DK1517899T3 - Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor - Google Patents

Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor

Info

Publication number
DK1517899T3
DK1517899T3 DK03735707T DK03735707T DK1517899T3 DK 1517899 T3 DK1517899 T3 DK 1517899T3 DK 03735707 T DK03735707 T DK 03735707T DK 03735707 T DK03735707 T DK 03735707T DK 1517899 T3 DK1517899 T3 DK 1517899T3
Authority
DK
Denmark
Prior art keywords
protease inhibitor
broad spectrum
hiv protease
substituted benzisoxazole
sulfonamide hiv
Prior art date
Application number
DK03735707T
Other languages
English (en)
Inventor
Dominique Louis Nest Surleraux
Bernhard Joanna Bern Vergouwen
Kock Herman Augustinus De
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1517899T3 publication Critical patent/DK1517899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03735707T 2002-05-17 2003-05-16 Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor DK1517899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076957 2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en) 2002-05-17 2003-05-16 Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
DK1517899T3 true DK1517899T3 (da) 2007-12-03

Family

ID=29433159

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03735707T DK1517899T3 (da) 2002-05-17 2003-05-16 Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor

Country Status (29)

Country Link
US (1) US7462636B2 (da)
EP (1) EP1517899B1 (da)
JP (2) JP4674084B2 (da)
KR (2) KR20100130234A (da)
CN (1) CN100582097C (da)
AP (1) AP2004003190A0 (da)
AR (1) AR039887A1 (da)
AT (1) ATE371652T1 (da)
AU (1) AU2003238074B2 (da)
BR (1) BR0310089A (da)
CA (1) CA2485903C (da)
CY (1) CY1107040T1 (da)
DE (1) DE60315984T2 (da)
DK (1) DK1517899T3 (da)
EA (1) EA010908B1 (da)
ES (1) ES2292976T3 (da)
HK (1) HK1076099A1 (da)
HR (1) HRP20050607B1 (da)
IL (1) IL165043A0 (da)
MX (1) MXPA04011466A (da)
MY (1) MY135226A (da)
NO (1) NO330184B1 (da)
NZ (1) NZ536496A (da)
PL (1) PL373425A1 (da)
PT (1) PT1517899E (da)
SI (1) SI1517899T1 (da)
TW (1) TWI356700B (da)
WO (1) WO2003097616A1 (da)
ZA (1) ZA200410156B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100130234A (ko) * 2002-05-17 2010-12-10 티보텍 파마슈티컬즈 광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드 ｈｉｖ 프로테아제 저해제
WO2005087728A1 (en) * 2004-03-11 2005-09-22 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
CN1997363B (zh) * 2004-05-07 2012-03-28 塞阔伊亚药品公司 抗耐药性反转录病毒蛋白酶抑制剂
RU2421459C2 (ru) 2005-02-25 2011-06-20 Тиботек Фармасьютикалз Лтд. Синтез предшественника ингибитора протеазы
CA2681718A1 (en) * 2007-03-23 2008-10-02 University Of Massachusetts Hiv-1 protease inhibitors
EP2170289B1 (en) * 2008-03-25 2012-02-15 Formac Pharmaceuticals N.v. Preparation method for solid disupersions
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) * 2010-01-14 2011-07-21 Universitätsklinikum Jena, 07743 Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
JP2016503395A (ja) 2012-10-31 2016-02-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 病害生物防除剤としての複素環化合物
WO2014137778A1 (en) * 2013-03-07 2014-09-12 Dow Global Technologies Llc Novel esterified cellulose ethers of very low viscosity

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO1994004492A1 (en) * 1992-08-25 1994-03-03 G.D. Searle & Co. Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69415326T2 (de) 1993-08-24 1999-06-02 G.D. Searle & Co., Chicago, Ill. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
DK0721331T3 (da) 1993-10-01 2002-02-11 Astrazeneca Ab Fremgangsmåde
US6143747A (en) * 1995-01-20 2000-11-07 G. D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
NZ306027A (en) 1995-03-10 1999-03-29 Searle & Co Heterocyclecarbonyl amino acid hydroxyethylamin sulfonamide derivatives, preparation and use as retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en) 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CA2240161C (en) 1996-05-20 2005-05-24 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
ATE241969T1 (de) 1997-03-26 2003-06-15 Janssen Pharmaceutica Nv Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033795A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
IL136940A0 (en) 1997-12-24 2001-06-14 Vertex Pharma Sulphonamide derivatives and pharmaceutical compositions containing the same
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
JP4776775B2 (ja) * 1998-06-23 2011-09-21 アメリカ合衆国 Ｈｉｖ感染哺乳動物を治療するための医薬組成物
KR100792391B1 (ko) 1999-10-06 2008-01-08 티보텍 파마슈티칼즈 리미티드 레트로바이러스 프로테아제 저해제로서의헥사하이드로푸로[2,3-ｂ]푸란-3-일-Ｎ-[3-[(1,3-벤조디옥솔-5-일설포닐)(이소부틸)아미노]-1-벤질-2-하이드록시프로필]카바메이트
AU2002257774B2 (en) * 2001-04-09 2007-08-30 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
KR20100130234A (ko) * 2002-05-17 2010-12-10 티보텍 파마슈티컬즈 광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드 ｈｉｖ 프로테아제 저해제

Also Published As

Publication number Publication date
TW200404538A (en) 2004-04-01
AP2004003190A0 (en) 2004-12-31
ES2292976T3 (es) 2008-03-16
MY135226A (en) 2008-02-29
NO330184B1 (no) 2011-02-28
AR039887A1 (es) 2005-03-09
US7462636B2 (en) 2008-12-09
ZA200410156B (en) 2005-11-30
NZ536496A (en) 2006-06-30
JP2011051999A (ja) 2011-03-17
EA200401524A1 (ru) 2005-06-30
US20050171173A1 (en) 2005-08-04
KR101019648B1 (ko) 2011-03-07
AU2003238074A1 (en) 2003-12-02
CN100582097C (zh) 2010-01-20
CA2485903C (en) 2011-08-16
CA2485903A1 (en) 2003-11-27
EP1517899A1 (en) 2005-03-30
CN1668605A (zh) 2005-09-14
BR0310089A (pt) 2005-02-15
MXPA04011466A (es) 2005-02-14
SI1517899T1 (sl) 2008-02-29
DE60315984T2 (de) 2008-05-29
CY1107040T1 (el) 2012-09-26
AU2003238074B2 (en) 2009-04-30
DE60315984D1 (de) 2007-10-11
PL373425A1 (en) 2005-08-22
KR20100130234A (ko) 2010-12-10
EA010908B1 (ru) 2008-12-30
JP2005527607A (ja) 2005-09-15
NO20045444L (no) 2005-02-16
KR20050013549A (ko) 2005-02-04
TWI356700B (en) 2012-01-21
JP4674084B2 (ja) 2011-04-20
PT1517899E (pt) 2007-11-16
IL165043A0 (en) 2005-12-18
WO2003097616A1 (en) 2003-11-27
EP1517899B1 (en) 2007-08-29
HRP20050607B1 (hr) 2014-07-04
ATE371652T1 (de) 2007-09-15
HK1076099A1 (en) 2006-01-06
HRP20050607A2 (en) 2006-02-28

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