IL47860A - 5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them - Google Patents

5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them

Info

Publication number: IL47860A
Authority: IL; Israel
Prior art keywords: andns; benzomorphans; tetrahydrofuryl; disubstituted; benzomorphans andns
Prior art date: 1974-08-05

Application number

IL47860A

Other languages

English (en)

Other versions

IL47860A0 (en

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-08-05

Filing date

1975-08-04

Publication date

1979-01-31

1975-08-04 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1975-11-25 Publication of IL47860A0 publication Critical patent/IL47860A0/xx

1979-01-31 Publication of IL47860A publication Critical patent/IL47860A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL47860A 1974-08-05 1975-08-04 5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them IL47860A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2437610A DE2437610A1 (de)	1974-08-05	1974-08-05	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
IL47860A0 IL47860A0 (en)	1975-11-25
IL47860A true IL47860A (en)	1979-01-31

Family

ID=5922448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL47860A IL47860A (en)	1974-08-05	1975-08-04	5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them

Country Status (27)

Country	Link
US (1)	US3982005A (hu)
JP (1)	JPS60358B2 (hu)
AT (1)	AT348140B (hu)
BE (1)	BE832099R (hu)
BG (3)	BG25090A3 (hu)
CA (1)	CA1049008A (hu)
CH (7)	CH613963A5 (hu)
CS (1)	CS189717B2 (hu)
DD (1)	DD122685A5 (hu)
DE (1)	DE2437610A1 (hu)
DK (1)	DK138992C (hu)
ES (6)	ES452765A1 (hu)
FI (1)	FI63229C (hu)
FR (1)	FR2320096A2 (hu)
GB (1)	GB1513950A (hu)
HU (1)	HU177952B (hu)
IE (1)	IE42216B1 (hu)
IL (1)	IL47860A (hu)
LU (1)	LU73138A1 (hu)
NL (1)	NL7509249A (hu)
NO (1)	NO143460C (hu)
PH (1)	PH13687A (hu)
PL (3)	PL99819B1 (hu)
RO (3)	RO67390A (hu)
SE (1)	SE425392B (hu)
SU (3)	SU591147A3 (hu)
ZA (1)	ZA754997B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4087532A (en) *	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
DE2716687A1 (de) *	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) *	1978-04-26	1979-10-30	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) *	1979-08-31	1981-04-09	Shin Etsu Chem Co Ltd	Production of alkenyloxy group-containing organopolysiloxane
ES2395081T3 (es)	2007-07-26	2013-02-08	Vitae Pharmaceuticals, Inc.	Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
EP2220048B1 (en)	2007-11-16	2017-01-25	Boehringer Ingelheim International GmbH	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja)	2007-12-11	2014-05-14	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2254872A2 (en)	2008-02-15	2010-12-01	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2723034A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001059A1 (es)	2008-05-01	2010-11-12	Boehringer Ingelheim Int	Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
AR071236A1 (es)	2008-05-01	2010-06-02	Vitae Pharmaceuticals Inc	Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
CL2009001151A1 (es)	2008-05-13	2010-08-13	Boehringer Ingelheim Int	Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
WO2010010157A2 (en)	2008-07-25	2010-01-28	Boehringer Ingelheim International Gmbh	INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
CN102119160B (zh)	2008-07-25	2014-11-05	贝林格尔·英格海姆国际有限公司	11β-羟基类固醇脱氢酶1的环状抑制剂
UA109255C2 (ru)	2009-04-30	2015-08-10	Берінгер Інгельхайм Інтернешнл Гмбх	Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja)	2009-06-11	2015-01-21	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh)	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja)	2010-06-16	2016-02-16	ヴァイティーファーマシューティカルズ，インコーポレイテッド	置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体
US20240002606A1 (en)	2020-11-26	2024-01-04	Shin-Etsu Chemical Co., Ltd.	Room temperature curable organopolysiloxane composition, article, hydrolyzable organosilane compound and method for producing same
JPWO2023032745A1 (hu)	2021-09-03	2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE582575A (hu) *	1958-09-22
US3700734A (en) *	1969-01-23	1972-10-24	Merck & Co Inc	2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) *	1971-02-08	1979-11-29	Boehringer Sohn Ingelheim	2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166801B2 (hu) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
DE2200596A1 (de) *	1972-01-07	1973-07-12	Boehringer Sohn Ingelheim	N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) *	1972-04-12	1981-03-12	C.H. Boehringer Sohn, 6507 Ingelheim	N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) *	1972-06-19	1974-01-31	Boehringer Sohn Ingelheim	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG031842A patent/BG25089A3/xx unknown
- 1975-08-02 BG BG030726A patent/BG25088A3/xx unknown
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
1979
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US3982005A (en)	1976-09-21
CH616421A5 (hu)	1980-03-31
AT348140B (de)	1979-01-25
IE42216L (en)	1976-02-05
ZA754997B (en)	1977-04-27
LU73138A1 (hu)	1977-04-13
SU587859A3 (ru)	1978-01-05
JPS60358B2 (ja)	1985-01-07
HU177952B (en)	1982-02-28
CS189717B2 (en)	1979-04-30
CA1049008A (en)	1979-02-20
DE2437610A1 (de)	1976-02-26
IE42216B1 (en)	1980-07-02
PH13687A (en)	1980-09-01
RO67390A (ro)	1981-06-30
AU8364675A (en)	1977-02-10
RO72736A (ro)	1982-09-09
SE425392B (sv)	1982-09-27
PL99816B1 (pl)	1978-08-31
NL7509249A (nl)	1976-02-09
CH615679A5 (hu)	1980-02-15
CH615677A5 (hu)	1980-02-15
ATA523775A (de)	1978-06-15
CH616420A5 (hu)	1980-03-31
NO143460C (no)	1981-02-18
DK352875A (da)	1976-02-06
BE832099R (fr)	1976-02-04
JPS5139673A (en)	1976-04-02
DD122685A5 (hu)	1976-10-20
NO143460B (no)	1980-11-10
NO752731L (hu)	1976-02-06
DK138992B (da)	1978-11-27
FR2320096B2 (hu)	1978-09-01
ES452764A1 (es)	1977-10-16
SU587858A3 (ru)	1978-01-05
DK138992C (da)	1979-04-30
SE7508789L (sv)	1976-02-10
BG25088A3 (en)	1978-07-12
ES452763A1 (es)	1977-10-01
FI63229C (fi)	1983-05-10
IL47860A0 (en)	1975-11-25
ES452767A1 (es)	1977-10-01
BG25090A3 (en)	1978-07-12
PL99819B1 (pl)	1978-08-31
CH615678A5 (hu)	1980-02-15
FI752211A (hu)	1976-02-06
ES452768A1 (es)	1977-10-01
ES452766A1 (es)	1977-10-01
RO72735A (ro)	1982-09-09
PL99838B1 (pl)	1978-08-31
ES452765A1 (es)	1977-10-16
GB1513950A (en)	1978-06-14
FI63229B (fi)	1983-01-31
CH615680A5 (hu)	1980-02-15
CH613963A5 (hu)	1979-10-31
FR2320096A2 (fr)	1977-03-04
BG25089A3 (en)	1978-07-12
SU591147A3 (ru)	1978-01-30

