IL102856A - Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl - - Google Patents

Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl -

Info

Publication number
IL102856A
IL102856A IL10285692A IL10285692A IL102856A IL 102856 A IL102856 A IL 102856A IL 10285692 A IL10285692 A IL 10285692A IL 10285692 A IL10285692 A IL 10285692A IL 102856 A IL102856 A IL 102856A
Authority
IL
Israel
Prior art keywords
methyl
methoxy
indol
methanol
compound
Prior art date
Application number
IL10285692A
Other languages
English (en)
Hebrew (he)
Other versions
IL102856A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL102856A0 publication Critical patent/IL102856A0/xx
Publication of IL102856A publication Critical patent/IL102856A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
IL10285692A 1991-09-05 1992-08-18 Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl - IL102856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919119001A GB9119001D0 (en) 1991-09-05 1991-09-05 Pharmaceutical agents

Publications (2)

Publication Number Publication Date
IL102856A0 IL102856A0 (en) 1993-01-31
IL102856A true IL102856A (en) 1996-12-05

Family

ID=10700953

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10285692A IL102856A (en) 1991-09-05 1992-08-18 Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl -

Country Status (21)

Country Link
US (2) US5352694A (ja)
EP (1) EP0531078B1 (ja)
JP (1) JP2914414B2 (ja)
KR (1) KR100254710B1 (ja)
AT (1) ATE138910T1 (ja)
AU (1) AU646587B2 (ja)
CA (1) CA2076722A1 (ja)
CZ (1) CZ281999B6 (ja)
DE (1) DE69211258T2 (ja)
DK (1) DK0531078T3 (ja)
FI (1) FI102372B (ja)
GB (2) GB9119001D0 (ja)
HK (1) HK18297A (ja)
HU (2) HU213410B (ja)
IL (1) IL102856A (ja)
NO (1) NO178370C (ja)
NZ (1) NZ244016A (ja)
RU (1) RU2095348C1 (ja)
SK (1) SK267092A3 (ja)
TW (1) TW302359B (ja)
ZA (1) ZA926374B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958780A (en) 1997-06-30 1999-09-28 Boston Advanced Technologies, Inc. Method for marking and identifying liquids
US6149914A (en) * 1999-07-12 2000-11-21 Patel; Jitendra Rambhai Asthma treatment
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
US20080206203A1 (en) 2004-07-14 2008-08-28 Inflammation Research Center Company Ltd. Method for Inhibiting Tumor Metastasis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524152A (en) * 1982-12-30 1985-06-18 Pennwalt Corporation 1-Cyano-3-(fluoroalkyl)guanidines for lowering blood pressure
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process
IL100091A (en) * 1990-12-12 1998-08-16 Zeneca Ltd Pharmaceutical preparations containing the physical form of [4] 5) Cyclopentyloxycarbyl (amino 1 methyl indole 3 methyl methyl [3 methoxybenzoyl [2 methylbenzole)
GB9027018D0 (en) * 1990-12-12 1991-01-30 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
KR930005976A (ko) 1993-04-20
ATE138910T1 (de) 1996-06-15
JPH05194385A (ja) 1993-08-03
FI102372B1 (fi) 1998-11-30
KR100254710B1 (ko) 2000-05-01
HU9202660D0 (en) 1992-10-28
CZ281999B6 (cs) 1997-04-16
CA2076722A1 (en) 1993-03-06
HU213410B (en) 1997-06-30
EP0531078A1 (en) 1993-03-10
FI923869A0 (fi) 1992-08-28
IL102856A0 (en) 1993-01-31
HUT69696A (en) 1995-09-28
NZ244016A (en) 1995-01-27
FI923869A (fi) 1993-03-06
HU210879A9 (en) 1995-09-28
GB9119001D0 (en) 1991-10-23
DE69211258T2 (de) 1996-10-02
DK0531078T3 (da) 1996-10-14
HK18297A (en) 1997-02-13
US5466826A (en) 1995-11-14
SK279657B6 (sk) 1999-02-11
AU2101292A (en) 1993-03-11
NO178370B (no) 1995-12-04
JP2914414B2 (ja) 1999-06-28
EP0531078B1 (en) 1996-06-05
AU646587B2 (en) 1994-02-24
NO923467L (no) 1993-03-08
TW302359B (ja) 1997-04-11
GB9216774D0 (en) 1992-09-23
NO178370C (no) 1996-03-13
SK267092A3 (en) 1999-02-11
US5352694A (en) 1994-10-04
FI102372B (fi) 1998-11-30
DE69211258D1 (de) 1996-07-11
CZ267092A3 (en) 1993-03-17
NO923467D0 (no) 1992-09-04
ZA926374B (en) 1993-03-05
RU2095348C1 (ru) 1997-11-10

Similar Documents

Publication Publication Date Title
TWI518072B (zh) 塔適那偉（ａｔａｚａｎａｖｉｒ）硫酸氫鹽之製法及其新穎的形式
US5354760A (en) Crystalline Tiagabine monohydrate, its preparation and use
JP4184666B2 (ja) カベルゴリンの結晶性形態ｉを調製するための方法
US20100174085A1 (en) crystalline polymorphic forms of fexofenadine
JP2000511875A (ja) 抗糖尿病活性を増強されたトログリタゾンの新規な多形型及びそれらの製造方法
TWI499584B (zh) ４－｛３－［順－六氫環戊［ｃ］吡咯－２（１ｈ）－基］丙氧基｝苯甲醯胺鹽酸鹽之晶形及其合成方法及含彼之醫藥組合物
AU2001278094B2 (en) Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperindinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride
JP2006151977A (ja) （ｒ）−３−［［（４−フルオロフェニル）スルホニル］アミノ］−１，２，３，４−テトラヒドロ−９ｈ−カルバゾール−９−プロパン酸（ラマトロバン）の熱力学的に安定な形態の結晶の製造方法
US5466826A (en) Process for preparing a physical form of pharmaceutical agent
AU2001278094A1 (en) Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperindinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride
CA2031897C (en) Carbamoyl derivatives
JPH0762002B2 (ja) シメチジン多形体ｂの製造法
CA2056068C (en) Process
KR100228328B1 (ko) (2r)-메틸-4,4,4-트리플루오로부틸아민 또는 이것의 산부가염을 제조하는 방법
JPS58164573A (ja) １−（４−クロロベンゾイル）−５−メトキシ−２−メチル−３−インド−ルアセトキシ酢酸類の製法

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees