IL251441B - תולדות אימידזו פירידין ותכשירי רוקחות המכילים אותן - Google Patents
תולדות אימידזו פירידין ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL251441B IL251441B IL251441A IL25144117A IL251441B IL 251441 B IL251441 B IL 251441B IL 251441 A IL251441 A IL 251441A IL 25144117 A IL25144117 A IL 25144117A IL 251441 B IL251441 B IL 251441B
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- pyridine derivatives
- imidazo pyridine
- imidazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462060249P | 2014-10-06 | 2014-10-06 | |
PCT/US2015/054221 WO2016057500A1 (en) | 2014-10-06 | 2015-10-06 | Heteroaryl compounds as btk inhibitors and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
IL251441A0 IL251441A0 (he) | 2017-05-29 |
IL251441B true IL251441B (he) | 2020-06-30 |
Family
ID=54337891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL251441A IL251441B (he) | 2014-10-06 | 2017-03-29 | תולדות אימידזו פירידין ותכשירי רוקחות המכילים אותן |
Country Status (19)
Country | Link |
---|---|
US (2) | US10253023B2 (he) |
EP (1) | EP3204382B1 (he) |
JP (1) | JP6856526B2 (he) |
KR (1) | KR102523111B1 (he) |
CN (1) | CN107001362A (he) |
AR (1) | AR102177A1 (he) |
AU (1) | AU2015328285B2 (he) |
BR (1) | BR112017006305B1 (he) |
CA (1) | CA2960401C (he) |
CL (1) | CL2017000786A1 (he) |
ES (1) | ES2907622T3 (he) |
IL (1) | IL251441B (he) |
MX (1) | MX2017004200A (he) |
NZ (1) | NZ729603A (he) |
PH (1) | PH12017500408B1 (he) |
RU (1) | RU2742122C2 (he) |
SG (1) | SG11201701573QA (he) |
WO (1) | WO2016057500A1 (he) |
ZA (1) | ZA201701501B (he) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY179781A (en) * | 2013-12-11 | 2020-11-13 | Biogen Ma Inc | Biaryl inhibitors of bruton's tyrosine kinase |
WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
HUE060680T2 (hu) | 2015-11-19 | 2023-04-28 | Incyte Corp | Heterociklusos vegyületek mint immunmodulátorok |
SG10202005790VA (en) | 2015-12-22 | 2020-07-29 | Incyte Corp | Heterocyclic compounds as immunomodulators |
TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
CA3028685A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
CN109641892B (zh) * | 2016-08-16 | 2021-07-02 | 默克专利有限公司 | 用作可逆btk抑制剂的2-氧代-咪唑并吡啶及其用途 |
EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
TW202241895A (zh) | 2016-09-09 | 2022-11-01 | 美商英塞特公司 | 吡唑并吡啶化合物及其用途 |
US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
WO2018049152A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
JP7149276B2 (ja) | 2016-12-22 | 2022-10-06 | インサイト・コーポレイション | Pd-l1内在化誘導物質としてのテトラヒドロイミダゾ[4,5-c]ピリジン誘導体 |
AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
CN106939009A (zh) * | 2017-03-31 | 2017-07-11 | 牡丹江医学院 | 一种用于治疗脑震荡的药物及其制备方法 |
JOP20190233A1 (ar) * | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
WO2019099294A1 (en) * | 2017-11-14 | 2019-05-23 | Merck Sharp & Dohme Corp. | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
PT3755703T (pt) | 2018-02-20 | 2022-08-16 | Incyte Corp | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida e compostos relacionados como inibidores de hpk1 para o tratamento do cancro |
CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
US20190330226A1 (en) * | 2018-04-26 | 2019-10-31 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
JP7328995B2 (ja) | 2018-05-11 | 2023-08-17 | インサイト・コーポレイション | Pd-l1免疫調節剤としてのテトラヒドロ-イミダゾ[4,5-c]ピリジン誘導体 |
CN110256446B (zh) * | 2018-08-01 | 2021-12-14 | 上海海雁医药科技有限公司 | 苯并杂环取代的环戊二烯并[4,5]吡咯并吡嗪-1-酮衍生物及其应用 |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
JP2021535133A (ja) * | 2018-08-28 | 2021-12-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ブルトン型チロシンキナーゼ(btk)の可逆的阻害剤としての縮合イミダゾピリジン |
EP3856348B1 (en) | 2018-09-25 | 2024-01-03 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之鹽 |
CN114555595B (zh) * | 2019-08-30 | 2023-12-26 | Tsd生命科学有限公司 | 咪唑并吡啶衍生物及将其作为有效成分的药学组合物 |
WO2021060307A1 (ja) * | 2019-09-25 | 2021-04-01 | 富士フイルム株式会社 | イミダゾピリジン化合物またはその塩および医薬組成物 |
EP4037773A1 (en) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
WO2021092264A1 (en) * | 2019-11-05 | 2021-05-14 | Dermira, Inc. | MrgprX2 ANTAGONISTS AND USES THEREOF |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021096849A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
TW202140002A (zh) | 2020-01-20 | 2021-11-01 | 美商健臻公司 | 用於復發型多發性硬化症的治療性酪胺酸激酶抑制劑 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
AU2021222197A1 (en) | 2020-02-20 | 2022-09-08 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
CN111171065A (zh) * | 2020-02-26 | 2020-05-19 | 上海博黑生物科技有限公司 | 一种(4-(1-((叔丁氧基羰基)氨基)环丙基)苯基)硼酸酯的合成方法 |
CN111423435B (zh) * | 2020-03-30 | 2021-10-15 | 厦门大学 | (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用 |
WO2021219071A1 (en) * | 2020-04-30 | 2021-11-04 | Beigene (Beijing) Co., Ltd. | Process for preparing protac btk degraders |
PE20232044A1 (es) * | 2020-09-21 | 2023-12-27 | Hutchison Medipharma Ltd | Compuestos heterociclicos de heteroarilo y usos de los mismos |
CN116234550A (zh) * | 2020-09-23 | 2023-06-06 | 劲方医药科技(上海)有限公司 | 芳甲酰取代的三环化合物及其制法和用途 |
CN114478528A (zh) * | 2020-10-28 | 2022-05-13 | 劲方医药科技(上海)有限公司 | 芳甲酰取代的三环化合物及其制法和用途 |
US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
CA3200844A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
MX2023006854A (es) | 2020-12-10 | 2023-07-20 | Genzyme Corp | Forma cristalina de tolebrutinib, metodo de preparacion y uso de la misma. |
WO2023174300A1 (zh) * | 2022-03-15 | 2023-09-21 | 劲方医药科技(上海)有限公司 | Btk抑制剂的晶型及其酸式盐和其酸式盐的晶型 |
WO2024129395A1 (en) * | 2022-12-16 | 2024-06-20 | Gwynant Therapeutics, Inc. | Btk inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101108722B1 (ko) * | 2002-01-07 | 2012-02-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 데아자퓨린 및 이의 용도 |
AR055669A1 (es) * | 2005-10-03 | 2007-08-29 | Astrazeneca Ab | Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales. |
CN101790527A (zh) * | 2006-07-20 | 2010-07-28 | 凯利普西斯公司 | Rho激酶的苯并噻吩抑制剂 |
JP2011526931A (ja) * | 2008-07-03 | 2011-10-20 | エグゼリクシス, インコーポレイテッド | Cdkモジュレーター |
WO2010036316A1 (en) * | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
CN102884071A (zh) * | 2009-10-06 | 2013-01-16 | 塔古西库斯生物株式会社 | 新型荧光性人工碱基 |
AR086992A1 (es) * | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
CA2841111A1 (en) * | 2011-07-08 | 2013-01-17 | Novartis Ag | Novel pyrrolo pyrimidine derivatives |
WO2013157021A1 (en) * | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
IN2012CH01573A (he) * | 2012-04-20 | 2015-07-10 | Advinus Therapeutics Ltd | |
WO2014064131A2 (en) * | 2012-10-26 | 2014-05-01 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
EP3444251B1 (en) * | 2013-12-11 | 2023-06-07 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
-
2015
- 2015-10-06 US US14/876,224 patent/US10253023B2/en active Active
- 2015-10-06 CN CN201580066142.0A patent/CN107001362A/zh active Pending
- 2015-10-06 AR ARP150103209A patent/AR102177A1/es unknown
- 2015-10-06 EP EP15784212.1A patent/EP3204382B1/en active Active
- 2015-10-06 JP JP2017518323A patent/JP6856526B2/ja active Active
- 2015-10-06 NZ NZ729603A patent/NZ729603A/en unknown
- 2015-10-06 BR BR112017006305-0A patent/BR112017006305B1/pt active IP Right Grant
- 2015-10-06 KR KR1020177012190A patent/KR102523111B1/ko active IP Right Grant
- 2015-10-06 SG SG11201701573QA patent/SG11201701573QA/en unknown
