ATE247967T1 - Pharmazeutische kombination mit einem trizyclischen komponent und mindestens einem aus zolpidem, zopiclone und brotizolam, zur behandlung von schlafstörungen - Google Patents
Pharmazeutische kombination mit einem trizyclischen komponent und mindestens einem aus zolpidem, zopiclone und brotizolam, zur behandlung von schlafstörungenInfo
- Publication number
- ATE247967T1 ATE247967T1 AT99923960T AT99923960T ATE247967T1 AT E247967 T1 ATE247967 T1 AT E247967T1 AT 99923960 T AT99923960 T AT 99923960T AT 99923960 T AT99923960 T AT 99923960T AT E247967 T1 ATE247967 T1 AT E247967T1
- Authority
- AT
- Austria
- Prior art keywords
- brotizolam
- zopiclone
- zolpidem
- treatment
- sleep disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16027098 | 1998-06-09 | ||
PCT/JP1999/003057 WO1999063977A2 (en) | 1998-06-09 | 1999-06-08 | Pharmaceutical combination comprising a tricyclic compound and at least one of zolpidem, zopiclone, triazolam and brotizolam for treating or preventing sleep disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE247967T1 true ATE247967T1 (de) | 2003-09-15 |
Family
ID=15711379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99923960T ATE247967T1 (de) | 1998-06-09 | 1999-06-08 | Pharmazeutische kombination mit einem trizyclischen komponent und mindestens einem aus zolpidem, zopiclone und brotizolam, zur behandlung von schlafstörungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US6348485B1 (de) |
EP (1) | EP1100508B8 (de) |
KR (1) | KR100642024B1 (de) |
CN (1) | CN1206996C (de) |
AR (1) | AR019639A1 (de) |
AT (1) | ATE247967T1 (de) |
AU (1) | AU4060599A (de) |
CA (1) | CA2332521C (de) |
DE (1) | DE69910795T2 (de) |
WO (1) | WO1999063977A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2305219A1 (de) * | 2000-11-17 | 2011-04-06 | Takeda Pharmaceutical Company Limited | Pharmazeutische Präparate ummantelt mit einer kopolyvidonhaltigen Umhüllung |
IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
AU2003285012A1 (en) * | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
JP3735668B2 (ja) * | 2002-11-27 | 2006-01-18 | 独立行政法人情報通信研究機構 | 脳機能測定装置及び脳機能測定方法 |
JP2008506630A (ja) * | 2003-05-19 | 2008-03-06 | サイエンコム・リミテッド | ゾルピデムの更なる治療的使用 |
PL1691811T3 (pl) * | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
US20050215521A1 (en) * | 2003-12-22 | 2005-09-29 | Karim Lalji | Modafinil combination therapy for improving sleep quality |
WO2005063297A2 (en) * | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
KR20130116378A (ko) * | 2004-02-17 | 2013-10-23 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 |
DE602005018763D1 (de) * | 2004-02-18 | 2010-02-25 | Sepracor Inc | Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität |
EP3216445A1 (de) * | 2004-05-28 | 2017-09-13 | Imaginot Pty Ltd. | Abgabesystem für eine orale therapeutische verbindung |
US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
TWI400220B (zh) * | 2004-09-13 | 2013-07-01 | Takeda Pharmaceutical | 光活性胺衍生物的製法 |
TW200626137A (en) * | 2004-12-13 | 2006-08-01 | Takeda Pharmaceuticals Co | Preventive or therapeutic agent for sleep disorder |
GT200600042A (es) * | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
CA2602267A1 (en) * | 2005-04-04 | 2006-10-12 | Takeda Pharmaceutical Company Limited | Use of ramelteon to treat and prevent depression and anxiety disorders |
US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
JP2008542299A (ja) * | 2005-05-25 | 2008-11-27 | トランセプト・ファーマシューティカルズ・インコーポレイテッド | 真夜中不眠症の治療のための固体組成物およびその治療方法 |
KR20080027783A (ko) * | 2005-06-22 | 2008-03-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 난용성 활성 성분을 함유하는 정제 |
FR2889811B1 (fr) * | 2005-08-19 | 2009-10-09 | Sanofi Aventis Sa | Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique. |
EP3449928A1 (de) * | 2005-11-28 | 2019-03-06 | Imaginot Pty Ltd. | Abgabesystem für eine orale therapeutische verbindung |
US20090048325A1 (en) * | 2006-03-20 | 2009-02-19 | Takeda Pharmaceutical Company Limited | Prophylactic or Therapeutic Agent for Irritable Bowel Syndrome |
US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
EP2098519A1 (de) * | 2007-05-31 | 2009-09-09 | Teva Pharmaceutical Industries Ltd. | Verfahren zur Synthese von Ramelteon und seinen Zwischenprodukten |
WO2009060318A2 (en) * | 2007-07-12 | 2009-05-14 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of ramelteon and processes for preparation thereof |
US20090082432A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched ramelteon |
US20110207949A1 (en) * | 2008-11-14 | 2011-08-25 | Watson Pharma Private Limited | Process for the preparation of ramelteon |
EP2370136A4 (de) * | 2008-12-01 | 2015-12-30 | Map Pharmaceuticals Inc | Inhalative freisetzungsverfahren und vorrichtungen |
WO2010074753A1 (en) * | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
CN102648192B (zh) * | 2009-09-29 | 2015-08-26 | 广州南沙龙沙有限公司 | 1,2,6,7-四氢-8h-茚并[5,4-b] 呋喃-8-酮的制备方法 |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
CA2861111C (en) | 2012-01-26 | 2021-11-23 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
ES2805376T3 (es) | 2012-12-18 | 2021-02-11 | Vanda Pharmaceuticals Inc | Tasimelteón para el tratamiento de trastornos del ritmo circadiano |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3987052A (en) | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
OA04285A (fr) | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
AT338799B (de) | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze |
FR2600650B1 (fr) | 1986-06-27 | 1988-09-09 | Synthelabo | Procede de preparation d'imidazopyridines et composes intermediaires |
IT1251544B (it) * | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
US5786357A (en) * | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
US6034239A (en) * | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
NZ330656A (en) * | 1996-03-08 | 1999-06-29 | Takeda Chemical Industries Ltd | Tricyclic compounds, their production and use |
GB9613969D0 (en) * | 1996-07-03 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
-
1999
- 1999-06-08 WO PCT/JP1999/003057 patent/WO1999063977A2/en not_active Application Discontinuation
- 1999-06-08 DE DE69910795T patent/DE69910795T2/de not_active Expired - Lifetime
- 1999-06-08 EP EP99923960A patent/EP1100508B8/de not_active Expired - Lifetime
- 1999-06-08 US US09/700,405 patent/US6348485B1/en not_active Expired - Fee Related
- 1999-06-08 KR KR1020007013921A patent/KR100642024B1/ko not_active IP Right Cessation
- 1999-06-08 AT AT99923960T patent/ATE247967T1/de not_active IP Right Cessation
- 1999-06-08 CN CNB998071668A patent/CN1206996C/zh not_active Expired - Fee Related
- 1999-06-08 AU AU40605/99A patent/AU4060599A/en not_active Abandoned
- 1999-06-08 CA CA002332521A patent/CA2332521C/en not_active Expired - Fee Related
- 1999-06-09 AR ARP990102736A patent/AR019639A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU4060599A (en) | 1999-12-30 |
CN1309565A (zh) | 2001-08-22 |
CA2332521A1 (en) | 1999-12-16 |
DE69910795D1 (de) | 2003-10-02 |
DE69910795T2 (de) | 2004-06-17 |
WO1999063977A3 (en) | 2001-03-29 |
KR20010052676A (ko) | 2001-06-25 |
CN1206996C (zh) | 2005-06-22 |
CA2332521C (en) | 2009-02-10 |
WO1999063977A2 (en) | 1999-12-16 |
EP1100508A2 (de) | 2001-05-23 |
EP1100508B1 (de) | 2003-08-27 |
EP1100508B8 (de) | 2004-01-07 |
KR100642024B1 (ko) | 2006-11-06 |
AR019639A1 (es) | 2002-02-27 |
US6348485B1 (en) | 2002-02-19 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |