IT1250421B - Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. - Google Patents

Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.

Info

Publication number
IT1250421B
IT1250421B ITMI911486A ITMI911486A IT1250421B IT 1250421 B IT1250421 B IT 1250421B IT MI911486 A ITMI911486 A IT MI911486A IT MI911486 A ITMI911486 A IT MI911486A IT 1250421 B IT1250421 B IT 1250421B
Authority
IT
Italy
Prior art keywords
bio
composition
pharmaceutical composition
controlled release
adhesive properties
Prior art date
Application number
ITMI911486A
Other languages
English (en)
Inventor
Giancarlo Santus
Giuseppe Bottoni
Giovanni Sala
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of ITMI911486A0 publication Critical patent/ITMI911486A0/it
Priority to ITMI911486A priority Critical patent/IT1250421B/it
Priority to JP4130545A priority patent/JPH07215843A/ja
Priority to ES92109080T priority patent/ES2091363T3/es
Priority to DK92109080.9T priority patent/DK0516141T3/da
Priority to AT92109080T priority patent/ATE141159T1/de
Priority to DE69212710T priority patent/DE69212710T2/de
Priority to EP92109080A priority patent/EP0516141B1/en
Publication of ITMI911486A1 publication Critical patent/ITMI911486A1/it
Priority to US08/174,191 priority patent/US5472704A/en
Application granted granted Critical
Publication of IT1250421B publication Critical patent/IT1250421B/it
Priority to GR960401981T priority patent/GR3020813T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Abstract

Viene descritta una composizione farmaceutica per il rilascio controllato di farmaci avente la proprietà di aderire ai tessuti biologici. Tale composizione ha come componenti caratteristiche una pluralità di unità di piccole dimensioni atte a consentire il rilascio graduale del principio attivo in esse contenuto ed uno strato polimerico bio-adesivo che ricopre individualmente la superficie di ognuna di dette unità. La composizione permette di mantenere separata la funzione che controlla il rilascio dalla funzione che fornisce la bio-adesione ed è adattabile sia alla somministrazione per via orale sia a quella per via oculare, rettale, vaginale, nasale o periodontale. Viene anche descritto un procedimento vantaggioso per ottenere detta composizione.
ITMI911486A 1991-05-30 1991-05-30 Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. IT1250421B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI911486A IT1250421B (it) 1991-05-30 1991-05-30 Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
JP4130545A JPH07215843A (ja) 1991-05-30 1992-05-22 生物学的付着性を有する徐放性薬理組成物
AT92109080T ATE141159T1 (de) 1991-05-30 1992-05-29 Pharmazeutische zusammensetzung mit kontrollierter freigabe und bioadhäsiven eigenschaften
DK92109080.9T DK0516141T3 (da) 1991-05-30 1992-05-29 Farmaceutisk kontrolleret-afgivelsespræparat med bioadhæsive egenskaber
ES92109080T ES2091363T3 (es) 1991-05-30 1992-05-29 Compuesto farmaceutico de liberacion controlada con propiedades bioadhesivas.
DE69212710T DE69212710T2 (de) 1991-05-30 1992-05-29 Pharmazeutische Zusammensetzung mit kontrollierter Freigabe und bioadhäsiven Eigenschaften
EP92109080A EP0516141B1 (en) 1991-05-30 1992-05-29 Pharmaceutical controlled-release composition with bioadhesive properties
US08/174,191 US5472704A (en) 1991-05-30 1993-12-27 Pharmaceutical controlled-release composition with bioadhesive properties
GR960401981T GR3020813T3 (en) 1991-05-30 1996-08-16 Pharmaceutical controlled-release composition with bioadhesive properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911486A IT1250421B (it) 1991-05-30 1991-05-30 Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.

Publications (3)

Publication Number Publication Date
ITMI911486A0 ITMI911486A0 (it) 1991-05-30
ITMI911486A1 ITMI911486A1 (it) 1992-11-30
IT1250421B true IT1250421B (it) 1995-04-07

Family

ID=11360019

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911486A IT1250421B (it) 1991-05-30 1991-05-30 Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.

Country Status (9)

Country Link
US (1) US5472704A (it)
EP (1) EP0516141B1 (it)
JP (1) JPH07215843A (it)
AT (1) ATE141159T1 (it)
DE (1) DE69212710T2 (it)
DK (1) DK0516141T3 (it)
ES (1) ES2091363T3 (it)
GR (1) GR3020813T3 (it)
IT (1) IT1250421B (it)

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US5472704A (en) 1995-12-05
DE69212710D1 (de) 1996-09-19
ITMI911486A0 (it) 1991-05-30
ITMI911486A1 (it) 1992-11-30
DE69212710T2 (de) 1996-12-19
GR3020813T3 (en) 1996-11-30
EP0516141A1 (en) 1992-12-02
EP0516141B1 (en) 1996-08-14
ES2091363T3 (es) 1996-11-01
JPH07215843A (ja) 1995-08-15
ATE141159T1 (de) 1996-08-15

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