- 2015-10-06 RU RU2017115852A patent/RU2742122C2/ru active
- 2015-10-06 CA CA2960401A patent/CA2960401C/en active Active
- 2015-10-06 WO PCT/US2015/054221 patent/WO2016057500A1/en active Application Filing
- 2015-10-06 AU AU2015328285A patent/AU2015328285B2/en active Active
- 2015-10-06 ES ES15784212T patent/ES2907622T3/es active Active
- 2015-10-06 MX MX2017004200A patent/MX2017004200A/es unknown
-
2017
- 2017-02-28 ZA ZA2017/01501A patent/ZA201701501B/en unknown
- 2017-03-03 PH PH12017500408A patent/PH12017500408B1/en unknown
- 2017-03-29 IL IL251441A patent/IL251441B/he active IP Right Grant
- 2017-03-31 CL CL2017000786A patent/CL2017000786A1/es unknown
-
2019
- 2019-04-08 US US16/378,383 patent/US11098041B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3204382A1 (en) | 2017-08-16 |
PH12017500408A1 (en) | 2017-07-17 |
MX2017004200A (es) | 2017-06-15 |
US11098041B2 (en) | 2021-08-24 |
RU2742122C2 (ru) | 2021-02-02 |
IL251441A0 (he) | 2017-05-29 |
CA2960401C (en) | 2022-07-26 |
EP3204382B1 (en) | 2021-12-01 |
NZ729603A (en) | 2022-02-25 |
KR20170066566A (ko) | 2017-06-14 |
US20190233417A1 (en) | 2019-08-01 |
AU2015328285A1 (en) | 2017-03-23 |
SG11201701573QA (en) | 2017-03-30 |
RU2017115852A (ru) | 2018-11-12 |
BR112017006305B1 (pt) | 2024-02-20 |
CL2017000786A1 (es) | 2017-12-29 |
BR112017006305A2 (pt) | 2017-12-12 |
WO2016057500A1 (en) | 2016-04-14 |
JP2017533897A (ja) | 2017-11-16 |
JP6856526B2 (ja) | 2021-04-07 |
PH12017500408B1 (en) | 2017-07-17 |
CA2960401A1 (en) | 2016-04-14 |
ZA201701501B (en) | 2019-06-26 |
AR102177A1 (es) | 2017-02-08 |
KR102523111B1 (ko) | 2023-04-18 |
ES2907622T3 (es) | 2022-04-25 |
CN107001362A (zh) | 2017-08-01 |
RU2017115852A3 (he) | 2019-04-19 |
AU2015328285B2 (en) | 2019-07-18 |
US10253023B2 (en) | 2019-04-09 |
US20160096834A1 (en) | 2016-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL251441B (he) | תולדות אימידזו פירידין ותכשירי רוקחות המכילים אותן | |
IL282584A (he) | תולדות קווינולין ותכשירי רוקחות המכילים אותן | |
IL258082B (he) | תולדות בנזאימידאזול ותכשירי רוקחות המכילים אותן | |
IL250158A0 (he) | תולדות נאפטירידין ואיזוקווינולין, הכנתן ותכשירי רוקחות המכילים אותן | |
IL247062A0 (he) | תרכובות הטרוציקליות הכנתן ותכשירי רוקחות המכילים אותן | |
IL256609B (he) | תולדות פירידין, הכנתן ותכשירי רוקחות המכילים אותן | |
IL253519A0 (he) | תולדות פירידאזינון מאקרוציקליות ותכשירי רוקחות המכילים אותן | |
GB201409471D0 (en) | Pharmaceutical composition | |
IL250422B (he) | תולדות פירולידינון, ותכשירי רוקחות המכילים אותן | |
IL248744A0 (he) | תולדות בוטאנאמיד הטרוציקליות, הכנתן ותרופות המכילות אותן | |
IL246630B (he) | תולדות פירימידין פיראזוליל ותכשירי רוקחות המכילים אותן | |
IL249803A0 (he) | תולדות אזאפניל ותכשירי רוקחות המכילים אותן | |
IL250267B (he) | תולדות אינדוליזין, הכנתן ותכשירי רוקחות המכילים אותן | |
GB201409488D0 (en) | Pharmaceutical composition | |
GB201409485D0 (en) | Pharmaceutical composition | |
IL249308B (he) | תולדות קווינולין , הכנתן ותכשירי רוקחות המכילים אותן | |
ZA201701066B (en) | Pyridine derivatives and anti-mycobacterial use thereof | |
IL248090A0 (he) | תכשירי רוקחות מוצקות המכילות נגזרות ביופטארין ושימושים בהם | |
EP3091983A4 (en) | Products and pharmaceutical compositions | |
ZA201703398B (en) | Pharmaceutical composition and methods | |
PT3202759T (pt) | Derivado de alfa-aminoamida e composição farmacêutica contendo o mesmo | |
HK1232211A1 (zh) | 二甲基吡啶胺衍生物及其醫藥用途 | |
ZA201607353B (en) | Bicyclic derivatives and pharmaceutical composition including the same | |
GB201400117D0 (en) | Pharmaceutical composition | |
GB2529605B (en) | Pharmaceutical composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |