HUP9901438A2 - Terápiás hatású pirimidinszármazékok - Google Patents

Terápiás hatású pirimidinszármazékok

Info

Publication number
HUP9901438A2
HUP9901438A2 HU9901438A HUP9901438A HUP9901438A2 HU P9901438 A2 HUP9901438 A2 HU P9901438A2 HU 9901438 A HU9901438 A HU 9901438A HU P9901438 A HUP9901438 A HU P9901438A HU P9901438 A2 HUP9901438 A2 HU P9901438A2
Authority
HU
Hungary
Prior art keywords
hydrogen atom
deoxyglucopyranosyl
oac
pipe powder
acyl
Prior art date
Application number
HU9901438A
Other languages
English (en)
Inventor
Stephen Martin Courtney
Original Assignee
Oxford Glycosciences (Uk) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512868.2A external-priority patent/GB9512868D0/en
Priority claimed from GBGB9608372.0A external-priority patent/GB9608372D0/en
Priority claimed from GBGB9608547.7A external-priority patent/GB9608547D0/en
Application filed by Oxford Glycosciences (Uk) Limited filed Critical Oxford Glycosciences (Uk) Limited
Publication of HUP9901438A2 publication Critical patent/HUP9901438A2/hu
Publication of HUP9901438A3 publication Critical patent/HUP9901438A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyületek - ahől aképletben R jelentése halőgénatőm, Y jelentése hidrőgénatőm, -NH2, -SH vagy -OH csőpőrt, X jelentése (a) általánős képletű csőpőrt, amelyben vagy R1 vagy R2 egy kötés, és a másik hidrőgénatőm, vagy R3 vagy R4 hidrőgénatőm, és a másik hidrőgénatőm, -OH, -OAc vagy -NHAcképletű csőpőrt, vagy R5 -OH csőpőrt vagy -OAc csőpőrt, vagy R7 vagy R8 hidrőgénatőm, és a másik -OH vagy -OAc csőpőrt, R9 hidrőgénatőm, -CH2OH vagy -CH2OAc csőpőrt - és enantiőmerjeik,azzal a kikötéssel, hőgy ha R4 jelentése -OH, -OAc vagy -NHAc csőpőrt, akkőr R8 jelentésehidrőgénatőm; és ha R3 jelentése hidrőgénatőm vagy hidrőxilcsőpőrt, és R4 jelentésehidrőgénatőm, és R5, R7 és R8 jelentése hidrőxilcsőpőrt, akkőr avegyület az L-enantiőmertől eltérő főrmában van; és ha R4, R5 és R7 jelentése egyaránt -OAc csőpőrt, akkőr R9 jelentése -CH2OH csőpőrttól eltérő; és a vegyületek a 2-dezőxi--D-ribőpiranőzil-bróm-5-űraciltól, a 2-dezőxi-a-D-ribőpiranőzil-1-bróm-5-űraciltól, az1-(-D-2-dezőxi-glűkőpiranőzil)-5-flűőr-űraciltól, az 1-(a-D-2-dezőxi-glűkőpiranőzil)-5-flűőr-űraciltól, az 1-(a-D-2-dezőxi-glűkőpiranőzil)-5-bróm-űraciltól, az 1-(-D-2-dezőxi-glűkőpiranőzil)-5-bróm-űraciltól,az 1-(-D-2-dezőxi-glűkőpiranőzil)-5-bróm-űraciltól, az 1-(a-D-2-dezőxi-glűkőpiranőzil)-5-jód-űraciltól és az 1-(-D-2-dezőxi-glűkőpiranőzil)-5-jód-űraciltól eltérőek. ŕ
HU9901438A 1995-06-23 1996-06-24 Therapeutic pyrimidine compounds HUP9901438A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9512868.2A GB9512868D0 (en) 1995-06-23 1995-06-23 Therapeutic compounds
GBGB9608372.0A GB9608372D0 (en) 1996-04-23 1996-04-23 Therapeutic compounds
GBGB9608547.7A GB9608547D0 (en) 1996-04-25 1996-04-25 Therapeutic compounds
US1676296P 1996-05-03 1996-05-03
US1697396P 1996-05-07 1996-05-07

Publications (2)

Publication Number Publication Date
HUP9901438A2 true HUP9901438A2 (hu) 1999-08-30
HUP9901438A3 HUP9901438A3 (en) 2000-07-28

Family

ID=27517294

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901438A HUP9901438A3 (en) 1995-06-23 1996-06-24 Therapeutic pyrimidine compounds

Country Status (16)

Country Link
US (1) US5945406A (hu)
EP (1) EP0851866B1 (hu)
JP (1) JPH11507942A (hu)
KR (1) KR19990028344A (hu)
CN (1) CN1196059A (hu)
AT (1) ATE204878T1 (hu)
AU (1) AU6234296A (hu)
CA (1) CA2225247A1 (hu)
DE (1) DE69614867T2 (hu)
ES (1) ES2162078T3 (hu)
HU (1) HUP9901438A3 (hu)
ID (1) ID16479A (hu)
IL (1) IL122700A0 (hu)
NO (1) NO976043L (hu)
PL (1) PL328266A1 (hu)
WO (1) WO1997000882A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
DE19741715A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6344460B1 (en) * 1999-03-19 2002-02-05 Lonza Inc. Propynyl uracils
US20050143300A1 (en) * 2003-10-10 2005-06-30 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
WO2010005799A2 (en) * 2008-07-11 2010-01-14 Board Of Regents, The University Of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
HUE056881T2 (hu) 2013-04-05 2022-03-28 Univ Texas Antiproliferatív hatású 2-deoxi-monoszaccharid észterek

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4248999A (en) * 1976-10-28 1981-02-03 Sankyo Company Limited 5-Fluorouracil derivatives and process for preparing thereof
DK149818C (da) * 1976-10-28 1987-04-06 Sankyo Co Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater
JPS55153796A (en) * 1979-05-21 1980-11-29 Meiji Seika Kaisha Ltd 5-fluorouracil nucleoside and its preparation
JPS5829798A (ja) * 1981-08-15 1983-02-22 Tetsuo Suami ヌクレオシド類似体
JPS5872599A (ja) * 1981-10-27 1983-04-30 Kanto Ishi Pharma Co Ltd 複合糖質誘導体
EP0119650A3 (en) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-insulin conjugates useful in treating diabetics
JP2696393B2 (ja) * 1989-05-09 1998-01-14 株式会社日本抗体研究所 チミン誘導体及びこれを含有する抗ｈｉｖ剤
JPH0517494A (ja) * 1991-07-10 1993-01-26 Nippon Shoji Kk グルコサミン誘導体
EP0788507B1 (en) * 1994-10-24 2004-12-15 Genencor International, Inc. L-pyranosyl nucleosides
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds

Also Published As

Publication number Publication date
ATE204878T1 (de) 2001-09-15
EP0851866B1 (en) 2001-08-29
NO976043L (no) 1998-02-20
JPH11507942A (ja) 1999-07-13
HUP9901438A3 (en) 2000-07-28
EP0851866A1 (en) 1998-07-08
ID16479A (id) 1997-10-02
DE69614867D1 (de) 2001-10-04
WO1997000882A1 (en) 1997-01-09
IL122700A0 (en) 1998-12-06
ES2162078T3 (es) 2001-12-16
NO976043D0 (no) 1997-12-22
US5945406A (en) 1999-08-31
AU6234296A (en) 1997-01-22
KR19990028344A (ko) 1999-04-15
CA2225247A1 (en) 1997-01-09
DE69614867T2 (de) 2002-04-11
MX9710529A (es) 1998-08-30
CN1196059A (zh) 1998-10-14
PL328266A1 (en) 1999-01-18

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