IL33859A - S-triazolo(4,3-a)(1,4)-benzodiazepines - Google Patents

S-triazolo(4,3-a)(1,4)-benzodiazepines

Info

Publication number
IL33859A
IL33859A IL33859A IL3385970A IL33859A IL 33859 A IL33859 A IL 33859A IL 33859 A IL33859 A IL 33859A IL 3385970 A IL3385970 A IL 3385970A IL 33859 A IL33859 A IL 33859A
Authority
IL
Israel
Prior art keywords
benzodiazepine
phenyl
chloro
compound
triazolo
Prior art date
Application number
IL33859A
Other languages
English (en)
Other versions
IL33859A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123060&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL33859(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL33859A0 publication Critical patent/IL33859A0/xx
Priority to IL38810A priority Critical patent/IL38810A0/xx
Publication of IL33859A publication Critical patent/IL33859A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
IL33859A 1969-03-17 1970-02-09 S-triazolo(4,3-a)(1,4)-benzodiazepines IL33859A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL38810A IL38810A0 (en) 1970-02-09 1972-02-22 Novel benzodiazepines and their production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80793369A 1969-03-17 1969-03-17
US04/872,394 US3987052A (en) 1969-03-17 1969-10-29 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Publications (2)

Publication Number Publication Date
IL33859A0 IL33859A0 (en) 1970-04-20
IL33859A true IL33859A (en) 1973-01-30

Family

ID=27123060

Family Applications (1)

Application Number Title Priority Date Filing Date
IL33859A IL33859A (en) 1969-03-17 1970-02-09 S-triazolo(4,3-a)(1,4)-benzodiazepines

Country Status (18)

Country Link
US (1) US3987052A (de)
JP (1) JPS4940239B1 (de)
AU (2) AU490626B2 (de)
BE (1) BE747493A (de)
BR (1) BR7017488D0 (de)
CH (1) CH535788A (de)
DE (1) DE2012190C3 (de)
ES (1) ES376689A1 (de)
FR (1) FR2034999A1 (de)
GB (1) GB1291631A (de)
HK (1) HK61677A (de)
IL (1) IL33859A (de)
NL (2) NL172510C (de)
OA (1) OA03446A (de)
PH (1) PH9329A (de)
PL (1) PL80541B1 (de)
SE (1) SE387641B (de)
YU (1) YU35139B (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE779988R (fr) * 1969-03-17 1972-08-29 Upjohn Co Nouvelles 6-phenyl-4h-s-triazolo(4,3-a)(1,4)- benzodiazepines douees d'activite pharmacologique et leur procede de
BE758921A (fr) * 1969-11-15 1971-04-16 Takeda Chemical Industries Ltd Derives de benzodiazepine
BE759099A (fr) * 1969-11-18 1971-04-30 Takeda Chemical Industries Ltd Procede de fabrication de composes heterocycliques
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
DE2156472A1 (de) * 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
CH544764A (de) * 1971-01-21 1974-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3709898A (en) * 1971-02-09 1973-01-09 Upjohn Co Process for the production of triazolobenzodiazepines and intermediates
YU36376B (en) * 1971-03-03 1983-06-30 Upjohn Co Process for producing dihalo-6-phenyltriazolobenzodiazepine-5-n-oxide
DE2164777A1 (de) * 1971-03-03 1972-09-07 Upjohn Co 8-Nitro-6-(o-halogenphenyl)-l-methyl-4H-s-triazolo eckige Klammer auf 4,3-a eckige Klammer zu-eckige Klammer auf 1-4 eckige Klammer zu benzodiazepine und diese enthaltende pharmazeutische Präparate
DE2164778C2 (de) * 1971-03-03 1984-07-05 The Upjohn Co., Kalamazoo, Mich. 6-(o-Chlorphenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepin und dieses enthaltende pharmazeutische Präparat
CH545302A (de) * 1971-04-08 1974-01-13 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3759943A (en) * 1971-04-28 1973-09-18 Upjohn Co Amido and amino triazolo benzodiazepines
GB1331015A (en) * 1971-04-28 1973-09-19 Upjohn Co 1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines
US4141902A (en) 1971-04-28 1979-02-27 The Upjohn Company 1-Halomethyl-6-phenyl-4H-s-[4,3-a][1,4]benzodiazepines
US3709899A (en) 1971-04-28 1973-01-09 Upjohn Co 6-phenyl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines and their production
GB1323277A (en) * 1971-05-10 1973-07-11 Upjohn Co Triazolobenzodiazepines
US3734922A (en) * 1971-05-11 1973-05-22 Upjohn Co Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US4000289A (en) * 1971-07-08 1976-12-28 The Upjohn Company Animal feed and process
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
US3870793A (en) * 1971-08-09 1975-03-11 Upjohn Co Animal feed and process
GB1373300A (en) * 1971-09-08 1974-11-06 Upjohn Co Triazolobenzodiazepines and the manufacture thereof
US3767661A (en) * 1971-09-13 1973-10-23 Upjohn Co 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
GB1381158A (en) * 1971-09-13 1975-01-22 Upjohn Co Benzodiazepines and the manufacture thereof
US3714178A (en) * 1971-09-30 1973-01-30 Upjohn Co 6,7-DIHYDRO-7-ALKYL-5H-1,2,4-TRIAZOLO[4,3-d][1,4]BENZODIAZEPINES AND THEIR PRODUCTION
BE790838A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant
FI53821C (fi) * 1971-11-15 1978-08-10 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
FR2128552A2 (en) * 1972-03-02 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as anxiolytic agents, muscle relaxants
CH572056A5 (de) * 1972-11-28 1976-01-30 Ciba Geigy Ag
CH579083A5 (de) * 1972-12-29 1976-08-31 Ciba Geigy Ag
US4978753A (en) * 1973-01-15 1990-12-18 The Upjohn Company 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones
US4082761A (en) * 1973-09-04 1978-04-04 The Upjohn Company Triazolo[4,3-a][1,4]benzodiazepinium quaternary salts
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4455307A (en) * 1982-01-04 1984-06-19 The Upjohn Company Antihypertensive use of triazolobenzodiazepines
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
DE3332830A1 (de) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden
US4481208A (en) * 1983-06-06 1984-11-06 The Upjohn Company Treatment of panic disorders with estazolam
US4514407A (en) * 1983-03-17 1985-04-30 The Upjohn Company 1-Ethanamine-triazolo-benzodiazepines as diuretics
US4689413A (en) * 1983-03-17 1987-08-25 The Upjohn Company Triazolo-benzodiazepine-1-ethanamines as diuretics
US4474699A (en) * 1983-05-25 1984-10-02 The Upjohn Company Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4634703A (en) * 1985-10-25 1987-01-06 Bristol-Myers Company Method for alleviation of panic disorders
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
US4856303A (en) * 1988-07-21 1989-08-15 Whirlpool Corporation Agitator thrust spacer for automatic washer
US5225198A (en) * 1991-08-27 1993-07-06 Cygnus Therapeutic Systems Transdermal administration of short or intermediate half-life benzodiazepines
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
DE69420419T2 (de) * 1993-09-29 1999-12-23 Alza Corp Hautpermeabilitaetserhöher bestehend aus monoglycerid/laktat estern
ATE247967T1 (de) 1998-06-09 2003-09-15 Takeda Chemical Industries Ltd Pharmazeutische kombination mit einem trizyclischen komponent und mindestens einem aus zolpidem, zopiclone und brotizolam, zur behandlung von schlafstörungen
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
JP2005503425A (ja) * 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004104493A2 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
KR20060095765A (ko) * 2003-09-26 2006-09-01 알자 코포레이션 알프라졸람의 제어 송달용 삼투성 제형
US20050163843A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Alprazolam formulations
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
AU2004322756B2 (en) 2004-08-12 2011-04-14 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US8277840B2 (en) * 2005-07-22 2012-10-02 Emcure Pharmaceuticals Limited Sustained release formulation of alprazolam
US20070087055A1 (en) * 2005-10-14 2007-04-19 David Jan Directly compressible extended release alprazolam formulation
US20070218135A1 (en) * 2006-03-14 2007-09-20 Glenmark Pharmaceuticals Limited Sustained release matrix pharmaceutical composition
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
US8106189B2 (en) * 2007-10-03 2012-01-31 Centaur Chemicals Pvt Ltd Process for preparation of triazol-benzodiazepine derivatives
ES2403193T3 (es) 2008-02-05 2013-05-16 Laboratorios Bago S.A. Composiciones que comprenden alprazolam para el tratamiento del insomnio primario y del insomnio asociado con estados de ansiedad y procedimientos para su preparación
CA2756690C (en) 2008-03-28 2016-08-16 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
US10289671B2 (en) * 2008-05-07 2019-05-14 Microsoft Technology Licensing, Llc Graphically displaying selected data sources within a grid
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
PL3415139T3 (pl) 2011-06-14 2022-07-11 Neurelis, Inc. Podawanie benzodiazepiny
EP3535253A1 (de) 2016-11-01 2019-09-11 H. Hoffnabb-La Roche Ag 1,3-dihydro-1,4-benzodiazepin-2-thione zur behandlung von zns-bedingten erkrankungen
HRP20240106T1 (hr) 2016-12-09 2024-04-12 Alexza Pharmaceuticals, Inc. Alprazolam za uporabu u liječenju epilepsije
CN109748922B (zh) * 2019-01-15 2020-04-14 山东安信制药有限公司 一种阿普***i晶型的制备方法
BR112022018828A2 (pt) * 2020-03-31 2022-11-22 Hoffmann La Roche Derivados de benzodiazepina como gaba a gamma1 pams
EP3901155A1 (de) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG Neue benzodiazepinderivate als gaba a gamma1 pam

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US2891862A (en) * 1956-11-06 1959-06-23 Eastman Kodak Co Stabilized photographic silver halide emulsions
NL126389C (de) * 1962-07-10
US3523947A (en) * 1966-11-23 1970-08-11 Hoffmann La Roche 1-cyclic amidine-5-aryl-1,4-benzodiazepine and process

Also Published As

Publication number Publication date
CH535788A (de) 1973-04-15
NL170857B (nl) 1982-08-02
PH9329A (en) 1975-09-23
NL170857C (nl) 1983-01-03
NL172510B (nl) 1983-04-18
ES376689A1 (es) 1972-05-01
NL172510C (nl) 1983-09-16
FR2034999A1 (fr) 1970-12-18
AU8550075A (en) 1975-12-18
BR7017488D0 (pt) 1973-02-13
BE747493A (fr) 1970-09-17
YU34570A (en) 1979-04-30
DE2012190A1 (de) 1970-09-24
SE387641B (sv) 1976-09-13
AU8549975A (en) 1975-12-18
OA03446A (fr) 1971-03-30
NL8100081A (nl) 1981-04-29
DE2012190B2 (de) 1980-03-06
NL7003750A (nl) 1970-09-21
AU490626B2 (en) 1975-12-18
HK61677A (en) 1977-12-23
FR2034999B1 (de) 1973-07-13
PL80541B1 (pl) 1975-08-30
YU35139B (en) 1980-09-25
GB1291631A (en) 1972-10-04
US3987052A (en) 1976-10-19
DE2012190C3 (de) 1980-11-13
JPS4940239B1 (de) 1974-10-31
AU491139B2 (en) 1975-12-18
IL33859A0 (en) 1970-04-20

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