IL127216A0 - Antibodies to the ed-b domain of fibronectin their construction and uses - Google Patents
Antibodies to the ed-b domain of fibronectin their construction and usesInfo
- Publication number
- IL127216A0 IL127216A0 IL12721697A IL12721697A IL127216A0 IL 127216 A0 IL127216 A0 IL 127216A0 IL 12721697 A IL12721697 A IL 12721697A IL 12721697 A IL12721697 A IL 12721697A IL 127216 A0 IL127216 A0 IL 127216A0
- Authority
- IL
- Israel
- Prior art keywords
- fibronectin
- domain
- antibodies
- construction
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
PCT/GB1997/001412 WO1997045544A1 (fr) | 1996-05-24 | 1997-05-23 | Anticorps contre le domaine ed-b de la fibronectine, leur construction et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
IL127216A0 true IL127216A0 (en) | 1999-09-22 |
Family
ID=10794298
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12721697A IL127216A0 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin their construction and uses |
IL127216A IL127216A (en) | 1996-05-24 | 1998-11-23 | Antibody-specific antibody or fragment - Fibronectin B – ED embryos, process for their preparation and use |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL127216A IL127216A (en) | 1996-05-24 | 1998-11-23 | Antibody-specific antibody or fragment - Fibronectin B – ED embryos, process for their preparation and use |
Country Status (29)
Country | Link |
---|---|
US (3) | US7273924B1 (fr) |
EP (1) | EP0906426B1 (fr) |
JP (2) | JP4750912B2 (fr) |
KR (2) | KR20050010081A (fr) |
CN (1) | CN100447159C (fr) |
AT (1) | ATE361364T1 (fr) |
AU (1) | AU729081B2 (fr) |
BG (1) | BG65138B1 (fr) |
BR (1) | BR9709350B1 (fr) |
CA (1) | CA2256308C (fr) |
CZ (1) | CZ295531B6 (fr) |
DE (1) | DE69737683T2 (fr) |
DK (1) | DK0906426T3 (fr) |
EA (1) | EA004329B1 (fr) |
ES (1) | ES2286831T3 (fr) |
GB (1) | GB9610967D0 (fr) |
HK (1) | HK1020990A1 (fr) |
HU (1) | HUP0200546A2 (fr) |
IL (2) | IL127216A0 (fr) |
IS (1) | IS2508B (fr) |
NO (1) | NO324904B1 (fr) |
NZ (1) | NZ333083A (fr) |
PL (1) | PL188557B1 (fr) |
PT (1) | PT906426E (fr) |
SI (1) | SI0906426T1 (fr) |
SK (1) | SK285916B6 (fr) |
TR (1) | TR199802416T2 (fr) |
UA (1) | UA74129C2 (fr) |
WO (1) | WO1997045544A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
ES2373966T3 (es) * | 2000-02-24 | 2012-02-10 | Philogen S.P.A. | Composiciones y procedimientos para el tratamiento de la angiogénesis en lesiones patológicas. |
AU4243201A (en) * | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
WO2001085777A2 (fr) | 2000-05-09 | 2001-11-15 | Greenville Hospital System | Peptides therapeutiques formant des pores |
AU2001281824A1 (en) * | 2000-06-15 | 2001-12-24 | Patrizia Castellani | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
ES2312478T3 (es) * | 2000-09-07 | 2009-03-01 | Bayer Schering Pharma Aktiengesellschaft | Receptor del dominio edb de fibronectina (ii). |
IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
EP1461360B1 (fr) | 2002-01-03 | 2010-08-18 | Bayer Schering Pharma Aktiengesellschaft | Conjugues comprenant un anticorps specifique du domaine ed-b de la fibronectine et leur utilisation pour detecter et traiter les tumeurs |
EP2174958A1 (fr) * | 2002-03-11 | 2010-04-14 | Philogen S.p.A. | Anticorps dérivés de l19 dirigé contre ed-b et le ciblage de la vascularisation tumorale |
KR101257584B1 (ko) | 2002-07-15 | 2013-04-23 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도 |
BRPI0408315A (pt) | 2003-03-14 | 2006-03-07 | Wyeth Corp | anticorpo isolado, composição farmacêutica, ácido nucleico isolado, vetor de expressão, célula hospedeira, métodos de produzir um anticorpo, de gerar um anticorpo ou fragmento de ligação de antìgeno, de regular uma resposta imune, de tratar ou prevenir um distúrbio associado com célula imune em um paciente, de tratar ou prevenir um distúrbio hiperproliferativo em um paciente, e, kit de diagnóstico |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
EP1702069A2 (fr) | 2004-01-05 | 2006-09-20 | EMD Lexigen Research Center Corp. | Interleukine-12 ciblee sur la fibronectine oncofoetale |
US7943294B2 (en) | 2004-07-30 | 2011-05-17 | Hologic, Inc. | Methods for detecting oncofetal fibronectin |
US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
EP1803814A1 (fr) * | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Procédé d'amélioration la capacité de sélection d'anticorps dans une bibliothèque d'affichage de phages |
EP1925664A1 (fr) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Protéines de liaison artificielles basées sur une région modifiée de type hélice alpha de l'ubiquitine |
US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
ATE548052T1 (de) * | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
EP2100621A1 (fr) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Conjugués de dendrimère de polyol de polyéther dotés de molécules effectrices pour le ciblage biologique |
EP2116555A1 (fr) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Utilisation d'une molécule radiomarquée se liant spécifiquement à la fibronectine ED-B dans un procédé de traitement du lymphome Hodgkin |
IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
ES2441803T3 (es) | 2009-12-14 | 2014-02-06 | Scil Proteins Gmbh | Un método para identificar proteínas de ubicuitina heteromultímeras modificadas con capacidad para unirse a ligandos |
WO2011110490A1 (fr) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Procédé pour la production de fragments d'anticorps scfv marqués radioactivement, kits et compositions |
WO2012171541A1 (fr) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Protéines hybrides humaines comportant des interférons et des protéines hétérodimériques modifiées par ubiquitine |
WO2012172055A1 (fr) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Protéines liantes dimères obtenues à partir d'ubiquitines modifiées |
US20150183846A1 (en) | 2012-06-13 | 2015-07-02 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
WO2014094799A1 (fr) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Fragments d'ubiquitine en tant que moyens pour prolonger la demi-vie sérique |
EP3029065B1 (fr) * | 2013-06-06 | 2020-05-27 | Hefei Lifeon Pharmaceutical Co. Ltd. | Anticorps humains contre le domaine ed-b de la fibronectine et utilisations de ceux-ci |
DK3253785T3 (da) | 2015-02-06 | 2019-07-08 | Navigo Proteins Gmbh | Hidtil ukendte egfr-bindingsproteiner |
AU2016293063B2 (en) | 2015-07-16 | 2018-11-08 | Navigo Proteins Gmbh | Novel immunoglobulin-binding proteins and their use in affinity purification |
US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
CN108291915B (zh) * | 2015-11-16 | 2021-01-05 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
JP7181612B2 (ja) | 2016-08-11 | 2022-12-01 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルカリ安定性免疫グロブリン結合タンパク質 |
KR102338660B1 (ko) | 2016-10-17 | 2021-12-10 | 화이자 인코포레이티드 | 항-edb 항체 및 항체-약물 접합체 |
EP3634999A1 (fr) | 2017-06-07 | 2020-04-15 | Philogen S.p.A. | Protéines de fusion d'anticorps anti-facteur de croissance endothéliale vasculaire/anti-fibronectine |
EP3689903A4 (fr) | 2017-09-30 | 2022-01-12 | Hefei Lifeon Pharmaceutical Co. Ltd. | Protéine se liant au domaine de la fibronectine b |
US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
EP3660039A1 (fr) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Immunoconjugués d'il2 |
WO2020070150A1 (fr) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Immunoconjugués d'il2 |
JOP20220035A1 (ar) | 2019-08-15 | 2023-01-30 | Janssen Biotech Inc | مواد وطرق لتحسين أجزاء المتغير أحادي السلسلة |
EP4073111A1 (fr) | 2019-12-11 | 2022-10-19 | Cilag GmbH International | Molécules de liaison multispécifiques comprenant des domaines de liaison ltbr et edb et leurs utilisations |
CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
WO2023131611A1 (fr) | 2022-01-04 | 2023-07-13 | Philogen S.P.A. | Combinaison d'une immunocytokine comprenant l'il-12 et un inhibiteur de kinase |
WO2024028258A1 (fr) | 2022-08-01 | 2024-02-08 | Philochem Ag | Conjugués de fractions de liaison au psma avec des agents cytotoxiques |
WO2024052333A1 (fr) | 2022-09-06 | 2024-03-14 | Philochem Ag | Ligands multivalents de protéine d'activation des fibroblastes pour applications d'administration ciblée |
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GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
DE3689598T2 (de) | 1985-01-28 | 1994-06-30 | Xoma Corp | Arab-promoter und verfahren zur herstellung von polypeptiden einschliesslich cecropinen mittels mikrobiologischer verfahren. |
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CA1341235C (fr) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Assemblage modulaire de genes d'anticorps, anticorps prepares de cette facon, ainsi que leur usage |
JPH02598A (ja) * | 1987-10-09 | 1990-01-05 | De La Rue Co Plc:The | 集積回路カード |
ATE140731T1 (de) | 1988-01-11 | 1996-08-15 | Xoma Corp | Plasmidvektor mit pectatlyase-signalsequenz |
IT1217724B (it) * | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
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JPH0276598A (ja) * | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ed−b抗体 |
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US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
WO1994007598A1 (fr) | 1992-09-25 | 1994-04-14 | Otsuka Pharmaceutical Factory, Inc. | Adsorbant pour fibronectine cellulaire, separation et purification de fibronectine et purification du sang |
US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
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US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
WO1996023816A1 (fr) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Proteines radiomarquees |
US6140470A (en) | 1995-06-30 | 2000-10-31 | Yale University | Human monoclonal anti-tumor antibodies |
US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
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TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
ES2373966T3 (es) | 2000-02-24 | 2012-02-10 | Philogen S.P.A. | Composiciones y procedimientos para el tratamiento de la angiogénesis en lesiones patológicas. |
AU4243201A (en) | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
EP1461360B1 (fr) | 2002-01-03 | 2010-08-18 | Bayer Schering Pharma Aktiengesellschaft | Conjugues comprenant un anticorps specifique du domaine ed-b de la fibronectine et leur utilisation pour detecter et traiter les tumeurs |
JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
-
1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Application Discontinuation
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 CA CA 2256308 patent/CA2256308C/fr not_active Expired - Lifetime
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/fr active IP Right Grant
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/fr not_active Expired - Lifetime
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active IP Right Cessation
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
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- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
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1998
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- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
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1999
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2007
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2008
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2013
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