FI63229C - Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9 beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9 beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter Download PDF

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Publication number
FI63229C
FI63229C FI752211A FI752211A FI63229C FI 63229 C FI63229 C FI 63229C FI 752211 A FI752211 A FI 752211A FI 752211 A FI752211 A FI 752211A FI 63229 C FI63229 C FI 63229C
Authority
FI
Finland
Prior art keywords
formula
compounds
dimethyl
tetrahydrofurfuryl
group
Prior art date
Application number
FI752211A
Other languages
English (en)
Finnish (fi)
Other versions
FI752211A (hu
FI63229B (fi
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI752211A publication Critical patent/FI752211A/fi
Application granted granted Critical
Publication of FI63229B publication Critical patent/FI63229B/fi
Publication of FI63229C publication Critical patent/FI63229C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI752211A 1974-08-05 1975-08-04 Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9 beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter FI63229C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
DE2437610 1974-08-05

Publications (3)

Publication Number Publication Date
FI752211A FI752211A (hu) 1976-02-06
FI63229B FI63229B (fi) 1983-01-31
FI63229C true FI63229C (fi) 1983-05-10

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
FI752211A FI63229C (fi) 1974-08-05 1975-08-04 Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9 beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter

Country Status (27)

Country Link
US (1) US3982005A (hu)
JP (1) JPS60358B2 (hu)
AT (1) AT348140B (hu)
BE (1) BE832099R (hu)
BG (3) BG25090A3 (hu)
CA (1) CA1049008A (hu)
CH (7) CH613963A5 (hu)
CS (1) CS189717B2 (hu)
DD (1) DD122685A5 (hu)
DE (1) DE2437610A1 (hu)
DK (1) DK138992C (hu)
ES (6) ES452765A1 (hu)
FI (1) FI63229C (hu)
FR (1) FR2320096A2 (hu)
GB (1) GB1513950A (hu)
HU (1) HU177952B (hu)
IE (1) IE42216B1 (hu)
IL (1) IL47860A (hu)
LU (1) LU73138A1 (hu)
NL (1) NL7509249A (hu)
NO (1) NO143460C (hu)
PH (1) PH13687A (hu)
PL (3) PL99819B1 (hu)
RO (3) RO67390A (hu)
SE (1) SE425392B (hu)
SU (3) SU591147A3 (hu)
ZA (1) ZA754997B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
ES2395081T3 (es) 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
EP2220048B1 (en) 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2254872A2 (en) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001059A1 (es) 2008-05-01 2010-11-12 Boehringer Ingelheim Int Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
CL2009001151A1 (es) 2008-05-13 2010-08-13 Boehringer Ingelheim Int Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体
US20240002606A1 (en) 2020-11-26 2024-01-04 Shin-Etsu Chemical Co., Ltd. Room temperature curable organopolysiloxane composition, article, hydrolyzable organosilane compound and method for producing same
JPWO2023032745A1 (hu) 2021-09-03 2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (hu) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166801B2 (hu) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
US3982005A (en) 1976-09-21
CH616421A5 (hu) 1980-03-31
AT348140B (de) 1979-01-25
IE42216L (en) 1976-02-05
ZA754997B (en) 1977-04-27
LU73138A1 (hu) 1977-04-13
SU587859A3 (ru) 1978-01-05
JPS60358B2 (ja) 1985-01-07
HU177952B (en) 1982-02-28
CS189717B2 (en) 1979-04-30
CA1049008A (en) 1979-02-20
DE2437610A1 (de) 1976-02-26
IE42216B1 (en) 1980-07-02
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
AU8364675A (en) 1977-02-10
RO72736A (ro) 1982-09-09
SE425392B (sv) 1982-09-27
PL99816B1 (pl) 1978-08-31
NL7509249A (nl) 1976-02-09
IL47860A (en) 1979-01-31
CH615679A5 (hu) 1980-02-15
CH615677A5 (hu) 1980-02-15
ATA523775A (de) 1978-06-15
CH616420A5 (hu) 1980-03-31
NO143460C (no) 1981-02-18
DK352875A (da) 1976-02-06
BE832099R (fr) 1976-02-04
JPS5139673A (en) 1976-04-02
DD122685A5 (hu) 1976-10-20
NO143460B (no) 1980-11-10
NO752731L (hu) 1976-02-06
DK138992B (da) 1978-11-27
FR2320096B2 (hu) 1978-09-01
ES452764A1 (es) 1977-10-16
SU587858A3 (ru) 1978-01-05
DK138992C (da) 1979-04-30
SE7508789L (sv) 1976-02-10
BG25088A3 (en) 1978-07-12
ES452763A1 (es) 1977-10-01
IL47860A0 (en) 1975-11-25
ES452767A1 (es) 1977-10-01
BG25090A3 (en) 1978-07-12
PL99819B1 (pl) 1978-08-31
CH615678A5 (hu) 1980-02-15
FI752211A (hu) 1976-02-06
ES452768A1 (es) 1977-10-01
ES452766A1 (es) 1977-10-01
RO72735A (ro) 1982-09-09
PL99838B1 (pl) 1978-08-31
ES452765A1 (es) 1977-10-16
GB1513950A (en) 1978-06-14
FI63229B (fi) 1983-01-31
CH615680A5 (hu) 1980-02-15
CH613963A5 (hu) 1979-10-31
FR2320096A2 (fr) 1977-03-04
BG25089A3 (en) 1978-07-12
SU591147A3 (ru) 1978-01-30

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Owner name: C.H. BOEHRINGER SOHN