country Link
US (1) US5407674A (it)
EP (1) EP0625517B1 (it)
JP (1) JPH07509259A (it)
KR (1) KR100315495B1 (it)
CN (1) CN1054381C (it)
AT (1) ATE174595T1 (it)
AU (1) AU6795194A (it)
CA (1) CA2140519A1 (it)
CZ (1) CZ286959B6 (it)
DE (2) DE69322619T2 (it)
DK (1) DK0625517T3 (it)
ES (1) ES2068166T3 (it)
FI (1) FI950207A0 (it)
GR (1) GR950300009T1 (it)
HK (1) HK1012628A1 (it)
HU (1) HU221503B (it)
IT (1) IT1261667B (it)
NO (1) NO310510B1 (it)
PL (1) PL178363B1 (it)
RU (1) RU2129551C1 (it)
SK (1) SK280873B6 (it)
WO (1) WO1994027984A1 (it)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4139993A1 (de) * 1991-12-04 1993-06-09 Merck Patent Gmbh, 6100 Darmstadt, De Pigmentzubereitung
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5756536A (en) * 1995-11-03 1998-05-26 Purdue Research Foundation Microbial transformation of taxol and cephalomannine
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
CA2188190A1 (en) 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
PE20061090A1 (es) * 2005-02-14 2006-10-12 Univ Florida State Res Found Preparaciones de taxanos sustituidos con esteres de ciclopropilo en c10
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
EP2007744B1 (en) 2006-04-03 2017-05-17 Pharmatherm Chemicals Inc. Thermal extraction method for producing a taxane extract
US8163792B2 (en) 2006-05-16 2012-04-24 Pharmascience Inc. IAP BIR domain binding compounds
US7905990B2 (en) 2007-11-20 2011-03-15 Ensyn Renewables, Inc. Rapid thermal conversion of biomass
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
US8242166B2 (en) * 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes
ES2625637T3 (es) 2010-02-12 2017-07-20 Pharmascience Inc. Compuestos de unión al dominio BIR IAP
US20110284359A1 (en) 2010-05-20 2011-11-24 Uop Llc Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
US9441887B2 (en) 2011-02-22 2016-09-13 Ensyn Renewables, Inc. Heat removal and recovery in biomass pyrolysis
US9347005B2 (en) 2011-09-13 2016-05-24 Ensyn Renewables, Inc. Methods and apparatuses for rapid thermal processing of carbonaceous material
US10041667B2 (en) 2011-09-22 2018-08-07 Ensyn Renewables, Inc. Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same
US9044727B2 (en) 2011-09-22 2015-06-02 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10400175B2 (en) 2011-09-22 2019-09-03 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9670413B2 (en) 2012-06-28 2017-06-06 Ensyn Renewables, Inc. Methods and apparatuses for thermally converting biomass
US10633606B2 (en) 2012-12-10 2020-04-28 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US10337726B2 (en) 2015-08-21 2019-07-02 Ensyn Renewables, Inc. Liquid biomass heating system
CN110366448B (zh) 2016-12-29 2023-05-02 安辛可再生能源有限公司 液体生物质的脱金属化

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206221A (en) * 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
IT1254515B (it) * 1992-03-06 1995-09-25 Indena Spa Tassani di interesse oncologico, loro metodo di preparazione ed uso
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol

Also Published As

Publication number Publication date
DK0625517T3 (da) 1999-08-23
PL178363B1 (pl) 2000-04-28
GR950300009T1 (en) 1995-03-31
ITRM930334A0 (it) 1993-05-20
AU6795194A (en) 1994-12-20
NO950184L (no) 1995-01-18
DE69322619D1 (de) 1999-01-28
HK1012628A1 (en) 1999-08-06
WO1994027984A1 (en) 1994-12-08
CN1110055A (zh) 1995-10-11
PL307089A1 (en) 1995-05-02
ATE174595T1 (de) 1999-01-15
SK6095A3 (en) 1995-07-11
NO310510B1 (no) 2001-07-16
RU2129551C1 (ru) 1999-04-27
ITRM930334A1 (it) 1994-11-20
DE625517T1 (de) 1995-07-13
HU9500152D0 (en) 1995-03-28
HU221503B (en) 2002-10-28
DE69322619T2 (de) 1999-06-24
CZ286959B6 (en) 2000-08-16
KR100315495B1 (ko) 2002-06-20
FI950207A (fi) 1995-01-18
JPH07509259A (ja) 1995-10-12
ES2068166T3 (es) 1999-03-01
CZ12295A3 (en) 1995-09-13
CN1054381C (zh) 2000-07-12
EP0625517B1 (en) 1998-12-16
CA2140519A1 (en) 1994-12-08
US5407674A (en) 1995-04-18
SK280873B6 (sk) 2000-08-14
RU95105981A (ru) 1996-10-27
EP0625517A1 (en) 1994-11-23
HUT72607A (en) 1996-05-28
ES2068166T1 (es) 1995-04-16
FI950207A0 (fi) 1995-01-18
NO950184D0 (no) 1995-01-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970529