ES2068166T3 - Taxano con actividad antitumoral. - Google Patents
Taxano con actividad antitumoral.Info
- Publication number
- ES2068166T3 ES2068166T3 ES93111366T ES93111366T ES2068166T3 ES 2068166 T3 ES2068166 T3 ES 2068166T3 ES 93111366 T ES93111366 T ES 93111366T ES 93111366 T ES93111366 T ES 93111366T ES 2068166 T3 ES2068166 T3 ES 2068166T3
- Authority
- ES
- Spain
- Prior art keywords
- taxano
- antitumoral activity
- antitumoral
- insulable
- antileukemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 241001116500 Taxus Species 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA NUEVA "TAXANE" QUE TIENE LA ESTRUCTURA (1), QUE ES AISLABLE DE LA CORTEZA DE LA RAIZ DE LAS PLANTAS DEL GENERO TAXUS. EL COMPONENTE (1) ESTA DOTADO DE ACTIVIDAD ANTITUMORAL SUPERIOR A LA DEL TAXOL, SIENDO EL PRIMERO ACTIVO, A DIFERENCIA DEL ULTIMO, TAMBIEN CONTRA LAS CELULAS RESISTENTES A LA ADRIAMICINA, Y COMO MEDICINA ANTILEUCEMICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM930334A IT1261667B (it) | 1993-05-20 | 1993-05-20 | Tassano ad attivita' antitumorale. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2068166T1 ES2068166T1 (es) | 1995-04-16 |
ES2068166T3 true ES2068166T3 (es) | 1999-03-01 |
Family
ID=11401772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93111366T Expired - Lifetime ES2068166T3 (es) | 1993-05-20 | 1993-07-15 | Taxano con actividad antitumoral. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5407674A (es) |
EP (1) | EP0625517B1 (es) |
JP (1) | JPH07509259A (es) |
KR (1) | KR100315495B1 (es) |
CN (1) | CN1054381C (es) |
AT (1) | ATE174595T1 (es) |
AU (1) | AU6795194A (es) |
CA (1) | CA2140519A1 (es) |
CZ (1) | CZ286959B6 (es) |
DE (2) | DE69322619T2 (es) |
DK (1) | DK0625517T3 (es) |
ES (1) | ES2068166T3 (es) |
FI (1) | FI950207A (es) |
GR (1) | GR950300009T1 (es) |
HK (1) | HK1012628A1 (es) |
HU (1) | HU221503B (es) |
IT (1) | IT1261667B (es) |
NO (1) | NO310510B1 (es) |
PL (1) | PL178363B1 (es) |
RU (1) | RU2129551C1 (es) |
SK (1) | SK280873B6 (es) |
WO (1) | WO1994027984A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4139993A1 (de) * | 1991-12-04 | 1993-06-09 | Merck Patent Gmbh, 6100 Darmstadt, De | Pigmentzubereitung |
IT1275936B1 (it) * | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
US5756536A (en) * | 1995-11-03 | 1998-05-26 | Purdue Research Foundation | Microbial transformation of taxol and cephalomannine |
US5965752A (en) * | 1996-08-23 | 1999-10-12 | Institut National De La Recherche Scientifique | Preparative scale isolation and purification of taxanes |
CA2188190A1 (en) | 1996-10-18 | 1998-04-18 | Sarala Balachandran | The semi-synthesis of a protected bacatin iii compound |
WO1998017656A1 (en) * | 1996-10-24 | 1998-04-30 | Institute Armand-Frappier | A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof |
EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
CA2368151A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes as antitumor agents |
US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
US7064980B2 (en) * | 2003-09-17 | 2006-06-20 | Sandisk Corporation | Non-volatile memory and method with bit line coupled compensation |
HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
US7169307B2 (en) * | 2004-09-02 | 2007-01-30 | Jian Liu | Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus |
US20060189679A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
WO2006122408A1 (en) | 2005-05-18 | 2006-11-23 | Aegera Therapeutics Inc. | Bir domain binding compounds |
EP3252128B1 (en) | 2006-04-03 | 2019-01-02 | Pharmatherm Chemicals Inc. | Thermal extraction method for producing a taxane extract |
JP5419685B2 (ja) | 2006-05-16 | 2014-02-19 | ファーマサイエンス・インコーポレイテッド | Iapbirドメイン結合タンパク質 |
US7905990B2 (en) | 2007-11-20 | 2011-03-15 | Ensyn Renewables, Inc. | Rapid thermal conversion of biomass |
EP2080764B1 (en) | 2008-01-18 | 2012-08-22 | INDENA S.p.A. | Solid forms of ortataxel |
US8242166B2 (en) * | 2008-03-31 | 2012-08-14 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes |
EP2534170B1 (en) | 2010-02-12 | 2017-04-19 | Pharmascience Inc. | Iap bir domain binding compounds |
US20110284359A1 (en) | 2010-05-20 | 2011-11-24 | Uop Llc | Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas |
US8499702B2 (en) | 2010-07-15 | 2013-08-06 | Ensyn Renewables, Inc. | Char-handling processes in a pyrolysis system |
US9441887B2 (en) | 2011-02-22 | 2016-09-13 | Ensyn Renewables, Inc. | Heat removal and recovery in biomass pyrolysis |
US9347005B2 (en) | 2011-09-13 | 2016-05-24 | Ensyn Renewables, Inc. | Methods and apparatuses for rapid thermal processing of carbonaceous material |
US10041667B2 (en) | 2011-09-22 | 2018-08-07 | Ensyn Renewables, Inc. | Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same |
US9044727B2 (en) | 2011-09-22 | 2015-06-02 | Ensyn Renewables, Inc. | Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material |
US10400175B2 (en) | 2011-09-22 | 2019-09-03 | Ensyn Renewables, Inc. | Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material |
US9109177B2 (en) | 2011-12-12 | 2015-08-18 | Ensyn Renewables, Inc. | Systems and methods for renewable fuel |
US9670413B2 (en) | 2012-06-28 | 2017-06-06 | Ensyn Renewables, Inc. | Methods and apparatuses for thermally converting biomass |
TWI645026B (zh) | 2013-06-26 | 2018-12-21 | 安信再生公司 | 可再生燃料之系統及方法 |
WO2017034981A1 (en) | 2015-08-21 | 2017-03-02 | Ensyn Renewables, Inc. | Liquid biomass heating system |
US10400176B2 (en) | 2016-12-29 | 2019-09-03 | Ensyn Renewables, Inc. | Demetallization of liquid biomass |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4206221A (en) * | 1979-01-03 | 1980-06-03 | The United States Of America As Represented By The Secretary Of Agriculture | Cephalomannine and its use in treating leukemic tumors |
US5157049A (en) * | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
FR2662441B1 (fr) * | 1990-05-22 | 1992-10-23 | Rhone Poulenc Sante | Procede de preparation enantioselective de derives de la phenylisoserine. |
US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
IT1254515B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | Tassani di interesse oncologico, loro metodo di preparazione ed uso |
US5200534A (en) * | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
-
1993
- 1993-05-20 IT ITRM930334A patent/IT1261667B/it active IP Right Grant
- 1993-07-07 US US08/088,319 patent/US5407674A/en not_active Expired - Fee Related
- 1993-07-15 DK DK93111366T patent/DK0625517T3/da active
- 1993-07-15 DE DE69322619T patent/DE69322619T2/de not_active Expired - Fee Related
- 1993-07-15 AT AT93111366T patent/ATE174595T1/de not_active IP Right Cessation
- 1993-07-15 DE DE0625517T patent/DE625517T1/de active Pending
- 1993-07-15 EP EP93111366A patent/EP0625517B1/en not_active Expired - Lifetime
- 1993-07-15 ES ES93111366T patent/ES2068166T3/es not_active Expired - Lifetime
-
1994
- 1994-05-03 JP JP7500149A patent/JPH07509259A/ja not_active Withdrawn
- 1994-05-03 RU RU95105981A patent/RU2129551C1/ru active
- 1994-05-03 CN CN94190306A patent/CN1054381C/zh not_active Expired - Fee Related
- 1994-05-03 SK SK60-95A patent/SK280873B6/sk unknown
- 1994-05-03 CA CA002140519A patent/CA2140519A1/en not_active Abandoned
- 1994-05-03 AU AU67951/94A patent/AU6795194A/en not_active Abandoned
- 1994-05-03 WO PCT/EP1994/001405 patent/WO1994027984A1/en active IP Right Grant
- 1994-05-03 CZ CZ1995122A patent/CZ286959B6/cs not_active IP Right Cessation
- 1994-05-03 PL PL94307089A patent/PL178363B1/pl unknown
- 1994-05-03 KR KR1019950700197A patent/KR100315495B1/ko not_active IP Right Cessation
- 1994-05-03 HU HU9500152A patent/HU221503B/hu not_active IP Right Cessation
-
1995
- 1995-01-18 FI FI950207A patent/FI950207A/fi unknown
- 1995-01-18 NO NO19950184A patent/NO310510B1/no not_active IP Right Cessation
- 1995-03-31 GR GR950300009T patent/GR950300009T1/el unknown
-
1998
- 1998-12-17 HK HK98113937A patent/HK1012628A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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