IL165043A0 - broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors - Google Patents

broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Info

Publication number
IL165043A0
IL165043A0 IL16504303A IL16504303A IL165043A0 IL 165043 A0 IL165043 A0 IL 165043A0 IL 16504303 A IL16504303 A IL 16504303A IL 16504303 A IL16504303 A IL 16504303A IL 165043 A0 IL165043 A0 IL 165043A0
Authority
IL
Israel
Prior art keywords
protease inhibitors
hiv protease
substituted benzisoxazole
sulfonamide hiv
broadspectrum
Prior art date
Application number
IL16504303A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of IL165043A0 publication Critical patent/IL165043A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL16504303A 2002-05-17 2003-05-16 broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors IL165043A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076957 2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en) 2002-05-17 2003-05-16 Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
IL165043A0 true IL165043A0 (en) 2005-12-18

Family

ID=29433159

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16504303A IL165043A0 (en) 2002-05-17 2003-05-16 broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Country Status (29)

Country Link
US (1) US7462636B2 (xx)
EP (1) EP1517899B1 (xx)
JP (2) JP4674084B2 (xx)
KR (2) KR20100130234A (xx)
CN (1) CN100582097C (xx)
AP (1) AP2004003190A0 (xx)
AR (1) AR039887A1 (xx)
AT (1) ATE371652T1 (xx)
AU (1) AU2003238074B2 (xx)
BR (1) BR0310089A (xx)
CA (1) CA2485903C (xx)
CY (1) CY1107040T1 (xx)
DE (1) DE60315984T2 (xx)
DK (1) DK1517899T3 (xx)
EA (1) EA010908B1 (xx)
ES (1) ES2292976T3 (xx)
HK (1) HK1076099A1 (xx)
HR (1) HRP20050607B1 (xx)
IL (1) IL165043A0 (xx)
MX (1) MXPA04011466A (xx)
MY (1) MY135226A (xx)
NO (1) NO330184B1 (xx)
NZ (1) NZ536496A (xx)
PL (1) PL373425A1 (xx)
PT (1) PT1517899E (xx)
SI (1) SI1517899T1 (xx)
TW (1) TWI356700B (xx)
WO (1) WO2003097616A1 (xx)
ZA (1) ZA200410156B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1517899T3 (da) * 2002-05-17 2007-12-03 Tibotec Pharm Ltd Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor
AU2005222435B2 (en) * 2004-03-11 2012-03-15 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
JP5073480B2 (ja) * 2004-05-07 2012-11-14 セコイア、ファーマシューティカルズ、インコーポレイテッド 耐性防止レトロウイルスプロテアーゼ阻害薬
CA2595295C (en) 2005-02-25 2014-07-08 Tibotec Pharmaceuticals Ltd. Protease inhibitor precursor synthesis
EP2139883A4 (en) * 2007-03-23 2011-06-22 Univ Massachusetts INHIBITORS OF HIV-1 PROTEASE
EP2170289B1 (en) * 2008-03-25 2012-02-15 Formac Pharmaceuticals N.v. Preparation method for solid disupersions
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) * 2010-01-14 2011-07-21 Universitätsklinikum Jena, 07743 Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
CN104884449A (zh) 2012-10-31 2015-09-02 拜尔农作物科学股份公司 作为害虫防治剂的新的杂环化合物
JP6267239B2 (ja) * 2013-03-07 2018-01-24 ダウ グローバル テクノロジーズ エルエルシー 極めて低粘度の新規エステル化セルロースエーテル

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
ES2123065T3 (es) * 1992-08-25 1999-01-01 Searle & Co Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
BR9407686A (pt) 1993-10-01 1997-02-04 Astra Ab Processo e aparelho para o tratamento de um medicamento em pó finamente dividido uso do aparelho e aglomerados
ATE382041T1 (de) * 1995-01-20 2008-01-15 Searle Llc Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
ES2190793T3 (es) * 1995-03-10 2003-08-16 Searle & Co Inhibidores de proteasas retrovirales de heterociclocarbonil aminoacido hidroxietilamino sulfonamida.
WO1997018205A1 (en) 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
HU227745B1 (en) 1996-05-20 2012-02-28 Janssen Pharmaceutica Nv Antifungal compositions containing itraconazole
JP3608800B2 (ja) 1997-03-26 2005-01-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗真菌剤およびポリマーでコートされたコアを有するペレット剤
WO1999033792A2 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
ID25551A (id) 1997-12-24 2000-10-12 Vertex Pharma Bahan baku obat penghambat protease aspartil
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033795A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
ATE500823T1 (de) * 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
AP1459A (en) 1999-10-06 2005-08-22 Tibotec Pharm Ltd Hexahydrofuro [2,3-b] furan-3- YL-N-{3-[(1,3- benzodioxol-5- ylsufonyl) (isobutyl) amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor.
HUP0303744A3 (en) * 2001-04-09 2008-03-28 Tibotec Pharm Ltd Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors and pharmaceutical compositions containing them
DK1517899T3 (da) * 2002-05-17 2007-12-03 Tibotec Pharm Ltd Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor

Also Published As

Publication number Publication date
NZ536496A (en) 2006-06-30
KR101019648B1 (ko) 2011-03-07
DE60315984T2 (de) 2008-05-29
KR20100130234A (ko) 2010-12-10
TW200404538A (en) 2004-04-01
JP2005527607A (ja) 2005-09-15
CY1107040T1 (el) 2012-09-26
HRP20050607B1 (hr) 2014-07-04
CA2485903A1 (en) 2003-11-27
JP4674084B2 (ja) 2011-04-20
US7462636B2 (en) 2008-12-09
EA010908B1 (ru) 2008-12-30
HRP20050607A2 (en) 2006-02-28
TWI356700B (en) 2012-01-21
AP2004003190A0 (en) 2004-12-31
PL373425A1 (en) 2005-08-22
DK1517899T3 (da) 2007-12-03
ATE371652T1 (de) 2007-09-15
US20050171173A1 (en) 2005-08-04
AR039887A1 (es) 2005-03-09
ES2292976T3 (es) 2008-03-16
HK1076099A1 (en) 2006-01-06
EP1517899A1 (en) 2005-03-30
MXPA04011466A (es) 2005-02-14
JP2011051999A (ja) 2011-03-17
NO20045444L (no) 2005-02-16
AU2003238074A1 (en) 2003-12-02
EA200401524A1 (ru) 2005-06-30
SI1517899T1 (sl) 2008-02-29
CN100582097C (zh) 2010-01-20
ZA200410156B (en) 2005-11-30
DE60315984D1 (de) 2007-10-11
CA2485903C (en) 2011-08-16
NO330184B1 (no) 2011-02-28
AU2003238074B2 (en) 2009-04-30
CN1668605A (zh) 2005-09-14
EP1517899B1 (en) 2007-08-29
BR0310089A (pt) 2005-02-15
PT1517899E (pt) 2007-11-16
WO2003097616A1 (en) 2003-11-27
MY135226A (en) 2008-02-29
KR20050013549A (ko) 2005-02-04

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees