HUP9903666A2 - Eljárás alacsony polidiszperziós indexű hialuronsav-frakció előállítására - Google Patents

Eljárás alacsony polidiszperziós indexű hialuronsav-frakció előállítására

Info

Publication number
HUP9903666A2
HUP9903666A2 HU9903666A HUP9903666A HUP9903666A2 HU P9903666 A2 HUP9903666 A2 HU P9903666A2 HU 9903666 A HU9903666 A HU 9903666A HU P9903666 A HUP9903666 A HU P9903666A HU P9903666 A2 HUP9903666 A2 HU P9903666A2
Authority
HU
Hungary
Prior art keywords
preparing
hyaluronic acid
polydispersion index
acid fraction
low polydispersion
Prior art date
Application number
HU9903666A
Other languages
English (en)
Inventor
Lanfranco Callegaro
Davide Renier
Original Assignee
Fidia Advanced Biopolymers S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers S.R.L. filed Critical Fidia Advanced Biopolymers S.R.L.
Publication of HUP9903666A2 publication Critical patent/HUP9903666A2/hu
Publication of HUP9903666A3 publication Critical patent/HUP9903666A3/hu
Publication of HU226949B1 publication Critical patent/HU226949B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya eljárás őlyan hialűrőnsavfrakció előállítására,amelynek átlagős mőlekűlatömege 5000 és 300 000 közötti,pőlidiszperziós indexe pedig alacsőnyabb, mint 1,7. A találmányértelmében eljárva a nagy mőlekűlatömegű hialűrőnsav kiindűlásianyagőt egyidejűleg nátriűm-hipőklőrittal és űltrahanggal kezelik. ŕ
HU9903666A 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index HU226949B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95PD000244A IT1282219B1 (it) 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
PCT/EP1996/005701 WO1997022629A1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index

Publications (3)

Publication Number Publication Date
HUP9903666A2 true HUP9903666A2 (hu) 2000-03-28
HUP9903666A3 HUP9903666A3 (en) 2001-03-28
HU226949B1 HU226949B1 (en) 2010-03-29

Family

ID=11391198

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903666A HU226949B1 (en) 1995-12-20 1996-12-19 A process for preparing a hyaluronic acid fraction having a low polydispersion index

Country Status (14)

Country Link
US (2) US6020484A (hu)
EP (1) EP0868437B1 (hu)
JP (1) JP4094059B2 (hu)
AT (1) ATE184024T1 (hu)
AU (1) AU703332B2 (hu)
CZ (1) CZ291394B6 (hu)
DE (1) DE69604087T2 (hu)
DK (1) DK0868437T3 (hu)
ES (1) ES2139402T3 (hu)
GR (1) GR3031973T3 (hu)
HU (1) HU226949B1 (hu)
IL (1) IL124909A (hu)
IT (1) IT1282219B1 (hu)
WO (1) WO1997022629A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
AU2003221078A1 (en) * 2002-04-08 2003-10-20 Denki Kagaku Kogyo Kabushiki Kaisha Therapeutic composition for bone infectious disease
AU2003230321B8 (en) * 2002-05-09 2009-07-30 Medigenes A pharmaceutical composition for treatment of wounds containing blood plasma or serum
JP4879482B2 (ja) * 2002-05-17 2012-02-22 ワイス・エルエルシー 骨原性タンパク質を送達するための注入可能な固体ヒアルロン酸キャリア
WO2004004671A1 (en) * 2002-07-02 2004-01-15 Procyte Corporation Compositions containing peptide copper complexes and soft tissue fillers
US20060183709A1 (en) * 2005-02-15 2006-08-17 Ahmad Alkayali Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
WO2007099830A1 (ja) * 2006-02-24 2007-09-07 Q.P. Corporation 新規な低分子ヒアルロン酸および／またはその塩、ならびにこれを用いた化粧料、医薬組成物および食品組成物
JP2009541372A (ja) * 2006-06-28 2009-11-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 複数のヒアルロン酸画分を含む化粧用と医療用の組成物
WO2008003321A2 (en) * 2006-07-07 2008-01-10 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic use
JP2009545637A (ja) 2006-08-04 2009-12-24 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 分岐ヒアルロン酸及びその製造方法
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
AU2008322629B2 (en) * 2007-11-13 2013-05-16 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
US20130209531A1 (en) * 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
CN113512134B (zh) * 2021-07-30 2022-05-20 梅晔生物医药股份有限公司 一种全分子量分布的透明质酸钠及其制备方法和应用
JP7503278B1 (ja) 2024-02-09 2024-06-20 株式会社ブルー・スターR&D 低分子ヒアルロン酸の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
DK171029B1 (da) * 1983-10-11 1996-04-22 Fidia Spa Hyaluronsyrefraktion, fremgangsmåde til fremstilling deraf samt ophthalmiske præparater indeholdende hyaluronsyrefraktion
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8713747D0 (en) * 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) * 1989-03-20 1994-09-28 株式会社紀文食品 低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Also Published As

Publication number Publication date
WO1997022629A1 (en) 1997-06-26
ITPD950244A1 (it) 1997-06-20
EP0868437A1 (en) 1998-10-07
JP4094059B2 (ja) 2008-06-04
HUP9903666A3 (en) 2001-03-28
EP0868437B1 (en) 1999-09-01
DE69604087T2 (de) 2000-02-24
DK0868437T3 (da) 2000-03-13
CZ188998A3 (cs) 1998-09-16
CZ291394B6 (cs) 2003-02-12
GR3031973T3 (en) 2000-03-31
ES2139402T3 (es) 2000-02-01
ITPD950244A0 (hu) 1995-12-20
HU226949B1 (en) 2010-03-29
AU703332B2 (en) 1999-03-25
AU1374997A (en) 1997-07-14
US6232303B1 (en) 2001-05-15
IT1282219B1 (it) 1998-03-16
ATE184024T1 (de) 1999-09-15
IL124909A (en) 2002-09-12
JP2000502141A (ja) 2000-02-22
US6020484A (en) 2000-02-01
IL124909A0 (en) 1999-01-26
DE69604087D1 (de) 1999-10-07

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