Publication	Publication Date	Title
IL47860A (en)	1979-01-31	5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them
IL53485A0 (en)	1978-01-31	2,3-dioxypiperazine derivatives
PH11423A (en)	1978-01-09	1,1-diaryl-1-oxadiazol-alkylamines
AU7742875A (en)	1976-07-22	New phenol-acetals
HK56980A (en)	1980-10-16	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
AU497120B2 (en)	1978-11-30	Polyhydroxy-alkyl-3,5-disubstituted-2, 4,6-triiodo-carbanilates
IE42364L (en)	1976-06-03	Hydroxyphenylacetonitriles.
ATA392274A (de)	1975-11-15	Einrichtung zum antrieb einer durchbiegungsausgleichwalze
ZA75254B (en)	1976-01-28	17 alpha-ethynyl (5-alpha), 2-androsten, 17 beta-ol
GB1487457A (en)	1977-09-28	5,7-dihydroxy-tetraisoquinoline derivatives
MY7900192A (en)	1979-12-31	2,3-dioxopiperazine derivatives
IL48002A0 (en)	1975-11-25	5-cyanoalkyl-1,3,4-thiadiazole-2-ylureas
ZA75954B (en)	1976-01-28	1,2,4-triazolidin-3-ones
ZA756191B (en)	1976-09-29	1,4-oxazepines
GB1516534A (en)	1978-07-05	Basically substituted 3,4-dihydro-2h-isoquinolin-1-thione
IL47507A0 (en)	1975-08-31	2,-3-dihydroestra-1,3,5(10)-trieno-(16alpha,17alpha-beta)furan-17beta-ols
NZ178880A (en)	1978-06-20	13-alkyl-d-jomogon-(4,16-or5(10),16)-dien-17 -ols
AU498671B2 (en)	1979-03-22	1-aryl-2-oxo-hexahydro-2,4,5,6,7,7a-indoles
NZ177843A (en)	1978-04-03	9-thia,-oxothia-and-dioxothia-11,12-seco-prostaglandins
IE41250B1 (en)	1979-11-21	2,2-bis-hydroxymethylalkanesulphonates
PH11939A (en)	1978-09-15	5,6-dibenzyloxy-2-aminotetralol derivatives
ZA751663B (en)	1976-02-25	N-substitute 1,2,4-triazoles
PH13018A (en)	1979-11-09	1,2,4-triazolidin-2-ones
CA1029373A (en)	1978-04-11	1,2,4-dithiaaz-3-enes
IL57740A (en)	1980-05-30	2,2-dihalovinyloxybenzaldehydes